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Ryan Casement · SciRah

Researcher profile · Semantic Scholar

Ryan Casement

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Ryan Casement — researcher profile on SciRah

h-index: 6
Works: 7
Citations: 409

Most-cited papers

Targeted protein degradation via intramolecular bivalent glues
Oliver Hsia, Matthias Hinterndorfer, A. Cowan, K. Iso +17 more
2023bioRxiv186 citations Open access
Semantic Scholar
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders
Alexander Hanzl, Ryan Casement, H. Imrichova, S. Hughes +7 more
2022Nature Chemical Biology113 citations Open access
Semantic Scholar
Mechanistic and Structural Features of PROTAC Ternary Complexes.
Ryan Casement, A. Bond, Conner Craigon, A. Ciulli
2021Methods in molecular biology54 citations Open access
Semantic Scholar
Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2
S. Ramachandran, N. Makukhin, K. Haubrich, M. Nagala +7 more
2023Nature Communications36 citations Open access
Semantic Scholar
Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel–Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers
Lan Phuong Vu, Claudia J Diehl, Ryan Casement, A. Bond +8 more
2023Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
Dual E3 ligase recruitment by monovalent degraders for tunable SMARCA 2/4 degradation
Valentina A. Spiteri, Dmitri Segal, Alejandro Correa-Sáez, Kentaro Iso +11 more
2026Nature Chemical Biology7 citations Open access
Semantic Scholar
Dual E3 ligase recruitment by monovalent degraders enables redundant and tuneable degradation of SMARCA2/4
Valentina A. Spiteri, D. Segal, Alejandro Correa-Sáez, Kentaro Iso +11 more
2025bioRxiv4 citations Open access
Semantic Scholar

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