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J. Grubb · SciRah

Researcher profile · Semantic Scholar

J. Grubb

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J. Grubb — researcher profile on SciRah

h-index: 46
Works: 92
Citations: 6,302

Most-cited papers

Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling
Alfonso Gonzalez-Noriega, J. Grubb, Venugopal Talkad, William S. Sly
1980Journal of Cell Biology642 citations Open access
Semantic Scholar
Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers.
O. Türeci, U. Şahin, Evi Vollmar, S. Siemer +7 more
1998Proceedings of the National Academy of Sciences of the United States of America371 citations Open access
Semantic Scholar
Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells
D. Whittington, A. Waheed, B. Ulmasov, G. N. Shah +3 more
2001Proceedings of the National Academy of Sciences of the United States of America324 citations Open access
Semantic Scholar
Structure of human β-glucuronidase reveals candidate lysosomal targeting and active-site motifs
Sanjeev Jain, William B. Drendel, Zhi-Wei Chen, F. Mathews +2 more
1996Nature Structural Biology230 citations
Semantic Scholar
The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells.
A. Oshima, Catherine M. Nolan, J. W. Kyle, J. Grubb +1 more
1988Journal of Biological Chemistry216 citations Open access
Semantic Scholar
Enzyme replacement therapy for murine mucopolysaccharidosis type VII.
M. Sands, C. Vogler, J. W. Kyle, J. Grubb +4 more
1994Journal of Clinical Investigation193 citations Open access
Semantic Scholar
Overcoming the blood-brain barrier with high-dose enzyme replacement therapy in murine mucopolysaccharidosis VII.
C. Vogler, B. Levy, J. Grubb, Nancy Galvin +4 more
2005Proceedings of the National Academy of Sciences of the United States of America171 citations Open access
Semantic Scholar
Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier.
A. Urayama, J. Grubb, W. Sly, W. Banks
2004Proceedings of the National Academy of Sciences of the United States of America165 citations Open access
Semantic Scholar
Expression of a novel transmembrane carbonic anhydrase isozyme XII in normal human gut and colorectal tumors.
A. Kivelä, S. Parkkila, J. Saarnio, T. Karttunen +8 more
2000American Journal of Pathology161 citations Open access
Semantic Scholar
Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis
A. Waheed, J. Grubb, Xiao-Yan Zhou, S. Tomatsu +5 more
2002Proceedings of the National Academy of Sciences of the United States of America157 citations Open access
Semantic Scholar
Cloning, sequencing, and expression of cDNA for human beta-glucuronidase.
A. Oshima, J. W. Kyle, Raymond D. Miller, J. W. Hoffmann +6 more
1987Proceedings of the National Academy of Sciences of the United States of America142 citations Open access
Semantic Scholar
The insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor mediates IGF-II-induced motility in human rhabdomyosarcoma cells.
C. Minniti, E. Kohn, J. Grubb, W. Sly +4 more
1992Journal of Biological Chemistry138 citations
Semantic Scholar
Expression of membrane-associated carbonic anhydrase XIV on neurons and axons in mouse and human brain.
S. Parkkila, A. Parkkila, H. Rajaniemi, G. N. Shah +3 more
2001Proceedings of the National Academy of Sciences of the United States of America133 citations Open access
Semantic Scholar
Mutations and Polymorphisms in GUSB Gene in Mucopolysaccharidosis VII (Sly Syndrome)
S. Tomatsu, A. Montaño, D. Vũ, J. Grubb +1 more
2009Human Mutation122 citations Open access
Semantic Scholar
Chemically modified β-glucuronidase crosses blood–brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII
J. Grubb, C. Vogler, B. Levy, N. Galvin +2 more
2008Proceedings of the National Academy of Sciences of the United States of America117 citations Open access
Semantic Scholar
Mitochondrial carbonic anhydrase CA VB: differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles.
G. N. Shah, D. Hewett-Emmett, J. Grubb, M. C. Migas +3 more
2000Proceedings of the National Academy of Sciences of the United States of America112 citations Open access
Semantic Scholar
Carbonic anhydrase XIV is enriched in specific membrane domains of retinal pigment epithelium, Müller cells, and astrocytes
E. Nagelhus, T. M. Mathiisen, A. Bateman, F. Haug +4 more
2005Proceedings of the National Academy of Sciences of the United States of America99 citations Open access
Semantic Scholar
Expression, Assay, and Structure of the Extracellular Domain of Murine Carbonic Anhydrase XIV
Douglas A. Whittingtons, J. Grubb, A. Waheed, G. N. Shah +2 more
2004Journal of Biological Chemistry99 citations Open access
