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J. Holbrook · SciRah

Researcher profile · Semantic Scholar

J. Holbrook

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J. Holbrook — researcher profile on SciRah

h-index: 42
Works: 95
Citations: 6,782

Most-cited papers

Resistin is expressed in human macrophages and directly regulated by PPARγ activators
L. Patel, Amy C. Buckels, Ian J. Kinghorn, P. Murdock +4 more
2003849 citations
Semantic Scholar
Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators.
L. Patel, Amy C Buckels, I. Kinghorn, P. Murdock +4 more
2003Biochemical and Biophysical Research Communications - BBRC519 citations
Semantic Scholar
Cohort profile: Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study.
S. Soh, M. Tint, P. Gluckman, K. Godfrey +7 more
2014International Journal of Epidemiology490 citations
Semantic Scholar
Applications of machine learning to diagnosis and treatment of neurodegenerative diseases
Monika A. Myszczynska, P. Ojamies, A. Lacoste, Daniel Neil +5 more
2020Nature Reviews Neurology467 citations
Semantic Scholar
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
N. Kato, M. Loh, F. Takeuchi, N. Verweij +240 more
2015Nature Genetics346 citations Open access
Semantic Scholar
The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes
A. Teh, Hong Pan, Li Chen, M. Ong +21 more
2014Genome Research328 citations Open access
Semantic Scholar
Dynamics of Infant Gut Microbiota Are Influenced by Delivery Mode and Gestational Duration and Are Associated with Subsequent Adiposity
S. Dogra, O. Sakwinska, S. Soh, C. Ngom-Bru +8 more
2015mBio308 citations Open access
Semantic Scholar
Human Lymphocytes Interact Directly with CD47 through a Novel Member of the Signal Regulatory Protein (SIRP) Family1
G. Brooke, J. Holbrook, Marion H. Brown, A. Barclay
2004Journal of Immunology170 citations Open access
Semantic Scholar
Comprehensive Predictive Biomarker Analysis for MEK Inhibitor GSK1120212
Junping Jing, J. Greshock, J. Holbrook, A. Gilmartin +8 more
2011Molecular Cancer Therapeutics125 citations
Semantic Scholar
The translational value of rodent gastrointestinal functions: a cautionary tale.
G. Sanger, J. Holbrook, P. Andrews
2011TIPS - Trends in Pharmacological Sciences112 citations
Semantic Scholar
Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome
Xinyi Lin, I. Lim, Yonghui Wu, A. Teh +17 more
2017BMC Medicine110 citations Open access
Semantic Scholar
Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk
A. Qiu, Mo-Jun Shen, C. Buss, Y. Chong +12 more
2017Cerebral Cortex107 citations Open access
Semantic Scholar
Rate of establishing the gut microbiota in infancy has consequences for future health
S. Dogra, O. Sakwinska, S. Soh, C. Ngom-Bru +9 more
2015Gut microbes103 citations Open access
Semantic Scholar
COMT haplotypes modulate associations of antenatal maternal anxiety and neonatal cortical morphology.
A. Qiu, T. Tuan, M. Ong, Yue Li +10 more
2015American Journal of Psychiatry99 citations
Semantic Scholar
Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine
J. Holbrook, J. Parker, Kathleen T. Gallagher, Wendy S. Halsey +4 more
2011Journal of Translational Medicine94 citations Open access
Semantic Scholar
Global DNA Hypermethylation in Down Syndrome Placenta
Shengnan Jin, Yew K. Lee, Yen-Ching Lim, Zejun Zheng +7 more
2013PLoS Genetics93 citations Open access
Semantic Scholar
The role of positive selection in determining the molecular cause of species differences in disease
J. Vamathevan, Samiul Hasan, Richard D Emes, H. Amrine-Madsen +9 more
2008BMC Evolutionary Biology93 citations Open access
Semantic Scholar
Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin.
C. Olsson, J. Holbrook, Giulia Bompadre, E. Jönsson +4 more
