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R. Chaloupkova · SciRah

Researcher profile · Semantic Scholar

R. Chaloupkova

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R. Chaloupkova — researcher profile on SciRah

h-index: 33
Works: 187
Citations: 4,100

Most-cited papers

Strategies for Stabilization of Enzymes in Organic Solvents
V. Štěpánková, Šárka Bidmanová, T. Koudelakova, Z. Prokop +2 more
2013591 citations
Semantic Scholar
Exacerbation of substrate toxicity by IPTG in Escherichia coli BL21(DE3) carrying a synthetic metabolic pathway
P. Dvořák, Lukáš Chrást, P. Nikel, R. Fedr +6 more
2015Microbial Cell Factories222 citations Open access
Semantic Scholar
FireProt: Energy- and Evolution-Based Computational Design of Thermostable Multiple-Point Mutants
D. Bednář, Koen Beerens, E. Sebestova, J. Bendl +6 more
2015PLoS Comput. Biol.178 citations Open access
Semantic Scholar
Haloalkane dehalogenases: Biotechnological applications
T. Koudelakova, Šárka Bidmanová, P. Dvořák, A. Pavelka +3 more
2013Biotechnology Journal147 citations Open access
Semantic Scholar
Engineering enzyme stability and resistance to an organic cosolvent by modification of residues in the access tunnel.
T. Koudelakova, R. Chaloupkova, J. Brezovsky, Z. Prokop +10 more
2013Angewandte Chemie125 citations
Semantic Scholar
Engineering a de Novo Transport Tunnel
J. Brezovsky, P. Bábková, O. Degtjarik, Andrea Fořtová +8 more
2016115 citations
Semantic Scholar
Engineering the protein dynamics of an ancestral luciferase
A. Schenkmayerova, Gaspar P. Pinto, M. Toul, M. Marek +13 more
2021Nature Communications80 citations Open access
Semantic Scholar
Exploration of Enzyme Diversity by Integrating Bioinformatics with Expression Analysis and Biochemical Characterization
Pavel Vanacek, E. Sebestova, P. Bábková, Šárka Bidmanová +7 more
201876 citations Open access
Semantic Scholar
Computer-Assisted Engineering of Hyperstable Fibroblast Growth Factor 2
P. Dvořák, D. Bednář, Pavel Vanacek, Lukas Balek +15 more
2017bioRxiv74 citations Open access
Semantic Scholar
Impact of the access tunnel engineering on catalysis is strictly ligand‐specific
Shubhangi Kaushik, Sérgio M. Marques, P. Khirsariya, K. Paruch +5 more
2018The FEBS Journal69 citations Open access
Semantic Scholar
Instability restricts signaling of multiple fibroblast growth factors
M. Buchtová, R. Chaloupkova, M. Zakrzewska, I. Veselá +12 more
2015Cellular and Molecular Life Sciences62 citations Open access
Semantic Scholar
Dynamics and hydration explain failed functional transformation in dehalogenase design.
J. Sýkora, J. Brezovsky, T. Koudelakova, M. Lahoda +8 more
2014Nature Chemical Biology59 citations
Semantic Scholar
Suppression of protein inactivation during freezing by minimizing pH changes using ionic cryoprotectants.
Ľubica Krausková, J. Procházková, M. Klašková, L. Filipová +4 more
2016International journal of pharmaceutics57 citations
Semantic Scholar
Fibroblast Growth Factor 2 Protein Stability Provides Decreased Dependence on Heparin for Induction of FGFR Signaling and Alters ERK Signaling Dynamics
Z. Koledova, J. Sumbal, A. Rabata, G. de La Bourdonnaye +4 more
2019Front. Cell Dev. Biol.56 citations Open access
Semantic Scholar
Balancing the Stability–Activity Trade‐Off by Fine‐Tuning Dehalogenase Access Tunnels
V. Lišková, D. Bednář, T. Prudnikova, P. Řezáčová +6 more
201554 citations
Semantic Scholar
Ancestral Haloalkane Dehalogenases Show Robustness and Unique Substrate Specificity
P. Bábková, E. Sebestova, J. Brezovsky, R. Chaloupkova +1 more
2017ChemBioChem53 citations
Semantic Scholar
Expansion of Access Tunnels and Active‐Site Cavities Influence Activity of Haloalkane Dehalogenases in Organic Cosolvents
V. Štěpánková, Morteza Khabiri, J. Brezovsky, A. Pavelka +8 more
2013ChemBioChem44 citations
Semantic Scholar
Organic co‐solvents affect activity, stability and enantioselectivity of haloalkane dehalogenases
V. Štěpánková, J. Damborský, R. Chaloupkova
2013Biotechnology Journal44 citations
Semantic Scholar
Light-Emitting Dehalogenases: Reconstruction of Multifunctional Biocatalysts
R. Chaloupkova, V. Lišková, M. Toul, K. Marková +8 more
2019ACS Catalysis42 citations Open access
Semantic Scholar
