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M. Alvarez · SciRah

Researcher profile · Semantic Scholar

M. Alvarez

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M. Alvarez — researcher profile on SciRah

h-index: 22
Works: 54
Citations: 3,963

Most-cited papers

Integrative approaches for large-scale transcriptome-wide association studies
Alexander Gusev, Arthur Ko, Huwenbo Shi, G. Bhatia +21 more
2015Nature Genetics2,316 citations Open access
Semantic Scholar
Accurate estimation of cell composition in bulk expression through robust integration of single-cell information
B. Jew, M. Alvarez, Elior Rahmani, Zong Miao +6 more
2019Nature Communications412 citations Open access
Semantic Scholar
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease
O. Jamialahmadi, A. De Vincentis, Federica Tavaglione, F. Malvestiti +12 more
2024Nature Medicine113 citations Open access
Semantic Scholar
Amerindian-specific regions under positive selection harbour new lipid variants in Latinos
Arthur Ko, R. Cantor, D. Weissglas-Volkov, E. Nikkola +27 more
2014Nature Communications102 citations Open access
Semantic Scholar
Enhancing droplet-based single-nucleus RNA-seq resolution using the semi-supervised machine learning classifier DIEM
M. Alvarez, Elior Rahmani, B. Jew, K. Garske +7 more
2019Scientific Reports90 citations Open access
Semantic Scholar
Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells
Jie-Ying Yang, Maria Vamvini, P. Nigro, L. Ho +13 more
2022Cell Metabolism85 citations Open access
Semantic Scholar
Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS
David Z. Pan, K. Garske, M. Alvarez, Yash V. Bhagat +15 more
2018Nature Communications85 citations Open access
Semantic Scholar
Human liver single nucleus and single cell RNA sequencing identify a hepatocellular carcinoma-associated cell-type affecting survival
M. Alvarez, J. Benhammou, Nicholas Darci-Maher, S. French +5 more
2022Genome Medicine75 citations Open access
Semantic Scholar
Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI
B. W. van der Kolk, Sina Saari, Alen Lovric, M. Arif +22 more
2021Cell Reports Medicine65 citations Open access
Semantic Scholar
The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance
Zong Miao, M. Alvarez, Arthur Ko, Yash V. Bhagat +12 more
2020PLoS Genetics63 citations Open access
Semantic Scholar
Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries
Ulzee An, Ali Pazokitoroudi, M. Alvarez, Lianyun Huang +9 more
2022bioRxiv61 citations Open access
Semantic Scholar
RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice
D. Karunakaran, A. Turner, A. Duchez, S. Soubeyrand +26 more
2020Nature Metabolism53 citations Open access
Semantic Scholar
Polygenic prediction of body mass index and obesity through the life course and across ancestries
R. Smit, K. Wade, Qin Hui, J. Arias +496 more
2025Nature Medicine51 citations Open access
Semantic Scholar
Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation‐Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl‐Coenzyme A Desaturase As an Enhancer RNA
J. Benhammou, Arthur Ko, M. Alvarez, M. Kaikkonen +9 more
2019Hepatology Communications41 citations Open access
Semantic Scholar
Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery
B. W. van der Kolk, M. Muniandy, D. Kamińska, M. Alvarez +19 more
2021Journal of Clinical Endocrinology and Metabolism37 citations Open access
Semantic Scholar
β2-Spectrin (SPTBN1) as a Therapeutic Target for Diet-Induced Liver Disease and Preventing Cancer Development
Shuyun Rao, Xiao-Chun Yang, Kazufumi Ohshiro, S. Zaidi +20 more
2021Science Translational Medicine36 citations Open access
Semantic Scholar
Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes
David Z. Pan, Zong Miao, Caroline Comenho, S. Rajkumar +17 more
