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B. Flynn · SciRah

Researcher profile · Semantic Scholar

B. Flynn

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B. Flynn — researcher profile on SciRah

h-index: 31
Works: 126
Citations: 2,914

Most-cited papers

One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization.
B. Flynn, E. Hamel, M. Jung
2002Journal of Medicinal Chemistry212 citations Open access
Semantic Scholar
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
N. Jiménez-Vargas, Luke A. Pattison, Pei-Shen Zhao, T. Lieu +23 more
2018Proceedings of the National Academy of Sciences of the United States of America156 citations Open access
Semantic Scholar
A novel palladium-mediated coupling approach to 2,3-disubstituted benzo(b)thiophenes and its application to the synthesis of tubulin binding agents.
B. Flynn, P. Verdier-Pinard, E. Hamel
2001Organic Letters151 citations
Semantic Scholar
Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5- trimethoxybenzoyl)benzo[b]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties
B. Flynn, G. Gill, Damian Grobelny, Jason Chaplin +11 more
2011Journal of Medicinal Chemistry135 citations Open access
Semantic Scholar
Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes.
L. Aurelio, C. Valant, B. Flynn, P. Sexton +2 more
2009Journal of Medicinal Chemistry124 citations
Semantic Scholar
Iodine-induced reaction cascades for the rapid construction of variously substituted benzothiophenes.
Karl O. Hessian, B. Flynn
2003Organic Letters124 citations
Semantic Scholar
The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4.
B. Flynn, Guy P. Flynn, E. Hamel, M. Jung
2001Bioorganic & Medicinal Chemistry Letters102 citations Open access
Semantic Scholar
Selective endo and exo iodocyclizations in the synthesis of quinolines and indoles.
Karl O. Hessian, B. Flynn
2006Organic Letters90 citations Open access
Semantic Scholar
BNC105: A Novel Tubulin Polymerization Inhibitor That Selectively Disrupts Tumor Vasculature and Displays Single-Agent Antitumor Efficacy
G. Kremmidiotis, A. Leske, T. Lavranos, Donna M. Beaumont +5 more
2010Molecular Cancer Therapeutics74 citations Open access
Semantic Scholar
The concise synthesis of chalcone, indanone and indenone analogues of combretastatin A4.
Daniel J. Kerr, E. Hamel, M. Jung, B. Flynn
2007Bioorganic & Medicinal Chemistry73 citations
Semantic Scholar
From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II).
L. Aurelio, C. Scullino, M. Pitman, Anna E. Sexton +7 more
2016Journal of Medicinal Chemistry56 citations Open access
Semantic Scholar
Alternating iodonium-mediated reaction cascades giving indole- and quinoline-containing polycycles.
Rosliana Halim, P. Scammells, B. Flynn
2008Organic Letters55 citations
Semantic Scholar
Multicomponent coupling approach to (+/-)-frondosin B and a ring-expanded analogue.
Daniel J. Kerr, A. Willis, B. Flynn
2004Organic Letters54 citations
Semantic Scholar
A convenient two step protocol for the synthesis of cyclopentenones and indanones, including an asymmetric variant.
Daniel J. Kerr, Christiane Metje, B. Flynn
2003Chemical Communications53 citations
Semantic Scholar
2-Aminothienopyridazines as Novel Adenosine A1 Receptor Allosteric Modulators and Antagonists
Gemma N Ferguson, C. Valant, J. Horne, Heidi Figler +6 more
2008Journal of Medicinal Chemistry50 citations Open access
Semantic Scholar
Oxazolidinone-promoted, torquoselective Nazarov cyclizations.
Daniel J. Kerr, Michael Miletic, Jason Chaplin, Jonathan M. White +1 more
2012Organic Letters49 citations
Semantic Scholar
5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers.
L. Aurelio, Heidi Figler, B. Flynn, J. Linden +1 more
