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N. Okeley · SciRah

Researcher profile · Semantic Scholar

N. Okeley

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N. Okeley — researcher profile on SciRah

h-index: 23
Works: 57
Citations: 3,612

Most-cited papers

Antibody-drug conjugates: targeted drug delivery for cancer.
S. Alley, N. Okeley, P. Senter
2010Current Opinion in Chemical Biology647 citations
Semantic Scholar
Contribution of linker stability to the activities of anticancer immunoconjugates.
S. Alley, Dennis R. Benjamin, S. Jeffrey, N. Okeley +3 more
2008Bioconjugate chemistry430 citations
Semantic Scholar
Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate
N. Okeley, J. Miyamoto, Xin-Qun Zhang, R. Sanderson +4 more
2010Clinical Cancer Research379 citations Open access
Semantic Scholar
Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models.
Fu Li, Kim K. Emmerton, M. Jonas, Xin-Qun Zhang +7 more
2016Cancer Research290 citations Open access
Semantic Scholar
A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology.
S. Jeffrey, P. Burke, Robert P. Lyon, David W Meyer +17 more
2013Bioconjugate chemistry234 citations
Semantic Scholar
Development of orally active inhibitors of protein and cellular fucosylation
N. Okeley, S. Alley, M. Anderson, T. Boursalian +12 more
2013Proceedings of the National Academy of Sciences of the United States of America177 citations Open access
Semantic Scholar
Development and properties of beta-glucuronide linkers for monoclonal antibody-drug conjugates.
S. Jeffrey, J. Andreyka, Starr X Bernhardt, K. Kissler +8 more
2006Bioconjugate chemistry148 citations
Semantic Scholar
Facile chemoselective synthesis of dehydroalanine-containing peptides.
N. Okeley, Yan-Tao Zhu, W. A. van der Donk
2000Organic Letters136 citations
Semantic Scholar
The Pharmacologic Basis for Antibody-Auristatin Conjugate Activity
S. Alley, Xin-Qun Zhang, N. Okeley, M. Anderson +3 more
2009Journal of Pharmacology and Experimental Therapeutics134 citations
Semantic Scholar
Metabolic engineering of monoclonal antibody carbohydrates for antibody-drug conjugation.
N. Okeley, B. Toki, Xin-Qun Zhang, S. Jeffrey +3 more
2013Bioconjugate chemistry117 citations
Semantic Scholar
Optimization of a PEGylated Glucuronide-Monomethylauristatin E Linker for Antibody–Drug Conjugates
P. Burke, Joseph Z. Hamilton, S. Jeffrey, J. Hunter +10 more
2016Molecular Cancer Therapeutics103 citations Open access
Semantic Scholar
Anti-CD30 diabody-drug conjugates with potent antitumor activity
Kristine M. Kim, C. Mcdonagh, Lori Westendorf, Lindsay L. Brown +10 more
2008Molecular Cancer Therapeutics87 citations Open access
Semantic Scholar
Potent antitumor activity of the anti-CD19 auristatin antibody drug conjugate hBU12-vcMMAE against rituximab-sensitive and -resistant lymphomas.
H. Gerber, May Kung-Sutherland, I. Stone, Carol A Morris-Tilden +10 more
2009Blood85 citations Open access
Semantic Scholar
Novel cofactors via post-translational modifications of enzyme active sites.
N. Okeley, W. A. van der Donk
2000Chemistry and Biology83 citations Open access
Semantic Scholar
SpaC and NisC, the cyclases involved in subtilin and nisin biosynthesis, are zinc proteins.
N. Okeley, Moushumi Paul, J. Stasser, N. Blackburn +1 more
2003Biochemistry72 citations
Semantic Scholar
Intracellular Actions of Group IIA Secreted Phospholipase A2 and Group IVA Cytosolic Phospholipase A2 Contribute to Arachidonic Acid Release and Prostaglandin Production in Rat Gastric Mucosal Cells and Transfected Human Embryonic Kidney Cells*
Zhang-Lin Ni, N. Okeley, Brian P. Smart, M. Gelb
2006Journal of Biological Chemistry68 citations Open access
Semantic Scholar
Engineered cysteine antibodies: an improved antibody-drug conjugate platform with a novel mechanism of drug-linker stability