Site-specific analysis of protein hydration based on unnatural amino acid fluorescence.
Mariana Amaro, J. Brezovsky, Silvia Kováčová, J. Sýkora +9 more
2015Journal of the American Chemical Society31 citations
Semantic Scholar
Lincomycin Biosynthesis Involves a Tyrosine Hydroxylating Heme Protein of an Unusual Enzyme Family
J. Novotná, J. Olšovská, P. Novák, P. Mojzeš +8 more
2013PLoS ONE30 citations Open access
Semantic Scholar
Evolutionary Analysis As a Powerful Complement to Energy Calculations for Protein Stabilization
Koen Beerens, S. Mazurenko, Antonin Kunka, Sérgio M. Marques +8 more
2018ACS Catalysis29 citations Open access
Semantic Scholar
Comparison of catalysis by haloalkane dehalogenases in aqueous solutions of deep eutectic and organic solvents
V. Štěpánková, Pavel Vanacek, J. Damborský, R. Chaloupkova
201429 citations
Semantic Scholar
Catalytic Cycle of Haloalkane Dehalogenases Toward Unnatural Substrates Explored by Computational Modeling
Sérgio M. Marques, Zuzana Dunajova, Z. Prokop, R. Chaloupkova +2 more
2017Journal of Chemical Information and Modeling27 citations
Semantic Scholar
The Position of His-Tag in Recombinant OspC and Application of Various Adjuvants Affects the Intensity and Quality of Specific Antibody Response after Immunization of Experimental Mice
M. Krupka, J. Mašek, L. Barkocziova, Pavlína Turánek Knotigová +14 more
2016PLoS ONE26 citations Open access
Semantic Scholar
DspA from Strongylocentrotus purpuratus: The first biochemically characterized haloalkane dehalogenase of non-microbial origin.
Andrea Fořtová, E. Sebestova, V. Štěpánková, T. Koudelakova +3 more
2013Biochimie23 citations Open access
Semantic Scholar
Cation-specific effects on enzymatic catalysis driven by interactions at the tunnel mouth.
V. Štěpánková, J. Paterová, J. Damborský, P. Jungwirth +2 more
2013Journal of Physical Chemistry B23 citations
Semantic Scholar
Structural and functional analysis of a novel haloalkane dehalogenase with two halide-binding sites.
R. Chaloupkova, T. Prudnikova, P. Řezáčová, Z. Prokop +9 more
2014Acta Crystallographica Section D: Biological Crystallography22 citations
Semantic Scholar
Deciphering the Structural Basis of High Thermostability of Dehalogenase from Psychrophilic Bacterium Marinobacter sp. ELB17
Lukáš Chrást, K. Tratsiak, Joan Planas-Iglesias, Lukas Daniel +6 more
2019Microorganisms21 citations Open access
Semantic Scholar
Structure-Function Relationships and Engineering of Haloalkane Dehalogenases
Piia Kokkonen, T. Koudelakova, R. Chaloupkova, Lukas Daniel +2 more
2019Aerobic Utilization of Hydrocarbons, Oils, and Lipids20 citations
Semantic Scholar
Mechanism-Based Strategy for Optimizing HaloTag Protein Labeling
Sérgio M. Marques, Michaela Slanska, K. Chmelova, R. Chaloupkova +6 more
2022JACS Au19 citations Open access
Semantic Scholar
Different Structural Origins of the Enantioselectivity of Haloalkane Dehalogenases toward Linear β-Haloalkanes: Open-Solvated versus Occluded-Desolvated Active Sites.
V. Lišková, V. Štěpánková, D. Bednář, J. Brezovsky +3 more
2017Angewandte Chemie19 citations
Semantic Scholar
The effect of a unique halide‐stabilizing residue on the catalytic properties of haloalkane dehalogenase DatA from Agrobacterium tumefaciens C58
Khomaini Hasan, Artur Góra, J. Brezovsky, R. Chaloupkova +5 more
2013The FEBS Journal18 citations
Semantic Scholar
Crystallographic analysis of 1,2,3-trichloropropane biodegradation by the haloalkane dehalogenase DhaA31.
M. Lahoda, J. Mesters, A. Stsiapanava, R. Chaloupkova +3 more
2014Acta Crystallographica Section D: Biological Crystallography17 citations
Semantic Scholar
Structures of hyperstable ancestral haloalkane dehalogenases show restricted conformational dynamics
P. Bábková, Zuzana Dunajova, R. Chaloupkova, J. Damborský +2 more
2020Computational and Structural Biotechnology Journal14 citations Open access
Semantic Scholar
Computational Enzyme Stabilization Can Affect Folding Energy Landscapes and Lead to Catalytically Enhanced Domain-Swapped Dimers
K. Marková, Antonin Kunka, K. Chmelova, M. Havlásek +9 more
2021ACS Catalysis13 citations Open access
Semantic Scholar
Are time-dependent fluorescence shifts at the tunnel mouth of haloalkane dehalogenase enzymes dependent on the choice of the chromophore?
