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J. Groden · SciRah

Researcher profile · Semantic Scholar

J. Groden

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J. Groden — researcher profile on SciRah

h-index: 49
Works: 134
Citations: 14K

Most-cited papers

Pathology of mouse models of intestinal cancer: consensus report and recommendations.
G. Boivin, K. Washington, Kan Yang, J. Ward +11 more
2003Gastroenterology518 citations Open access
Semantic Scholar
Biology of the adenomatous polyposis coli tumor suppressor.
K. Goss, J. Groden
2000Journal of Clinical Oncology448 citations
Semantic Scholar
beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer.
Wilson M. Clements, Jiang Wang, A. Sarnaik, O. Kim +4 more
2002Cancer Research381 citations
Semantic Scholar
Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
S. Kaiser, Young-Kyu Park, J. Franklin, Richard B. Halberg +33 more
2007Genome Biology339 citations Open access
Semantic Scholar
MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer
N. Valeri, C. Braconi, Pierluigi Gasparini, C. Murgia +27 more
2014Cancer Cell294 citations Open access
Semantic Scholar
Enhanced Tumor Formation in Mice Heterozygous for Blm Mutation
K. Goss, M. Risinger, Jennifer J. Kordich, M. Sanz +6 more
2002Science224 citations
Semantic Scholar
Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation.
M. C. Scott, K. Wakamatsu, S. Ito, A. L. Kadekaro +7 more
2002Journal of Cell Science212 citations
Semantic Scholar
BLM Heterozygosity and the Risk of Colorectal Cancer
S. Gruber, N. Ellis, G. Rennert, K. Offit +20 more
2002Science208 citations
Semantic Scholar
Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: Implications for therapeutic targeting
W. Hankey, W. Frankel, J. Groden
2018Cancer Metastasis Review195 citations Open access
Semantic Scholar
Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2.
Kate Lillard-Wetherell, A. Machwe, G. Langland, K. Combs +6 more
2004Human Molecular Genetics167 citations
Semantic Scholar
The Werner and Bloom syndrome proteins catalyze regression of a model replication fork.
A. Machwe, Liren Xiao, J. Groden, David K. Orren
2006Biochemistry149 citations
Semantic Scholar
Tumor predisposition and cancer syndromes as models to study gene X environment interactions
M. Carbone, S. Arron, B. Beutler, A. Bononi +19 more
2020Nature Reviews. Cancer126 citations Open access
Semantic Scholar
RecQ Family Members Combine Strand Pairing and Unwinding Activities to Catalyze Strand Exchange*
A. Machwe, Liren Xiao, J. Groden, S. Matson +1 more
2005Journal of Biological Chemistry125 citations Open access
Semantic Scholar
The Bloom's Syndrome Protein (BLM) Interacts with MLH1 but Is Not Required for DNA Mismatch Repair*
G. Langland, Jennifer J. Kordich, J. Creaney, K. Goss +4 more
2001Journal of Biological Chemistry114 citations Open access
Semantic Scholar
beta-Catenin/Wnt signaling regulates expression of the membrane type 3 matrix metalloproteinase in gastric cancer.
A. Lowy, Wilson M. Clements, J. Bishop, Ling Kong +5 more
2006Cancer Research111 citations Open access
Semantic Scholar
Transcriptional profiles of intestinal tumors in Apc(Min) mice are unique from those of embryonic intestine and identify novel gene targets dysregulated in human colorectal tumors.
T. Reichling, K. Goss, Daniel J. Carson, R. Holdcraft +4 more
2005Cancer Research93 citations
Semantic Scholar
Phosphatidylinositol 3-Kinase (PI3K) Signaling via Glycogen Synthase Kinase-3 (Gsk-3) Regulates DNA Methylation of Imprinted Loci*
