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D. Margolis · SciRah

Researcher profile · Semantic Scholar

D. Margolis

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D. Margolis — researcher profile on SciRah

h-index: 69
Works: 242
Citations: 18K

Most-cited papers

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract
Yixuan J. Hou, K. Okuda, C. Edwards, David R. Martinez +39 more
2020Cell1,427 citations Open access
Semantic Scholar
The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients
L. Premkumar, Bruno Segovia-Chumbez, R. Jadi, David R. Martinez +20 more
2020Science immunology858 citations Open access
Semantic Scholar
SARS-CoV-2 D614G Variant Exhibits Efficient Replication ex vivo and Transmission in vivo
Yixuan J. Hou, S. Chiba, Peter J. Halfmann, C. Ehre +22 more
2020Science842 citations Open access
Semantic Scholar
Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo
Christopher C. Nixon, M. Mavigner, G. Sampey, A. Brooks +39 more
2020Nature269 citations Open access
Semantic Scholar
The Replication-Competent HIV-1 Latent Reservoir is Primarily Established Near the Time of Therapy Initiation
M. Abrahams, S. Joseph, N. Garrett, L. Tyers +13 more
2019Science Translational Medicine191 citations Open access
Semantic Scholar
Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency
N. Archin, J. Kirchherr, J. Sung, G. Clutton +10 more
2017Journal of Clinical Investigation183 citations Open access
Semantic Scholar
Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells
J. McBRIEN, M. Mavigner, L. Franchitti, S. Smith +24 more
2020Nature178 citations Open access
Semantic Scholar
Degradation of Polycomb Repressive Complex 2 with an EED-targeted Bivalent Chemical Degrader
F. Potjewyd, Anne-Marie W. Turner, Joshua Beri, Justin M. Rectenwald +6 more
2019bioRxiv146 citations Open access
Semantic Scholar
HIV latency is reversed by ACSS2-driven histone crotonylation
G. Jiang, D. Nguyen, N. Archin, S. Yukl +8 more
2018Journal of Clinical Investigation143 citations Open access
Semantic Scholar
Brain microglia serve as a persistent HIV reservoir despite durable antiretroviral therapy
Yu-Yang Tang, A. Chaillon, S. Gianella, L. Wong +24 more
2023Journal of Clinical Investigation133 citations Open access
Semantic Scholar
Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex Vivo
C. Garrido, M. Abad-Fernández, M. Tuyishime, J. Pollara +3 more
2018Journal of Virology117 citations Open access
Semantic Scholar
Multi-omics analyses reveal that HIV-1 alters CD4 T cell immunometabolism to fuel virus replication
Hai-Tao Guo, Qi Wang, Khader Ghneim, Li Wang +11 more
2021Nature Immunology109 citations Open access
Semantic Scholar
Single-Cell Analysis of Quiescent HIV Infection Reveals Host Transcriptional Profiles that Regulate Proviral Latency
Todd Bradley, G. Ferrari, B. Haynes, D. Margolis +1 more
2018bioRxiv102 citations Open access
Semantic Scholar
Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP
Samuel W. Olson, Anne-Marie W. Turner, J. Arney, Irfana Saleem +4 more
2022Molecules and Cells86 citations Open access
Semantic Scholar
HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers
R. Sharaf, Guinevere Q. Lee, Xiao-Ming Sun, B. Etemad +21 more
2018Journal of Clinical Investigation81 citations Open access
Semantic Scholar
HIV antibodies for treatment of HIV infection
D. Margolis, R. Koup, G. Ferrari
2017Immunological Reviews69 citations Open access
Semantic Scholar
HDAC inhibition induces HIV-1 protein and enables immune-based clearance following latency reversal.
Guo-Xin Wu, M. Swanson, A. Talla, Donald J. Graham +13 more
2017JCI Insight67 citations Open access
Semantic Scholar
