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M. Pellecchia · SciRah

Researcher profile · Semantic Scholar

M. Pellecchia

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M. Pellecchia — researcher profile on SciRah

h-index: 62
Works: 264
Citations: 14K

Most-cited papers

Targeting the Bcl-2 Family for Cancer Therapy
S. Thomas, B. Quinn, Swadesh K. Das, R. Dash +8 more
2012Expert opinion on therapeutic targets269 citations Open access
Semantic Scholar
ADAR1 Activation Drives Leukemia Stem Cell Self-renewal by Impairing Let-7 Biogenesis
M. Zipeto, A. Court, A. Sadarangani, Nathaniel P. Delos-Santos +16 more
2016Cell Stem Cell218 citations Open access
Semantic Scholar
A pan-BCL2 inhibitor renders bone marrow resident human leukemia stem cells sensitive to tyrosine kinase inhibition
D. Goff, Angela Court Recart, A. Sadarangani, Hye-Jung E. Chun +31 more
2013Cell Stem Cell197 citations Open access
Semantic Scholar
Bcl-2 Antiapoptotic Family Proteins and Chemoresistance in Cancer.
Santanu Maji, Sanjay Panda, S. K. Samal, O. Shriwas +6 more
2018Advances in Cancer Research184 citations
Semantic Scholar
Functional Specialization in Proline Biosynthesis of Melanoma
J. De Ingeniis, B. Ratnikov, A. Richardson, D. Scott +7 more
2012PLoS ONE155 citations Open access
Semantic Scholar
Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia.
Rongqing Pan, V. Ruvolo, Jun Wei, M. Konopleva +4 more
2015Blood138 citations Open access
Semantic Scholar
Covalent Inhibitors of Protein-Protein Interactions Targeting Lysine, Tyrosine, or Histidine Residues
L. Gambini, C. Baggio, P. Udompholkul, J. Jossart +3 more
2019Journal of Medicinal Chemistry98 citations Open access
Semantic Scholar
NMR-Based Approaches for the Identification and Optimization of Inhibitors of Protein–Protein Interactions
E. Barile, M. Pellecchia
2014Chemical Reviews98 citations Open access
Semantic Scholar
A novel targeted system to deliver chemotherapeutic drugs to EphA2-expressing cancer cells
Si Wang, W. Placzek, J. Stebbins, S. Mitra +6 more
2012Journal of Medicinal Chemistry98 citations Open access
Semantic Scholar
Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin
T. Kegelman, Bainan Wu, Swadesh K. Das, Sarmistha Talukdar +12 more
2016Proceedings of the National Academy of Sciences of the United States of America94 citations Open access
Semantic Scholar
MDA-9/Syntenin and IGFBP-2 Promote Angiogenesis in Human Melanoma
Swadesh K. Das, S. Bhutia, B. Azab, T. Kegelman +10 more
2012Cancer Research93 citations Open access
Semantic Scholar
New p32/gC1qR Ligands for Targeted Tumor Drug Delivery
Lauri Paasonen, Shweta Sharma, G. Braun, V. R. Kotamraju +8 more
2016ChemBioChem79 citations Open access
Semantic Scholar
HTS by NMR of Combinatorial Libraries: A Fragment-Based Approach to Ligand Discovery
Bainan Wu, Ziming Zhang, R. Noberini, E. Barile +5 more
2013Chemistry and Biology77 citations Open access
Semantic Scholar
Human resistin protects against endotoxic shock by blocking LPS–TLR4 interaction
Jessica C. Jang, Jiang Li, L. Gambini, Hashini M Batugedara +5 more
2017Proceedings of the National Academy of Sciences of the United States of America75 citations Open access
Semantic Scholar
Ironing out cell death mechanisms.
John Calvin Reed, M. Pellecchia
2012Cell73 citations Open access
Semantic Scholar
A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum
S. Varadarajan, E. Bampton, Joshua L. Smalley, Kayoko Tanaka +8 more
2012Cell Death and Differentiation70 citations Open access
Semantic Scholar
Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of BrafV600E::Pten−/− melanoma
M. Scortegagna, Chelsea M. Ruller, Yong-Mei Feng, R. Lazova +7 more
2013Oncogene65 citations Open access
Semantic Scholar
Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma
Swadesh K. Das, S. Bhutia, Upneet K. Sokhi, B. Azab +8 more
2012Cancer Research65 citations Open access
Semantic Scholar
Mcl-1 is an important therapeutic target for oral squamous cell carcinomas
