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H. Vischer · SciRah

Researcher profile · Semantic Scholar

H. Vischer

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H. Vischer — researcher profile on SciRah

h-index: 39
Works: 152
Citations: 4,693

Most-cited papers

Pharmacological modulation of chemokine receptor function
D. Scholten, M. Canals, D. Maussang, L. Roumen +5 more
2012British Journal of Pharmacology266 citations Open access
Semantic Scholar
Llama-derived Single Variable Domains (Nanobodies) Directed against Chemokine Receptor CXCR7 Reduce Head and Neck Cancer Cell Growth in Vivo
D. Maussang, Azra Mujić-Delić, F. Descamps, Catelijne Stortelers +10 more
2013Journal of Biological Chemistry154 citations Open access
Semantic Scholar
Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
H. Vischer, M. Siderius, R. Leurs, M. Smit
2014Nature reviews. Drug discovery93 citations
Semantic Scholar
Function-specific virtual screening for GPCR ligands using a combined scoring method
A. Kooistra, H. Vischer, Daniel A McNaught-Flores, R. Leurs +2 more
2016Scientific Reports79 citations Open access
Semantic Scholar
The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth
R. Heukers, Tian-Chi Fan, Raymond H. de Wit, Jeffrey R. van Senten +15 more
2018Oncogene78 citations Open access
Semantic Scholar
Identification and profiling of CXCR3–CXCR4 chemokine receptor heteromer complexes
A. Watts, M. V. van Lipzig, Werner C. Jaeger, R. Seeber +10 more
2013British Journal of Pharmacology75 citations Open access
Semantic Scholar
Virtual Fragment Screening: Discovery of Histamine H3 Receptor Ligands Using Ligand-Based and Protein-Based Molecular Fingerprints
F. Sirci, E. P. Istyastono, H. Vischer, A. Kooistra +7 more
2012Journal of Chemical Information and Modeling70 citations
Semantic Scholar
Ligand Residence Time at G-protein–Coupled Receptors—Why We Should Take Our Time To Study It
Carsten Hoffmann, M. Castro, A. Rinken, R. Leurs +2 more
2015Molecular Pharmacology69 citations
Semantic Scholar
G Protein–Coupled Receptor Multimers: A Question Still Open Despite the Use of Novel Approaches
H. Vischer, M. Castro, J. Pin
2015Molecular Pharmacology59 citations Open access
Semantic Scholar
Genetically encoded sensors for measuring histamine release both in vitro and in vivo
Hui Dong, Mengyao Li, Yu-Qi Yan, Tong-Rui Qian +8 more
2022bioRxiv58 citations Open access
Semantic Scholar
β-Arrestin Recruitment and G Protein Signaling by the Atypical Human Chemokine Decoy Receptor CCX-CKR*
A. Watts, Folkert Verkaar, Miranda M. C. Van der Lee, Claudia A. W. Timmerman +7 more
2013Journal of Biological Chemistry57 citations Open access
Semantic Scholar
Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells
Leigh A. Stoddart, A. Vernall, Mónica Bouzo-Lorenzo, Reggie Bosma +7 more
2018Scientific Reports54 citations Open access
Semantic Scholar
Pharmacological characterization of a small‐molecule agonist for the chemokine receptor CXCR3
D. Scholten, Meritxell Canals, M. Wijtmans, S. D. de Munnik +6 more
2012British Journal of Pharmacology54 citations Open access
Semantic Scholar
Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology
Niels J. Hauwert, Tamara A. M. Mocking, Daniel da Costa Pereira, A. Kooistra +10 more
2018Journal of the American Chemical Society53 citations Open access
Semantic Scholar
Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors
S. D. de Munnik, M. Smit, R. Leurs, H. Vischer
2015Frontiers in Pharmacology50 citations Open access
Semantic Scholar
Constitutive ß-Catenin Signaling by the Viral Chemokine Receptor US28
Ellen V. Langemeijer, E. Slinger, S. D. de Munnik, A. Schreiber +6 more
2012PLoS ONE49 citations Open access
Semantic Scholar
Detailed analysis of biased histamine H4 receptor signalling by JNJ 7777120 analogues
S. Nijmeijer, H. Vischer, Francesco Sirci, S. Schultes +5 more
2013British Journal of Pharmacology42 citations Open access
Semantic Scholar
Differential Involvement of ACKR3 C-Tail in β-Arrestin Recruitment, Trafficking and Internalization
A. Zarca, C. Perez, J. van den Bor, J. Bebelman +6 more
2021Cells39 citations Open access
Semantic Scholar
The long duration of action of the second generation antihistamine bilastine coincides with its long residence time at the histamine H1 receptor
Reggie Bosma, J. van den Bor, H. Vischer, L. Labeaga +1 more
2018European Journal of Pharmacology36 citations Open access
