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M. Knowles · SciRah

Researcher profile · Semantic Scholar

M. Knowles

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M. Knowles — researcher profile on SciRah

h-index: 69
Works: 235
Citations: 16K

Most-cited papers

Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity
M. Knowles, C. Hurst
2014Nature Reviews. Cancer1,203 citations
Semantic Scholar
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer
S. Lindskrog, F. Prip, P. Lamy, A. Taber +43 more
2021Nature Communications305 citations Open access
Semantic Scholar
Genomic Subtypes of Non-Invasive Bladder Cancer with Distinct Metabolic Profile, Clinical Outcome and Female Gender Bias in KDM6A Mutation Frequency
C. Hurst, Olivia Alder, F. Platt, A. Droop +14 more
2017Cancer Cell262 citations Open access
Semantic Scholar
Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine.
C. Hurst, F. Platt, M. Knowles
2014European Urology160 citations
Semantic Scholar
Affimer proteins are versatile and renewable affinity reagents
C. Tiede, R. Bedford, Sophie J. Heseltine, Gina A. Smith +42 more
2017eLife150 citations Open access
Semantic Scholar
Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3 mutant cancer
M. T. Herrera-Abreu, A. Pearson, James Campbell, S. Shnyder +3 more
2013Cancer Discovery126 citations Open access
Semantic Scholar
A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges
E. di Martino, D. Tomlinson, M. Knowles
2012Advances in Urology126 citations Open access
Semantic Scholar
Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changes
Claire F. Taylor, F. Platt, C. Hurst, H. Thygesen +1 more
2013Human Molecular Genetics91 citations Open access
Semantic Scholar
Proteomic studies of urinary biomarkers for prostate, bladder and kidney cancers
S. Wood, M. Knowles, D. Thompson, P. Selby +1 more
2013Nature reviews. Urology88 citations
Semantic Scholar
The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study
T. D. Bunney, S. Wan, N. Thiyagarajan, L. Sutto +7 more
2015EBioMedicine82 citations Open access
Semantic Scholar
FGFR3 Translocations in Bladder Cancer: Differential Sensitivity to HSP90 Inhibition Based on Drug Metabolism
J. Acquaviva, Su-Qin He, Chao-Hua Zhang, J. Jimenez +10 more
2014Molecular Cancer Research75 citations Open access
Semantic Scholar
Hypoxia regulates FGFR3 expression via HIF-1α and miR-100 and contributes to cell survival in non-muscle invasive bladder cancer
C. Blick, A. Ramachandran, S. Wigfield, R. McCormick +7 more
2013British Journal of Cancer65 citations Open access
Semantic Scholar
Oncolytic Immunotherapy for Bladder Cancer Using Coxsackie A21 Virus
N. Annels, Mehreen Arif, Guy Simpson, M. Denyer +10 more
2018Molecular Therapy: Oncolytics59 citations Open access
Semantic Scholar
TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p
J. Berrout, Eleni Kyriakopoulou, Lavanya Moparthi, Alexandra S. Hogea +26 more
2017Nature Communications59 citations Open access
Semantic Scholar
A place for precision medicine in bladder cancer: targeting the FGFRs.
E. di Martino, D. Tomlinson, Sarah V. Williams, M. Knowles
2016Future Oncology57 citations Open access
Semantic Scholar
Stage-stratified molecular profiling of non-muscle-invasive bladder cancer enhances biological, clinical, and therapeutic insight
C. Hurst, Guo Cheng, F. Platt, Mauro A. A. Castro +16 more
2021Cell Reports Medicine56 citations Open access
Semantic Scholar
Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer.
T. Rafnar, P. Sulem, G. Thorleifsson, S. Vermeulen +71 more
