B. R. Grubb

Most-cited papers

Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease.
Hirotoshi Matsui, B. R. Grubb, R. Tarran, S. Randell +3 more
1998Cell1,201 citations Open access
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Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice
M. Mall, B. R. Grubb, J. Harkema, W. O'Neal +1 more
2004Nature Medicine964 citations
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Muc5b Is Required for Airway Defense
Michelle G. Roy, A. Livraghi-Butrico, Ashley A. Fletcher, Melissa M. McElwee +39 more
2013Nature716 citations Open access
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Pathophysiology of gene-targeted mouse models for cystic fibrosis.
B. R. Grubb, R. Boucher
1999Physiological Reviews415 citations
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Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans
B. R. Grubb, R. Pickles, Hong Ye, J. Yankaskas +5 more
1994Nature366 citations
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Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice.
L. Clarke, B. R. Grubb, J. Yankaskas, C. Cotton +2 more
1994Proceedings of the National Academy of Sciences of the United States of America365 citations Open access
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Defective Epithelial Chloride Transport in a Gene-Targeted Mouse Model of Cystic Fibrosis
L. Clarke, B. R. Grubb, S. Gabriel, O. Smithies +2 more
1992Science342 citations
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Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium
Raymond D. Coakley, B. R. Grubb, A. M. Paradiso, J. Gatzy +4 more
2003Proceedings of the National Academy of Sciences of the United States of America292 citations Open access
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The Relative Roles of Passive Surface Forces and Active Ion Transport in the Modulation of Airway Surface Liquid Volume and Composition
R. Tarran, B. R. Grubb, J. Gatzy, C. Davis +1 more
2001The Journal of General Physiology264 citations Open access
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The CF salt controversy: in vivo observations and therapeutic approaches.
R. Tarran, B. R. Grubb, D. Parsons, M. Picher +3 more
2001Molecules and Cells263 citations Open access
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Role of gammaENaC subunit in lung liquid clearance and electrolyte balance in newborn mice. Insights into perinatal adaptation and pseudohypoaldosteronism.
Pierre M. Barker, Mytrang Nguyen, J. Gatzy, B. R. Grubb +5 more
1998Journal of Clinical Investigation247 citations Open access
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Transmembrane Protein 16A (TMEM16A) Is a Ca2+-regulated Cl– Secretory Channel in Mouse Airways*
J. Rock, W. O'Neal, S. Gabriel, S. Randell +3 more
2009Journal of Biological Chemistry243 citations Open access
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Nucleotide Release Provides a Mechanism for Airway Surface Liquid Homeostasis*
E. Lazarowski, R. Tarran, B. R. Grubb, C. van Heusden +2 more
2004Journal of Biological Chemistry243 citations Open access
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Hyperabsorption of Na+ and raised Ca(2+)-mediated Cl- secretion in nasal epithelia of CF mice.
B. R. Grubb, Ralph N. Vick, R. Boucher
1994American Journal of Physiology229 citations
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Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs
C. Ehre, E. Worthington, R. Liesman, B. R. Grubb +5 more
2012Proceedings of the National Academy of Sciences of the United States of America196 citations Open access
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Effect of Loss of P2Y2 Receptor Gene Expression on Nucleotide Regulation of Murine Epithelial Cl−Transport*
V. Cressman, E. Lazarowski, László Homolya, R. Boucher +2 more
1999Journal of Biological Chemistry195 citations Open access
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A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism.
E. Hummler, Pierre M. Barker, Colleen L. Talbot, Qing Wang +8 more
1997Proceedings of the National Academy of Sciences of the United States of America174 citations Open access
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Intestinal physiology and pathology in gene-targeted mouse models of cystic fibrosis.
B. R. Grubb, Sherif E. Gabriel
1997American Journal of Physiology162 citations
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Reduced Three-Dimensional Motility in Dehydrated Airway Mucus Prevents Neutrophil Capture and Killing Bacteria on Airway Epithelial Surfaces1
Hirotoshi Matsui, M. Verghese, M. Kesimer, Ute E. Schwab +4 more
2005Journal of Immunology151 citations Open access
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Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia.
K. Okuda, H. Dang, Yoshihiko Kobayashi, G. Carraro +27 more
2020American Journal of Respiratory and Critical Care Medicine149 citations Open access
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Extracellular nucleotides block bone mineralization in vitro: evidence for dual inhibitory mechanisms involving both P2Y2 receptors and pyrophosphate.
I. Orriss, Jennifer C. Utting, A. Brandao-Burch, K. Colston +3 more
2007Endocrinology138 citations Open access
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Salt restriction induces pseudohypoaldosteronism type 1 in mice expressing low levels of the beta-subunit of the amiloride-sensitive epithelial sodium channel.
Sylvain Pradervand, Pierre M. Barker, Qing Wang, Stephen A. Ernst +8 more
1999Proceedings of the National Academy of Sciences of the United States of America129 citations Open access
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Anomalies in ion transport in CF mouse tracheal epithelium.
B. R. Grubb, A. M. Paradiso, R. C. Boucher
1994American Journal of Physiology110 citations
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Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease
A. Livraghi-Butrico, B. R. Grubb, K. J. Wilkinson, A. Volmer +4 more
2016Mucosal Immunology106 citations Open access
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Ion transport across the jejunum in normal and cystic fibrosis mice.