HIV post-treatment controllers have distinct immunological and virological features
B. Etemad, Xiao-Ming Sun, Yijia Li, M. Melberg +24 more
2023Proceedings of the National Academy of Sciences of the United States of America63 citations Open access
Semantic Scholar
Sex Disparities and Neutralizing-Antibody Durability to SARS-CoV-2 Infection in Convalescent Individuals
A. Markmann, Natasa Giallourou, D. Bhowmik, Yixuan J. Hou +20 more
2021Msphere55 citations Open access
Semantic Scholar
Sequence Evaluation and Comparative Analysis of Novel Assays for Intact Proviral HIV-1 DNA
C. Gaebler, S. Falcinelli, Elina Stoffel, Jenna Read +14 more
2020Journal of Virology55 citations Open access
Semantic Scholar
New Frontiers in Measuring and Characterizing the HIV Reservoir
S. Falcinelli, Cristina Ceriani, D. Margolis, N. Archin
2019Frontiers in Microbiology55 citations Open access
Semantic Scholar
Chromatin Regulation and the Histone Code in HIV Latency
Anne-Marie W. Turner, D. Margolis
2017The Yale Journal of Biology and Medicine53 citations
Semantic Scholar
Epigenomic characterization of latent HIV infection identifies latency regulating transcription factors
S. Jefferys, S. Burgos, J. Peterson, Sara R. Selitsky +7 more
2020bioRxiv49 citations Open access
Semantic Scholar
Longitudinal dynamics of intact HIV proviral DNA and outgrowth virus frequencies in a cohort of ART-treated individuals.
S. Falcinelli, K. Kilpatrick, Jenna Read, Ross Murtagh +12 more
2020Journal of Infectious Diseases44 citations Open access
Semantic Scholar
Stable Latent HIV Infection and Low-Level Viremia Despite Treatment with the Broadly Neutralizing Antibody VRC07-523LS and the Latency Reversal Agent Vorinostat.
C. Gay, K. James, M. Tuyishime, S. Falcinelli +19 more
2021Journal of Infectious Diseases39 citations Open access
Semantic Scholar
Assessing the impact of AGS-004, a dendritic cell-based immunotherapy, and vorinostat on persistent HIV-1 Infection
C. Gay, J. Kuruc, S. Falcinelli, J. Warren +19 more
2020Scientific Reports39 citations Open access
Semantic Scholar
Impact of biological sex on immune activation and frequency of the latent HIV reservoir during suppressive antiretroviral therapy.
S. Falcinelli, B. Shook-Sa, Morgan G. Dewey, S. Sridhar +16 more
2020Journal of Infectious Diseases37 citations Open access
Semantic Scholar
Improved Killing of HIV-infected Cells Using Three Neutralizing and Non-neutralizing Antibodies.
M. Tuyishime, C. Garrido, S. Jha, M. Moeser +7 more
2020Journal of Clinical Investigation35 citations Open access
Semantic Scholar
The HIV-1 latent reservoir is largely sensitive to circulating T cells
J. Warren, Shuntai Zhou, Yin-Yan Xu, M. Moeser +14 more
2020eLife35 citations Open access
Semantic Scholar
SMAC Mimetic Plus Triple-Combination Bispecific HIVxCD3 Retargeting Molecules in SHIV.C.CH505-Infected, Antiretroviral Therapy-Suppressed Rhesus Macaques
A. Dashti, Chevaughn Waller, M. Mavigner, N. Schoof +13 more
2020Journal of Virology32 citations Open access
Semantic Scholar
γδ T cells: an immunotherapeutic approach for HIV cure strategies.
C. Garrido, Matthew L Clohosey, Chloe P. Whitworth, M. Hudgens +2 more
2018JCI Insight32 citations Open access
Semantic Scholar
Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo
S. Falcinelli, J. Peterson, Anne-Marie W. Turner, D. Irlbeck +27 more
2022Journal of Clinical Investigation31 citations Open access
Semantic Scholar
HIV Persistence on Antiretroviral Therapy and Barriers to a Cure.
J. Sung, D. Margolis
2018Advances in Experimental Medicine and Biology31 citations
Semantic Scholar
Measuring the Inducible, Replication-Competent HIV Reservoir Using an Ultra-Sensitive p24 Readout, the Digital ELISA Viral Outgrowth Assay