Mariana Amaro, J. Brezovsky, Silvia Kováčová, Lukas Maier +5 more
2013Journal of Physical Chemistry B11 citations
Semantic Scholar
A Haloalkane Dehalogenase from Saccharomonospora viridis Strain DSM 43017, a Compost Bacterium with Unusual Catalytic Residues, Unique (S)-Enantiopreference, and High Thermostability
K. Chmelova, E. Sebestova, V. Lišková, Andy Beier +4 more
2020Applied and Environmental Microbiology10 citations Open access
Semantic Scholar
Kinetics of binding of fluorescent ligands to enzymes with engineered access tunnels
Shubhangi Kaushik, Z. Prokop, J. Damborský, R. Chaloupkova
2017The FEBS Journal10 citations Open access
Semantic Scholar
Crystal structure of the cold-adapted haloalkane dehalogenase DpcA from Psychrobacter cryohalolentis K5.
K. Tratsiak, T. Prudnikova, I. Drienovská, J. Damborský +6 more
2019Acta Crystallographica Section F Structural Biology Communications8 citations Open access
Semantic Scholar
Hydrolases in Non-Conventional Media: Implications for Industrial Biocatalysis
V. Štěpánková, J. Damborský, R. Chaloupkova
20158 citations
Semantic Scholar
Differences in crystallization of two LinB variants from Sphingobium japonicum UT26.
O. Degtjarik, R. Chaloupkova, P. Řezáčová, M. Kuty +2 more
2013Acta Crystallographica. Section F : Structural Biology and Crystallization Communications7 citations Open access
Semantic Scholar
Crystallographic analysis of new psychrophilic haloalkane dehalogenases: DpcA from Psychrobacter cryohalolentis K5 and DmxA from Marinobacter sp. ELB17.
K. Tratsiak, O. Degtjarik, I. Drienovská, Lukáš Chrást +5 more
2013Acta Crystallographica. Section F : Structural Biology and Crystallization Communications7 citations Open access
Semantic Scholar
The future for the application of fibroblast growth factor 2 in modern wound healing.
J. Holoubek, B. Lipovy, M. Knoz, T. Kempný +3 more
2022Burns6 citations
Semantic Scholar
Stabilization of Haloalkane Dehalogenase Structure by Interfacial Interaction with Ionic Liquids
A. Shaposhnikova, M. Kuty, R. Chaloupkova, J. Damborský +3 more
2021Crystals6 citations Open access
Semantic Scholar
Structural and catalytic effects of surface loop-helix transplantation within haloalkane dehalogenase family
M. Marek, R. Chaloupkova, T. Prudnikova, Yukari Sato +4 more
2020Computational and Structural Biotechnology Journal6 citations Open access
Semantic Scholar
Release of halide ions from the buried active site of the haloalkane dehalogenase LinB revealed by stopped-flow fluorescence analysis and free energy calculations.
Jana Hladílková, Z. Prokop, R. Chaloupkova, J. Damborský +1 more
2013Journal of Physical Chemistry B6 citations
Semantic Scholar
Increased thermal stability of FGF10 leads to ectopic signaling during development
Aleksandra A. Czyrek, Karolina Baran, Eva Hrubá, Aneta Horackova +31 more
2025Cellular and Molecular Life Sciences5 citations Open access
Semantic Scholar
Computer-assisted stabilization of fibroblast growth factor FGF-18
J. Vilím, Tereza Ghazalova, Eliska Petulova, Aneta Horackova +5 more
2023Computational and Structural Biotechnology Journal5 citations Open access
Semantic Scholar
Novel approach in control release monitoring of protein-based bioactive substances from injectable PLGA-PEG-PLGA hydrogel
Klára Lysáková, Kristýna Hlináková, K. Kutálková, R. Chaloupkova +3 more
2022eXPRESS Polymer Letters5 citations Open access
Semantic Scholar

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J. Damborský×47
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Z. Prokop×25
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J. Brezovsky×18
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V. Štěpánková×14
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V. Štěpánková — researcher profile on SciRah

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D. Bednář — researcher profile on SciRah

E. Sebestova×9

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T. Koudelakova×8

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T. Koudelakova — researcher profile on SciRah

Ivana Kutá Smatanová×8

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P. Řezáčová×8

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T. Prudnikova×6

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