B. R. Grubb
1995American Journal of Physiology105 citations
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Inactivation of Chibby affects function of motile airway cilia
V. Voronina, K. Takemaru, P. Treuting, D. Love +5 more
2009Journal of Cell Biology101 citations Open access
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Airway and lung pathology due to mucosal surface dehydration in β-Epithelial Na+ Channel-overexpressing mice: role of TNFα and IL-4Rα signaling, influence of neonatal development, and limited efficacy of glucocorticoid treatment
A. Livraghi, B. R. Grubb, E. J. Hudson, K. J. Wilkinson +5 more
2009Journal of Immunology100 citations Open access
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Enhanced In Vivo Airway Gene Transfer via Transient Modification of Host Barrier Properties with a Surface-Active Agent
D. Parsons, B. R. Grubb, Larry G. Johnson, Richard C. Boucher
1998Human Gene Therapy100 citations
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An Improved Inhaled Mucolytic to Treat Airway Muco‐obstructive Diseases
C. Ehre, Z. Rushton, Boya Wang, Lauren N. Hothem +13 more
2019American Journal of Respiratory and Critical Care Medicine97 citations Open access
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Conditional deletion of dnaic1 in a murine model of primary ciliary dyskinesia causes chronic rhinosinusitis.
L. Ostrowski, W. Yin, T. D. Rogers, Katie B Busalacchi +3 more
2010American Journal of Respiratory Cell and Molecular Biology93 citations Open access
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Human Alveolar Type II Cells Secrete and Absorb Liquid in Response to Local Nucleotide Signaling*
Peter F. Bove, B. R. Grubb, Seiko F. Okada, C. Ribeiro +4 more
2010Journal of Biological Chemistry84 citations Open access
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Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and Mucociliary Clearance.
Ximena M. Bustamante-Marin, W. Yin, P. Sears, Michael E Werner +15 more
2019American Journal of Human Genetics80 citations Open access
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Airway Surface Liquid Volume Regulation Determines Different Airway Phenotypes in Liddle Compared with βENaC-overexpressing Mice*
M. Mall, B. Button, Bjarki Johannesson, Zhe Zhou +10 more
2010Journal of Biological Chemistry72 citations Open access
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The Cystic Fibrosis Transmembrane Conductance Regulator Is Regulated by a Direct Interaction with the Protein Phosphatase 2A*
W. Thelin, M. Kesimer, R. Tarran, S. Kreda +4 more
2005Journal of Biological Chemistry71 citations Open access
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Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration
Y. Mikami, B. R. Grubb, T. D. Rogers, H. Dang +18 more
2023Science Translational Medicine66 citations Open access
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SERCA pump inhibitors do not correct biosynthetic arrest of deltaF508 CFTR in cystic fibrosis.
B. R. Grubb, S. Gabriel, A. Mengos, M. Gentzsch +6 more
2006American Journal of Respiratory Cell and Molecular Biology65 citations Open access
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In Vivo Airway Surface Liquid Cl− Analysis with Solid-State Electrodes
R. Caldwell, B. R. Grubb, R. Tarran, R. Boucher +2 more
2002The Journal of General Physiology58 citations Open access
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Expression of the amino acid transporter ATB 0+ in lung: possible role in luminal protein removal.
J. Sloan, B. R. Grubb, S. Mager
2003American Journal of Physiology - Lung cellular and Molecular Physiology57 citations
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Isolation and culture of airway epithelial cells from chronically infected human lungs
S. Randell, D. Walstad, Ute E. Schwab, B. R. Grubb +1 more
2001In vitro Cellular & Developmental Biology-Animal56 citations
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Intestinal ion transport in NKCC1-deficient mice.
B. R. Grubb, Eddie Lee, Amy J. Pace, Beverly H. Koller +1 more
2000American Journal of Physiology - Gastrointestinal and Liver Physiology55 citations
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Mucociliary transport determined by in vivo microdialysis in the airways of normal and CF mice.
B. R. Grubb, James H. Jones, R. C. Boucher
2004American Journal of Physiology - Lung cellular and Molecular Physiology54 citations
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Reduced mucociliary clearance in old mice is associated with a decrease in Muc5b mucin.
B. R. Grubb, A. Livraghi-Butrico, T. D. Rogers, W. Yin +2 more
2016American Journal of Physiology - Lung cellular and Molecular Physiology53 citations Open access
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Alterations in airway ion transport in NKCC1-deficient mice.
B. R. Grubb, Amy J. Pace, Eddie Lee, Beverly H. Koller +1 more
2001American Journal of Physiology - Cell Physiology53 citations
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Enhanced colonic Na+ absorption in cystic fibrosis mice versus normal mice.
B. R. Grubb, R. Boucher
1997American Journal of Physiology53 citations
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Restoring ciliary function to differentiated Primary Ciliary Dyskinesia cells with a lentiviral vector
L. Ostrowski, W. Yin, Manij Patel, J. Sechelski +4 more
2014Gene Therapy51 citations Open access
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Loss of Cftr function exacerbates the phenotype of Na(+) hyperabsorption in murine airways.
A. Livraghi-Butrico, E. J. Kelly, K. J. Wilkinson, T. D. Rogers +6 more
2013American Journal of Physiology - Lung cellular and Molecular Physiology46 citations Open access
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Expression of CFTR from a ciliated cell-specific promoter is ineffective at correcting nasal potential difference in CF mice
L. Ostrowski, W. Yin, P. S. Diggs, T. D. Rogers +2 more
2007Gene Therapy40 citations Open access
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Regional differences in rat conjunctival ion transport activities.
Dongfang Yu, W. Thelin, T. D. Rogers, M. Stutts +3 more
2012American Journal of Physiology - Cell Physiology37 citations Open access
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Ion transport across the normal and CF neonatal murine intestine.
B. R. Grubb
1999American Journal of Physiology - Gastrointestinal and Liver Physiology36 citations
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Genetically determined heterogeneity of lung disease in a mouse model of airway mucus obstruction.
A. Livraghi-Butrico, B. R. Grubb, E. J. Kelly, K. J. Wilkinson +5 more
2012Physiological Genomics33 citations Open access
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