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B. Nolen · SciRah

Researcher profile · Semantic Scholar

B. Nolen

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B. Nolen — researcher profile on SciRah

h-index: 26
Works: 85
Citations: 3,861

Most-cited papers

Regulation of protein kinases; controlling activity through activation segment conformation.
B. Nolen, Susan S. Taylor, G. Ghosh
2004Molecules and Cells1,154 citations Open access
Semantic Scholar
Characterization of two classes of small molecule inhibitors of Arp2/3 complex
B. Nolen, N. Tomašević, A. Russell, D. Pierce +5 more
2009Nature541 citations Open access
Semantic Scholar
Small molecules CK-666 and CK-869 inhibit Arp2/3 complex by blocking an activating conformational change
B. Hetrick, Min-Suk Han, Luke A. Helgeson, B. Nolen
2013Chemistry and Biology336 citations Open access
Semantic Scholar
Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2.
J. Ngo, S. Chakrabarti, Jian-hua Ding, A. Velazquez-Dones +5 more
2005Molecules and Cells222 citations Open access
Semantic Scholar
Structural and biochemical characterization of two binding sites for nucleation-promoting factor WASp-VCA on Arp2/3 complex
S. Ti, C. Jurgenson, B. Nolen, T. D. Pollard
2011Proceedings of the National Academy of Sciences of the United States of America133 citations Open access
Semantic Scholar
Mechanism of synergistic activation of Arp2/3 complex by cortactin and N-WASP
Luke A. Helgeson, B. Nolen
2013eLife127 citations Open access
Semantic Scholar
Processive phosphorylation of alternative splicing factor/splicing factor 2
Brandon E. Aubol, S. Chakrabarti, J. Ngo, J. Shaffer +4 more
2003Proceedings of the National Academy of Sciences of the United States of America113 citations Open access
Semantic Scholar
Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP.
B. Nolen, R. Littlefield, T. D. Pollard
2004Proceedings of the National Academy of Sciences of the United States of America94 citations Open access
Semantic Scholar
The structure of Sky1p reveals a novel mechanism for constitutive activity
B. Nolen, Chi Y. Yun, Chung F. Wong, J. McCammon +2 more
2001Nature Structural Biology83 citations
Semantic Scholar
WISH/DIP/SPIN90 proteins form a class of Arp2/3 complex activators that function without preformed actin filaments
Andrew R. Wagner, Qing Luan, Su-Ling Liu, B. Nolen
2013Current Biology82 citations Open access
Semantic Scholar
Structural basis for regulation of Arp2/3 complex by GMF
Qing Luan, B. Nolen
2013Nature Structural &Molecular Biology73 citations Open access
Semantic Scholar
Insights into the influence of nucleotides on actin family proteins from seven structures of Arp2/3 complex.
B. Nolen, T. D. Pollard
2007Molecules and Cells73 citations Open access
Semantic Scholar
Mechanism of a Concentration-dependent Switch between Activation and Inhibition of Arp2/3 Complex by Coronin*
Su-Ling Liu, Karen Needham, J. May, B. Nolen
2011Journal of Biological Chemistry71 citations Open access
Semantic Scholar
Interactions with Actin Monomers, Actin Filaments, and Arp2/3 Complex Define the Roles of WASP Family Proteins and Cortactin in Coordinately Regulating Branched Actin Networks*
Luke A. Helgeson, Julianna G Prendergast, Andrew R. Wagner, Max Rodnick-Smith +1 more
2014Journal of Biological Chemistry59 citations Open access
Semantic Scholar
Structure of Arp2/3 complex at a branched actin filament junction resolved by single-particle cryo-electron microscopy
Bojian Ding, Heidy Y. Narvaez-Ortiz, Yuvraj Singh, Glen M. Hocky +2 more
2022Proceedings of the National Academy of Sciences of the United States of America58 citations Open access
Semantic Scholar
Role and structural mechanism of WASP-triggered conformational changes in branched actin filament nucleation by Arp2/3 complex
Max Rodnick-Smith, Qing Luan, Su-Ling Liu, B. Nolen