2008Bioorganic & Medicinal Chemistry44 citations
Semantic Scholar
Solid-phase synthesis of 2,3-disubstituted benzo[b]thiophenes and benzo[b]selenophenes.
C. Bui, B. Flynn
2006Journal of combinatorial chemistry43 citations
Semantic Scholar
A multi-component coupling approach to benzo[b]furans and indoles.
Jason Chaplin, B. Flynn
2001Chemical Communications43 citations
Semantic Scholar
Asymmetric synthesis of (+)- and (-)-pauciflorol F: confirmation of absolute stereochemistry.
Daniel J. Kerr, Michael Miletic, Narasimhulu Manchala, Jonathan M. White +1 more
2013Organic Letters42 citations
Semantic Scholar
Richter cyclization and co-cyclization reactions of triazene-masked diazonium ions
A. Goeminne, P. Scammells, Shane M. Devine, B. Flynn
201042 citations
Semantic Scholar
The role of dihydrosphingolipids in disease
R. Magaye, Feby Savira, Y. Hua, D. Kelly +4 more
2018Cellular and Molecular Life Sciences41 citations Open access
Semantic Scholar
An efficient synthesis and substitution of 3-aroyl-2-bromobenzo[b]furans.
G. Gill, D. Grobelny, Jason Chaplin, B. Flynn
2008Journal of Organic Chemistry41 citations Open access
Semantic Scholar
Opposing auxiliary conformations produce the same torquoselectivity in an oxazolidinone-directed Nazarov cyclization.
B. Flynn, Narasimhulu Manchala, E. Krenske
2013Journal of the American Chemical Society40 citations
Semantic Scholar
A reductive-coupling plus Nazarov cyclization sequence in the asymmetric synthesis of five-membered carbocycles.
Daniel J. Kerr, Jonathan M. White, B. Flynn
2010Journal of Organic Chemistry40 citations
Semantic Scholar
Sustained endosomal release of a neurokinin-1 receptor antagonist from nanostars provides long-lasting relief of chronic pain
R. Latorre, Paulina D. Ramírez-García, Alan Hegron, James L. Grace +14 more
2022Biomaterials36 citations Open access
Semantic Scholar
3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists
L. Aurelio, C. Valant, Heidi Figler, B. Flynn +4 more
2009Bioorganic & Medicinal Chemistry36 citations Open access
Semantic Scholar
Attenuating PI3K/Akt- mTOR pathway reduces dihydrosphingosine 1 phosphate mediated collagen synthesis and hypertrophy in primary cardiac cells.
R. Magaye, Feby Savira, Y. Hua, X. Xiong +6 more
2021International Journal of Biochemistry and Cell Biology34 citations Open access
Semantic Scholar
Synthesis of Thieno‐Fused Heterocycles through Reiterative Iodocyclization
L. Aurelio, Rohan Volpe, Rosliana Halim, P. Scammells +1 more
201431 citations
Semantic Scholar
An efficient synthesis of (+/-)-frondosin B using a Stille-Heck reaction sequence.
Kye-Simeon Masters, B. Flynn
2010Organic and biomolecular chemistry28 citations Open access
Semantic Scholar
Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3.
J. Cianci, J. Baell, B. Flynn, R. Gable +3 more
2008Bioorganic & Medicinal Chemistry Letters28 citations Open access
Semantic Scholar
From α,β‐Unsaturated Fischer Carbene Complexes to Highly Substituted 3‐Ethoxycyclopentadienes, Masked Cyclopentenones
Yao-Ting Wu, B. Flynn, H. Schirmer, Frank J. Funke +4 more
200428 citations
Semantic Scholar
Scaffold-divergent synthesis of ring-fused indoles, quinolines, and quinolones via iodonium-induced reaction cascades.
Rosliana Halim, L. Aurelio, P. Scammells, B. Flynn
2013Journal of Organic Chemistry27 citations
Semantic Scholar
Effects of conformational restriction of 2-amino-3-benzoylthiophenes on A(1) adenosine receptor modulation.
L. Aurelio, C. Valant, B. Flynn, P. Sexton +3 more
2010Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
Multistereocenter-Containing Cyclopentanoids from Ynamides via Oxazolidinone-Controlled Nazarov Cyclization.
