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J. Oram · SciRah

Researcher profile · Semantic Scholar

J. Oram

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J. Oram — researcher profile on SciRah

h-index: 66
Works: 143
Citations: 16K

Most-cited papers

Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL.
T. Vaisar, S. Pennathur, P. Green, Sina A. Gharib +17 more
2007Journal of Clinical Investigation978 citations Open access
Semantic Scholar
The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway.
R. Lawn, David P. Wade, M. Garvin, Xing-Bo Wang +5 more
1999Journal of Clinical Investigation773 citations Open access
Semantic Scholar
ABCA1 Is the cAMP-inducible Apolipoprotein Receptor That Mediates Cholesterol Secretion from Macrophages*
J. Oram, R. Lawn, M. Garvin, D. Wade
2000Journal of Biological Chemistry567 citations Open access
Semantic Scholar
ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease.
J. Oram, J. Heinecke
2005Physiological Reviews545 citations Open access
Semantic Scholar
ABCA1 : The gatekeeper for eliminating excess tissue cholesterol
J. Oram
2001498 citations
Semantic Scholar
The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport.
Constanze Bergt, S. Pennathur, Xiao-Yun Fu, Jaeman Byun +9 more
2004Proceedings of the National Academy of Sciences of the United States of America468 citations Open access
Semantic Scholar
Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease.
G. Francis, R. Knopp, J. Oram
1995Journal of Clinical Investigation428 citations Open access
Semantic Scholar
Apolipoprotein-mediated removal of cellular cholesterol and phospholipids.
J. Oram, S. Yokoyama
1996Journal of Lipid Research360 citations Open access
Semantic Scholar
The Macrophage Cholesterol Exporter ABCA1 Functions as an Anti-inflammatory Receptor*
Chongren Tang, Yuhua Liu, P. Kessler, A. Vaughan +1 more
2009Journal of Biological Chemistry295 citations Open access
Semantic Scholar
ABCG1 Redistributes Cell Cholesterol to Domains Removable by High Density Lipoprotein but Not by Lipid-depleted Apolipoproteins*
A. Vaughan, J. Oram
2005Journal of Biological Chemistry280 citations Open access
Semantic Scholar
HDL apolipoproteins and ABCA1: partners in the removal of excess cellular cholesterol.
J. Oram
2003Arteriosclerosis, Thrombosis and Vascular Biology280 citations Open access
Semantic Scholar
ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins.
J. Oram, A. Vaughan
2000Current Opinion in Lipidology279 citations
Semantic Scholar
Human Atherosclerotic Intima and Blood of Patients with Established Coronary Artery Disease Contain High Density Lipoprotein Damaged by Reactive Nitrogen Species*
S. Pennathur, Constanze Bergt, Bao-Hai Shao, Jaeman Byun +10 more
2004Journal of Biological Chemistry272 citations Open access
Semantic Scholar
ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL Published, JLR Papers in Press, August 10, 2006.
A. Vaughan, J. Oram
2006Journal of Lipid Research269 citations Open access
Semantic Scholar
Tangier disease and ABCA1.
J. Oram
2000Biochimica et Biophysica Acta240 citations
Semantic Scholar
Tyrosine 192 in Apolipoprotein A-I Is the Major Site of Nitration and Chlorination by Myeloperoxidase, but Only Chlorination Markedly Impairs ABCA1-dependent Cholesterol Transport*
Bao-Hai Shao, Constanze Bergt, Xiao-Yun Fu, P. Green +4 more
2005Journal of Biological Chemistry235 citations Open access
Semantic Scholar
Unsaturated Fatty Acids Inhibit Cholesterol Efflux from Macrophages by Increasing Degradation of ATP-binding Cassette Transporter A1*
Yu-Tong Wang, J. Oram
2002Journal of Biological Chemistry230 citations Open access
Semantic Scholar
Thematic review series: The Immune System and Atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease? Published, JLR Papers in Press, February 1, 2005. DOI 10.1194/jlr.R400017-JLR200