2008General and Comparative Endocrinology93 citations
Semantic Scholar
Parkin pathway activation mitigates glioma cell proliferation and predicts patient survival.
Calvin W. S. Yeo, F. Ng, C. Chai, Jeanne M. M. Tan +10 more
2012Cancer Research90 citations
Semantic Scholar
Maternal Smoking During Pregnancy Induces Persistent Epigenetic Changes Into Adolescence, Independent of Postnatal Smoke Exposure and Is Associated With Cardiometabolic Risk
S. Rauschert, P. Melton, G. Burdge, J. Craig +8 more
2019Frontiers in Genetics88 citations Open access
Semantic Scholar
Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood
Rae-Chi Huang, Emma S. Garratt, Hong Pan, Yonghui Wu +6 more
2015Epigenetics83 citations Open access
Semantic Scholar
Epigenetic age acceleration in adolescence associates with BMI, inflammation and risk score for middle age cardiovascular disease
Rae-Chi Huang, K. Lillycrop, L. Beilin, K. Godfrey +9 more
2019Journal of Clinical Endocrinology and Metabolism79 citations Open access
Semantic Scholar
Maternal dysglycaemia, changes in the infant’s epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial
E. Antoun, N. Kitaba, P. Titcombe, K. Dalrymple +13 more
2020PLoS Medicine78 citations Open access
Semantic Scholar
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes
Li Chen, Hong Pan, T. Tuan, A. Teh +17 more
2015Development and Psychopathology75 citations
Semantic Scholar
Novel region discovery method for Infinium 450K DNA methylation data reveals changes associated with aging in muscle and neuronal pathways
M. Ong, J. Holbrook
2013Aging Cell75 citations Open access
Semantic Scholar
ST3GAL1-Associated Transcriptomic Program in Glioblastoma Tumor Growth, Invasion, and Prognosis
Y. Chong, E. Sandanaraj, L. Koh, M. Thangaveloo +13 more
2015Journal of the National Cancer Institute74 citations Open access
Semantic Scholar
Measuring the methylome in clinical samples
Hong Pan, Li Chen, S. Dogra, Ai Ling Teh +14 more
2012Epigenetics74 citations Open access
Semantic Scholar
ANRIL Promoter DNA Methylation: A Perinatal Marker for Later Adiposity
K. Lillycrop, R. Murray, C. Cheong, A. Teh +30 more
2017EBioMedicine72 citations Open access
Semantic Scholar
The early care environment and DNA methylome variation in childhood
Elika Garg, Li Chen, Thao T. T. Nguyen, I. Pokhvisneva +17 more
2018Development and Psychopathology71 citations Open access
Semantic Scholar
Ethnic differences translate to inadequacy of high-risk screening for gestational diabetes mellitus in an Asian population: a cohort study
Y. Chong, S. Cai, H. Lin, S. Soh +13 more
2014BMC Pregnancy and Childbirth68 citations Open access
Semantic Scholar
Predicting functional decline and survival in amyotrophic lateral sclerosis
M. Ong, P. Tan, J. Holbrook
2017PLoS ONE67 citations Open access
Semantic Scholar
HIF3A association with adiposity: the story begins before birth
Hong Pan, Xinyi Lin, Yonghui Wu, Li Chen +16 more
2015Epigenomics66 citations Open access
Semantic Scholar
Immunomodulatory effects of etanercept in a model of brain injury act through attenuation of the acute‐phase response
S. Campbell, Yan-Yan Jiang, Andrew E. M. Davis, R. Farrands +3 more
2007Journal of Neurochemistry66 citations
Semantic Scholar
ACSL1 Is Associated With Fetal Programming of Insulin Sensitivity and Cellular Lipid Content.
R. Joseph, Jeremie Poschmann, R. Sukarieh, Peh Gek Too +9 more
2015Molecular Endocrinology58 citations Open access
Semantic Scholar
Proteomic identification and early validation of complement 1 inhibitor and pigment epithelium‐derived factor: Two novel biomarkers of Alzheimer's disease in human plasma
P. Cutler, Emma L. Akuffo, Wanda M. Bodnar, Deborah M. Briggs +17 more