E. Stuelke, K. James, J. Kirchherr, B. Allard +5 more
2020Frontiers in Immunology27 citations Open access
Semantic Scholar
Quantification of the Latent HIV-1 Reservoir Using Ultra Deep Sequencing and Primer ID In A Viral Outgrowth Assay
Sook-Kyung Lee, Shuntai Zhou, P. L. Baldoni, E. Spielvogel +4 more
2017Journal of Acquired Immune Deficiency Syndromes24 citations Open access
Semantic Scholar
Evaluation of EED Inhibitors as a Class of PRC2-Targeted Small Molecules for HIV Latency Reversal
Anne-Marie W. Turner, R. Dronamraju, F. Potjewyd, Katherine M. Sholtis +7 more
2020ACS Infectious Diseases23 citations Open access
Semantic Scholar
In Vivo Administration of Histone Deacetylase Inhibitors Does Not Impair Natural Killer Cell Function in HIV+ Individuals
C. Garrido, M. Tolstrup, O. Søgaard, T. A. Rasmussen +4 more
2019AIDS (London)23 citations Open access
Semantic Scholar
Longitudinal Dynamics of Intact HIV Proviral DNA and Outgrowth Virus Frequencies in a Cohort of Individuals Receiving Antiretroviral Therapy
Falcinelli, Kilpatrick, Murtagh, Ghofrani +6 more
202121 citations
Semantic Scholar
Determinants of the efficacy of HIV latency-reversing agents and implications for drug and treatment design.
Rui-An Ke, Jessica M. Conway, D. Margolis, A. Perelson
2018JCI Insight21 citations Open access
Semantic Scholar
HIV-Specific T Cell Responses Are Highly Stable on Antiretroviral Therapy
Yin-Yan Xu, Ilana M. Trumble, J. Warren, G. Clutton +11 more
2019Molecular Therapy: Methods & Clinical Development20 citations Open access
Semantic Scholar
CD8+ lymphocytes do not impact SIV reservoir establishment under ART
M. Statzu, Wang Jin, Emily J. Fray, A. Wong +25 more
2023Nature Microbiology18 citations Open access
Semantic Scholar
Crotonylation sensitizes IAPi-induced disruption of latent HIV by enhancing p100 cleavage into p52
Da-Jiang Li, Morgan G. Dewey, Li Wang, S. Falcinelli +7 more
2021iScience18 citations Open access
Semantic Scholar
The SMAC Mimetic AZD5582 is a Potent HIV Latency Reversing Agent
G. Sampey, D. Irlbeck, E. Browne, Matt Kanke +9 more
2018bioRxiv18 citations Open access
Semantic Scholar
HIV-Specific T Cells Generated from Naive T Cells Suppress HIV In Vitro and Recognize Wide Epitope Breadths.
Shabnum Patel, Elizabeth A. Chorvinsky, Shuroug Albihani, C. Cruz +5 more
2018Molecular Therapy18 citations Open access
Semantic Scholar
Transcriptomic Signatures of Human Immunodeficiency Virus Post-Treatment Control
Adam Wedrychowski, H. Martin, Yijia Li, S. Telwatte +13 more
2022Journal of Virology17 citations Open access
Semantic Scholar
Integrated Single-cell Multiomic Analysis of HIV Latency Reversal Reveals Novel Regulators of Viral Reactivation
Manickam Ashokkumar, Wen-Wen Mei, J. Peterson, Yuriko Harigaya +8 more
2022bioRxiv16 citations Open access
Semantic Scholar
A truncated HIV Tat demonstrates potent and specific latency reversal activity
E. Van Gulck, Marion Pardons, E. Nijs, Nick Verheyen +14 more
2023bioRxiv15 citations Open access
Semantic Scholar
Microglia-Specific Promoter Activities of HEXB Gene
S. Shah, L. Wong, Kendra Ellis, Brittany H. Bodnar +11 more
2022Frontiers in Cellular Neuroscience15 citations Open access
Semantic Scholar
CD8 Lymphocyte Depletion Enhances the Latency Reversal Activity of the SMAC Mimetic AZD5582 in ART-Suppressed Simian Immunodeficiency Virus-Infected Rhesus Macaques
M. Mavigner, Laura E. Liao, A. Brooks, Rui-An Ke +15 more
2021Journal of Virology15 citations Open access
Semantic Scholar
How Unavoidable Are Analytical Treatment Interruptions in HIV Cure-Related Studies?
D. Margolis, S. Deeks
2019Journal of Infectious Diseases15 citations Open access
Semantic Scholar

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