A. Chait, C. Han, J. Oram, Jay W. Heinecke
2005Journal of Lipid Research221 citations Open access
Semantic Scholar
ABCA1 redistributes membrane cholesterol independent of apolipoprotein interactions Published, JLR Papers in Press, April 16, 2003. DOI 10.1194/jlr.M300078-JLR200
A. Vaughan, J. Oram
2003Journal of Lipid Research203 citations Open access
Semantic Scholar
Myeloperoxidase Impairs ABCA1-dependent Cholesterol Efflux through Methionine Oxidation and Site-specific Tyrosine Chlorination of Apolipoprotein A-I*
Bao-Hai Shao, Michael N. Oda, Constanze Bergt, Xiao-Yun Fu +4 more
2006Journal of Biological Chemistry193 citations Open access
Semantic Scholar
Membrane Lipid Domains Distinct from Cholesterol/Sphingomyelin-Rich Rafts Are Involved in the ABCA1-mediated Lipid Secretory Pathway*
A. Mendez, Guo-Rong Lin, D. Wade, R. Lawn +1 more
2001Journal of Biological Chemistry190 citations Open access
Semantic Scholar
Myeloperoxidase: An oxidative pathway for generating dysfunctional HDL
Bao-Hai Shao, Michael N. Oda, J. Oram, J. Heinecke
2010Chemical Research in Toxicology182 citations Open access
Semantic Scholar
ATP-binding cassette transporter A1 and cholesterol trafficking
J. Oram
2002Current Opinion in Lipidology170 citations
Semantic Scholar
Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux
Sandhya Sankaranarayanan, J. Oram, B. Asztalos, A. Vaughan +4 more
2009Journal of Lipid Research164 citations Open access
Semantic Scholar
Phospholipid Transfer Protein Interacts with and Stabilizes ATP-binding Cassette Transporter A1 and Enhances Cholesterol Efflux from Cells*
J. Oram, G. Wolfbauer, A. Vaughan, Chongren Tang +1 more
2003Journal of Biological Chemistry156 citations Open access
Semantic Scholar
HDL suppresses the type I interferon response, a family of potent antiviral immunoregulators, in macrophages challenged with lipopolysaccharide
Masashi Suzuki, David K. Pritchard, L. Becker, A. Hoofnagle +10 more
2010Circulation139 citations Open access
Semantic Scholar
Advanced glycation end product precursors impair ABCA1-dependent cholesterol removal from cells.
M. Passarelli, Chongren Tang, Thomas O. McDonald, K. O'Brien +3 more
2005Diabetes138 citations Open access
Semantic Scholar
Modifying Apolipoprotein A-I by Malondialdehyde, but Not by an Array of Other Reactive Carbonyls, Blocks Cholesterol Efflux by the ABCA1 Pathway*
Bao-Hai Shao, S. Pennathur, I. Pagani, Michael N. Oda +3 more
2010Journal of Biological Chemistry135 citations Open access
Semantic Scholar
Myeloperoxidase: an inflammatory enzyme for generating dysfunctional high density lipoprotein.
Bao-Hai Shao, Michael N. Oda, J. Oram, J. Heinecke
2006Current Opinion in Cardiology129 citations
Semantic Scholar
The cell cholesterol exporter ABCA1 as a protector from cardiovascular disease and diabetes.
Chongren Tang, J. Oram
2009Biochimica et Biophysica Acta124 citations
Semantic Scholar
ATP-binding Cassette Transporter A1 Mediates Cellular Secretion of α-Tocopherol*
J. Oram, A. Vaughan, R. Stocker
2001Journal of Biological Chemistry123 citations Open access
Semantic Scholar
LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1 Published, JLR Papers in Press, February 16, 2004. DOI 10.1194/jlr.M400011-JLR200
Yu-Tong Wang, B. Kurdi-Haidar, J. Oram
2004Journal of Lipid Research121 citations Open access
Semantic Scholar
Janus Kinase 2 Modulates the Apolipoprotein Interactions with ABCA1 Required for Removing Cellular Cholesterol*
Chongren Tang, A. Vaughan, J. Oram
2004Journal of Biological Chemistry118 citations Open access
Semantic Scholar
Phospholipid transfer protein enhances removal of cellular cholesterol and phospholipids by high-density lipoprotein apolipoproteins.
G. Wolfbauer, J. Albers, J. Oram
