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R. Brakenhoff · SciRah

Researcher profile · Semantic Scholar

R. Brakenhoff

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R. Brakenhoff — researcher profile on SciRah

h-index: 69
Works: 376
Citations: 21K

Most-cited papers

Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis.
H. Mehanna, M. Taberna, C. von Buchwald, S. Tous +26 more
2023The Lancet Oncology254 citations Open access
Semantic Scholar
Detection and localization of early- and late-stage cancers using platelet RNA.
Sjors In 't Veld, M. Arkani, Edward Post, Mafalda Antunes-Ferreira +112 more
2022Cancer Cell128 citations Open access
Semantic Scholar
DPHL: A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery
Tian-Sheng Zhu, Y. Zhu, Yue Xuan, Huan-Huan Gao +72 more
2020Genomics, Proteomics & Bioinformatics85 citations Open access
Semantic Scholar
The unveiled reality of human papillomavirus as risk factor for oral cavity squamous cell carcinoma
I. Nauta, D. Heideman, A. Brink, Berdine van der Steen +5 more
2021International Journal of Cancer71 citations Open access
Semantic Scholar
Outcome prediction of head and neck squamous cell carcinoma by MRI radiomic signatures
Steven W. Mes, F. V. van Velden, B. Peltenburg, C. Peeters +12 more
2020European Radiology71 citations Open access
Semantic Scholar
Resection Margins in Head and Neck Cancer Surgery: An Update of Residual Disease and Field Cancerization
A. S. Pierik, C. Leemans, R. Brakenhoff
2021Cancers56 citations Open access
Semantic Scholar
Privacy-preserving distributed learning of radiomics to predict overall survival and HPV status in head and neck cancer
M. Bogowicz, A. Jochems, T. Deist, S. Tanadini-Lang +29 more
2020Scientific Reports55 citations Open access
Semantic Scholar
Targeting the cell cycle in head and neck cancer by Chk1 inhibition: a novel concept of bimodal cell death
A. V. van Harten, Marijke Buijze, R. van der Mast, M. Rooimans +6 more
2019Oncogenesis54 citations Open access
Semantic Scholar
Advancing interdisciplinary research in head and neck cancer through a multicenter longitudinal prospective cohort study: the NETherlands QUality of life and BIomedical Cohort (NET-QUBIC) data warehouse and biobank
I. V. Verdonck-de Leeuw, F. Jansen, R. Brakenhoff, J. Langendijk +5 more
2019BMC Cancer54 citations Open access
Semantic Scholar
Annual malignant transformation rate of oral leukoplakia remains consistent: A long-term follow-up study.
I. Evren, E. Brouns, L. Wils, J. Poell +4 more
2020Oral Oncology53 citations
Semantic Scholar
The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets.
J. Knol, Mengge Lyu, F. Böttger, Madalena Nunes Monteiro +44 more
2025Cancer Cell48 citations Open access
Semantic Scholar
Computed tomography-derived radiomic signature of head and neck squamous cell carcinoma (peri)tumoral tissue for the prediction of locoregional recurrence and distant metastasis after concurrent chemo-radiotherapy
S. Keek, S. Sanduleanu, F. Wesseling, R. D. de Roest +16 more
2020PLoS ONE45 citations Open access
Semantic Scholar
Elucidating the genetic landscape of oral leukoplakia to predict malignant transformation.
L. Wils, J. Poell, A. Brink, I. Evren +4 more
2022Clinical Cancer Research44 citations Open access
Semantic Scholar
Incorporation of differentiated dysplasia improves prediction of oral leukoplakia at increased risk of malignant progression
L. Wils, J. Poell, I. Evren, M. S. Koopman +4 more
2020Modern Pathology43 citations Open access
Semantic Scholar
Comprehensive multiparameter genetic analysis improves circulating tumor DNA detection in head and neck cancer patients.
Steven W. Mes, A. Brink, E. Sistermans, R. Straver +4 more
2020Oral Oncology40 citations Open access
Semantic Scholar
Unmet Needs and Perspectives in Oral Cancer Prevention
J. Bouaoud, P. Bossi, M. Elkabets, S. Schmitz +14 more
2022Cancers34 citations Open access
Semantic Scholar
Comparative analysis of immune infiltrates in head and neck cancers across anatomical sites
T. Muijlwijk, D. Nijenhuis, S. Ganzevles, A. Brink +9 more
2024Journal for ImmunoTherapy of Cancer32 citations Open access
Semantic Scholar
Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification
