Researcher profile · Semantic Scholar

Patrick Y. Lu

h-index: 19
Works: 35
Citations: 3,397

Most-cited papers

Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle.
R. Schiffelers, A. Ansari, Jun Xu, Qin Zhou +6 more
2004Nucleic Acids Research897 citations Open access
Semantic Scholar
Oligonucleotide Aptamers: New Tools for Targeted Cancer Therapy
Hongguang Sun, Xun Zhu, Patrick Y. Lu, R. Rosato +2 more
2014Molecular Therapy: Nucleic Acids501 citations Open access
Semantic Scholar
Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque
Baojian Li, Qingquan Tang, Du Cheng, C. Qin +8 more
2005Nature Medicine440 citations Open access
Semantic Scholar
Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis.
Bumseok Kim, Q. Tang, P. Biswas, Jun Xu +7 more
2004American Journal of Pathology260 citations Open access
Semantic Scholar
Harnessing in vivo siRNA delivery for drug discovery and therapeutic development
F. Xie, M. Woodle, Patrick Y. Lu
2006Drug Discovery Today177 citations Open access
Semantic Scholar
In Vivo Application of RNA Interference: From Functional Genomics to Therapeutics
Patrick Y. Lu, F. Xie, M. Woodle
2005Advances in Genetics173 citations Open access
Semantic Scholar
Role of miR-132 in angiogenesis after ocular infection with herpes simplex virus.
S. Mulik, John J Xu, P. Reddy, N. Rajasagi +4 more
2012American Journal of Pathology116 citations Open access
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Prophylactic and Therapeutic Effects of Small Interfering Rna Targeting Sars-Coronavirus
B. Zheng, Y. Guan, Qingquan Tang, Du Cheng +9 more
2003Antiviral Therapy97 citations Open access
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Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth
Zhenwen Yan, Hua-Fei Zou, F. Tian, J. Grandis +3 more
2008Molecular Cancer Therapeutics94 citations Open access
Semantic Scholar
Safety of Adenovirus-Mediated Transfer of the Human Cystic Fibrosis Transmembrane Conductance Regulator cDNA to the Lungs of Nonhuman Primates
R. Wilmott, R. Amin, Carlos Perez, S. Wert +9 more
1996Human Gene Therapy78 citations
Semantic Scholar
Advances in Systemic siRNA Delivery
Q. Leng, M. Woodle, Patrick Y. Lu, A. Mixson
2009Drugs of the future71 citations Open access
Semantic Scholar
Modulation of angiogenesis with siRNA inhibitors for novel therapeutics
Patrick Y. Lu, F. Xie, M. Woodle
2005Trends in Molecular Medicine71 citations Open access
Semantic Scholar
siRNA-mediated antitumorigenesis for drug target validation and therapeutics.
Patrick Y. Lu, F. Xie, M. Woodle
2003Current opinion in molecular therapeutics (Print)68 citations
Semantic Scholar
Systemic delivery of HK Raf-1 siRNA polyplexes inhibits MDA-MB-435 xenografts
Q. Leng, Puthupparampil V. Scaria, Patrick Y. Lu, M. Woodle +1 more
2008Cancer Gene Therapy57 citations Open access
Semantic Scholar
Simultaneous silencing of TGF-β1 and COX-2 reduces human skin hypertrophic scar through activation of fibroblast apoptosis
Jia Zhou, Yixuan Zhao, V. Simonenko, John J Xu +13 more
2017OncoTarget55 citations Open access
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Role of miR-155 in the pathogenesis of herpetic stromal keratitis.
S. Bhela, S. Mulik, Fernanda Giménez, P. Reddy +6 more
2015American Journal of Pathology55 citations Open access
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Transporting silence: design of carriers for siRNA to angiogenic endothelium.
