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K. Lee · SciRah

Researcher profile · Semantic Scholar

K. Lee

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K. Lee — researcher profile on SciRah

h-index: 29
Works: 69
Citations: 2,083

Most-cited papers

Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain
B. Inceoglu, A. Bettaieb, C. A. Trindade da Silva, K. Lee +2 more
2015Proceedings of the National Academy of Sciences of the United States of America173 citations Open access
Semantic Scholar
Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative
B. Hammock, C. McReynolds, K. Wagner, A. Buckpitt +6 more
2021Journal of Medicinal Chemistry133 citations Open access
Semantic Scholar
Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis
Padmini Sirish, Ning Li, Jun-Yan Liu, K. Lee +7 more
2013Proceedings of the National Academy of Sciences of the United States of America98 citations Open access
Semantic Scholar
Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy
K. Lee, Jun-Yan Liu, K. Wagner, S. Pakhomova +15 more
2014Journal of Medicinal Chemistry93 citations Open access
Semantic Scholar
Soluble epoxide hydrolase inhibitor attenuates lipopolysaccharide-induced acute lung injury and improves survival in mice
Yong Zhou, Tian Liu, J. Duan, Ping-Song Li +8 more
2017Shock82 citations Open access
Semantic Scholar
An Omega-3 Epoxide of Docosahexaenoic Acid Lowers Blood Pressure in Angiotensin-II Dependent Hypertension
A. Ulu, K. Lee, C. Miyabe, Jun Yang +3 more
2014Journal of Cardiovascular Pharmacology81 citations Open access
Semantic Scholar
Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids
Amy A. Rand, B. Barnych, C. Morisseau, T. Cajka +3 more
2017Proceedings of the National Academy of Sciences of the United States of America75 citations Open access
Semantic Scholar
Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways
K. Lee, Jun Yang, Jun Niu, C. Ng +6 more
2019ACS Central Science73 citations Open access
Semantic Scholar
Targeted metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as a novel therapeutic target of colon tumorigenesis
Weicang Wang, Jun Yang, M. Edin, Yu-Xin Wang +20 more
2019Cancer Research70 citations Open access
Semantic Scholar
Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures
B. Inceoglu, D. Żółkowska, H. Yoo, K. Wagner +7 more
2013PLoS ONE62 citations Open access
Semantic Scholar
Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3β signaling
Bing-qing Deng, Ying Luo, Xin Kang, Chang-Bin Li +9 more
2017Proceedings of the National Academy of Sciences of the United States of America57 citations Open access
Semantic Scholar
Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission
Marie Hennebelle, Zhi-Chao Zhang, A. Metherel, Alex P. Kitson +8 more
2017Scientific Reports55 citations Open access
Semantic Scholar
Soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3- (1-propionylpiperidin-4-yl) urea attenuates bleomycin-induced pulmonary fibrosis in mice
Yong Zhou, Jun Yang, Guo-Ying Sun, Tian Liu +7 more
2015Cell and Tissue Research55 citations Open access
Semantic Scholar
Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation
Yu-Xin Wang, Jun Yang, Weicang Wang, K. Sanidad +8 more
2020Proceedings of the National Academy of Sciences of the United States of America51 citations Open access
Semantic Scholar
Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors
V. Burmistrov, C. Morisseau, K. Lee, Diyala S. Shihadih +3 more
2014Bioorganic & Medicinal Chemistry Letters50 citations Open access
Semantic Scholar
Cytochrome P450 oxidase 2C inhibition adds to ω-3 long-chain polyunsaturated fatty acids protection against retinal and choroidal neovascularization
Yan Gong, Z. Fu, M. Edin, Chi-Hsiu Liu +15 more
2016Arteriosclerosis, Thrombosis and Vascular Biology45 citations Open access
Semantic Scholar
Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation
