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B. Tehan · SciRah

Researcher profile · Semantic Scholar

B. Tehan

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B. Tehan — researcher profile on SciRah

h-index: 27
Works: 81
Citations: 3,656

Most-cited papers

Structure of the adenosine A2A receptor in complex with ZM241385 and the xanthines XAC and caffeine
A. S. Doré, N. Robertson, J. Errey, I. Ng +9 more
2011Structure555 citations Open access
Semantic Scholar
Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain
A. S. Doré, K. Okrasa, Jayesh C. Patel, M. Serrano-Vega +9 more
2014Nature415 citations
Semantic Scholar
Discovery of 1,2,4-Triazine Derivatives as Adenosine A2A Antagonists using Structure Based Drug Design
M. Congreve, S. P. Andrews, A. S. Doré, K. Hollenstein +8 more
2012Journal of Medicinal Chemistry318 citations Open access
Semantic Scholar
Structural insight into allosteric modulation of protease-activated receptor 2
R. Cheng, C. Fiez-Vandal, O. Schlenker, K. Edman +24 more
2017Nature216 citations
Semantic Scholar
Unifying family A GPCR theories of activation.
B. Tehan, A. Bortolato, F. Blaney, M. Weir +1 more
2014Pharmacology and Therapeutics200 citations
Semantic Scholar
Biophysical Fragment Screening of the β1-Adrenergic Receptor: Identification of High Affinity Arylpiperazine Leads Using Structure-Based Drug Design
J. Christopher, Jason L. Brown, A. S. Doré, J. Errey +8 more
2013Journal of Medicinal Chemistry160 citations Open access
Semantic Scholar
Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile).
J. Christopher, S. J. Aves, K. Bennett, A. S. Doré +8 more
2015Journal of Medicinal Chemistry159 citations Open access
Semantic Scholar
Comparisons of the Hbv and HIV Polymerase, and Antiviral Resistance Mutations
A. Bartholomeusz, B. Tehan, D. Chalmers
2003Antiviral Therapy131 citations Open access
Semantic Scholar
Biophysical Mapping of the Adenosine A2A Receptor
A. Zhukov, S. P. Andrews, J. Errey, N. Robertson +5 more
2011Journal of Medicinal Chemistry125 citations Open access
Semantic Scholar
Water Network Perturbation in Ligand Binding: Adenosine A2A Antagonists as a Case Study
A. Bortolato, B. Tehan, M. Bodnarchuk, J. Essex +1 more
2013Journal of Chemical Information and Modeling123 citations
Semantic Scholar
Structure of Class B GPCRs: new horizons for drug discovery
A. Bortolato, A. S. Doré, K. Hollenstein, B. Tehan +2 more
2014British Journal of Pharmacology108 citations Open access
Semantic Scholar
Estimation of pKa Using Semiempirical Molecular Orbital Methods. Part 1: Application to Phenols and Carboxylic Acids.
B. Tehan, E. J. Lloyd, M. G. Wong, W. Pitt +3 more
2002107 citations
Semantic Scholar
Pharmacology and physiology of gastrointestinal enteroendocrine cells
O. Mace, B. Tehan, F. Marshall
2015Pharmacology Research & Perspectives86 citations Open access
Semantic Scholar
High end GPCR design: crafted ligand design and druggability analysis using protein structure, lipophilic hotspots and explicit water networks
J. Mason, A. Bortolato, Dahlia R. Weiss, Francesca Deflorian +2 more
2013In Silico Pharmacology80 citations Open access
Semantic Scholar
Orthosteric and Allosteric Modes of Interaction of Novel Selective Agonists of the M1 Muscarinic Acetylcholine Receptor
V. Avlani, C. Langmead, E. Guida, M. Wood +5 more
2010Molecular Pharmacology76 citations
Semantic Scholar
From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease
Alastair J. H. Brown, Sophie J. Bradley, F. Marshall, Giles A. Brown +44 more
2021Cell75 citations Open access
Semantic Scholar
Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis
M. Rappas, Ammar A. E. Ali, K. Bennett, Jason Brown +15 more
2019Journal of Medicinal Chemistry71 citations Open access
Semantic Scholar
Pharmacology and Structure of Isolated Conformations of the Adenosine A2A Receptor Define Ligand Efficacy
K. Bennett, B. Tehan, G. Lebon, C. G. Tate +3 more
2013Molecular Pharmacology70 citations Open access
Semantic Scholar
Estimation of pKa Using Semiempirical Molecular Orbital Methods. Part 2: Application to Amines, Anilines and Various Nitrogen Containing Heterocyclic Compounds.
B. Tehan, E. J. Lloyd, M. G. Wong, W. Pitt +2 more
200265 citations
Semantic Scholar
A Consensus Neural Network-Based Technique for Discriminating Soluble and Poorly Soluble Compounds
D. Manallack, B. Tehan, E. Gancia, B. Hudson +4 more
2003Journal of chemical information and computer sciences56 citations
Semantic Scholar
Novel N-Substituted Benzimidazolones as Potent, Selective, CNS-Penetrant, and Orally Active M1 mAChR Agonists.
Brian W. Budzik, V. Garzya, Dongchuan Shi, G. Walker +10 more
2010ACS Medicinal Chemistry Letters52 citations Open access
Semantic Scholar
Mutagenic Mapping Suggests a Novel Binding Mode for Selective Agonists of M1 Muscarinic Acetylcholine Receptors
G. Lebon, C. Langmead, B. Tehan, E. Hulme
2009Molecular Pharmacology50 citations Open access
Semantic Scholar
Roof and Floor of the Muscarinic Binding Pocket: Variations in the Binding Modes of Orthosteric Ligands
J. A. Goodwin, E. Hulme, C. Langmead, B. Tehan
2007Molecular Pharmacology50 citations
Semantic Scholar
Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants
K. Harpsøe, Vignir Ísberg, B. Tehan, Dahlia R. Weiss +4 more
2015Scientific Reports43 citations Open access
Semantic Scholar
Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits
Jon Palacios-Filardo, Matt Udakis, Giles A. Brown, B. Tehan +4 more
2020Nature Communications39 citations Open access
Semantic Scholar
Phospho‐regulation, nucleotide binding and ion access control in potassium‐chloride cotransporters
G. Chi, R. Ebenhoch, H. Man, Hai-Ping Tang +23 more
2021EMBO Journal38 citations Open access
Semantic Scholar
GPCR-Bench: A Benchmarking Set and Practitioners' Guide for G Protein-Coupled Receptor Docking
Dahlia R. Weiss, A. Bortolato, B. Tehan, J. Mason
2016Journal of Chemical Information and Modeling31 citations
Semantic Scholar
Stabilised G protein-coupled receptors in structure-based drug design: a case study with adenosine A2A receptor
S. P. Andrews, B. Tehan
201324 citations
Semantic Scholar
The identification of novel orally active mGluR5 antagonist GSK2210875.
Maria Pilla, Michela Andreoli, M. Tessari, Sonia Delle-Fratte +16 more
2010Bioorganic & Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Discovery of HTL6641, a dual orexin receptor antagonist with differentiated pharmacodynamic properties
J. Christopher, S. J. Aves, Jason Brown, J. Errey +9 more
201517 citations
Semantic Scholar
The use of conformationally thermostabilised GPCRs in drug discovery: application to fragment, structure and biophysical techniques.
B. Tehan, J. Christopher
2016Current opinion in pharmacology (Print)16 citations
Semantic Scholar
Molecular field analysis of clozapine analogs in the development of a pharmacophore model of antipsychotic drug action.
B. Tehan, E. J. Lloyd, M. G. Wong
2001Journal of Molecular Graphics and Modelling11 citations
Semantic Scholar
4.26 – Seven Transmembrane G Protein-Coupled Receptors: Insights for Drug Design from Structure and Modeling
N. Barton, F. Blaney, S. L. Garland, B. Tehan +1 more
200710 citations
Semantic Scholar
Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918
L. Stott, Cheryl A. Brighton, J. Brown, R. Mould +9 more
2021Heliyon9 citations Open access
Semantic Scholar
Evaluating the enthalpic contribution to ligand binding using QM calculations: effect of methodology on geometries and interaction energies.
Duangkamol Gleeson, B. Tehan, M. Gleeson, J. Limtrakul
2012Organic and biomolecular chemistry8 citations
Semantic Scholar
The evolving role of hydrogen/deuterium exchange mass spectrometry in early-stage drug discovery.
Srinath Krishnamurthy, M. Musgaard, B. Tehan, Ali Jazayeri +1 more
2025Current Opinion in Structural Biology7 citations Open access
Semantic Scholar
Structure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulators.
K. Bennett, J. Christopher, B. Tehan
2020Advances in Pharmacology7 citations
Semantic Scholar
242 Molecular modelling and functional studies of adefovir resistant mutations in the hepatitis B virus polymerase selected during therapy
A. Bartholomeusz, S. Locarinini, A. Ayres, G. Thompson +6 more
20037 citations
Semantic Scholar
Impact of Recently Determined Crystallographic Structures of GPCRs on Drug Discovery
Francesca Deflorian, J. Mason, A. Bortolato, B. Tehan
20205 citations
Semantic Scholar
Potential for the Rational Design of Allosteric Modulators of Class C GPCRs.
J. Christopher, A. S. Doré, B. Tehan
2016Current Topics in Medicinal Chemistry5 citations
Semantic Scholar
Molecular mapping in the CNS.
M. G. Wong, B. Tehan, E. J. Lloyd
2002Current pharmaceutical design5 citations
Semantic Scholar
Methodologies for the Examination of Water in GPCRs.
A. Bortolato, B. Tehan, Robert T. Smith, J. Mason
2018Methods in molecular biology4 citations
Semantic Scholar
Author Correction: Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits
Jon Palacios-Filardo, Matt Udakis, Giles A. Brown, B. Tehan +4 more
2021Nature Communications2 citations Open access
Semantic Scholar
Crystal Structures of Toxicology Targets
F. Blaney, B. Tehan
20061 citations
Semantic Scholar
Analysis of agonism by dopamine at the dopaminergic D 2 G-protein coupled receptor based on comparative modelling of rhodopsin
B. Tehan, E. J. Lloyd, M. G. Wong, D. Chalmers
20021 citations
Semantic Scholar
Structure of Human Potassium Chloride Transporter KCC1 in NaCl (Subclass 1)
R. Ebenhoch, G. Chi, H. Man, D. Wang +20 more
20210 citations
Semantic Scholar
Potassium/Chloride Co-transporter 1 and 3 (KCC1/KCC3; SLC12A4/SLC12A6) A Target Enabling Package (TEP)
Q9UP95, Target Nominator, K. Duerr, R. Ebenhoch +25 more
20210 citations
Semantic Scholar
Structure of Human Potassium Chloride Transporter KCC1 in NaCl (Subclass 2)
R. Ebenhoch, G. Chi, H. Man, D. Wang +20 more
20210 citations
Semantic Scholar
Structure of Human Potassium Chloride Transporter KCC1 in NaCl (Reference Map)
R. Ebenhoch, G. Chi, H. Man, D. Wang +21 more
20210 citations
Semantic Scholar
Crystal structure of the Orexin-1 receptor in complex with Compound 14
M. Rappas, A. Ali, K. Bennett, J. Brown +15 more
20200 citations
Semantic Scholar

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