2014Human Molecular Genetics54 citations Open access
Semantic Scholar
Expression of Engrailed-2 (EN2) protein in bladder cancer and its potential utility as a urinary diagnostic biomarker.
R. Morgan, R. Bryan, S. Javed, F. Launchbury +8 more
2013European Journal of Cancer52 citations Open access
Semantic Scholar
Frequency of TERT Promoter Mutations in Prostate Cancer
R. Stoehr, H. Taubert, Ulrike Zinnall, J. Giedl +7 more
2015Pathobiology (Basel)48 citations Open access
Semantic Scholar
CALIBER: a phase II randomized feasibility trial of chemoablation with mitomycin‐C vs surgical management in low‐risk non‐muscle‐invasive bladder cancer
A. H. Mostafid, N. Porta, J. Cresswell, T. L. Griffiths +13 more
2020BJU International47 citations Open access
Semantic Scholar
Protein shedding in urothelial bladder cancer: prognostic implications of soluble urinary EGFR and EpCAM
R. Bryan, H. Regan, S. J. Pirrie, A. Devall +5 more
2015British Journal of Cancer47 citations Open access
Semantic Scholar
SnapShot: Bladder Cancer.
C. Hurst, J. Rosenberg, M. Knowles
2018Cancer Cell46 citations Open access
Semantic Scholar
PIK3CA mutation spectrum in urothelial carcinoma reflects cell context-dependent signaling and phenotypic outputs
RL Ross, J. Askham, M. Knowles
2013Oncogene44 citations Open access
Semantic Scholar
Mutational landscape of non-muscle-invasive bladder cancer.
C. Hurst, M. Knowles
2018Urologic oncology39 citations Open access
Semantic Scholar
Imatinib radiosensitises bladder cancer by targeting homologous recombination
B. Qiao, M. Kerr, B. Groselj, M. Teo +4 more
2013Cancer Research38 citations Open access
Semantic Scholar
Report From the International Society of Urological Pathology (ISUP) Consultation Conference On Molecular Pathology Of Urogenital Cancers. II. Molecular Pathology of Bladder Cancer
J. Warrick, M. Knowles, Allory Yves, T. van der Kwast +5 more
2020American Journal of Surgical Pathology37 citations Open access
Semantic Scholar
The Warburg effect as a therapeutic target for bladder cancers and intratumoral heterogeneity in associated molecular targets
J. Burns, C. Hurst, M. Knowles, R. Phillips +1 more
2021Cancer Science36 citations Open access
Semantic Scholar
FGFR3 mutation increases bladder tumourigenesis by suppressing acute inflammation
M. Foth, Nur Faezah Binti Ismail, J. Kung, D. Tomlinson +6 more
2018Journal of Pathology34 citations Open access
Semantic Scholar
Summary and Recommendations from the National Cancer Institute’s Clinical Trials Planning Meeting on Novel Therapeutics for Non-Muscle Invasive Bladder Cancer
S. Lerner, D. Bajorin, C. Dinney, J. Efstathiou +32 more
2016Bladder Cancer34 citations Open access
Semantic Scholar
FGFR3 expression in primary invasive bladder cancers and matched lymph node metastases.
R. Turo, P. Harnden, H. Thygesen, A. Fleischmann +4 more
2015Journal of Urology34 citations Open access
Semantic Scholar
TERT Core Promotor Mutations in Early-Onset Bladder Cancer
J. Giedl, A. Rogler, A. Wild, M. Riener +8 more
2016Journal of Cancer33 citations Open access
Semantic Scholar
Metastatic urothelial carcinoma.
M. Knowles, L. Dyrskjøt, E. Heath, J. Bellmunt +1 more
2021Cancer Cell31 citations Open access
Semantic Scholar
Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion
N. Hornigold, K. Dunn, R. Craven, A. Zougman +20 more
2020British Journal of Cancer30 citations Open access
Semantic Scholar
Molecular subtyping of invasive bladder cancer: time to divide and rule?
C. Hurst, M. Knowles
2014Cancer Cell29 citations Open access
Semantic Scholar
