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Hideharu Sekine · SciRah

Researcher profile · Semantic Scholar

Hideharu Sekine

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Hideharu Sekine — researcher profile on SciRah

h-index: 22
Works: 89
Citations: 1,709

Most-cited papers

Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates.
Y. Endo, Minoru Takahashi, Miki Nakao, H. Saiga +4 more
1998Journal of Immunology159 citations
Semantic Scholar
Complement Component C3 Is Not Required for Full Expression of Immune Complex Glomerulonephritis in MRL/lpr Mice
Hideharu Sekine, C. Reilly, I. Molano, G. Garnier +5 more
2001Journal of Immunology156 citations Open access
Semantic Scholar
Role for Msh5 in the regulation of Ig class switch recombination
Hideharu Sekine, R. Ferreira, Q. Pan-Hammarström, R. Graham +24 more
2007Proceedings of the National Academy of Sciences of the United States of America155 citations Open access
Semantic Scholar
Opsonic complement component C3 in the solitary ascidian, Halocynthia roretzi.
Masaru Nonaka, K. Azumi, Xin Ji, Chisato Namikawa-Yamada +8 more
1999Journal of Immunology140 citations Open access
Semantic Scholar
An Ancient Lectin-Dependent Complement System in an Ascidian: Novel Lectin Isolated from the Plasma of the Solitary Ascidian, Halocynthia roretzi1 2
Hideharu Sekine, A. Kenjo, K. Azumi, Gota Ohi +8 more
2001Journal of Immunology133 citations
Semantic Scholar
The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr mice
Hideharu Sekine, T. Kinser, F. Qiao, Efraín Martínez +4 more
2011Arthritis & Rheumatism78 citations Open access
Semantic Scholar
Enrichment of Anti-Glomerular Antigen Antibody-Producing Cells in the Kidneys of MRL/MpJ-Faslpr Mice1
Hideharu Sekine, Hiroshi Watanabe, G. Gilkeson
2004Journal of Immunology63 citations Open access
Semantic Scholar
Protective effect of beraprost sodium, a stable prostacyclin analogue, in development of monocrotaline-induced pulmonary hypertension.
Masayuki Miyata, Yuji Ueno, Hideharu Sekine, Osamu Ito +5 more
1996Journal of Cardiovascular Pharmacology55 citations Open access
Semantic Scholar
Tofacitinib inhibits granulocyte–macrophage colony-stimulating factor-induced NLRP3 inflammasome activation in human neutrophils
M. Furuya, T. Asano, Yuya Sumichika, Shuzo Sato +10 more
2018Arthritis Research & Therapy54 citations Open access
Semantic Scholar
The dual role of complement in the progression of renal disease in NZB/W F(1) mice and alternative pathway inhibition.
Hideharu Sekine, P. Ruiz, G. Gilkeson, S. Tomlinson
2011Molecular Immunology50 citations
Semantic Scholar
Absence of functional alternative complement pathway alleviates lupus cerebritis
J. Alexander, A. Jacob, P. Vezina, Hideharu Sekine +2 more
2007European Journal of Immunology49 citations Open access
Semantic Scholar
Evaluation of blood-brain barrier function by quotient alpha2 macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus
T. Asano, Hiromi Ito, Y. Kariya, Kyoka Hoshi +11 more
2017PLoS ONE43 citations Open access
Semantic Scholar
Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway
M. Hayashi, Takeshi Machida, Yumi Ishida, Y. Ogata +10 more
2019Journal of Immunology42 citations Open access
Semantic Scholar
The role of MASP-1/3 in complement activation.
Hideharu Sekine, Minoru Takahashi, D. Iwaki, T. Fujita
2013Advances in Experimental Medicine and Biology34 citations
Semantic Scholar
Factor D
Hideharu Sekine, Takeshi Machida, T. Fujita
2022Immunological Reviews30 citations
Semantic Scholar
Granular C3 Dermatosis.
T. Hashimoto, D. Tsuruta, A. Yasukochi, H. Imanishi +12 more
2016Acta Dermato-Venereologica30 citations Open access
Semantic Scholar
Essential Roles for Mannose-Binding Lectin-Associated Serine Protease-1/3 in the Development of Lupus-Like Glomerulonephritis in MRL/lpr Mice
Takeshi Machida, Natsumi Sakamoto, Yumi Ishida, Minoru Takahashi +2 more
2018Frontiers in Immunology27 citations Open access
Semantic Scholar
Complement Activation Products and Cytokines in Pachychoroid Neovasculopathy and Neovascular Age-Related Macular Degeneration
Yutaka Kato, Y. Oguchi, Tomoko Omori, Hiroaki Shintake +9 more
2020Investigative Ophthalmology and Visual Science23 citations Open access
Semantic Scholar
Role of MHC-Linked Genes in Autoantigen Selection and Renal Disease in a Murine Model of Systemic Lupus Erythematosus1
