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Izidor Sosič · SciRah

Researcher profile · Semantic Scholar

Izidor Sosič

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Izidor Sosič — researcher profile on SciRah

h-index: 26
Works: 104
Citations: 2,205

Most-cited papers

E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points
Aleša Bricelj, C. Steinebach, R. Kuchta, M. Gütschow +1 more
2021Frontiers in Chemistry155 citations Open access
Semantic Scholar
E3 ligase ligand chemistries: from building blocks to protein degraders.
Izidor Sosič, Aleša Bricelj, C. Steinebach
2022Chemical Society Reviews95 citations
Semantic Scholar
Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F.
M. Hrast, Izidor Sosič, R. Sink, S. Gobec
2014Bioorganic chemistry (Print)88 citations Open access
Semantic Scholar
Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders
C. Steinebach, Yuen Lam Dora Ng, Izidor Sosič, Chih-Shia Lee +12 more
2020Chemical Science87 citations Open access
Semantic Scholar
Novel Mechanism of Cathepsin B Inhibition by Antibiotic Nitroxoline and Related Compounds
B. Mirković, M. Renko, Samo Turk, Izidor Sosič +5 more
2011ChemMedChem85 citations Open access
Semantic Scholar
Antibacterial and β‐Lactamase Inhibitory Activity of Monocyclic β‐Lactams
L. Decuyper, M. Jukič, Izidor Sosič, Aleš Žula +2 more
2018Medicinal research reviews (Print)83 citations
Semantic Scholar
Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis.
R. Sink, Izidor Sosič, Matej Živec, Raquel Fernández-Menéndez +12 more
2015Journal of Medicinal Chemistry74 citations
Semantic Scholar
Structural characterization and biological evaluation of a clioquinol-ruthenium complex with copper-independent antileukaemic activity.
Martina Gobec, Jakob Kljun, Izidor Sosič, I. Mlinarič-Raščan +3 more
2014Dalton Transactions74 citations Open access
Semantic Scholar
Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives.
Izidor Sosič, B. Mirković, Katharina Arenz, B. Štefane +2 more
2013Journal of Medicinal Chemistry65 citations Open access
Semantic Scholar
Nitroxoline impairs tumor progression in vitro and in vivo by regulating cathepsin B activity
B. Mirković, B. Markelc, Miha Butinar, A. Mitrović +7 more
2015OncoTarget64 citations Open access
Semantic Scholar
A new 'golden age' for the antitubercular target InhA.
Kaja Rožman, Izidor Sosič, Raquel Fernández, R. Young +3 more
2017Drug Discovery Today59 citations
Semantic Scholar
Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents.
D. Knez, B. Brus, N. Coquelle, Izidor Sosič +5 more
2015Bioorganic & Medicinal Chemistry55 citations Open access
Semantic Scholar
Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF.
M. Hrast, Samo Turk, Izidor Sosič, D. Knez +8 more
2013European journal of medicinal chemistry45 citations Open access
Semantic Scholar
Influence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon Ligands.
Aleša Bricelj, Yuen Lam Dora Ng, Dominic Ferber, R. Kuchta +7 more
2021ACS Medicinal Chemistry Letters44 citations Open access
Semantic Scholar
Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs
C. Steinebach, Aleša Bricelj, Arunima Murgai, Izidor Sosič +17 more
2023Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Targeting the Deubiquitinase USP7 for Degradation with PROTACs
Arunima Murgai, Izidor Sosič, Martina Gobec, Patricia Lemnitzer +6 more
2022Chemical Communications40 citations Open access
Semantic Scholar
Nonpeptidic Selective Inhibitors of the Chymotrypsin-Like (β5 i) Subunit of the Immunoproteasome.
Izidor Sosič, Martina Gobec, B. Brus, D. Knez +9 more
2016Angewandte Chemie40 citations Open access
Semantic Scholar
Organoruthenated Nitroxoline Derivatives Impair Tumor Cell Invasion through Inhibition of Cathepsin B Activity