2016Proceedings of the National Academy of Sciences of the United States of America58 citations Open access
Semantic Scholar
Nucleotide-mediated conformational changes of monomeric actin and Arp3 studied by molecular dynamics simulations.
P. Dalhaimer, T. D. Pollard, B. Nolen
2008Journal of Molecular Biology54 citations Open access
Semantic Scholar
Cryo-EM reveals the transition of Arp2/3 complex from inactive to nucleation-competent state
Mohammed Shaaban, S. Chowdhury, B. Nolen
2020Nature Structural & Molecular Biology52 citations Open access
Semantic Scholar
Incompatibility with Formin Cdc12p Prevents Human Profilin from Substituting for Fission Yeast Profilin
O. Ezezika, N. Younger, Jia Lu, D. Kaiser +4 more
2009Journal of Biological Chemistry52 citations Open access
Semantic Scholar
Structure and Biochemical Properties of Fission Yeast Arp2/3 Complex Lacking the Arp2 Subunit*
B. Nolen, T. D. Pollard
2008Journal of Biological Chemistry42 citations Open access
Semantic Scholar
Structural Characterization and Computer-aided Optimization of a Small Molecule Inhibitor of Arp2/3 Complex, a Key Regulator of the Actin Cytoskeleton
Andrew W. Baggett, Z. Cournia, Min-Suk Han, G. Patargias +3 more
2012ChemMedChem39 citations Open access
Semantic Scholar
Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex
Max Rodnick-Smith, Su-Ling Liu, Connor J. Balzer, Qing Luan +1 more
2016Nature Communications36 citations Open access
Semantic Scholar
Identification of Wiskott-Aldrich syndrome protein (WASP) binding sites on the branched actin filament nucleator Arp2/3 complex
Qing Luan, A. Zelter, M. MacCoss, T. Davis +1 more
2018Proceedings of the National Academy of Sciences of the United States of America34 citations Open access
Semantic Scholar
Structure of the nucleation‐promoting factor SPIN90 bound to the actin filament nucleator Arp2/3 complex
Qing Luan, Su-Ling Liu, Luke A. Helgeson, B. Nolen
2018EMBO Journal31 citations Open access
Semantic Scholar
The RGG domain of Npl3p recruits Sky1p through docking interactions.
R. Lukasiewicz, B. Nolen, J. Adams, G. Ghosh
2007Journal of Molecular Biology26 citations
Semantic Scholar
Nucleotide-induced conformational changes in the Saccharomyces cerevisiae SR protein kinase, Sky1p, revealed by X-ray crystallography.
B. Nolen, J. Ngo, S. Chakrabarti, D. Vu +2 more
2003Biochemistry26 citations
Semantic Scholar
Insertions within the Actin Core of Actin-related Protein 3 (Arp3) Modulate Branching Nucleation by Arp2/3 Complex*
Su-Ling Liu, J. May, Luke A. Helgeson, B. Nolen
2012Journal of Biological Chemistry23 citations Open access
Semantic Scholar
Single turnover activation of Arp2/3 complex by Dip1 may balance nucleation of linear versus branched actin filaments
Connor J. Balzer, Andrew R. Wagner, Luke A. Helgeson, B. Nolen
2019Current Biology22 citations Open access
Semantic Scholar
Unconcerted conformational changes in Arp2/3 complex integrate multiple activating signals to assemble functional actin networks
Heidy Y. Narvaez-Ortiz, B. Nolen
2022Current Biology20 citations Open access
Semantic Scholar
Dip1 co-opts features of branching nucleation to create linear actin filaments that activate WASP-bound Arp2/3 complex
Connor J. Balzer, Andrew R. Wagner, Luke A. Helgeson, B. Nolen
2018Current Biology20 citations Open access
Semantic Scholar
Nucleotide- and activator-dependent structural and dynamic changes of Arp2/3 complex monitored by hydrogen/deuterium exchange and mass spectrometry
W. Zencheck, Hui Xiao, B. Nolen, R. Angeletti +2 more
2009Journal of Molecular Biology17 citations Open access
Semantic Scholar
Mechanistic insights into Sky1p, a yeast homologue of the mammalian SR protein kinases.
Brandon E. Aubol, B. Nolen, D. Vu, G. Ghosh +1 more
2002Biochemistry15 citations
Semantic Scholar
Improved analysis of crosslinking mass spectrometry data with Kojak 2.0, advanced by integration into the Trans-Proteomic Pipeline