Hideharu Sekine, Kareem Graham, Shenru Zhao, Margaret K. Elliott +3 more
2006Journal of Immunology23 citations Open access
Semantic Scholar
Deconstructing the lectin pathway in the pathogenesis of experimental inflammatory arthritis: essential role of the lectin ficolin B and mannose-binding protein-associated serine protease 2
N. Banda, Sumitra Acharya, R. Scheinman, G. Mehta +8 more
2017Journal of Immunology22 citations Open access
Semantic Scholar
A case of systemic lupus erythematosus complicated by pure red cell aplasia and idiopathic portal hypertension after thymectomy
H. Iwadate, Hiroko Kobayashi, Kiori Shio, E. Noguchi +7 more
2006Modern Rheumatology22 citations
Semantic Scholar
Effect of genetic deficiency of terminal deoxynucleotidyl transferase on autoantibody production and renal disease in MRL/lpr mice.
I. Molano, Shakisha T Redmond, Hideharu Sekine, Xian-Kui Zhang +4 more
2003Clinical Immunology22 citations
Semantic Scholar
Lessons learned from mice deficient in lectin complement pathway molecules.
N. Genster, Minoru Takahashi, Hideharu Sekine, Y. Endo +2 more
2014Molecular Immunology21 citations Open access
Semantic Scholar
Role of complement in a murine model of peanut-induced anaphylaxis.
T. Kodama, Hideharu Sekine, Minoru Takahashi, D. Iwaki +5 more
2012Immunobiology19 citations
Semantic Scholar
Evidence for Activation of Lectin and Classical Pathway Complement Components in Aqueous Humor of Neovascular Age-Related Macular Degeneration
Tomoko Omori, Y. Oguchi, Takeshi Machida, Yutaka Kato +10 more
2019Ophthalmic Research18 citations
Semantic Scholar
Targeting of Liver Mannan-Binding Lectin–Associated Serine Protease-3 with RNA Interference Ameliorates Disease in a Mouse Model of Rheumatoid Arthritis
N. Banda, D. Desai, R. Scheinman, Rasmus Pihl +8 more
2018ImmunoHorizons17 citations Open access
Semantic Scholar
Autoimmune disease mouse model exhibits pulmonary arterial hypertension
Koichi Sugimoto, K. Nakazato, Akihiko Sato, Satoshi Suzuki +5 more
2017PLoS ONE17 citations Open access
Semantic Scholar
Changes in complement activation products after anti-VEGF injection for choroidal neovascularization in age-related macular degeneration and pachychoroid disease
Keiichiro Tanaka, Y. Oguchi, Tomoko Omori, Yumi Ishida +10 more
2020Scientific Reports15 citations Open access
Semantic Scholar
Complement activation by autoantigen recognition in the growth process of benign prostatic hyperplasia
J. Hata, Takeshi Machida, Kanako Matsuoka, Seiji Hoshi +10 more
2019Scientific Reports15 citations Open access
Semantic Scholar
Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference-Mediated Gene Silencing
N. Banda, Sumitra Acharya, R. Scheinman, G. Mehta +6 more
2016Journal of Immunology15 citations Open access
Semantic Scholar
Comment on “Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function”
Minoru Takahashi, Hideharu Sekine, Y. Endo, T. Fujita
2013Journal of Immunology15 citations Open access
Semantic Scholar
Ulcerative colitis occurring in the course of rheumatoid arthritis: a case successfully treated with mesalamine enema.
K. Sugisaki, Fumiko Honma, H. Iwadate, Kiori Shio +9 more
2004Internal medicine13 citations Open access
Semantic Scholar
Complement activation products in tears of dry eye and meibomian gland dysfunction
Hiroki Maehara, Koki Norikawa, Keiichiro Tanaka, Yutaka Kato +6 more
2024Scientific Reports11 citations Open access
Semantic Scholar
ARMS2 and CFH Polymorphism and Intraocular Complement Activation in Neovascular Age-Related Macular Degeneration
Yutaka Kato, Y. Oguchi, Tomoko Omori, Akihito Kasai +8 more
2022Ophthalmology Science10 citations Open access
Semantic Scholar
HLA-B52-positive vasculo-Behçet disease: usefulness of magnetic resonance angiography, ultrasound study, and computed tomographic angiography for the early evaluation of multiarterial lesions
K. Sugisaki, R. Saito, T. Takagi, Kiori Shio +8 more
2005Modern Rheumatology9 citations
Semantic Scholar
A novel complement inhibitor sMAP‐FH targeting both the lectin and alternative complement pathways
Mika Takasumi, Tomoko Omori, Takeshi Machida, Yumi Ishida +8 more
2020The FASEB Journal8 citations Open access
Semantic Scholar
Circulating complement factor H levels are associated with disease severity and relapse in autoimmune hepatitis
M. Hayashi, K. Abe, M. Fujita, A. Takahashi +2 more
2022JHEP Reports7 citations Open access
Semantic Scholar
