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William H Frey II · SciRah

Researcher profile · Semantic Scholar

William H Frey II

HealthPartners Neuroscience, HealthPartners Center for Memory and Aging, University of Minnesota

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William H Frey II — researcher profile on SciRah

ORCID iD 0000-0002-6373-0794

h-index: 60
Works: 182
Citations: 15K

Most-cited papers

Intranasal delivery to the central nervous system: mechanisms and experimental considerations.
S. Dhuria, L. Hanson, William H Frey II
2010Journal of Pharmacy and Science1,205 citations
Semantic Scholar
Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration.
R. Thorne, G. Pronk, V. Padmanabhan, William H Frey II
2004Neuroscience957 citations
Semantic Scholar
Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype.
M. Reger, G. Watson, William H Frey II, L. Baker +8 more
2006Neurobiology of Aging646 citations
Semantic Scholar
Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults
M. Reger, G. S. Watson, P. Green, L. Baker +7 more
2008Journal of Alzheimer's Disease529 citations Open access
Semantic Scholar
Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence
J. Freiherr, M. Hallschmid, William H Frey II, Yvonne F. Brünner +5 more
2013CNS Drugs465 citations Open access
Semantic Scholar
Intranasal delivery of cells to the brain.
L. Danielyan, R. Schäfer, Andreas von Ameln-Mayerhofer, M. Buadze +9 more
2009European Journal of Cell Biology347 citations
Semantic Scholar
Intranasal Treatment of Central Nervous System Dysfunction in Humans
Colin D. Chapman, William H Frey II, S. Craft, L. Danielyan +3 more
2012Pharmaceutical Research300 citations Open access
Semantic Scholar
Mechanisms of mitochondrial dysfunction and energy deficiency in Alzheimer's disease.
Hani Atamna, William H Frey II
2007Mitochondrion (Amsterdam. Print)275 citations
Semantic Scholar
Therapeutic Efficacy of Intranasally Delivered Mesenchymal Stem Cells in a Rat Model of Parkinson Disease
L. Danielyan, R. Schäfer, Andreas von Ameln-Mayerhofer, F. Bernhard +15 more
2011Rejuvenation Research251 citations
Semantic Scholar
Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis.
T. M. Ross, P. M. Martinez, J. Renner, R. Thorne +2 more
2004Journal of Neuroimmunology244 citations
Semantic Scholar
Delivery of interferon-beta to the monkey nervous system following intranasal administration.
R. Thorne, L. Hanson, T. M. Ross, D. Tung +1 more
2008Neuroscience242 citations
Semantic Scholar
Intranasal Deferoxamine Provides Increased Brain Exposure and Significant Protection in Rat Ischemic Stroke
L. Hanson, Annina Roeytenberg, P. M. Martinez, V. Coppes +7 more
2009Journal of Pharmacology and Experimental Therapeutics221 citations Open access
Semantic Scholar
Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy.
G. Francis, J. Martínez, Wei Liu, Kevin Xu +7 more
2008Brain : a journal of neurology196 citations
Semantic Scholar
Chlamydophila (Chlamydia) pneumoniae in the Alzheimer's brain.
H. Gérard, U. Dreses-Werringloer, Kristin S. Wildt, Srilekha Deka +6 more
2006FEMS Immunology & Medical Microbiology188 citations Open access
Semantic Scholar
Trigeminal pathways deliver a low molecular weight drug from the nose to the brain and orofacial structures
N. J. Johnson, L. Hanson, William H Frey II
2010Molecular Pharmaceutics184 citations Open access
Semantic Scholar
Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease
Leah R. Hanson, William H Frey II
2008BMC Neuroscience183 citations Open access
Semantic Scholar
Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS
S. R. Alcala-Barraza, Michael S. Lee, L. Hanson, Abby A. McDonald +2 more
