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Sarah R. Klein · SciRah

Researcher profile · Semantic Scholar

Sarah R. Klein

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Sarah R. Klein — researcher profile on SciRah

h-index: 10
Works: 34
Citations: 1,474

Most-cited papers

Coinhibitory pathways in the B7-CD28 ligand-receptor family
F. Schildberg, Sarah R. Klein, G. Freeman, A. Sharpe
2016Immunity530 citations Open access
Semantic Scholar
Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model
D. Reardon, P. Gokhale, Sarah R. Klein, K. Ligon +14 more
2015Cancer immunology research390 citations Open access
Semantic Scholar
The Iron Chelator Dp44mT Causes DNA Damage and Selective Inhibition of Topoisomerase IIα in Breast Cancer Cells
V. Rao, Sarah R. Klein, K. Agama, E. Toyoda +3 more
2009Cancer Research141 citations Open access
Semantic Scholar
The Antioxidant Transcription Factor Nrf2 Negatively Regulates Autophagy and Growth Arrest Induced by the Anticancer Redox Agent Mitoquinone*
V. Rao, Sarah R. Klein, Spencer J Bonar, J. Zielonka +6 more
2010Journal of Biological Chemistry132 citations Open access
Semantic Scholar
Autophagy regulation in cancer development and therapy.
E. White, V. Martín, Juinn-lin Liu, Sarah R. Klein +4 more
2011American Journal of Cancer Research81 citations
Semantic Scholar
Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma
M. Speranza, Carmela Passaro, F. Ricklefs, K. Kasai +17 more
2018Neuro-Oncology66 citations Open access
Semantic Scholar
The E1B19K Oncoprotein Complexes with Beclin 1 to Regulate Autophagy in Adenovirus-Infected Cells
S. Piya, E. White, Sarah R. Klein, Hong Jiang +3 more
2011PLoS ONE50 citations Open access
Semantic Scholar
The iron chelator Dp44mT inhibits the proliferation of cancer cells but fails to protect from doxorubicin-induced cardiotoxicity in spontaneously hypertensive rats
V. Rao, Jun Zhang, Sarah R. Klein, P. Espandiari +4 more
2011Cancer Chemotherapy and Pharmacology24 citations
Semantic Scholar
Critical Role of Autophagy in the Processing of Adenovirus Capsid-Incorporated Cancer-Specific Antigens
Sarah R. Klein, Hong Jiang, Mohammad B Hossain, Xue-Mo Fan +5 more
2016PLoS ONE23 citations Open access
Semantic Scholar
Monitoring PD-1 phosphorylation to evaluate PD-1 signaling during anti-tumor immune responses
Xia Bu, Vikram R. Juneja, C. Reynolds, K. Mahoney +11 more
2021Cancer immunology research20 citations Open access
Semantic Scholar
Abstract 572: Inhibition of IDO1 with epacadostat enhances anti-tumor efficacy of PD-1 blockade in a syngeneic glioblastoma (GBM) model
D. Reardon, P. Gokhale, Sarah R. Klein, Kristen L Jones +7 more
20175 citations
Semantic Scholar
Alpha-synuclein promotes dopaminergic neuron death in Parkinson’s disease through microglial and NLRP3 activation
Sarah R. Klein
20204 citations Open access
Semantic Scholar
PD-1 blockade activates conventional CD4 T cells and the innate immune response during glioblastoma eradication
Sarah R. Klein, J. Ziello, M. Speranza, P. Gokhale +4 more
2018Journal of Immunology3 citations
Semantic Scholar
Advances in Oncolytic Virotherapy for Brain Tumors
R. Balvers, C. Gomez-Manzano, Hong Jiang, S. Piya +4 more
20133 citations
Semantic Scholar
Abstract B97: The role of JNK isoforms in adenovirus-induced autophagy: Implications for cancer immunotherapy using oncolytic adenoviruses.
Sarah R. Klein, Hong Jiang, S. Piya, Zhimin Lu +2 more
20132 citations
Semantic Scholar
IMMU-15. PD-1 BLOCKADE ACTIVATES CD4 T CELLS AND THE INNATE IMMUNE RESPONSE FOR GLIOBLASTOMA ERADICATION
Sarah R. Klein, M. Speranza, P. Gokhale, M. Wilkens +5 more
20171 citations Open access
Semantic Scholar
Immune checkpoint blockade activates effective anti-tumor immunity in an orthotopic model of glioblastoma (VAC12P.1119)