Narasimhulu Manchala, H. Y. Law, Daniel J. Kerr, Rohan Volpe +4 more
2017Journal of Organic Chemistry25 citations
Semantic Scholar
Linear and Angular Heteroacenes from Double-Electrophilic Cyclization (DEC) and DEC-Reductive Elimination of Diynes.
Akhil Gupta, B. Flynn
2017Organic Letters25 citations Open access
Semantic Scholar
A new approach to highly substituted cyclopentanoids from a concise formal synthesis of (+)-roseophilin.
Daniel J. Kerr, B. Flynn
2012Organic Letters25 citations Open access
Semantic Scholar
The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptor.
L. Aurelio, A. Christopoulos, B. Flynn, P. Scammells +2 more
2011Bioorganic & Medicinal Chemistry Letters24 citations
Semantic Scholar
Exogenous dihydrosphingosine 1 phosphate mediates collagen synthesis in cardiac fibroblasts through JAK/STAT signalling and regulation of TIMP1.
R. Magaye, Feby Savira, Y. Hua, X. Xiong +6 more
2020Cellular Signalling22 citations Open access
Semantic Scholar
Mechanisms of Carbonyl Activation by BINOL N-Triflylphosphoramides: Enantioselective Nazarov Cyclizations
Joseph P. Lovie-Toon, C. M. Tram, B. Flynn, E. Krenske
201721 citations Open access
Semantic Scholar
Mapping the Interactions of I2 , I(.) , I(-) , and I(+) with Alkynes and Their Roles in Iodocyclizations.
Rohan Volpe, L. Aurelio, Murray G Gillin, E. Krenske +1 more
2015Chemistry19 citations
Semantic Scholar
Sphingolipid imbalance and inflammatory effects induced by uremic toxins in heart and kidney cells are reversed by dihydroceramide desaturase 1 inhibition.
Feby Savira, R. Magaye, C. Scullino, B. Flynn +11 more
2021Toxicology Letters16 citations Open access
Semantic Scholar
An enantioselective double Diels-Alder approach to the tetracyclic framework of colombiasin A.
Jason Chaplin, A. Edwards, B. Flynn
2003Organic and biomolecular chemistry16 citations
Semantic Scholar
Highly functionalized five-membered carbocycles from (3-dialkylamino-1-ethoxyalkenylidene)pentacarbonylchromium complexes and alkynes: the effects of substituents, solvents, ligand additives, and reagent concentrations on the product distribution.
B. Flynn, H. Schirmer, M. Duetsch, A. de Meijere
2001Journal of Organic Chemistry15 citations
Semantic Scholar
BNC210, a negative allosteric modulator of the alpha 7 nicotinic acetylcholine receptor, demonstrates anxiolytic- and antidepressant-like effects in rodents.
S. O'Connor, B. Sleebs, I. Street, B. Flynn +9 more
2024Neuropharmacology13 citations Open access
Semantic Scholar
Convergent Total Syntheses of the Pentacyclic Lamellarins K, T, U and W via the Addition of Azomethine Ylides to Tethered Tolans.
B. Flynn, M. Banwell
201213 citations Open access
Semantic Scholar
Asymmetric synthesis of multiple quaternary stereocentre-containing cyclopentyls by oxazolidinone-promoted Nazarov cyclizations
Rohan Volpe, Romain J. Lepage, Jonathan M. White, E. Krenske +1 more
2018Chemical Science12 citations Open access
Semantic Scholar
Electrophilic Activation of P-Alkynes in the Synthesis of P-Substituted and P-Centered Heterocycles.
Akhil Gupta, B. Flynn
2016Journal of Organic Chemistry12 citations Open access
Semantic Scholar
A concise approach to the polycyclic scaffold of frondosin D.
Kye-Simeon Masters, B. Flynn
2008Journal of Organic Chemistry12 citations
Semantic Scholar
Polyynes to Polycycles: Domino Reactions Forming Polyfused Chalcogenophenes.
Annaliese S Dillon, B. Flynn
2020Organic Letters11 citations
Semantic Scholar

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M. Jung — researcher profile on SciRah

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R. Magaye — researcher profile on SciRah