Padmini Sirish, Ning Li, V. Timofeyev, Xiao-Dong Zhang +17 more
2016Circulation: Arrhythmia and Electrophysiology44 citations Open access
Semantic Scholar
Pro-atherogenic Role of Smooth Muscle Nox4-based NADPH oxidase
Xiao-Yong Tong, Alok R. Khandelwal, Xiaojuan Wu, Zaicheng Xu +13 more
2016Journal of Molecular and Cellular Cardiology44 citations Open access
Semantic Scholar
ω-3 polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice
Weicang Wang, Jun Yang, Yoshiki Nimiya, K. Lee +6 more
2017Journal of Nutritional Biochemistry42 citations Open access
Semantic Scholar
Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia
Ranran Tu, Jillian S. Armstrong, K. Lee, B. Hammock +2 more
2018Scientific Reports41 citations Open access
Semantic Scholar
Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation[S]
C. Morisseau, Aaron T. Wecksler, C. Deng, Hua Dong +4 more
2014Journal of Lipid Research40 citations Open access
Semantic Scholar
Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization
Eiichi Hasegawa, Saori Inafuku, L. Mulki, Y. Okunuki +15 more
2017Proceedings of the National Academy of Sciences of the United States of America39 citations Open access
Semantic Scholar
Brain oxylipin concentrations following hypercapnia/ischemia: effects of brain dissection and dissection time[S]
Marie Hennebelle, A. Metherel, Alex P. Kitson, Y. Otoki +5 more
2018Journal of Lipid Research37 citations Open access
Semantic Scholar
Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase
Ping-Ping Hu, Xiaojuan Wu, Alok R. Khandelwal, Wei-Min Yu +10 more
2017Biochimica et Biophysica Acta - Molecular Basis of Disease34 citations Open access
Semantic Scholar
Epoxy fatty acids mediate analgesia in murine diabetic neuropathy
K. Wagner, K. Lee, Jun Yang, B. Hammock
2016European Journal of Pain33 citations Open access
Semantic Scholar
Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues
C. Morisseau, S. Kodani, S. Kamita, Jun Yang +2 more
2021International Journal of Molecular Sciences32 citations Open access
Semantic Scholar
A new sensitive LC/MS/MS analysis of vitamin D metabolites using a click derivatization reagent, 2-nitrosopyridine[S]
Debin Wan, Jun Yang, B. Barnych, S. Hwang +5 more
2017Journal of Lipid Research30 citations Open access
Semantic Scholar
Ingestion of the epoxide hydrolase inhibitor AUDA modulates immune responses of the mosquito, Culex quinquefasciatus during blood feeding
Jiawen Xu, C. Morisseau, Jun Yang, K. Lee +2 more
2016Insect Biochemistry and Molecular Biology30 citations Open access
Semantic Scholar
Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis
Amit Sharma, M. A. Khan, S. Levick, K. Lee +2 more
2016International Journal of Molecular Sciences29 citations Open access
Semantic Scholar
A method for sorting and pairwise selection of nanobodies for the development of highly sensitive sandwich immunoassays
M. Rossotti, M. Pírez, A. González-Techera, Yong-Liang Cui +7 more
2015Analytical Chemistry29 citations Open access
Semantic Scholar
Preparation and Evaluation of Soluble Epoxide Hydrolase Inhibitors with Improved Physical Properties and Potencies for Treating Diabetic Neuropathic Pain
K. Lee, J. C. Ng, Jun Yang, S. Hwang +3 more
2020Bioorganic & Medicinal Chemistry25 citations Open access
Semantic Scholar
Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia
A. Bettaieb, Shinichiro Koike, Ming-Fo Hsu, Yoshihiro Ito +11 more
2017Biochimica et Biophysica Acta - General Subjects25 citations Open access
Semantic Scholar
Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation
Yue Zhang, G. Hong, K. Lee, B. Hammock +4 more
2017Journal of Neurochemistry24 citations Open access
Semantic Scholar
Förster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase
K. Lee, C. Morisseau, Jun Yang, Peng-Cheng Wang +2 more
2012Analytical Biochemistry22 citations Open access
Semantic Scholar
PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells
V. Samokhvalov, Igor Zlobine, K. Jamieson, P. Jurasz +4 more
2014Toxicology Letters21 citations Open access
Semantic Scholar
Inactivation of Cys674 in SERCA2 increases BP by inducing endoplasmic reticulum stress and soluble epoxide hydrolase
Gang Liu, Fuhua Wu, Xiao-Li Jiang, Y. Que +7 more
2019British Journal of Pharmacology20 citations Open access
Semantic Scholar
trans, trans-2,4-decadienal, a lipid peroxidation product, induces inflammatory responses via Hsp90- or 14-3-3ζ-dependent mechanisms
Yu-Xin Wang, Devon Dattmore, Weicang Wang, G. Pohnert +6 more
2019Journal of Nutritional Biochemistry20 citations Open access
Semantic Scholar
Chemical Synthesis and Biological Evaluation of ω-Hydroxy Polyunsaturated Fatty Acids
S. H. Hwang, K. Wagner, Jian Xu, Jun Yang +5 more
2016Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Target-Mediated Drug Disposition (TMDD) – a Class Effect of Soluble Epoxide Hydrolase (sEH) Inhibitors
Guo-Hua An, K. Lee, Jun Yang, B. Hammock
2020Journal of clinical pharmacology17 citations Open access
Semantic Scholar
Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac stem cell‐based therapy
Padmini Sirish, Phung N. Thai, J. Lee, Jun Yang +14 more
2020Stem Cells Translational Medicine16 citations Open access
Semantic Scholar
Active-site flexibility and substrate specificity in a bacterial virulence factor: crystallographic snapshots of an epoxide hydrolase
K. Hvorecny, C. Bahl, S. Kitamura, K. Lee +3 more
2017Structure16 citations Open access
Semantic Scholar
Lipidome modulation by dietary omega-3 polyunsaturated fatty acid supplementation or selective soluble epoxide hydrolase inhibition suppresses rough LPS-accelerated glomerulonephritis in lupus-prone mice
Olivia K. Favor, P. Chauhan, Elham Pourmand, A. M. Edwards +6 more
2023Frontiers in Immunology12 citations Open access
Semantic Scholar
Soluble Epoxide Hydrolase Pharmacological Inhibition Decreases Alveolar Bone Loss by Modulating Host Inflammatory Response, RANK-Related Signaling, Endoplasmic Reticulum Stress, and Apoptosis
C. A. Trindade-da-Silva, A. Bettaieb, M. Napimoga, K. Lee +6 more
2017Journal of Pharmacology and Experimental Therapeutics12 citations Open access
Semantic Scholar
Soluble Epoxide Hydrolase Inhibition and Epoxyeicosatrienoic Acid Treatment Improve Vascularization of Engineered Skin Substitutes
D. Supp, J. Hahn, Kevin McFarland, K. Combs +5 more
2016Plastic and Reconstructive Surgery, Global Open12 citations Open access
Semantic Scholar
Selection of Potent Inhibitors of Soluble Epoxide Hydrolase for Usage in Veterinary Medicine
Diyala S. Shihadih, Todd R. Harris, S. Kodani, S. Hwang +6 more
2020Frontiers in Veterinary Science10 citations Open access
Semantic Scholar
Simultaneous Target-Mediated Drug Disposition Model for Two Small-Molecule Compounds Competing for Their Pharmacological Target: Soluble Epoxide Hydrolase
Nan Wu, B. Hammock, K. Lee, Guo-Hua An
2020Journal of Pharmacology and Experimental Therapeutics10 citations Open access
Semantic Scholar
Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase
K. Lee, N. M. Henriksen, C. Ng, Jun Yang +5 more
2016Archives of Biochemistry and Biophysics10 citations Open access
Semantic Scholar
Centrality of Myeloid-Lineage Phagocytes in Particle-Triggered Inflammation and Autoimmunity
Olivia K. Favor, J. Pestka, Melissa A. Bates, K. Lee
2021Frontiers in Toxicology9 citations Open access
Semantic Scholar
The epoxy fatty acid pathway enhances cAMP in mammalian cells through multiple mechanisms
N. Matsumoto, Nalin Singh, K. Lee, B. Barnych +2 more
2022Prostaglandins & other lipid mediators8 citations Open access
Semantic Scholar
Synthesis of Cyclooxygenase Metabolites of 8,9-Epoxyeicosatrienoic Acid (EET): 11- and 15-Hydroxy 8,9-EETs
B. Barnych, Amy A. Rand, T. Cajka, K. Lee +1 more
2017Organic and biomolecular chemistry6 citations Open access
Semantic Scholar

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