2021Genome Medicine35 citations Open access
Semantic Scholar
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease
S. Romeo, O. Jamialahmadi, A. De Vincentis, F. Tavaglione +12 more
2024Research Square34 citations Open access
Semantic Scholar
Remote Ischemic Conditioning Alters Methylation and Expression of Cell Cycle Genes in Aneurysmal Subarachnoid Hemorrhage
E. Nikkola, Azim N. Laiwalla, Arthur Ko, M. Alvarez +6 more
2015Stroke33 citations Open access
Semantic Scholar
Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease
Nicholas Darci-Maher, M. Alvarez, U. T. Arasu, Ilakya Selvarajan +16 more
2023EBioMedicine30 citations Open access
Semantic Scholar
Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease
Seung Hyuk T. Lee, K. Garske, U. T. Arasu, A. Kar +18 more
2024EBioMedicine23 citations Open access
Semantic Scholar
Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions
A. Kar, M. Alvarez, K. Garske, Huiling Huang +10 more
2024Genome Medicine23 citations Open access
Semantic Scholar
Reverse gene-environment interaction approach to identify variants influencing body-mass index in humans
K. Garske, David Z. Pan, Zong Miao, Yash V. Bhagat +11 more
2019Nature Metabolism21 citations Open access
Semantic Scholar
ASElux: an ultra‐fast and accurate allelic reads counter
Zong Miao, M. Alvarez, P. Pajukanta, Arthur Ko
2018Bioinform.14 citations Open access
Semantic Scholar
Cell-Type Composition Affects Adipose Gene Expression Associations With Cardiometabolic Traits
S. M. Brotman, Anniina Oravilahti, Jonathan D. Rosen, M. Alvarez +18 more
2023Diabetes11 citations Open access
Semantic Scholar
Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue
Z. Chen, Sankha Subhra Das, A. Kar, Seung Hyuk T. Lee +17 more
2025Nature Genetics10 citations Open access
Semantic Scholar
Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition
V. Männistö, D. Kamińska, P. Käkelä, M. Neuvonen +7 more
2020Hepatology Communications9 citations Open access
Semantic Scholar
Molecular characterization of the lipid GWAS signal on chromosome 18q11.2 implicates HNF4A-mediated regulation of the TMEM241 gene
Alejandra Rodríguez, Luis Gonzalez, Arthur Ko, M. Alvarez +13 more
2016Arteriosclerosis, Thrombosis and Vascular Biology8 citations Open access
Semantic Scholar
Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association With Insulin Resistance and Altered BCAA Metabolism
R. Å. Jersin, D. Tallapragada, Linn Skartveit, M. S. Bjune +12 more
2023Journal of Clinical Endocrinology and Metabolism7 citations Open access
Semantic Scholar
Family-specific aggregation of lipid GWAS variants confers the susceptibility to familial hypercholesterolemia in a large Austrian family
E. Nikkola, Arthur Ko, M. Alvarez, R. Cantor +16 more
2017Atherosclerosis6 citations Open access
Semantic Scholar
Integration of single cell omics with biobank data discovers trans effects of SREBF1 abdominal obesity risk variants on adipocyte expression of more than 100 genes
M. G. Sukhatme, A. Kar, U. T. Arasu, S. H. Lee +16 more
2024medRxiv5 citations Open access
Semantic Scholar
An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns
Milena Deal, A. Kar, Seung Hyuk T. Lee, M. Alvarez +14 more
2024American Journal of Human Genetics5 citations Open access
Semantic Scholar
Publisher Correction: Accurate estimation of cell composition in bulk expression through robust integration of single-cell information
B. Jew, M. Alvarez, Elior Rahmani, Zong Miao +6 more
2020Nature Communications5 citations Open access
Semantic Scholar
Cross-tissue single nucleus RNA-sequencing discovers tissue-resident adipocytes involved in propanoate metabolism in the human heart
Sankha Subhra Das, A. Kar, S. Rajkumar, Seung Hyuk T. Lee +3 more
