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A. Fletcher · SciRah

Researcher profile · Semantic Scholar

A. Fletcher

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A. Fletcher — researcher profile on SciRah

h-index: 36
Works: 95
Citations: 5,150

Most-cited papers

Vertex models of epithelial morphogenesis.
A. Fletcher, Miriam Osterfield, R. Baker, S. Shvartsman
2014Biophysical Journal617 citations Open access
Semantic Scholar
Chaste: An Open Source C++ Library for Computational Physiology and Biology
Gary R. Mirams, Christopher J. Arthurs, M. Bernabeu, R. Bordas +13 more
2013PLoS Comput. Biol.452 citations Open access
Semantic Scholar
Chaste: A test-driven approach to software development for biological modelling
J. Pitt-Francis, P. Pathmanathan, M. Bernabeu, R. Bordas +15 more
2009Computer Physics Communications278 citations Open access
Semantic Scholar
Comparing individual-based approaches to modelling the self-organization of multicellular tissues
James M. Osborne, A. Fletcher, Joe M. Pitt-Francis, P. Maini +1 more
2016bioRxiv241 citations Open access
Semantic Scholar
Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon
A. Baker, B. Cereser, S. Melton, A. Fletcher +9 more
2019Cell Reports188 citations Open access
Semantic Scholar
An integrative computational model for intestinal tissue renewal
I. V. van Leeuwen, Gary R. Mirams, A. Walter, A. Fletcher +17 more
2009Cell Proliferation175 citations Open access
Semantic Scholar
Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance
D. Nichol, P. Jeavons, A. Fletcher, R. Bonomo +5 more
2015PLoS Comput. Biol.165 citations Open access
Semantic Scholar
Implementing vertex dynamics models of cell populations in biology within a consistent computational framework.
A. Fletcher, James M. Osborne, P. Maini, D. Gavaghan
2013Progress in Biophysics and Molecular Biology161 citations Open access
Semantic Scholar
Mechanisms and mechanics of cell competition in epithelia
J. Vincent, A. Fletcher, L. ALberto Baena-Lopez
2013Nature reviews. Molecular cell biology147 citations Open access
Semantic Scholar
Migration and horizontal gene transfer divide microbial genomes into multiple niches
R. Niehus, Sara Mitri, A. Fletcher, K. Foster
2015Nature Communications141 citations Open access
Semantic Scholar
A hybrid approach to multi-scale modelling of cancer
J. Osborne, A. Walter, S. K. Kershaw, Gary R. Mirams +6 more
2010Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences137 citations Open access
Semantic Scholar
A computational study of discrete mechanical tissue models
P. Pathmanathan, J. Cooper, A. Fletcher, Gary R. Mirams +5 more
2009Physical Biology123 citations Open access
Semantic Scholar
Report edback Loop Controls Root Growth in Arabidopsis
R. D. Ioio, Carla Galinha, A. Fletcher, Stephen P. Grigg +7 more
2012121 citations
Semantic Scholar
Cell proliferation within small intestinal crypts is the principal driving force for cell migration on villi
Aimée Parker, Oliver J. Maclaren, A. Fletcher, D. Muraro +5 more
2016The FASEB Journal117 citations Open access
Semantic Scholar
Unipolar distributions of junctional Myosin II identify cell stripe boundaries that drive cell intercalation throughout Drosophila axis extension
Robert J. Tetley, G. Blanchard, A. Fletcher, Richard J. Adams +1 more
2016eLife110 citations Open access
Semantic Scholar
Mechanocellular models of epithelial morphogenesis
A. Fletcher, Fergus R. Cooper, R. Baker
2017Philosophical Transactions of the Royal Society B: Biological Sciences103 citations Open access
Semantic Scholar
Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation
Aimée Parker, Laura C. Vaux, A. Patterson, A. Modasia +6 more
2019Cell Death and Disease98 citations Open access
Semantic Scholar
Morphological Plant Modeling: Unleashing Geometric and Topological Potential within the Plant Sciences
Alexander Bucksch, Acheampong Atta-Boateng, A. Azihou, Mathilde A. F. Balduzzi +34 more
2017bioRxiv96 citations Open access
Semantic Scholar
Chaste: Cancer, Heart and Soft Tissue Environment
Fergus R. Cooper, Ruth Baker, M. Bernabeu, R. Bordas +25 more
2020Journal of Open Source Software89 citations Open access
Semantic Scholar
Oxygen consumption dynamics in steady-state tumour models
D. R. Grimes, A. Fletcher, M. Partridge
2014Royal Society Open Science87 citations Open access
Semantic Scholar
An ancient Turing-like patterning mechanism regulates skin denticle development in sharks
Rory L. Cooper, Alexandre P. Thiery, A. Fletcher, D. Delbarre +2 more
2018Science Advances79 citations Open access
Semantic Scholar
A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt.
Gary R. Mirams, A. Fletcher, P. Maini, H. Byrne
2012Journal of Theoretical Biology71 citations Open access
Semantic Scholar
Mathematical modeling of monoclonal conversion in the colonic crypt.
A. Fletcher, C. Breward, S. Chapman
2012Journal of Theoretical Biology67 citations Open access
Semantic Scholar
Spatial Metrics of Tumour Vascular Organisation Predict Radiation Efficacy in a Computational Model
Jacob G. Scott, A. Fletcher, A. Anderson, P. Maini
2015bioRxiv64 citations Open access
Semantic Scholar
The tricellular vertex-specific adhesion molecule Sidekick facilitates polarised cell intercalation during Drosophila axis extension
Tara M. Finegan, Nathan Hervieux, Alexander Nestor-Bergmann, A. Fletcher +2 more