Peter Y. F. Zeng, M. Cecchini, J. Barrett, M. Shammas-Toma +39 more
2022EBioMedicine32 citations Open access
Semantic Scholar
Secreted protein markers in oral squamous cell carcinoma (OSCC)
M. Mumtaz, I. Bijnsdorp, F. Böttger, S. Piersma +5 more
2021Clinical Proteomics31 citations Open access
Semantic Scholar
Development of a multiomics database for personalized prognostic forecasting in head and neck cancer: The Big Data to Decide EU Project
S. Cavalieri, L. De Cecco, R. Brakenhoff, M. Serafini +23 more
2020Head and Neck30 citations Open access
Semantic Scholar
Proteome analysis of non-small cell lung cancer cell line secretomes and patient sputum reveals biofluid biomarker candidates for cisplatin response prediction.
F. Böttger, Tieneke B. M. Schaaij-Visser, Inge de Reus, S. Piersma +6 more
2019Journal of Proteomics27 citations
Semantic Scholar
Hallmarks of a genomically distinct subclass of head and neck cancer
T. Muijlwijk, I. Nauta, Anabel van der Lee, Kari J. T. Grünewald +12 more
2024Nature Communications25 citations Open access
Semantic Scholar
In Vitro CRISPR-Cas12a-Based Detection of Cancer-Associated TP53 Hotspot Mutations Beyond the crRNA Seed Region
K. Kohabir, Lars O. Nooi, A. Brink, R. Brakenhoff +2 more
2023The CRISPR Journal25 citations Open access
Semantic Scholar
Biological Determinants of Chemo-Radiotherapy Response in HPV-Negative Head and Neck Cancer: A Multicentric External Validation
M. van der Heijden, P. Essers, M. D. de Jong, R. D. de Roest +11 more
2020Frontiers in Oncology25 citations Open access
Semantic Scholar
Digital pathology-aided assessment of tumor-infiltrating T lymphocytes in advanced stage, HPV-negative head and neck tumors
E. D. de Ruiter, R. D. de Roest, R. Brakenhoff, C. Leemans +3 more
2020Cancer Immunology and Immunotherapy24 citations Open access
Semantic Scholar
Psychoneurological Symptoms and Biomarkers of Stress and Inflammation in Newly Diagnosed Head and Neck Cancer Patients: A Network Analysis
Angelina M. M. Santoso, F. Jansen, C. Peeters, R. J. Baatenburg de Jong +7 more
2022Current Oncology23 citations Open access
Semantic Scholar
Oral cancer prediction by noninvasive genetic screening
J. Poell, L. Wils, A. Brink, R. Dietrich +8 more
2022International Journal of Cancer23 citations Open access
Semantic Scholar
Study retention and attrition in a longitudinal cohort study including patient-reported outcomes, fieldwork and biobank samples: results of the Netherlands quality of life and Biomedical cohort study (NET-QUBIC) among 739 head and neck cancer patients and 262 informal caregivers
F. Jansen, R. Brakenhoff, R. J. Baatenburg de Jong, J. Langendijk +5 more
2022BMC Medical Research Methodology23 citations Open access
Semantic Scholar
The course of health-related quality of life from diagnosis to two years follow-up in patients with oropharyngeal cancer: does HPV status matter?
Laura H. A. Korsten, F. Jansen, B. Lissenberg-Witte, M. Vergeer +3 more
2021Supportive Care in Cancer23 citations Open access
Semantic Scholar
MRI-based radiomic prognostic signature for locally advanced oral cavity squamous cell carcinoma: development, testing and comparison with genomic prognostic signatures
Anna Corti, L. De Cecco, S. Cavalieri, Deborah Lenoci +11 more
2023Biomarker Research22 citations Open access
Semantic Scholar
Associations between clinical and histopathological characteristics in oral leukoplakia
I. Evren, E. Brouns, J. Poell, L. Wils +3 more
2021Oral Diseases22 citations Open access
Semantic Scholar
Disease outcome and associated factors after definitive platinum based chemoradiotherapy for advanced stage HPV-negative head and neck cancer.
R. D. de Roest, M. van der Heijden, F. Wesseling, E. D. de Ruiter +13 more
2022Radiotherapy and Oncology21 citations Open access
Semantic Scholar
A Prospectively Validated Prognostic Model for Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck Based on Radiomics of Computed Tomography Images
S. Keek, F. Wesseling, H. Woodruff, J. E. van Timmeren +16 more
2021Cancers21 citations Open access
Semantic Scholar
Molecular Characterization of Locally Relapsed Head and Neck Cancer after Concomitant Chemoradiotherapy
R. D. de Roest, Steven W. Mes, J. Poell, A. Brink +6 more
2019Clinical Cancer Research21 citations