2008PROTEOMICS - Clinical Applications57 citations
Semantic Scholar
Association of physical activity and sedentary behavior with depression and anxiety symptoms during pregnancy in a multiethnic cohort of Asian women
N. Padmapriya, J. Bernard, Shen Liang, S. Loy +68 more
2016Archives of Women's Mental Health53 citations
Semantic Scholar
Maternal prenatal anxiety and child brain-derived neurotrophic factor (BDNF) genotype: Effects on internalizing symptoms from 4 to 15 years of age
K. O’Donnell, V. Glover, J. Holbrook, T. O'Connor
2014Development and Psychopathology53 citations
Semantic Scholar
Comparison of Methyl-capture Sequencing vs. Infinium 450K methylation array for methylome analysis in clinical samples
A. Teh, Hong Pan, Xinyi Lin, Yu-Bin Lim +11 more
2016Epigenetics52 citations Open access
Semantic Scholar
Insights from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) Cohort Study
S. Soh, Y. Chong, K. Kwek, S. Saw +4 more
2014Annals of Nutrition and Metabolism52 citations
Semantic Scholar
Vitamin B12 supplementation influences methylation of genes associated with Type 2 diabetes and its intermediate traits.
D. K. Yadav, Smeeta Shrestha, K. Lillycrop, C. Joglekar +5 more
2018Epigenomics49 citations
Semantic Scholar
Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptor.
A. Calver, David Michalovich, T. Testa, M. Robbins +10 more
2003Brain Research. Molecular Brain Research46 citations
Semantic Scholar
A comparative analysis of the evolutionary relationship between diet and enzyme targeting in bats, marsupials and other mammals
G. Birdsey, J. Lewin, J. Holbrook, V. Simpson +2 more
2005Proceedings of the Royal Society of London. Biological Sciences42 citations Open access
Semantic Scholar
Is cellular heterogeneity merely a confounder to be removed from epigenome-wide association studies?
J. Holbrook, Rae-Chi Huang, S. Barton, R. Saffery +1 more
2017Epigenomics41 citations Open access
Semantic Scholar
DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up
K. O’Donnell, Li Chen, J. MacIsaac, L. McEwen +14 more
2018Translational Psychiatry39 citations Open access
Semantic Scholar
Gene, Environment and Methylation (GEM): a tool suite to efficiently navigate large scale epigenome wide association studies and integrate genotype and interaction between genotype and environment
Hong Pan, J. Holbrook, N. Karnani, C. Kwoh
2016BMC Bioinformatics39 citations Open access
Semantic Scholar
Epigenome‐wide association study of sarcopenia: findings from the Hertfordshire Sarcopenia Study (HSS)
E. Antoun, Emma S. Garratt, Andrea Taddei, M. A. Burton +18 more
2021Journal of Cachexia, Sarcopenia and Muscle37 citations Open access
Semantic Scholar
Association between perinatal methylation of the neuronal differentiation regulator HES1 and later childhood neurocognitive function and behaviour
K. Lillycrop, P. Costello, A. Teh, R. Murray +19 more
2015International Journal of Epidemiology37 citations Open access
Semantic Scholar
Perinatal DNA methylation at CDKN2A is associated with offspring bone mass: Findings from the Southampton Women’s Survey
E. Curtis, R. Murray, P. Titcombe, E. Cook +11 more
2017Journal of Bone and Mineral Research36 citations Open access
Semantic Scholar
Choice of surrogate tissue influences neonatal EWAS findings
Xinyi Lin, A. Teh, Li Chen, I. Lim +14 more
2017BMC Medicine31 citations Open access
Semantic Scholar
In Epigenomic Studies, Including Cell-Type Adjustments in Regression Models Can Introduce Multicollinearity, Resulting in Apparent Reversal of Direction of Association
S. Barton, P. Melton, P. Titcombe, R. Murray +5 more
2019Frontiers in Genetics29 citations Open access
Semantic Scholar

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