M. Hoopmann, David D. Shteynberg, A. Zelter, Michael Riffle +7 more
2023Journal of Proteome Research14 citations Open access
Semantic Scholar
Synergy between Wsp1 and Dip1 may initiate assembly of endocytic actin networks
Connor J. Balzer, Michael L. James, Heidy Y. Narvaez-Ortiz, Luke A. Helgeson +2 more
2020bioRxiv13 citations Open access
Semantic Scholar
Novel destabilization of nucleotide binding by the gamma phosphate of ATP in the yeast SR protein kinase Sky1p.
Brandon E. Aubol, B. Nolen, J. Shaffer, G. Ghosh +1 more
2003Biochemistry13 citations
Semantic Scholar
The intrinsically disordered cytoplasmic tail of a dendrite branching receptor uses two distinct mechanisms to regulate the actin cytoskeleton
Daniel A. Kramer, Heidy Y. Narvaez-Ortiz, U. Patel, Rebecca Shi +4 more
2023bioRxiv7 citations Open access
Semantic Scholar
Molecular dynamics simulations support a multistep pathway for activation of branched actin filament nucleation by Arp2/3 complex
Yuvraj Singh, Glen M. Hocky, B. Nolen
2023Journal of Biological Chemistry7 citations Open access
Semantic Scholar
Activation of Arp2/3 complex by SPIN90 dimer in linear actin filament nucleation
J. Francis, A. Pathri, Kankipati Teja Shyam, Sridhar Sripada +5 more
2025Nature Structural & Molecular Biology5 citations Open access
Semantic Scholar
Analysis of functional surfaces on the actin nucleation promoting factor Dip1 required for Arp2/3 complex activation and endocytic actin network assembly
Su-Ling Liu, Heidy Y. Narvaez-Ortiz, Matthew R. Miner, J. Kiemel +6 more
2022Journal of Biological Chemistry5 citations Open access
Semantic Scholar
Small Molecules CK-666 and CK-869 Block an Activating Conformational Change to Inhibit Arp2/3 Complex
B. Hetrick, Min-Suk Han, B. Nolen
20123 citations Open access
Semantic Scholar
Arp2/3 involvement in intercellular bridge membrane fluctuations and constriction during neural stem cell divisions
Bryce LaFoya, Michelle N. Ortman, Adam Fries, B. Nolen +1 more
2026iScience2 citations Open access
Semantic Scholar
Both Las17-binding sites on Arp2/3 complex are important for branching nucleation and assembly of functional endocytic actin networks in S. cerevisiae
Heidy Y. Narvaez-Ortiz, Michael J. Lynch, Su-Ling Liu, Adam Fries +1 more
2024Journal of Biological Chemistry2 citations Open access
Semantic Scholar
Dendrite branching receptor HPO-30 uses two novel mechanisms 1 to regulate actin cytoskeletal remodeling
Daniel A. Kramer, Heidy Y. Narvaez-Ortiz, Julien Roche, B. Nolen +1 more
20222 citations
Semantic Scholar
Direct actin monomer delivery is a WASP-specific requirement for Arp2/3 complex activation
Sofia Carlson, B. Nolen
2026Journal of Molecular Biology1 citations
Semantic Scholar
Peer Review #1 of "Four tyrosine residues of the rice immune receptor XA21 are not required for interaction with the co-receptor OsSERK2 or resistance to Xanthomonas oryzae pv. oryzae (v0.2)"
D. Caddell, T. Wei, S. Saha, M. Oh +227 more
20181 citations Open access
Semantic Scholar
Structure of Arp2/3 complex with bound inhibitor CK-869
B. Nolen, M. Han
20131 citations
Semantic Scholar
Abstract 1750: The C. elegans PVD dendrite branching receptor HPO-30 regulates actin polymerization through two distinct mechanisms
Daniel A. Kramer, Heidy Y. Narvaez-Ortiz, Rebecca Shi, Kang-Li Shen +2 more
2023Journal of Biological Chemistry0 citations Open access
Semantic Scholar
Structural Perspective into Activation of Arp2-3 Complex for Nucleating Linear and Branched Actin Assemblies
Bojian Ding, Heidy Y. Narvaez-Ortiz, B. Nolen, S. Chowdhury
20210 citations Open access
Semantic Scholar
Structure of S. pombe Arp2/3 complex in inactive state
M. Shaaban, B. Nolen, S. Chowdhury
20200 citations
Semantic Scholar
Cryo-EM Reveals Actin Filament Nucleation by Activated Arp2/3 Complex
S. Chowdhury, M. Shaaban, B. Nolen
20200 citations Open access
Semantic Scholar

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