Semantic Scholar
Clinical Validity of a Prognostic Gene Expression Cluster-Based Model in Human Papillomavirus–Positive Oropharyngeal Carcinoma
S. Cavalieri, M. Serafini, Andrea Carenzo, S. Canevari +13 more
2021JCO Precision Oncology20 citations Open access
Semantic Scholar
The role of differentiated dysplasia in the prediction of malignant transformation of oral leukoplakia.
L. Wils, J. Poell, L. Peferoen, I. Evren +5 more
2023Journal of Oral Pathology & Medicine18 citations Open access
Semantic Scholar
Oral Leukoplakia Classification and Staging System with Incorporation of Differentiated Dysplasia.
E. Brouns, I. Evren, L. Wils, J. Poell +3 more
2022Oral Diseases18 citations Open access
Semantic Scholar
Epithelial-to-mesenchymal transition is a prognostic marker for patient outcome in advanced stage HNSCC patients treated with chemoradiotherapy.
M. van der Heijden, P. Essers, C. Verhagen, S. Willems +8 more
2020Radiotherapy and Oncology18 citations Open access
Semantic Scholar
Targeted Treatment of Head and Neck (Pre)Cancer: Preclinical Target Identification and Development of Novel Therapeutic Applications
A. V. van Harten, R. Brakenhoff
2021Cancers17 citations Open access
Semantic Scholar
TNM 8 staging system beyond p16: Double HPV/p16 status is superior to p16 alone in predicting outcome in oropharyngeal squamous cell carcinoma.
C. von Buchwald, K. K. Jakobsen, A. Carlander, S. Tous +29 more
2024European Journal of Cancer16 citations Open access
Semantic Scholar
Immune cell topography of head and neck cancer
T. Muijlwijk, D. Nijenhuis, S. Ganzevles, Fatima Ekhlas +8 more
2024Journal for ImmunoTherapy of Cancer15 citations Open access
Semantic Scholar
Acute Hypoxia Profile is a Stronger Prognostic Factor than Chronic Hypoxia in Advanced Stage Head and Neck Cancer Patients
M. van der Heijden, M. D. de Jong, C. Verhagen, R. D. de Roest +7 more
2019Cancers15 citations Open access
Semantic Scholar
Circulating T cell status and molecular imaging may predict clinical benefit of neoadjuvant PD-1 blockade in oral cancer
N. E. Wondergem, Iris H. C. Miedema, R. van de Ven, G. Zwezerijnen +16 more
2024Journal for ImmunoTherapy of Cancer14 citations Open access
Semantic Scholar
Intratumor genetic heterogeneity and head and neck cancer relapse.
A. S. Pierik, J. Poell, A. Brink, M. S. Walsum +6 more
2024Radiotherapy and Oncology13 citations Open access
Semantic Scholar
An antibody-drug conjugate directed to tissue factor shows preclinical anti-tumor activity in head and neck cancer as a single agent and in combination with chemoradiotherapy.
J. Bakema, Marijke Stigter-van Walsum, Jeffrey R. Harris, S. Ganzevles +7 more
2023Molecular Cancer Therapeutics11 citations
Semantic Scholar
Secretome and immune cell attraction analysis of head and neck cancers
T. Muijlwijk, N. E. Wondergem, Fatima Ekhlas, Naomi Remkes +8 more
2024Cancer Immunology and Immunotherapy10 citations Open access
Semantic Scholar
The course of health-related quality of life in the first 2 years after a diagnosis of head and neck cancer: the role of personal, clinical, psychological, physical, social, lifestyle, disease-related, and biological factors
I. V. Verdonck-de Leeuw, Laura H. A. Korsten, A. V. van Nieuwenhuizen, R. J. Baatenburg de Jong +11 more
2023Supportive Care in Cancer10 citations Open access
Semantic Scholar
Chemopreventive targeted treatment of head and neck precancer by Wee1 inhibition
A. V. van Harten, D. D. de Boer, S. R. Martens-de Kemp, Marijke Buijze +7 more
2020Scientific Reports10 citations Open access
Semantic Scholar
Correction: Computed tomography-derived radiomic signature of head and neck squamous cell carcinoma (peri)tumoral tissue for the prediction of locoregional recurrence and distant metastasis after concurrent chemo-radiotherapy
S. Keek, S. Sanduleanu, F. Wesseling, Reinout de Roest +16 more
2020PLoS ONE10 citations Open access
Semantic Scholar
Development and validation of a novel and rapid molecular detection method for high-risk HPV in formalin-fixed paraffin-embedded tumor tissue.
Steven W. Mes, D. Heideman, E. Bloemena, A. Brink +3 more
2019Journal of Molecular Diagnostics10 citations Open access
Semantic Scholar

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