From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor.
Lewis D Turner, C. Trinh, Ryan A Hubball, Kyle M Orritt +4 more
2021Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Next-generation sequencing identifies germline MRE11A variants as markers of radiotherapy outcomes in muscle-invasive bladder cancer
M. Teo, L. Dyrskjøt, J. Nsengimana, C. Buchwald +10 more
2014Annals of Oncology28 citations Open access
Semantic Scholar
Modeling the mechanical stiffness of pancreatic ductal adenocarcinoma
Delanyo Kpeglo, Matt D. G. Hughes, Lorna Dougan, M. Haddrick +3 more
2022Matrix Biology Plus27 citations Open access
Semantic Scholar
Bladder cancer: Multi-omic profiling refines the molecular view
C. Hurst, M. Knowles
2018Nature Reviews Clinical Oncology25 citations Open access
Semantic Scholar
Fibroblast growth factor receptor (FGFR) alterations in squamous differentiated bladder cancer: a putative therapeutic target for a small subgroup
P. Baldia, A. Maurer, Timon Heide, M. Rose +6 more
2016OncoTarget25 citations Open access
Semantic Scholar
The Lund molecular taxonomy applied to non-muscle-invasive urothelial carcinoma.
N. Marzouka, P. Eriksson, C. Bernardo, C. Hurst +4 more
2022Journal of Molecular Diagnostics24 citations Open access
Semantic Scholar
FGFR3 – a Central Player in Bladder Cancer Pathogenesis?
M. Knowles
2020Bladder Cancer24 citations Open access
Semantic Scholar
ETV5 links the FGFR3 and Hippo signalling pathways in bladder cancer
E. di Martino, Olivia Alder, C. Hurst, M. Knowles
2019Scientific Reports24 citations Open access
Semantic Scholar
Assessing the quality of studies on the diagnostic accuracy of tumor markers
P. Goebell, A. Kamat, R. Sylvester, P. Black +9 more
2014Urologic oncology23 citations Open access
Semantic Scholar
Alteration of Cell–Cell and Cell–Matrix Adhesion in Urothelial Cells: An Oncogenic Mechanism for Mutant FGFR3
E. di Martino, G. Kelly, J. Roulson, M. Knowles
2014Molecular Cancer Research23 citations Open access
Semantic Scholar
Identification of Mutations in Distinct Regions of p85 Alpha in Urothelial Cancer
R. Ross, J. Burns, Claire F. Taylor, P. Mellor +2 more
2013PLoS ONE20 citations Open access
Semantic Scholar
An integrated genomic, transcriptional and protein investigation of FGFRL1 as a putative 4p16.3 deletion target in bladder cancer
E. di Martino, Claire F. Taylor, J. Roulson, M. Knowles
2013Genes, Chromosomes and Cancer17 citations
Semantic Scholar
Affimer-based impedimetric biosensors for fibroblast growth factor receptor 3 (FGFR3): a novel tool for detection and surveillance of recurrent bladder cancer
Pattanapong Thangsunan, Nidhi Lal, C. Tiede, Sophie L. Moul +7 more
202116 citations Open access
Semantic Scholar
The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function
L. Stadler, D. Tomlinson, T. Lee, M. Knowles +1 more
2014Cell Death and Disease16 citations Open access
Semantic Scholar
Identification of an Indazole-Based Pharmacophore for the Inhibition of FGFR Kinases Using Fragment-Led de Novo Design.
Lewis D Turner, A. J. Summers, Laura O. Johnson, M. Knowles +1 more
2017ACS Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Unique signalling connectivity of FGFR3-TACC3 oncoprotein revealed by quantitative phosphoproteomics and differential network analysis
Benedetta Lombardi, P. Ashford, A. Moya-García, A. Rust +6 more
2017OncoTarget15 citations Open access
Semantic Scholar

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C. Hurst — researcher profile on SciRah
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