Semantic Scholar
Mouse model of N-acetylgalactosamine-6-sulfate sulfatase deficiency (Galns-/-) produced by targeted disruption of the gene defective in Morquio A disease.
S. Tomatsu, K. Orii, C. Vogler, J. Nakayama +11 more
2003Human Molecular Genetics98 citations Open access
Semantic Scholar
Distinctive regulation of the functional linkage between the human cation-independent mannose 6-phosphate receptor and GTP-binding proteins by insulin-like growth factor II and mannose 6-phosphate.
Y. Murayama, T. Okamoto, E. Ogata, T. Asano +6 more
1990Journal of Biological Chemistry97 citations Open access
Semantic Scholar
Glycosylation-independent targeting enhances enzyme delivery to lysosomes and decreases storage in mucopolysaccharidosis type VII mice.
J. Lebowitz, J. Grubb, J. Maga, D. Schmiel +2 more
2004Proceedings of the National Academy of Sciences of the United States of America93 citations Open access
Semantic Scholar
Identification of carbonic anhydrase XII as the membrane isozyme expressed in the normal human endometrial epithelium.
Pepe Karhumaa, S. Parkkila, O. Türeci, Abdul Waheed +7 more
2000Molecular human reproduction93 citations Open access
Semantic Scholar
Development and Testing of New Screening Method for Keratan Sulfate in Mucopolysaccharidosis IVA
S. Tomatsu, K. Okamura, T. Taketani, K. Orii +23 more
2004Pediatric Research89 citations
Semantic Scholar
Carbonic anhydrase XIV: luminal expression suggests key role in renal acidification.
Kari Kaunisto, S. Parkkila, H. Rajaniemi, A. Waheed +2 more
2002Kidney International86 citations Open access
Semantic Scholar
Mannose 6-phosphate receptor-mediated transport of sulfamidase across the blood-brain barrier in the newborn mouse.
A. Urayama, J. Grubb, W. Sly, W. Banks
2008Molecular Therapy83 citations Open access
Semantic Scholar
The role of glycosylation and phosphorylation in the expression of active human beta-glucuronidase.
J. Shipley, J. Grubb, W. Sly
1993Journal of Biological Chemistry83 citations Open access
Semantic Scholar
Enhancement of drug delivery to bone: characterization of human tissue-nonspecific alkaline phosphatase tagged with an acidic oligopeptide.
T. Nishioka, S. Tomatsu, M. Gutiérrez, Ken-ichi Miyamoto +10 more
2006Molecular Genetics and Metabolism82 citations Open access
Semantic Scholar
Carbonic anhydrase II deficiency: diagnosis and carrier detection using differential enzyme inhibition and inactivation.
Vasantha Sundaram, P. Rumbolo, J. Grubb, P. Strisciuglio +1 more
1986American Journal of Human Genetics77 citations
Semantic Scholar
Active site residues of human beta-glucuronidase. Evidence for Glu(540) as the nucleophile and Glu(451) as the acid-base residue.
M. R. Islam, Shunji Tomatsu, Gul N. Shah, J. Grubb +2 more
1999Journal of Biological Chemistry76 citations Open access
Semantic Scholar
Purification and kinetic analysis of recombinant CA XII, a membrane carbonic anhydrase overexpressed in certain cancers.
B. Ulmasov, Abdul Waheed, G. N. Shah, J. Grubb +3 more
2000Proceedings of the National Academy of Sciences of the United States of America75 citations Open access
Semantic Scholar
Assessment of bone dysplasia by micro-CT and glycosaminoglycan levels in mouse models for mucopolysaccharidosis type I, IIIA, IVA, and VII
Daniel J. Rowan, S. Tomatsu, J. Grubb, A. Montaño +1 more
2012Journal of Inherited Metabolic Disease74 citations Open access
Semantic Scholar
Biodistribution, Kinetics, and Efficacy of Highly Phosphorylated and Non-phosphorylated β-Glucuronidase in the Murine Model of Mucopolysaccharidosis VII*
M. Sands, C. Vogler, Kevin K. Ohlemiller, Marie S. Roberts +3 more
2001Journal of Biological Chemistry74 citations Open access
Semantic Scholar
New Strategies for Enzyme Replacement Therapy for Lysosomal Storage Diseases
J. Grubb, C. Vogler, W. Sly
2010Rejuvenation Research72 citations Open access
Semantic Scholar
Localization of Carbonic Anhydrase XII to the Basolateral Membrane of H+-secreting Cells of Mouse and Rat Kidney
Matti S. Kyllönen, S. Parkkila, H. Rajaniemi, A. Waheed +4 more
2003Journal of Histochemistry and Cytochemistry69 citations
Semantic Scholar
Mutational analysis of a patient with mucopolysaccharidosis type VII, and identification of pseudogenes.
J. Shipley, M. Klinkenberg, B.-M. Wu, D. R. Bachinsky +2 more
1993American Journal of Human Genetics66 citations
Semantic Scholar
[38] Isolation of fibroblasts from patients
W. Sly, J. Grubb
197966 citations
Semantic Scholar
Development of MPS IVA mouse (Galnstm(hC79S.mC76S)slu) tolerant to human N-acetylgalactosamine-6-sulfate sulfatase.
S. Tomatsu, M. Gutiérrez, T. Nishioka, Masamichi Yamada +12 more