Anthony P. Popkie, Leigh C. Zeidner, Ashley M. Albrecht, A. D'Ippolito +8 more
2010Journal of Biological Chemistry87 citations Open access
Semantic Scholar
The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway.
C. Heinen, K. Goss, J. Cornelius, G. Babcock +3 more
2002Gastroenterology83 citations Open access
Semantic Scholar
Expression of guanylin is downregulated in mouse and human intestinal adenomas.
Kris A. Steinbrecher, T. Tuohy, Kathleen J. Heppner Goss, M.Catherine Scott +3 more
2000Biochemical and Biophysical Research Communications - BBRC78 citations Open access
Semantic Scholar
Crosslinks and crosstalk: human cancer syndromes and DNA repair defects.
M. Risinger, J. Groden
2004Cancer Cell74 citations Open access
Semantic Scholar
Attenuated APC alleles produce functional protein from internal translation initiation
Kathleen J. Heppner Goss, C. Trzepacz, T. Tuohy, J. Groden
2002Proceedings of the National Academy of Sciences of the United States of America73 citations Open access
Semantic Scholar
The Ashkenazic Jewish Bloom syndrome mutation blmAsh is present in non-Jewish Americans of Spanish ancestry.
N. Ellis, S. Ciocci, M. Proytcheva, D. Lennon +2 more
1998American Journal of Human Genetics73 citations Open access
Semantic Scholar
Dysregulation of β-Catenin Expression Correlates With Tumor Differentiation in Pancreatic Duct Adenocarcinoma
A. Lowy, C. Fenoglio-Preiser, O. Kim, Jennifer J. Kordich +4 more
2003Annals of Surgical Oncology65 citations
Semantic Scholar
The BLM helicase is necessary for normal DNA double-strand break repair.
G. Langland, J. Elliott, Yuling Li, J. Creaney +2 more
2002Cancer Research65 citations
Semantic Scholar
Telomerase-associated Protein 1, HSP90, and Topoisomerase IIα Associate Directly with the BLM Helicase in Immortalized Cells Using ALT and Modulate Its Helicase Activity Using Telomeric DNA Substrates*
Saumitri Bhattacharyya, Jeremy K. Keirsey, B. Russell, Juraj Kavecansky +4 more
2009Journal of Biological Chemistry64 citations Open access
Semantic Scholar
BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription.
P. Grierson, Kate Lillard, G. Behbehani, K. Combs +3 more
2012Human Molecular Genetics60 citations Open access
Semantic Scholar
Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlin
Jin-Jun Meng, D. J. Lowrie, hao-Ting sun, E. Dorsey +5 more
2000Journal of Neuroscience Research60 citations
Semantic Scholar
Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors.
Wilson M. Clements, A. Lowy, J. Groden
2003Clinical colorectal cancer58 citations
Semantic Scholar
Mouse Models of Intestinal Cancer.
Erin M. Perchiniak, J. Groden
200954 citations
Semantic Scholar
The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminus.
J. Qian, A. Sarnaik, T. Bonney, Jeremy K. Keirsey +7 more
2008Gastroenterology49 citations Open access
Semantic Scholar
The identical 5' splice-site acceptor mutation in five attenuated APC families from Newfoundland demonstrates a founder effect
L. Spirio, J. Green, J. Robertson, M. Robertson +7 more
1999Human Genetics49 citations
Semantic Scholar
Restoration of E-cadherin/beta-catenin expression in pancreatic cancer cells inhibits growth by induction of apoptosis.
A. Lowy, Joy Knight, J. Groden
2002Surgery48 citations
Semantic Scholar
Human sarcomas are mosaic for telomerase-dependent and telomerase-independent telomere maintenance mechanisms: implications for telomere-based therapies.
A. Gocha, G. Nuovo, O. Iwenofu, J. Groden
2013American Journal of Pathology45 citations Open access
Semantic Scholar