Sarah R. Klein, P. Gokhale, Kristen L Jones, A. Saur +5 more
2015Journal of Immunology1 citations
Semantic Scholar
Phosphoproteomics reveals GITR agonism differentially regulates inflammatory vs. regulatory T cell subsets.
A. Davis, Lori Cunningham, M. Stokes, Alissa J. Nelson +7 more
2021Journal of Immunology0 citations
Semantic Scholar
Microglial and NLRP3 Activation Is Responsible for Alpha-Synuclein Initiating Dopaminergic Neuronal Pathology in Parkinson’s Disease
Sarah R. Klein
20200 citations
Semantic Scholar
Monitoring PD-1 Signaling in Tumor Infiltrating Lymphocytes
Xia Bu, Vikram R. Juneja, Katheleen M. Mahoney, Carol G. Renolds +10 more
2019Journal of Immunology0 citations
Semantic Scholar
Abstract B33: Coexpression and frequency of immune checkpoint proteins in the tumor microenvironment analyzed via multiplex immunohistochemistry
J. Ziello, Sarah R. Klein, K. Crosby
2018Tumor Microenvironment0 citations
Semantic Scholar
IMMU-19. PD-1 BLOCKADE ACTIVATES CD4 T CELLS AND THE INNATE IMMUNE RESPONSE FOR GLIOBLASTOMA ERADICATION
M. Speranza, Sarah R. Klein, P. Gokhale, M. Wilkens +5 more
2018Neuro-Oncology0 citations Open access
Semantic Scholar
Abstract 5689: Characterization of immune infiltrate and checkpoint protein expression patterns in murine syngeneic tumors via multiplex immunohistochemistry
J. Ziello, Sarah R. Klein, K. Crosby
2018Immunology0 citations
Semantic Scholar
Abstract 2688: Multiplex IHC detection of immune checkpoint receptors in the tumor microenvironment
J. Ziello, Sarah R. Klein, E. Alonzo, H. Haack
20170 citations
Semantic Scholar
Abstract B84: Preclinical analysis of combinatorial glioblastoma therapy with the prodrug-mediated gene therapy vector AdV-TK and immune checkpoint inhibition
M. Speranza, F. Ricklefs, Carmela Passaro, Sarah R. Klein +11 more
20170 citations
Semantic Scholar
Abstract A075: Preclinical analysis of combinatorial glioblastoma therapy with the prodrug-mediated gene therapy vector AdV-TK and immune checkpoint inhibition in GBM therapy
M. Speranza, K. Kasai, F. Ricklefs, Sarah R. Klein +11 more
20160 citations
Semantic Scholar
EXTH-23. PRECLINICAL ANALYSIS OF COMBINATORIAL GLIOBLASTOMA THERAPY WITH THE PRODRUG-MEDIATED GENE THERAPY VECTOR AdV-tk AND IMMUNE CHECKPOINT INHIBITION
M. Speranza, K. Kasai, F. Ricklefs, Sarah R. Klein +11 more
20160 citations Open access
Semantic Scholar
Abstract 726: Oncolytic adenoviruses modulate autophagy in cancer cells via sumoylation of LC3
S. Piya, Hong Jiang, Sarah R. Klein, W. K. Alfred Yung +3 more
20140 citations
Semantic Scholar
Abstract 3644: C-Jun N-terminal kinases and autophagy promote adenoviral and ectopic tumor-associated antigen presentation
Sarah R. Klein
20140 citations
Semantic Scholar
C-JUN N-TERMINAL KINASES REGULATE ADENOVIRUS-MEDIATED AUTOPHAGY AND ANTIGEN PRESENTATION
Sarah R. Klein
20130 citations
Semantic Scholar
Abstract 2871: JNK1-phosphorylation of Bcl-2 is essential for adenoviral-induced autophagic cell death in glioma cells
Sarah R. Klein, S. Piya, E. White, Hong Jiang +3 more
20110 citations
Semantic Scholar
Review Article Autophagy regulation in cancer development and therapy
E. White, V. Martín, Juinn-lin Liu, Sarah R. Klein +4 more
20110 citations
Semantic Scholar
Abstract 4452: Induction of cell and autophagy by the anticancer redox agent mitoquinone is regulated by Nrf2
V. Rao, Sarah R. Klein, N. Mizuno, J. Zielonka +2 more
20100 citations
Semantic Scholar
599 POSTER The iron chelator di-2-pyridylketone-4,4,-dimethyl-3- thiosemicarbazone causes DNA damage in breast cancer cells
V. Rao, Sarah R. Klein, K. Agama, Y. Pommier +1 more
20080 citations
Semantic Scholar

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S. Piya — researcher profile on SciRah

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