Association of the FCN2 Gene Promoter Region Polymorphisms with Very Low Birthweight in Preterm Neonates
A. Szala-Poździej, A. St. Świerzko, Gabriela Gajek, M. Kufelnicka-Babout +10 more
2022International Journal of Molecular Sciences7 citations Open access
Semantic Scholar
Tear fluid and complement activation products in tears after ocular surgery
Hiroki Maehara, Koki Norikawa, Keiichiro Tanaka, Yutaka Kato +5 more
2023BMC Ophthalmology6 citations Open access
Semantic Scholar
The complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway retains MASP-3 in the circulation
Kohei Kusakari, Takeshi Machida, Yumi Ishida, Tomoko Omori +5 more
2022Frontiers in Immunology6 citations Open access
Semantic Scholar
Association of the toll-like receptor 9 gene polymorphisms with Behcet's disease in a Japanese population.
Natsumi Sakamoto, Hideharu Sekine, Hiroko Kobayashi, Yukio Sato +1 more
2012Fukushima Journal of Medical Science6 citations Open access
Semantic Scholar
A novel MBL-like lectin isolated from the plasma of the solitary ascidian, Halocynthia roretzi
Hideharu Sekine, M. Matsushita, Y. Endo, K. Azumi +2 more
19986 citations
Semantic Scholar
Analysis of peripheral blood mononuclear cell stimulated with pyruvate dehydrogenase complex, T-cell receptors from patients with primary biliary cirrhosis
H. Ochiai, Hideharu Sekine, H. Ohira, Masahito Kuroda +4 more
1998Journal of gastroenterology6 citations
Semantic Scholar
Polymorphisms of the FCN2 Gene 3’UTR Region and Their Clinical Associations in Preterm Newborns
A. St. Świerzko, D. Jarych, Gabriela Gajek, Karolina Chojnacka +12 more
2021Frontiers in Immunology5 citations Open access
Semantic Scholar
Inhibitory oligodeoxynucleotide improves glomerulonephritis and prolongs survival in MRL-lpr/lpr mice.
Namiko Hoshi, Hiroshi Watanabe, Hiroko Kobayashi, Hideharu Sekine +5 more
2007Fukushima Journal of Medical Science5 citations Open access
Semantic Scholar
Association of low ficolin-2 concentration in cord serum with respiratory distress syndrome in preterm newborns
Gabriela Gajek, A. St. Świerzko, D. Jarych, D. Mikulski +13 more
2023Frontiers in Immunology4 citations Open access
Semantic Scholar
Association between serum ficolin-1 level and disease progression in primary biliary cholangitis
M. Hayashi, K. Abe, M. Fujita, A. Takahashi +2 more
2020PLoS ONE4 citations Open access
Semantic Scholar
Anaphylatoxin concentration in aqueous and vitreous humor in the eyes with vitreoretinal interface abnormalities.
Y. Oguchi, T. Sekiryu, Tomoko Omori, Yutaka Kato +6 more
2020Experimental Eye Research4 citations
Semantic Scholar
Comment on “Reassessment of the Role of Mut S Homolog 5 in Ig Class Switch Recombination Shows Lack of Involvement in cis- and trans-Switching”
Hideharu Sekine, R. Ferreira, Q. Pan-Hammarström, L. Hammarström +2 more
2009Journal of Immunology4 citations Open access
Semantic Scholar
Complement factor C3 is not required for full expression of lupus nephritis in MRL/lpr mice
Hideharu Sekine, H. Colten, G. Garnier, A. Circolo +1 more
20003 citations
Semantic Scholar

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Takeshi Machida×15
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Takeshi Machida — researcher profile on SciRah
T. Fujita×14
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T. Fujita — researcher profile on SciRah
Y. Endo×10
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Y. Endo — researcher profile on SciRah
Minoru Takahashi×10
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Minoru Takahashi — researcher profile on SciRah

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Tomoko Omori×10

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Tomoko Omori — researcher profile on SciRah

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G. Gilkeson — researcher profile on SciRah

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Yumi Ishida — researcher profile on SciRah

M. Matsushita×7

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M. Matsushita — researcher profile on SciRah

Hiroshi Watanabe×7

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Hiroshi Watanabe — researcher profile on SciRah

Hiroko Kobayashi×7

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Hiroko Kobayashi — researcher profile on SciRah

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T. Sekiryu — researcher profile on SciRah