A. Mitrović, Jakob Kljun, Izidor Sosič, M. Uršič +4 more
2019Inorganic Chemistry36 citations Open access
Semantic Scholar
Second-generation sulfonamide inhibitors of D-glutamic acid-adding enzyme: activity optimisation with conformationally rigid analogues of D-glutamic acid.
Izidor Sosič, H. Barreteau, M. Simčič, R. Sink +9 more
2011European journal of medicinal chemistry34 citations Open access
Semantic Scholar
Clioquinol-ruthenium complex impairs tumour cell invasion by inhibiting cathepsin B activity.
A. Mitrović, Jakob Kljun, Izidor Sosič, S. Gobec +2 more
2016Dalton Transactions31 citations Open access
Semantic Scholar
Inhibition of endopeptidase and exopeptidase activity of cathepsin B impairs extracellular matrix degradation and tumour invasion
A. Mitrović, B. Mirković, Izidor Sosič, S. Gobec +1 more
2016Biological chemistry31 citations
Semantic Scholar
4,6-Substituted-1,3,5-triazin-2(1H)-ones as monocyclic catalytic inhibitors of human DNA topoisomerase IIα targeting the ATP binding site.
Barbara Pogorelčnik, Matej Janezic, Izidor Sosič, S. Gobec +2 more
2015Bioorganic & Medicinal Chemistry31 citations Open access
Semantic Scholar
A MedChem toolbox for cereblon-directed PROTACs.
C. Steinebach, Izidor Sosič, S. Lindner, Aleša Bricelj +6 more
2019MedChemComm29 citations Open access
Semantic Scholar
Cathepsin B inhibitors: Further exploration of the nitroxoline core.
Izidor Sosič, A. Mitrović, Hrvoje Ćurić, D. Knez +4 more
2018Bioorganic & Medicinal Chemistry Letters29 citations Open access
Semantic Scholar
Molecular dynamics to enhance structure-based virtual screening on cathepsin B
Mitja Ogrizek, Samo Turk, Samo Lešnik, Izidor Sosič +6 more
2015Journal of Computer-Aided Molecular Design28 citations
Semantic Scholar
Redox-Based Inactivation of Cysteine Cathepsins by Compounds Containing the 4-Aminophenol Moiety
B. Mirković, Izidor Sosič, S. Gobec, J. Kos
2011PLoS ONE26 citations Open access
Semantic Scholar
Structure-guided optimization of 4,6-substituted-1,3,5-triazin-2(1H)-ones as catalytic inhibitors of human DNA topoisomerase IIα.
Kaja Bergant, Matej Janezic, Katja Valjavec, Izidor Sosič +6 more
2019European journal of medicinal chemistry25 citations Open access
Semantic Scholar
Redox active or thiol reactive? Optimization of rapid screens to identify less evident nuisance compounds.
M. Proj, D. Knez, Izidor Sosič, S. Gobec
2022Drug Discovery Today24 citations Open access
Semantic Scholar
Nep1-like proteins as a target for plant pathogen control
Katja Pirc, Vesna Hodnik, T. Snoj, T. Lenarčič +14 more
2021PLoS Pathogens24 citations Open access
Semantic Scholar
A patent review of immunoproteasome inhibitors
Eva Ogorevc, Eva Shannon Schiffrer, Izidor Sosič, S. Gobec
2018Expert Opinion on Therapeutic Patents24 citations
Semantic Scholar
New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold.
S. Pajk, Matej Živec, R. Sink, Izidor Sosič +14 more
2016European journal of medicinal chemistry24 citations Open access
Semantic Scholar
MurD enzymes from different bacteria: evaluation of inhibitors.
H. Barreteau, Izidor Sosič, Samo Turk, Jan Humljan +9 more
2012Biochemical Pharmacology23 citations
Semantic Scholar
Synthesis of aminoboronic acid derivatives: an update on recent advances
Andrej Šterman, Izidor Sosič, S. Gobec, Zdenko Časar
2019Organic Chemistry Frontiers22 citations
Semantic Scholar
Structure-Activity Relationships of Novel Tryptamine-Based Inhibitors of Bacterial Transglycosylase.
Izidor Sosič, M. Anderluh, M. Sova, Martina Gobec +6 more
2015Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
Assessment of Tractable Cysteines for Covalent Targeting by Screening Covalent Fragments
L. Petri, Péter Ábrányi-Balogh, Imre Tímea, G. Pálfy +16 more