2010Journal of drug targeting (Print)170 citations Open access
Semantic Scholar
Brain Insulin Signaling and Alzheimer's Disease: Current Evidence and Future Directions
H. Schiöth, S. Craft, Samantha J. Brooks, William H Frey II +1 more
2011Molecular Neurobiology167 citations Open access
Semantic Scholar
Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease
L. Danielyan, Roman Klein, L. Hanson, M. Buadze +3 more
2010Rejuvenation Research153 citations
Semantic Scholar
Intranasal insulin as a therapeutic option in the treatment of cognitive impairments.
C. Benedict, William H Frey II, H. Schiöth, B. Schultes +2 more
2011Experimental Gerontology152 citations
Semantic Scholar
Intranasal Delivery of Bone Marrow-Derived Mesenchymal Stem Cells, Macrophages, and Microglia to the Brain in Mouse Models of Alzheimer's and Parkinson's Disease
L. Danielyan, S. Beer-Hammer, A. Stolzing, R. Schäfer +11 more
2014Cell Transplantation144 citations Open access
Semantic Scholar
New therapeutic approach for brain tumors: Intranasal delivery of telomerase inhibitor GRN163.
R. Hashizume, T. Ozawa, S. Gryaznov, A. Bollen +3 more
2008Neuro-Oncology142 citations Open access
Semantic Scholar
Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain
C. Toth, Nicole M Jedrzejewski, Connie L. Ellis, William H Frey II
2010Molecular Pain141 citations Open access
Semantic Scholar
Intranasal drug targeting of hypocretin-1 (orexin-A) to the central nervous system.
S. Dhuria, L. Hanson, William H Frey II
2009Journal of Pharmacy and Science132 citations
Semantic Scholar
Strategies for Intranasal Delivery of Therapeutics for the Prevention and Treatment of NeuroAIDS
L. Hanson, William H Frey II
2007Journal of Neuroimmune Pharmacology120 citations
Semantic Scholar
Intranasal delivery of insulin via the olfactory nerve pathway
D. Renner, Aleta L. Svitak, Nathan J. Gallus, M. Ericson +2 more
2012The Journal of pharmacy and pharmacology106 citations
Semantic Scholar
Novel Vasoconstrictor Formulation to Enhance Intranasal Targeting of Neuropeptide Therapeutics to the Central Nervous System
S. Dhuria, L. Hanson, William H Frey II
2009Journal of Pharmacology and Experimental Therapeutics103 citations
Semantic Scholar
The window of opportunity for treatment of focal cerebral ischemic damage with noninvasive intranasal insulin-like growth factor-I in rats.
Xin-Feng Liu, John R. Fawcett, L. Hanson, William H Frey II
2004Journal of Stroke & Cerebrovascular Diseases98 citations
Semantic Scholar
Intranasal Insulin Ameliorates Experimental Diabetic Neuropathy
G. Francis, J. Martínez, Wei Liu, Thuhien M. Nguyen +6 more
2009Diabetes92 citations Open access
Semantic Scholar
Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke
Nsikan Akpan, Esther Serrano-Saiz, B. Zacharia, M. Otten +10 more
2011Journal of Neuroscience89 citations Open access
Semantic Scholar
Free D- and L-amino acids in ventricular cerebrospinal fluid from Alzheimer and normal subjects
G. Fisher, N. Lorenzo, H. Abe, E. Fujita +4 more
2005Amino Acids88 citations
Semantic Scholar
Human and rodent amyloid-beta peptides differentially bind heme: relevance to the human susceptibility to Alzheimer's disease.
Hani Atamna, William H Frey II, Novie Ko
2009Archives of Biochemistry and Biophysics79 citations
Semantic Scholar
Oxytocin and Migraine Headache
A. Tzabazis, S. Kori, Jordan Mechanic, James Miller +11 more
2017Headache77 citations
Semantic Scholar
Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice
J. Fine, A. Baillargeon, D. Renner, N. Hoerster +8 more
2012Experimental Brain Research76 citations
Semantic Scholar
Intranasal insulin treatment of an experimental model of moderate traumatic brain injury