Santanu Maji, S. K. Samal, Laxmipriya Pattanaik, S. Panda +6 more
2015OncoTarget62 citations Open access
Semantic Scholar
Reduction of Circulating Cancer Cells and Metastases in Breast-Cancer Models by a Potent EphA2-Agonistic Peptide–Drug Conjugate
A. Salem, Si Wang, Sandrine Billet, Jie-Fu Chen +7 more
2018Journal of Medicinal Chemistry61 citations Open access
Semantic Scholar
Control of Paneth cell fate, intestinal inflammation and tumorigenesis by PKCλ/ι
Y. Nakanishi, M. Reina-Campos, Naoko Nakanishi, V. Lladó +10 more
2016Cell Reports59 citations Open access
Semantic Scholar
MDA-9/syntenin is a key regulator of glioma pathogenesis.
T. Kegelman, Swadesh K. Das, Bin Hu, M. Bacolod +10 more
2014Neuro-Oncology58 citations Open access
Semantic Scholar
Targeting tumor invasion: the roles of MDA-9/Syntenin
T. Kegelman, Swadesh K. Das, Luni Emdad, Bin Hu +6 more
2014Expert opinion on therapeutic targets54 citations Open access
Semantic Scholar
PDK1 and SGK3 contribute to the growth of BRAF mutant melanomas and are potential therapeutic targets
M. Scortegagna, E. Lau, Tong-Wu Zhang, Yong-Mei Feng +13 more
2015Cancer Research53 citations Open access
Semantic Scholar
Structure Based Design of Covalent Siah Inhibitors
J. Stebbins, E. Santelli, Yong-Mei Feng, S. De +6 more
2013Chemistry and Biology53 citations Open access
Semantic Scholar
High-throughput screening by Nuclear Magnetic Resonance (HTS by NMR) for the identification of PPIs antagonists
Bainan Wu, E. Barile, S. De, Jun Wei +2 more
2015Current Topics in Medicinal Chemistry52 citations Open access
Semantic Scholar
Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis.
S. Varadarajan, M. Butterworth, Jun Wei, M. Pellecchia +2 more
2013Neoplasia52 citations Open access
Semantic Scholar
Aryl-fluorosulfate-based Lysine Covalent pan-Inhibitors of Apoptosis Proteins (IAP) Antagonists with Cellular Efficacy
C. Baggio, P. Udompholkul, L. Gambini, A. Salem +3 more
2019Journal of Medicinal Chemistry46 citations Open access
Semantic Scholar
Pancreatic cancer combination therapy using a BH3 mimetic and a synthetic tetracycline
B. Quinn, R. Dash, Siddik Sarkar, B. Azab +7 more
2015Cancer Research43 citations Open access
Semantic Scholar
Therapeutic targeting of MMP-12 for the treatment of chronic obstructive pulmonary disease
C. Baggio, J. Velazquez, M. Fragai, T. Nordgren +1 more
2020Journal of Medicinal Chemistry41 citations Open access
Semantic Scholar
Design of Potent pan-IAP and Lys-Covalent XIAP selective Inhibitors Using a Thermodynamics Driven Approach
C. Baggio, L. Gambini, P. Udompholkul, A. Salem +5 more
2018Journal of Medicinal Chemistry41 citations Open access
Semantic Scholar
Potent and selective EphA4 agonists for the treatment of ALS
Bainan Wu, S. De, A. Kulinich, A. Salem +7 more
2017Cell Chemical Biology41 citations Open access
Semantic Scholar
hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents
E. Barile, G. Marconi, S. De, C. Baggio +6 more
2016ACS Chemical Biology40 citations Open access
Semantic Scholar
Therapy of pancreatic cancer via an EphA2 receptor-targeted delivery of gemcitabine
B. Quinn, Si Wang, E. Barile, Swadesh K. Das +8 more
2016OncoTarget39 citations Open access
Semantic Scholar
Design and characterization of novel EphA2 agonists for targeted delivery of chemotherapy to cancer cells
Bainan Wu, Si Wang, S. De, E. Barile +7 more
2015Chemistry and Biology37 citations Open access
Semantic Scholar
SOLUTION STRUCTURE OF THE FIRST SAM DOMAIN OF ODIN AND BINDING STUDIES WITH THE EPHA2 RECEPTOR
F. A. Mercurio, Daniela Marasco, L. Pirone, E. Pedone +2 more
2012Biochemistry36 citations Open access
Semantic Scholar
Design, synthesis, and structural characterization of lysine covalent BH3 peptides targeting Mcl-1
L. Gambini, P. Udompholkul, C. Baggio, A. Muralidharan +4 more
2021Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
SBI-0640756 attenuates the growth of clinically unresponsive melanomas by disrupting the eIF4F translation initiation complex