1999Biochimica et Biophysica Acta116 citations
Semantic Scholar
Acrolein Impairs ATP Binding Cassette Transporter A1-dependent Cholesterol Export from Cells through Site-specific Modification of Apolipoprotein A-I*
Bao-Hai Shao, Xiao-Yun Fu, Thomas O. McDonald, P. Green +4 more
2005Journal of Biological Chemistry114 citations Open access
Semantic Scholar
Molecular basis of cholesterol homeostasis: lessons from Tangier disease and ABCA1.
J. Oram
2002Trends in Molecular Medicine101 citations
Semantic Scholar
Unsaturated Fatty Acids Phosphorylate and Destabilize ABCA1 through a Phospholipase D2 Pathway*
Yu-Tong Wang, J. Oram
2005Journal of Biological Chemistry99 citations Open access
Semantic Scholar
Cellular cholesterol transport and efflux in fibroblasts are abnormal in subjects with familial HDL deficiency.
M. Marcil, Lu Yu, L. Krimbou, B. Boucher +3 more
1999Arteriosclerosis, Thrombosis and Vascular Biology97 citations
Semantic Scholar
Oxidation of apolipoprotein A-I by myeloperoxidase impairs the initial interactions with ABCA1 required for signaling and cholesterol export1
Bao-Hai Shao, Chongren Tang, J. Heinecke, J. Oram
2010Journal of Lipid Research95 citations Open access
Semantic Scholar
Apolipoprotein A-I Attenuates Palmitate-Mediated NF-κB Activation by Reducing Toll-Like Receptor-4 Recruitment into Lipid Rafts
Andrew M. Cheng, Priya Handa, Sanshiro Tateya, Jay Schwartz +5 more
2012PLoS ONE89 citations Open access
Semantic Scholar
Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a protein kinase C δ pathway Published, JLR Papers in Press, February 28, 2007.
Yu-Tong Wang, J. Oram
2007Journal of Lipid Research84 citations Open access
Semantic Scholar
Janus kinase 2 modulates the lipid-removing but not protein-stabilizing interactions of amphipathic helices with ABCA1 Published, JLR Papers in Press, October 6, 2005.
Chongren Tang, A. Vaughan, G. Anantharamaiah, J. Oram
2006Journal of Lipid Research82 citations Open access
Semantic Scholar
A Macrophage Sterol-Responsive Network Linked to Atherogenesis
L. Becker, S. Gharib, Angela D. Irwin, E. Wijsman +3 more
2010Cell Metabolism81 citations Open access
Semantic Scholar
Diabetes reduces the cholesterol exporter ABCA1 in mouse macrophages and kidneys1
Chongren Tang, J. Kanter, K. Bornfeldt, R. Leboeuf +1 more
2010Journal of Lipid Research80 citations Open access
Semantic Scholar
Sterol Efflux Mediated by Endogenous Macrophage ApoE Expression Is Independent of ABCA1
Zhi-Hua Huang, Chen Y Lin, J. Oram, T. Mazzone
2001Arteriosclerosis, Thrombosis and Vascular Biology75 citations
Semantic Scholar
Apolipoprotein binding to protruding membrane domains during removal of excess cellular cholesterol.
Guo-Rong Lin, J. Oram
2000Atherosclerosis69 citations
Semantic Scholar
ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation ** This work was supported by National Institutes of Health Grant RO1HL-55362. Published, JLR Papers in Press, September 5, 2008.
A. Vaughan, Chongren Tang, J. Oram
2009Journal of Lipid Research68 citations Open access
Semantic Scholar
ATP-binding cassette transporter A1 mediates cellular secretion of alpha-tocopherol.
J. Oram, A. Vaughan, R. Stocker
2001Journal of Biological Chemistry65 citations
Semantic Scholar
Oxidative tyrosylation of HDL enhances the depletion of cellular cholesteryl esters by a mechanism independent of passive sterol desorption.
G. A. Francis, J. Oram, J. W. Heinecke, E. Bierman
1996Biochemistry65 citations
Semantic Scholar
Serum Amyloid A Facilitates the Binding of HDL from Mice Injected with Lipopolysaccharide to Vascular Proteoglycans
T. Chiba, M. Chang, Shari Wang, T. Wight +7 more
2011Arteriosclerosis, Thrombosis and Vascular Biology62 citations Open access
Semantic Scholar

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