2019bioRxiv63 citations Open access
Semantic Scholar
The evolution of strategy in bacterial warfare via the regulation of bacteriocins and antibiotics
R. Niehus, Nuno Oliveira, Aming Li, A. Fletcher +1 more
2021eLife62 citations Open access
Semantic Scholar
Ten Simple Rules for a Successful Cross-Disciplinary Collaboration
B. Knapp, R. Bardenet, M. Bernabeu, R. Bordas +16 more
2015PLoS Comput. Biol.62 citations Open access
Semantic Scholar
Seven challenges in the multiscale modeling of multicellular tissues
A. Fletcher, James M. Osborne
2020WIREs Mechanisms of Disease61 citations Open access
Semantic Scholar
Ten Simple Rules for Effective Computational Research
James M. Osborne, M. Bernabeu, M. Bruna, B. Calderhead +16 more
2014PLoS Comput. Biol.57 citations Open access
Semantic Scholar
Tissue tension and not interphase cell shape determines cell division orientation in the Drosophila follicular epithelium
Tara M. Finegan, Da-Xiang Na, Christian M. Cammarota, A. V. Skeeters +5 more
2018EMBO Journal53 citations Open access
Semantic Scholar
Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis
Ben Lambert, Adam L. MacLean, A. Fletcher, Alexander N. Combes +2 more
2017Journal of Mathematical Biology53 citations Open access
Semantic Scholar
The devil is in the mesoscale: Mechanical and behavioural heterogeneity in collective cell movement.
G. Blanchard, A. Fletcher, L. Schumacher
2019Seminars in Cell and Developmental Biology43 citations Open access
Semantic Scholar
Patterning of Wound-Induced Intercellular Ca2+ Flashes in a Developing Epithelium
C. Narciso, Qinfeng Wu, Pavel A. Brodskiy, George Garston +3 more
2015Physical Biology43 citations Open access
Semantic Scholar
Modelling the role of the basement membrane beneath a growing epithelial monolayer.
S. Dunn, A. Fletcher, S. Chapman, D. Gavaghan +1 more
2012Journal of Theoretical Biology42 citations Open access
Semantic Scholar
Capabilities and Limitations of Tissue Size Control through Passive Mechanical Forces
J. Kursawe, Pavel A. Brodskiy, J. Zartman, R. Baker +1 more
2015bioRxiv40 citations Open access
Semantic Scholar
Toward a quantitative understanding of the Wnt/β‐catenin pathway through simulation and experiment
B. Lloyd-Lewis, A. Fletcher, T. Dale, Helen M. Byrne
2013Wiley Interdisciplinary Reviews: Systems Biology and Medicine37 citations
Semantic Scholar
Approximate Bayesian computation reveals the importance of repeated measurements for parameterising cell-based models of growing tissues
J. Kursawe, R. Baker, A. Fletcher
2017bioRxiv34 citations Open access
Semantic Scholar
Impact of implementation choices on quantitative predictions of cell-based computational models
J. Kursawe, R. Baker, A. Fletcher
2017bioRxiv34 citations Open access
Semantic Scholar
Mathematical Modeling of the Metastatic Process
Jacob G. Scott, P. Gerlee, D. Basanta, A. Fletcher +2 more
201330 citations
Semantic Scholar
Toward Engineering Biosystems With Emergent Collective Functions
Thomas E. Gorochowski, Sabine Hauert, Jan-Ulrich Kreft, L. Marucci +16 more
2020Frontiers in Bioengineering and Biotechnology23 citations Open access
Semantic Scholar
Of mitogens and morphogens: modelling Sonic Hedgehog mechanisms in vertebrate development
Ian J. Groves, M. Placzek, A. Fletcher
2020Philosophical Transactions of the Royal Society of London. Biological Sciences23 citations Open access
Semantic Scholar
Multiscale modelling of intestinal crypt organization and carcinogenesis
A. Fletcher, P. Murray, P. Maini
201523 citations Open access
Semantic Scholar
A filter-flow perspective of haematogenous metastasis offers a non-genetic paradigm for personalised cancer therapy
Jacob G. Scott, A. Fletcher, P. Maini, A. Anderson +1 more
2014European Journal of Cancer23 citations Open access
Semantic Scholar
A hierarchical Bayesian model for understanding the spatiotemporal dynamics of the intestinal epithelium
Oliver J. Maclaren, Aimée Parker, C. Pin, S. Carding +4 more
2017PLoS Comput. Biol.22 citations Open access
Semantic Scholar
Chaste: An Open Source C plus plus Library for Computational Physiology and Biology
Gary R. Mirams, Christopher J. Arthurs, M. Bernabeu, R. Bordas +13 more
201322 citations
Semantic Scholar
Adhesion-regulated junction slippage controls cell intercalation dynamics in an Apposed-Cortex Adhesion Model
Alexander Nestor-Bergmann, G. Blanchard, Nathan Hervieux, A. Fletcher +2 more
2022PLoS Comput. Biol.21 citations Open access
Semantic Scholar
Conserved gene signalling and a derived patterning mechanism underlie the development of avian footpad scales
Rory L. Cooper, Victoria J. Lloyd, N. Di-Poï, A. Fletcher +2 more
2019EvoDevo21 citations Open access
Semantic Scholar
An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells
Simon G. Godwin, Daniel Ward, Elisa Pedone, Martin E. Homer +2 more
2017npj Systems Biology and Applications21 citations Open access
Semantic Scholar
Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon
A. Baker, B. Cereser, S. Melton, A. Fletcher +9 more
2014Cell Reports21 citations Open access
Semantic Scholar
Metabolic Alterations During the Growth of Tumour Spheroids
Katarzyna Bloch, Hannah Smith, Victoria Hamel Parsons, D. Gavaghan +4 more
2013Cell Biochemistry and Biophysics21 citations
Semantic Scholar

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