Semantic Scholar
Chemokine cooperativity is caused by competitive glycosaminoglycan binding
Folkert Verkaar, Jody van Offenbeek, Miranda M. C. Van der Lee, Lambertus H. C. J. van Lith +11 more
2014Journal of Immunology36 citations Open access
Semantic Scholar
Optical control of Class A G protein-coupled receptors with photoswitchable ligands.
M. Wijtmans, Ivana Josimovic, H. Vischer, R. Leurs
2022Current opinion in pharmacology (Print)34 citations Open access
Semantic Scholar
Photoswitching the Efficacy of a Small-Molecule Ligand for a Peptidergic GPCR: from Antagonism to Agonism.
X. Gómez-Santacana, S. D. de Munnik, Prashanna Vijayachandran, Daniel da Costa Pereira +5 more
2018Angewandte Chemie33 citations Open access
Semantic Scholar
Homogeneous, Real-Time NanoBRET Binding Assays for the Histamine H3 and H4 Receptors on Living Cells
Tamara A. M. Mocking, E. W. E. Verweij, H. Vischer, R. Leurs
2018Molecular Pharmacology33 citations Open access
Semantic Scholar
CXCR4-Specific Nanobodies as Potential Therapeutics for WHIM syndrome
Raymond H. de Wit, R. Heukers, H. J. Brink, Angela Arsova +6 more
2017Journal of Pharmacology and Experimental Therapeutics32 citations Open access
Semantic Scholar
Aquaporin-4 and GPRC5B: old and new players in controlling brain oedema
E. Passchier, Sven Kerst, Eelke Brouwers, E. M. Hamilton +20 more
2023Brain : a journal of neurology31 citations Open access
Semantic Scholar
Development of a Conformational Histamine H3 Receptor Biosensor for the Synchronous Screening of Agonists and Inverse Agonists
Hannes Schihada, Xiao-Yuan Ma, U. Zabel, H. Vischer +4 more
2020ACS Sensors30 citations Open access
Semantic Scholar
The Target Residence Time of Antihistamines Determines Their Antagonism of the G Protein-Coupled Histamine H1 Receptor
Reggie Bosma, G. Witt, L. Vaas, Ivana Josimovic +4 more
2017Frontiers in Pharmacology30 citations Open access
Semantic Scholar
Small and colorful stones make beautiful mosaics: fragment-based chemogenomics.
C. de Graaf, H. Vischer, G. D. de Kloe, A. Kooistra +7 more
2013Drug Discovery Today28 citations
Semantic Scholar
Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 983.36 of the human histamine H4 receptor
S. Nijmeijer, H. Engelhardt, S. Schultes, A. C. van de Stolpe +8 more
2013British Journal of Pharmacology28 citations Open access
Semantic Scholar
Label-free impedance responses of endogenous and synthetic chemokine receptor CXCR3 agonists correlate with Gi-protein pathway activation.
A. Watts, D. Scholten, L. Heitman, H. Vischer +1 more
2012Biochemical and Biophysical Research Communications - BBRC28 citations
Semantic Scholar
The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines
S. D. de Munnik, A. Kooistra, Jody van Offenbeek, S. Nijmeijer +4 more
2015PLoS ONE27 citations Open access
Semantic Scholar
Mapping histamine H4 receptor–ligand binding modes
S. Schultes, S. Nijmeijer, H. Engelhardt, A. Kooistra +5 more
201327 citations
Semantic Scholar
A Photoswitchable Agonist for the Histamine H3 Receptor, a Prototypic Family A G‐Protein‐Coupled Receptor
Niels J. Hauwert, Tamara A. M. Mocking, Daniel da Costa Pereira, Kenny Lion +5 more
2019Angewandte Chemie26 citations Open access
Semantic Scholar
BRET-based β-arrestin2 recruitment to the histamine H1 receptor for investigating antihistamine binding kinetics.
Reggie Bosma, Ryo Moritani, R. Leurs, H. Vischer
2016Pharmacological Research26 citations
Semantic Scholar
Identification of Ligand Binding Hot Spots of the Histamine H1 Receptor following Structure-Based Fragment Optimization.
S. Kuhne, A. Kooistra, Reggie Bosma, A. Bortolato +6 more
2016Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
Probe dependency in the determination of ligand binding kinetics at a prototypical G protein-coupled receptor
Reggie Bosma, Leigh A. Stoddart, Victoria Georgi, Mónica Bouzo-Lorenzo +9 more
2019Scientific Reports23 citations Open access
Semantic Scholar
Differential Role of Serines and Threonines in Intracellular Loop 3 and C-Terminal Tail of the Histamine H4 Receptor in β-Arrestin and G Protein-Coupled Receptor Kinase Interaction, Internalization, and Signaling
E. W. E. Verweij, Betty Al Araaj, W. R. Prabhata, R. Prihandoko +4 more
2020ACS Pharmacology & Translational Science22 citations Open access
Semantic Scholar
Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists.