2020ChemBioChem20 citations Open access
Semantic Scholar
Addition of 2-(ethylamino)acetonitrile group to nitroxoline results in significantly improved anti-tumor activity in vitro and in vivo
A. Mitrović, Izidor Sosič, Š. Kos, U. L. Tratar +8 more
2017OncoTarget20 citations Open access
Semantic Scholar
Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti‐SARS‐CoV‐2 Activity
Bianca Schulte, Maria König, B. Escher, Sophie Wittenburg +9 more
2022ChemMedChem18 citations Open access
Semantic Scholar
Recent Advances in the Synthesis of Acylboranes and Their Widening Applicability
Andrej Šterman, Izidor Sosič, S. Gobec, Zdenko Časar
2020ACS Omega18 citations Open access
Semantic Scholar
Design, synthesis, and characterization of PROTACs targeting the androgen receptor in prostate and lung cancer models
Lukas M Gockel, V. Pfeifer, Fabian Baltes, Rafael D. Bachmaier +5 more
2022Archiv der Pharmazie16 citations Open access
Semantic Scholar
A Facile Synthesis of Ligands for the von Hippel–Lindau E3 Ligase
M. Gütschow, C. Steinebach, Sabine Anna Voell, Lan Phuong Vu +3 more
2020Synthesis16 citations Open access
Semantic Scholar
N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo–keto reductase AKR1C3
M. Sinreih, Izidor Sosič, Nataša Beranič, Samo Turk +4 more
2012Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins.
Nataša Beranič, P. Brožič, B. Brus, Izidor Sosič +2 more
2012Journal of Steroid Biochemistry and Molecular Biology16 citations
Semantic Scholar
Cathepsin inhibitors nitroxoline and its derivatives inhibit SARS-CoV-2 infection
Rafaela Milan Bonotto, A. Mitrović, Izidor Sosič, Pamela Martínez-Orellana +4 more
2023Antiviral Research15 citations Open access
Semantic Scholar
Nitroxoline and its derivatives are potent inhibitors of metallo-β-lactamases.
Anna Proschak, Giada Martinelli, Denia Frank, Marco J. Rotter +8 more
2021European journal of medicinal chemistry14 citations
Semantic Scholar
In Silico Design and Enantioselective Synthesis of Functionalized Monocyclic 3-Amino-1-carboxymethyl-β-lactams as Inhibitors of Penicillin-Binding Proteins of Resistant Bacteria.
L. Decuyper, Sari Deketelaere, Lore Vanparys, M. Jukič +7 more
2018Chemistry14 citations Open access
Semantic Scholar
The Binding Mode of Second-Generation Sulfonamide Inhibitors of MurD: Clues for Rational Design of Potent MurD Inhibitors
M. Simčič, Izidor Sosič, M. Hodošček, H. Barreteau +3 more
2012PLoS ONE14 citations Open access
Semantic Scholar
Targeting TAK1: Evolution of inhibitors, challenges, and future directions.
Nika Strašek Benedik, M. Proj, C. Steinebach, M. Sova +1 more
2025Pharmacology and Therapeutics13 citations Open access
Semantic Scholar
Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel–Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers
Lan Phuong Vu, Claudia J Diehl, Ryan Casement, A. Bond +8 more
2023Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
Tunable Heteroaromatic Nitriles for Selective Bioorthogonal Click Reaction with Cysteine
M. Proj, Nika Strašek, S. Pajk, D. Knez +1 more
2023Bioconjugate chemistry11 citations Open access
Semantic Scholar
Discovery of selective fragment-sized immunoproteasome inhibitors.
Levente Kollár, Martina Gobec, Bence Szilágyi, M. Proj +9 more
2021European journal of medicinal chemistry11 citations Open access
Semantic Scholar

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C. Steinebach×12
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J. Kos×11
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M. Gütschow×10
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Aleša Bricelj — researcher profile on SciRah

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A. Mitrović×7

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