Fiona Brabazon, Colin M. Wilson, Shalini Jaiswal, John Calvin Reed +2 more
2017Journal of Cerebral Blood Flow and Metabolism66 citations Open access
Semantic Scholar
Oxytocin receptor: Expression in the trigeminal nociceptive system and potential role in the treatment of headache disorders
A. Tzabazis, Jordan Mechanic, James Miller, M. Klukinov +10 more
2016Cephalalgia64 citations
Semantic Scholar
Intranasal Adeno-Associated Virus Mediated Gene Delivery and Expression of Human Iduronidase in the Central Nervous System: A Noninvasive and Effective Approach for Prevention of Neurologic Disease in Mucopolysaccharidosis Type I
L. Belur, Alexander Temme, Kelly M. Podetz-Pedersen, M. Riedl +8 more
2017Human Gene Therapy62 citations Open access
Semantic Scholar
A Single-Dose Pilot Trial of Intranasal Rapid-Acting Insulin in Apolipoprotein E4 Carriers with Mild–Moderate Alzheimer’s Disease
M. Rosenbloom, T. Barclay, Maria Pyle, Brian Owens +4 more
2014CNS Drugs62 citations
Semantic Scholar
Intranasal delivery of siRNA to the olfactory bulbs of mice via the olfactory nerve pathway.
D. Renner, William H Frey II, L. Hanson
2012Neuroscience Letters61 citations
Semantic Scholar
Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation.
J. Fine, D. Renner, A. Forsberg, Rachel A. Cameron +6 more
2015Neuroscience Letters58 citations
Semantic Scholar
Mechanisms of Intranasal Deferoxamine in Neurodegenerative and Neurovascular Disease
Jacob Kosyakovsky, J. Fine, William H Frey II, L. Hanson
2021Pharmaceuticals56 citations Open access
Semantic Scholar
Lysosomal enzyme can bypass the blood-brain barrier and reach the CNS following intranasal administration.
D. Wolf, L. Hanson, E. Aronovich, Zhenhong Nan +3 more
2012Molecular Genetics and Metabolism56 citations
Semantic Scholar
Apoptotic Gene Expression in Alzheimer's Disease Hippocampal Tissue
Farrah D. Sajan, F. Martiniuk, D. Marcus, William H Frey II +3 more
2007American Journal of Alzheimers Disease & Other Dementias53 citations Open access
Semantic Scholar
Intranasally delivered TGF-beta1 enters brain and regulates gene expressions of its receptors in rats.
Yu-ping Ma, Min-min Ma, S. Ge, Rui-bing Guo +4 more
2007Brain Research Bulletin50 citations
Semantic Scholar
Intranasal delivery of deferoxamine reduces spatial memory loss in APP/PS1 mice
L. Hanson, J. Fine, D. Renner, Aleta L. Svitak +6 more
2012Drug Delivery and Translational Research48 citations
Semantic Scholar
Subacute Intranasal Administration of Tissue Plasminogen Activator Increases Functional Recovery and Axonal Remodeling after Stroke in Rats
Zhong-Wu Liu, Yi Li, Li Zhang, Hong-Qi Xin +4 more
2011Neurobiology of Disease48 citations Open access
Semantic Scholar
Intranasal delivery of low-dose insulin ameliorates motor dysfunction and dopaminergic cell death in a 6-OHDA rat model of Parkinson's Disease.
J. Fine, Benjamin M. Stroebel, K. A. Faltesek, K. Terai +7 more
2020Neuroscience Letters47 citations
Semantic Scholar
Intranasal administration delivers peptoids to the rat central nervous system.
T. M. Ross, R. Zuckermann, C. Reinhard, William H Frey II
2008Neuroscience Letters45 citations
Semantic Scholar
Intranasal Losartan Decreases Perivascular Beta Amyloid, Inflammation, and the Decline of Neurogenesis in Hypertensive Rats
H. Drews, Konstantin Yenkoyan, A. Lourhmati, M. Buadze +9 more
2019Neurotherapeutics43 citations Open access
Semantic Scholar
Intranasal deferoxamine affects memory loss, oxidation, and the insulin pathway in the streptozotocin rat model of Alzheimer's disease.
J. Fine, A. Forsberg, Benjamin M. Stroebel, K. A. Faltesek +9 more
2017Journal of Neurological Sciences43 citations
Semantic Scholar

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