2023Arteriosclerosis, Thrombosis and Vascular Biology4 citations Open access
Semantic Scholar
Long-range chromosomal interactions increase and mark repressed gene expression during adipogenesis
K. Garske, Caroline Comenho, David Z. Pan, M. Alvarez +4 more
2022Epigenetics4 citations Open access
Semantic Scholar
Single-cell dissection of obesity-exercise axis in adipose-muscle tissues
Jie-Ying Yang, Maria Vamvini, P. Nigro, L. Ho +10 more
2021bioRxiv4 citations Open access
Semantic Scholar
Isolation of Nuclei from Human Snap-frozen Liver Tissue for Single-nucleus RNA Sequencing.
M. Alvarez, J. Benhammou, Shuyun Rao, Lopa Mishra +2 more
2023Bio-protocol3 citations Open access
Semantic Scholar
Single-cell DNA methylome and 3D genome atlas of the human subcutaneous adipose tissue
Z. Chen, Sankha Subhra Das, A. Kar, Seung Hyuk T. Lee +15 more
2024bioRxiv2 citations Open access
Semantic Scholar
Author Correction: Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS
David Z. Pan, K. Garske, M. Alvarez, Yash V. Bhagat +15 more
2018Nature Communications2 citations Open access
Semantic Scholar
Lessons from single cell omics: admixed American ancestry and sex confer cardiometabolic disease risk in Mexicans
A. Kar, Seung Hyuk T. Lee, M. Alvarez, S. Rajkumar +15 more
2026Genome Medicine1 citations Open access
Semantic Scholar
Decreased degree of adipocyte differentiation in visceral adipose tissue contributes to metabolic dysfunction-associated steatotic liver disease
K. Gelev, Seung Hyuk T. Lee, M. Alvarez, R. Mancina +15 more
2026Nature Communications1 citations Open access
Semantic Scholar
The effect of obesity and aging on NAD+/Sirtuin metabolism transcription and DNA methylation in subcutaneous adipose tissue of monozygotic twin pairs discordant for BMI
H. Lapatto, B. W. van der Kolk, M. Muniandy, S. Heinonen +14 more
2026International Journal of Obesity1 citations Open access
Semantic Scholar
Sex‐Specific Subcutaneous Adipose Tissue Transcriptome in Obesity: Insights From Monozygotic Twin Pairs Discordant for BMI
Hanna Haltia, M. Muniandy, S. Heinonen, S. Saari +9 more
2025Obesity1 citations Open access
Semantic Scholar
Human liver single nucleus and single cell RNA sequencing identify a hepatocellular carcinoma-associated cell-type affecting survival
M. Alvarez, J. Benhammou, Nicholas Darci-Maher, S. French +5 more
2022Genome Medicine1 citations Open access
Semantic Scholar
Correction to: Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes
David Z. Pan, Zong Miao, Caroline Comenho, S. Rajkumar +17 more
2021Genome Medicine1 citations Open access
Semantic Scholar
Publisher Correction: RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice
D. Karunakaran, A. Turner, A. Duchez, S. Soubeyrand +26 more
2020Nature Metabolism1 citations Open access
Semantic Scholar
Su1496 - The Long Intergenic, Non-Coding RNA, Olmalinc, Influences Lipid Metabolism in Hepatocytes by Regulating SREBP1 and SREBP2, and may Play a Critical Role in the Development of NAFLD
J. Benhammou, Arthur Ko, M. Alvarez, D. Kamińska +3 more
20181 citations
Semantic Scholar
Integration of single cell omics with biobank data discovers allele-specific trans effects of SREBF1 on adipocyte expression of nearly 100 genes
M. G. Sukhatme, A. Kar, Seung Hyuk T. Lee, K. Gelev +21 more
2026Genome Medicine0 citations Open access
Semantic Scholar
Publisher Correction: Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease
O. Jamialahmadi, A. De Vincentis, F. Tavaglione, F. Malvestiti +12 more
2025Nature Medicine0 citations Open access
Semantic Scholar
Decomposition of Bulk Expression with Single-Cell Sequencing [R package BisqueRNA version 1.0.4]
B. Jew, M. Alvarez
20200 citations
Semantic Scholar

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