I. Adlere, S. Sun, A. Zarca, L. Roumen +14 more
2019European journal of medicinal chemistry21 citations Open access
Semantic Scholar
Route to Prolonged Residence Time at the Histamine H1 Receptor: Growing from Desloratadine to Rupatadine
Reggie Bosma, Zhiyong Wang, A. Kooistra, N. Bushby +9 more
2019Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Adhesion GPCRs in immunology.
S. Nijmeijer, H. Vischer, R. Leurs
2016Biochemical Pharmacology20 citations
Semantic Scholar
Optical control of the β2-adrenergic receptor with opto-prop-2: A cis-active azobenzene analog of propranolol
Reggie Bosma, Nicola C. Dijon, Yang Zheng, Hannes Schihada +11 more
2022iScience17 citations Open access
Semantic Scholar
BRET-Based Biosensors to Measure Agonist Efficacies in Histamine H1 Receptor-Mediated G Protein Activation, Signaling and Interactions with GRKs and β-Arrestins
E. W. E. Verweij, Reggie Bosma, Mei-Chun Gao, J. van den Bor +5 more
2022International Journal of Molecular Sciences16 citations Open access
Semantic Scholar
Combinatorial Consensus Scoring for Ligand-Based Virtual Fragment Screening: A Comparative Case Study for Serotonin 5-HT3A, Histamine H1, and Histamine H4 Receptors
S. Schultes, A. Kooistra, H. Vischer, S. Nijmeijer +4 more
2015Journal of Chemical Information and Modeling16 citations
Semantic Scholar
Structural basis of ligand recognition and design of antihistamines targeting histamine H4 receptor
R. Xia, Shuang Shi, Zhenmei Xu, H. Vischer +9 more
2024Nature Communications14 citations Open access
Semantic Scholar
Bispyrimidines as potent histamine H(4) receptor ligands: delineation of structure-activity relationships and detailed H(4) receptor binding mode.
H. Engelhardt, S. Schultes, C. de Graaf, S. Nijmeijer +10 more
2013Journal of Medicinal Chemistry14 citations Open access
Semantic Scholar
Identification of Key Structural Motifs Involved in 7 Transmembrane Signaling of Adhesion GPCRs
M. Arimont, Melanie van der Woude, R. Leurs, H. Vischer +2 more
2019ACS Pharmacology & Translational Science13 citations Open access
Semantic Scholar
A toolbox of molecular photoswitches to modulate the CXCR3 chemokine receptor with light
X. Gómez-Santacana, S. D. de Munnik, Tamara A. M. Mocking, Niels J. Hauwert +6 more
2019Beilstein Journal of Organic Chemistry13 citations Open access
Semantic Scholar
Pharmacological characterization of seven human histamine H3 receptor isoforms
Mei-Chun Gao, Mabel E. Dekker, R. Leurs, H. Vischer
2023bioRxiv12 citations Open access
Semantic Scholar
Optimization of Peptide Linker-Based Fluorescent Ligands for the Histamine H1 Receptor
Z. Kok, Leigh A. Stoddart, Sarah J. Mistry, Tamara A. M. Mocking +5 more
2022Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
Development of a Profiling Strategy for Metabolic Mixtures by Combining Chromatography and Mass Spectrometry with Cell-Based GPCR Signaling
S. Nijmeijer, H. Vischer, A. F. Rudebeck, F. Fleurbaaij +4 more
2012Journal of biomolecular screening12 citations Open access
Semantic Scholar

Frequent co-authors

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R. Leurs×40
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R. Leurs — researcher profile on SciRah
C. de Graaf×16
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C. de Graaf — researcher profile on SciRah
M. Smit×14
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M. Smit — researcher profile on SciRah
M. Wijtmans×13
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M. Wijtmans — researcher profile on SciRah

×12

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I. D. de Esch — researcher profile on SciRah

S. Nijmeijer×12

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S. Nijmeijer — researcher profile on SciRah

A. Kooistra×10

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A. Kooistra — researcher profile on SciRah

Reggie Bosma×9

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Reggie Bosma — researcher profile on SciRah

S. D. de Munnik×8

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S. D. de Munnik — researcher profile on SciRah

Tamara A. M. Mocking×5

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Tamara A. M. Mocking — researcher profile on SciRah

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S. Schultes — researcher profile on SciRah

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D. Maussang — researcher profile on SciRah