Maternally inherited nonsyndromic hearing loss.
R. Friedman, Y. Bykhovskaya, Carolyn M. Sue, Salvatore DiMauro +8 more
1999American journal of medical genetics44 citations
Semantic Scholar
Novel germline APC variants in patients with multiple adenomas
S. Pedemonte, S. Sciallero, V. Gismondi, P. Stagnaro +8 more
1998Genes, Chromosomes and Cancer41 citations
Semantic Scholar
Heterozygous germline BLM mutations increase susceptibility to asbestos and mesothelioma
A. Bononi, Keisuke Goto, Guntulu Ak, Yoshie Yoshikawa +23 more
2020Proceedings of the National Academy of Sciences of the United States of America39 citations Open access
Semantic Scholar
Macrophage Apoptosis by Anthrax Lethal Factor Through p 38 MAP Kinase Inhibition
K. Goss, M. Risinger, Jennifer J. Kordich, M. Sanz +6 more
200239 citations
Semantic Scholar
Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells
S. Acharya, Zeenia Kaul, A. Gocha, Alaina R Martinez +3 more
2014PLoS ONE38 citations Open access
Semantic Scholar
Collaborating functions of BLM and DNA topoisomerase I in regulating human rDNA transcription
P. Grierson, S. Acharya, J. Groden
2012Mutation research38 citations Open access
Semantic Scholar
The APC Tumor Suppressor Promotes Transcription-Independent Apoptosis In vitro11 NIH CA 63517 (J. Groden) and CA 53683 (M.C. Barton) and Albert J. Ryan Foundation (K. Steigerwald).
K. Steigerwald, G. Behbehani, K. Combs, M. Barton +1 more
2005Molecular Cancer Research38 citations
Semantic Scholar
Unwinding Protein Complexes in ALTernative Telomere Maintenance
Saumitri Bhattacharyya, April Sandy, J. Groden
2009Journal of Cellular Biochemistry32 citations Open access
Semantic Scholar
BLM helicase is activated in BCR/ABL leukemia cells to modulate responses to cisplatin
A. Słupianek, Ewa Gurdek, Mateusz Koptyra, M. Nowicki +3 more
2005Oncogene31 citations Open access
Semantic Scholar
WRN Loss Induces Switching of Telomerase-Independent Mechanisms of Telomere Elongation
A. Gocha, S. Acharya, J. Groden
2014PLoS ONE30 citations Open access
Semantic Scholar
Chromosome breakage is regulated by the interaction of the BLM helicase and topoisomerase IIα
B. Russell, Saumitri Bhattacharyya, Jeremy K. Keirsey, April Sandy +5 more
2011Cancer Research30 citations Open access
Semantic Scholar
Alternative mechanisms of telomere lengthening: permissive mutations, DNA repair proteins and tumorigenic progression
April Renee Sandy Gocha, Julia Harris, J. Groden
2012Mutation research29 citations Open access
Semantic Scholar
Novel protein isoforms of the APC tumor suppressor in neural tissue
R. Pyles, I. Santoro, J. Groden, L. Parysek
1998Oncogene27 citations Open access
Semantic Scholar
BLM helicase complements disrupted type II telomere lengthening in telomerase-negative sgs1 yeast.
Kate Lillard-Wetherell, K. Combs, J. Groden
2005Cancer Research25 citations
Semantic Scholar
The mitochondrial protein hTID-1 partners with the caspase-cleaved APC tumor suppressor to facilitate apoptosis
J. Qian, Erin M. Perchiniak, K. Sun, J. Groden
2009Gastroenterology23 citations Open access
Semantic Scholar
Numerous colonic adenomas in an individual with Bloom's syndrome.
A. Lowy, Jennifer J. Kordich, V. Gismondi, L. Varesco +2 more
2001Gastroenterology23 citations
Semantic Scholar
Identification of endometrial cancer methylation features using combined methylation analysis methods
Michael P Trimarchi, P. Yan, J. Groden, R. Bundschuh +1 more
2017PLoS ONE22 citations Open access
Semantic Scholar

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