2005Human Molecular Genetics61 citations
Semantic Scholar
Epinephrine enhances lysosomal enzyme delivery across the blood–brain barrier by up-regulation of the mannose 6-phosphate receptor
A. Urayama, J. Grubb, W. Banks, W. Sly
2007Proceedings of the National Academy of Sciences of the United States of America56 citations Open access
Semantic Scholar
Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors
W. Sly, C. Vogler, J. Grubb, B. Levy +4 more
2006Proceedings of the National Academy of Sciences of the United States of America56 citations Open access
Semantic Scholar
Carbonic anhydrase XIV identified as the membrane CA in mouse retina: strong expression in Müller cells and the RPE.
J. Ochrietor, Michael F. Clamp, T. Moroz, J. Grubb +4 more
2005Experimental Eye Research56 citations
Semantic Scholar
Characterization and pharmacokinetic study of recombinant human N-acetylgalactosamine-6-sulfate sulfatase.
S. Tomatsu, A. Montaño, M. Gutiérrez, J. Grubb +9 more
2007Molecular Genetics and Metabolism54 citations
Semantic Scholar
The overexpressed human 46-kDa mannose 6-phosphate receptor mediates endocytosis and sorting of beta-glucuronidase.
H. Watanabe, J. Grubb, William S. Sly
1990Proceedings of the National Academy of Sciences of the United States of America51 citations Open access
Semantic Scholar
Expression of Membrane-bound Carbonic Anhydrases IV, IX, and XIV in the Mouse Heart
R. Scheibe, G. Gros, S. Parkkila, A. Waheed +4 more
2006Journal of Histochemistry and Cytochemistry49 citations Open access
Semantic Scholar
Cloning, sequencing, and functional characterization of the murine 46-kDa mannose 6-phosphate receptor.
Zhong-Min Ma, J. Grubb, William S. Sly
1991Journal of Biological Chemistry49 citations Open access
Semantic Scholar
Role of the 6-phosphomannosyl-enzyme receptor in intracellular transport and adsorptive pinocytosis of lysosomal enzymes.
William S. Sly, H. Fischer, A. González-Noriega, J. Grubb +1 more
1981Methods in Cell Biology49 citations
Semantic Scholar
Acidic amino acid tag enhances response to enzyme replacement in mucopolysaccharidosis type VII mice.
A. Montaño, H. Oikawa, S. Tomatsu, T. Nishioka +11 more
2008Molecular Genetics and Metabolism48 citations
Semantic Scholar
Identification of Glu-540 as the Catalytic Nucleophile of Human β-Glucuronidase Using Electrospray Mass Spectrometry*
A. Wong, Shou-Ming He, J. Grubb, W. Sly +1 more
1998Journal of Biological Chemistry46 citations Open access
Semantic Scholar
C-terminal processing of human beta-glucuronidase. The propeptide is required for full expression of catalytic activity, intracellular retention, and proper phosphorylation.
M. R. Islam, J. Grubb, William S. Sly
1993Journal of Biological Chemistry41 citations Open access
Semantic Scholar
Demonstration of the heterozygous state for I-cell disease and pseudo-Hurler polydystrophy by assay of N-acetylglucosaminylphosphotransferase in white blood cells and fibroblasts.
A. Varki, M. L. Reitman, A. Vannier, S. Kornfeld +2 more
1982American Journal of Human Genetics41 citations
Semantic Scholar
Active site mutant transgene confers tolerance to human β-glucuronidase without affecting the phenotype of MPS VII mice
W. Sly, C. Vogler, J. Grubb, Mi Zhou +5 more
2001Proceedings of the National Academy of Sciences of the United States of America40 citations Open access
Semantic Scholar

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W. Sly×30
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W. Sly — researcher profile on SciRah
G. N. Shah×11
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G. N. Shah — researcher profile on SciRah
S. Tomatsu×11
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S. Tomatsu — researcher profile on SciRah
C. Vogler×10
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C. Vogler — researcher profile on SciRah

×9

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A. Waheed — researcher profile on SciRah

William S. Sly×8

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William S. Sly — researcher profile on SciRah

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T. Nishioka — researcher profile on SciRah

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B. Levy — researcher profile on SciRah

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A. Montaño — researcher profile on SciRah

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M. Gutiérrez — researcher profile on SciRah

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S. Parkkila — researcher profile on SciRah

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H. Rajaniemi — researcher profile on SciRah