R. Schiffelers, A. Mixson, A. Ansari, M. Fens +8 more
2005Journal of Controlled Release41 citations Open access
Semantic Scholar
Application of siRNA Against SARS in the Rhesus Macaque Model
Qingquan Tang, Baojian Li, M. Woodle, Patrick Y. Lu
2008Methods in molecular biology36 citations Open access
Semantic Scholar
Delivering Small Interfering RNA for Novel Therapeutics
Patrick Y. Lu, M. Woodle
2008Methods in molecular biology27 citations Open access
Semantic Scholar
Nanoparticles deliver RNAi therapy
M. Woodle, Patrick Y. Lu
200519 citations Open access
Semantic Scholar
Therapy of Respiratory Viral Infections with Intranasal siRNAs
S. Barik, Patrick Y. Lu
2014Methods in molecular biology12 citations
Semantic Scholar
Effect on tumor growth by TGF-β1/COX-2 siRNA combination product (STP705) in a human cholangiocarcinoma (HuCCT-1) xenograft tumor model in nude mice.
Michael Molyneaux, John J Xu, David M. Evans, Patrick Y. Lu
2019Journal of Clinical Oncology11 citations
Semantic Scholar
Leveraging therapeutic potential of multi-targeted siRNA inhibitors.
Qing Ge, John J Xu, David M. Evans, A. Mixson +2 more
2009Future Medicinal Chemistry11 citations
Semantic Scholar
A novel siRNA–gemcitabine construct as a potential therapeutic for treatment of pancreatic cancer
V. Simonenko, Xiao-Yong Lu, E. Roesch, Daniel Mutisya +7 more
2020NAR Cancer9 citations Open access
Semantic Scholar
15580 Effect of TGF-β1/COX-2 small interfering RNA combination product (STP705) on cell viability and tumor growth in a human squamous carcinoma xenograft tumor model in nude mice
Michael Molyneaux, B. Berman, John J Xu, David M. Evans +1 more
20207 citations
Semantic Scholar
Safety and Efficacy of TGF-β1/COX-2 Silencing Therapeutic in Adults With Cutaneous Squamous Cell Carcinoma In Situ.
M. Nestor, B. Berman, Patrick Y. Lu, Michael Molyneaux
2022Journal of Drugs in Dermatology6 citations
Semantic Scholar
Pulmonary Delivery of Small Interfering RNA for Novel Therapeutics
Qing Ge, David M. Evans, John J Xu, Harry Yang +1 more
20093 citations Open access
Semantic Scholar
RNA Interference Technology: Delivering siRNA in vivo for functional genomics and novel therapeutics
Patrick Y. Lu, M. Woodle
20053 citations
Semantic Scholar
Tumor targeted delivery of siRNA.
P. Scaria, R. Schiffelers, A. Ansari, Jun Xu +6 more
20043 citations
Semantic Scholar
PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE FOR ACTIVATION OF HUMAN FIBROBLAST AND MYOFIBROBLAST APOPTOSIS
Jia Zhou, Qingfeng Li, John J Xu, Patrick Y. Lu +1 more
20180 citations
Semantic Scholar
MULTI-TARGET READY RNAi therapeutics TO ARFRI WOUND HEALING OF SKIN
Patrick Y. Lu, Ling Li, V. Simonenko
20080 citations
Semantic Scholar
Small interfering RNA targeting RHBDF1 inhibits epithelial cancer cell growth in vitro and in vivo
Zhenwen Yan, Hua-Fei Zou, F. Tian, J. Grandis +3 more
20080 citations
Semantic Scholar
Multidirigidos RNAi therapeutic for healing skin wounds without scarring
Patrick Y. Lu, Ling Li, V. Simonenko
20080 citations
Semantic Scholar
Therapeutic Delivery of RNAi
Patrick Y. Lu
20070 citations
Semantic Scholar
Preclinical Study of mAb-siRNA Combination Anti-Angiogenesis Therapy for Treatment of Colorectal Cancer
Patrick Y. Lu, Q. Tang, F. Xie, Jun Xu +4 more
20050 citations
Semantic Scholar

×6

P. Scaria×5

A. Ansari×4

Qin Zhou×3