Yong-Mei Feng, A. Pinkerton, Laura Hulea, Tong-Wu Zhang +16 more
2015Cancer Research35 citations Open access
Semantic Scholar
Targeting Influenza A virus RNA Promoter
A. Bottini, S. De, Bainan Wu, Changyan Tang +2 more
2015Chemical Biology and Drug Design34 citations Open access
Semantic Scholar
Design, Synthesis and Bio-evaluation of an EphA2-based Targeted Delivery System
E. Barile, Si Wang, Swadesh K. Das, R. Noberini +5 more
2014ChemMedChem34 citations Open access
Semantic Scholar
Structure-Based Design of Novel EphA2 Agonistic Agents with Nanomolar Affinity in Vitro and in Cell
L. Gambini, A. Salem, P. Udompholkul, X. Tan +5 more
2018ACS Chemical Biology31 citations Open access
Semantic Scholar
Therapy of prostate cancer using a novel cancer terminator virus and a small molecule BH-3 mimetic
Siddik Sarkar, B. Quinn, Xue-Ning Shen, R. Dash +7 more
2015OncoTarget31 citations Open access
Semantic Scholar
Correction: A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication
Mi-Kyung Lee, A. Bottini, Meehyein Kim, M. F. Bardaro +4 more
201429 citations Open access
Semantic Scholar
Endoplasmic Reticulum Membrane Reorganization Is Regulated by Ionic Homeostasis
S. Varadarajan, Kayoko Tanaka, Joshua L. Smalley, E. Bampton +4 more
2013PLoS ONE29 citations Open access
Semantic Scholar
A Potent Anti-influenza Compound Blocks Fusion through Stabilization of the Prefusion Conformation of the Hemagglutinin Protein
K. White, Paul D. De Jesus, Zhong Chen, P. Abreu +13 more
2014ACS Infectious Diseases26 citations Open access
Semantic Scholar
Enhanced Prostate Cancer Gene Transfer and Therapy Using a Novel Serotype Chimera Cancer Terminator Virus (Ad.5/3-CTV)
B. Azab, R. Dash, Swadesh K. Das, S. Bhutia +11 more
2013Journal of Cellular Physiology24 citations Open access
Semantic Scholar
Selected Approaches for Rational Drug Design and High Throughput Screening to Identify Anti-Cancer Molecules
Michael Hedvat, Luni Emdad, Swadesh K. Das, Keetae Kim +23 more
2012Anti-Cancer Agents in Medicinal Chemistry24 citations Open access
Semantic Scholar
Examination of Epigenetic and other Molecular Factors Associated with mda-9/Syntenin Dysregulation in Cancer Through Integrated Analyses of Public Genomic Datasets
M. Bacolod, Swadesh K. Das, Upneet K. Sokhi, Steven P. Bradley +5 more
2015Advances in Cancer Research23 citations Open access
Semantic Scholar
Stability and cell permeability of sulfonyl fluorides in the design of Lys-covalent antagonists of protein-protein interactions
L. Gambini, P. Udompholkul, A. Salem, C. Baggio +1 more
2020ChemMedChem22 citations Open access
Semantic Scholar
Targefrin: A Potent Agent Targeting the Ligand Binding Domain of EphA2
C. Baggio, P. Udompholkul, L. Gambini, M. Pellecchia
2022Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar

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Swadesh K. Das×15
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Swadesh K. Das — researcher profile on SciRah
P. Fisher×14
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D. Sarkar×13
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D. Sarkar — researcher profile on SciRah
S. De×13
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S. De — researcher profile on SciRah

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Luni Emdad — researcher profile on SciRah

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L. Gambini — researcher profile on SciRah

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C. Baggio — researcher profile on SciRah

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E. Barile — researcher profile on SciRah

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Bainan Wu — researcher profile on SciRah

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B. Quinn — researcher profile on SciRah

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Jun Wei — researcher profile on SciRah

P. Udompholkul×8

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P. Udompholkul — researcher profile on SciRah