D. Sussman, Lori Westendorf, David W Meyer, C. Leiske +7 more
2018Protein engineering, design & selection : PEDS53 citations
Semantic Scholar
A Designed Probe for Acidic Phospholipids Reveals the Unique Enriched Anionic Character of the Cytosolic Face of the Mammalian Plasma Membrane*
N. Okeley, M. Gelb
2004Journal of Biological Chemistry45 citations Open access
Semantic Scholar
Synthesis of isotopically labeled arachidonic acids to probe the reaction mechanism of prostaglandin H synthase.
Sheng Peng, N. Okeley, A. Tsai, Gang Wu +2 more
2002Journal of the American Chemical Society44 citations
Semantic Scholar
Heterologous expression and purification of SpaB involved in subtilin biosynthesis.
Lili Xie, Champak Chatterjee, R. Balsara, N. Okeley +1 more
2002Biochemical and Biophysical Research Communications - BBRC31 citations
Semantic Scholar
The Fucosylation Inhibitor, 2-Fluorofucose, Inhibits Vaso-Occlusion, Leukocyte-Endothelium Interactions and NF-ĸB Activation in Transgenic Sickle Mice
J. Belcher, Chun-Sheng Chen, J. Nguyen, F. Abdulla +6 more
2015PLoS ONE29 citations Open access
Semantic Scholar
An in vitro assay using cultured Kupffer cells can predict the impact of drug conjugation on in vivo antibody pharmacokinetics.
David W Meyer, Lauren Bou, Sara Shum, M. Jonas +7 more
2020Molecular Pharmaceutics28 citations Open access
Semantic Scholar
SGN-CD228A Is an Investigational CD228-Directed Antibody–Drug Conjugate with Potent Antitumor Activity across a Wide Spectrum of Preclinical Solid Tumor Models
R. Mazahreh, Marsha L. Mason, J. Gosink, Devra J. Olson +20 more
2023Molecular Cancer Therapeutics23 citations Open access
Semantic Scholar
Advancing antibody drug conjugation: from the laboratory to a clinically approved anticancer drug.
N. Okeley, S. Alley, P. Senter
2014Hematology/Oncology Clinics of North America23 citations
Semantic Scholar
Structural Characterization of Arachidonyl Radicals Formed by Aspirin-treated Prostaglandin H Synthase-2*
A. Tsai, G. Palmer, Gang Wu, Sheng Peng +3 more
2002Journal of Biological Chemistry23 citations Open access
Semantic Scholar
Development of Novel Antibody–Camptothecin Conjugates
Ryan Lyski, Lauren Bou, Uland Y. Lau, David W Meyer +14 more
2020Molecular Cancer Therapeutics21 citations
Semantic Scholar
SGN-35, an Anti-CD30 Antibody-Drug Conjugate, Exhibits Potent Antitumor Activity for the Treatment of CD30+ Malignancies.
Kevin J. Hamblett, J. Barton, C. Cerveny, J. Andreyka +8 more
200520 citations
Semantic Scholar
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two
C. Ager, M. Reilley, C. Nicholas, Todd Bartkowiak +496 more
2016Journal for ImmunoTherapy of Cancer18 citations Open access
Semantic Scholar
Therapeutic and Prophylactic Antitumor Activity of an Oral Inhibitor of Fucosylation in Spontaneous Mammary Cancers
M. Disis, Lauren R. Corulli, E. Gad, Marlese R Koehnlein +4 more
2020Molecular Cancer Therapeutics14 citations Open access
Semantic Scholar
Specific Tumor Targeting and Potent Bystander Killing with SGN-35, an Anti-CD30 Antibody Drug Conjugate.
N. Okeley, S. Alley, C. Cerveny, J. Andreyka +6 more
20068 citations
Semantic Scholar
Abstract 4005: Understanding the mechanism of 2FF-induced immune modulation
Jessica J. Field, N. Okeley, Weiping Zeng, C. Law +2 more
20167 citations
Semantic Scholar
Abstract 3694: Relationship betweenin vivoantitumor activity of ADC and payload release in preclinical models
Fu Li, Xin-Qun Zhang, Kim K. Emmerton, M. Jonas +6 more
20147 citations
Semantic Scholar
Abstract DDT02-02: SGN-2FF: A novel small molecule inhibitor of fucosylation with preclinical antitumor activity through multiple immune mechanisms
S. Alley, M. O'Meara, S. Gardai, N. Okeley
20175 citations
Semantic Scholar
Corrigendum to: ‘Novel cofactors via post-translational modifications of enzyme active sites’
N. Okeley, W. A. van der Donk
20015 citations Open access
Semantic Scholar
Cancer Therapy : Preclinical Clinical Cancer Research Intracellular Activation of SGN-35 , a Potent Anti-CD 30 Antibody-Drug Conjugate
N. Okeley, J. Miyamoto, Xin-Qun Zhang, R. Sanderson +4 more
20104 citations
Semantic Scholar
Abstract 1786: Development and pharmacological properties of PEGylated glucuronide-auristatin linkers
P. Burke, Joseph Z. Hamilton, J. Hunter, S. Jeffrey +5 more
20143 citations
Semantic Scholar
Abstract B133: SEA technology: A novel strategy for enhancing antibody effector function
S. Alley, D. Sussman, S. Jeffrey, Lindsay Torrey +5 more
20093 citations
Semantic Scholar
Intracellular metabolism of antibody-drug conjugates: identification and quantitation of released drugs
S. Alley, N. Okeley, R. Sanderson, V. Nanayakkara +6 more
20063 citations
Semantic Scholar
Fucosylation Inhibitor, 2-Fluorofucose, Inhibits NF-κB Activation and Vaso-Occlusion In Transgenic Sickle Mice
Chun-Sheng Chen, J. Nguyen, N. Okeley, P. Senter +2 more
20132 citations
Semantic Scholar
507 POSTER Potent antitumor activity of the anti-CD19 auristatin antibody-drug conjugate hBU12-vcMMAE in rituximab sensitive and resistant lymphomas
H. Gerber, I. Stone, M. Kung-Sutherland, J. Miyamoto +6 more
20082 citations
Semantic Scholar
Abstract C113: Discovery of a novel auristatin antibody drug conjugate drug linker with equal efficacy and reduced bone marrow toxicity compared to vedotin
Noah A Bindman, Roma Yumul, Erica E McKinney, Scott Blackburn +14 more
2023Molecular Cancer Therapeutics1 citations
Semantic Scholar
Abstract 2885: Discovery of a tripeptide-based camptothecin drug-linker for antibody-drug conjugates with potent antitumor activity and a broad therapeutic window
Ryan Lyski, Lauren Bou, Margo Zaval, Kim K. Emmerton +9 more
2020Experimental and Molecular Therapeutics1 citations
Semantic Scholar
Abstract 648: Optimization of a PEGylated glucuronide-auristatin linker for antibody-drug conjugates
P. Burke, Joseph Z. Hamilton, S. Jeffrey, J. Hunter +5 more
20151 citations
Semantic Scholar
Abstract 4465: Differential MMAE delivery from ADCs utilizing the valine-citrulline-PAB and β-glucuronide cleavable linker systems
N. Okeley, Heather A. van Epps, Xin-Qun Zhang, J. Setter +3 more
20141 citations
Semantic Scholar
Abstract 4395: SEA technology: A novel strategy for enhancing antibody effector function
S. Alley, D. Sussman, S. Jeffrey, Lindsay Torrey +7 more
20101 citations
Semantic Scholar
Discovery of a Novel Tripeptide Linker that Broadens the Therapeutic Window of Auristatin-Based Antibody–Drug Conjugates by Reducing Bone Marrow Toxicity
Noah A Bindman, Forgivemore Magunda, Vineet Kumar, Niels V Rekers +15 more
2026Bioconjugate chemistry0 citations Open access
Semantic Scholar
Abstract 2895: Characterization of payload release from a novel camptothecin drug-linker
Julia H Cochran, Lauren Farr, Ryan Lyski, P. Senter +3 more
2020Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract 351: Uptake of antibody-drug conjugates by cultured Kupffer cells can predict pharmacokinetics
David W Meyer, Sara Shum, M. Jonas, M. Anderson +4 more
20160 citations
Semantic Scholar
Abstract PD3-08: Modulation of immunity with 2-fluorofucose (2FF) for breast cancer treatment and prevention
M. Disis, Lauren Rastetter, E. Gad, Marlese R Koehnlein +3 more
20160 citations
Semantic Scholar
Traitement du cancer à l'aide de 2-désoxy-2-fluoro-l-fucose en association avec un inhibiteur de point de contrôle
S. Gardai, Che-Leung Law, Peter D. Senter, N. Okeley +1 more
20160 citations
Semantic Scholar

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