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R. Prins · SciRah

Researcher profile · Semantic Scholar

R. Prins

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R. Prins — researcher profile on SciRah

h-index: 50
Works: 222
Citations: 15K

Most-cited papers

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma
T. Cloughesy, A. Mochizuki, J. Orpilla, W. Hugo +26 more
2018Nature Medicine1,236 citations Open access
Semantic Scholar
First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma
L. Liau, K. Ashkan, David D. Tran, J. Campian +65 more
2018Journal of Translational Medicine497 citations Open access
Semantic Scholar
Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma
L. Liau, K. Ashkan, S. Brem, J. Campian +69 more
2022JAMA Oncology422 citations Open access
Semantic Scholar
Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma
Alexander H. Lee, Lu Sun, A. Mochizuki, J. Reynoso +10 more
2021Nature Communications211 citations Open access
Semantic Scholar
Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma
J. Antonios, H. Soto, R. Everson, D. Moughon +11 more
2017Neuro-Oncology197 citations Open access
Semantic Scholar
PD-1 blockade enhances the vaccination-induced immune response in glioma
J. Antonios, H. Soto, R. Everson, J. Orpilla +8 more
2016JCI Insight153 citations Open access
Semantic Scholar
MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors
M. Kilian, Ron Sheinin, Chin-Leng Tan, M. Friedrich +17 more
2022bioRxiv103 citations Open access
Semantic Scholar
Detection of immune responses after immunotherapy in glioblastoma using PET and MRI
J. Antonios, H. Soto, R. Everson, D. Moughon +10 more
2017Proceedings of the National Academy of Sciences of the United States of America91 citations Open access
Semantic Scholar
The immune landscape of common CNS malignancies: implications for immunotherapy
M. Ott, R. Prins, A. Heimberger
2021Nature Reviews Clinical Oncology89 citations
Semantic Scholar
Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma
Jun-Hui Hu, P. Tan, Moe Ishihara, Nicholas A. Bayley +15 more
2021Signal Transduction and Targeted Therapy84 citations Open access
Semantic Scholar
Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma
E. Ladomersky, Li-Jie Zhai, Kristen L. Lauing, A. Bell +21 more
2020Clinical Cancer Research84 citations Open access
Semantic Scholar
ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma
V. Arrieta, Andrew X. Chen, J. Kane, Seong Jae Kang +38 more
2021Nature Cancer83 citations Open access
Semantic Scholar
Expression of PD-1 by T cells in malignant glioma patients reflects exhaustion and activation
T. Davidson, Alexander H. Lee, Melody S. Hsu, Shaina Sedighim +19 more
2018Clinical Cancer Research80 citations Open access
Semantic Scholar
Implementing liquid biopsies into clinical decision making for cancer immunotherapy
D. Quandt, H. Zucht, A. Amann, A. Wulf-Goldenberg +18 more
2017OncoTarget78 citations Open access
Semantic Scholar
Unique challenges for glioblastoma immunotherapy - Discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology.
P. Chuntova, Frances E. Chow, P. Watchmaker, M. Galvez +31 more
2020Neuro-Oncology77 citations Open access
Semantic Scholar
Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities
M. Garrett, J. Sperry, D. Braas, Weihong Yan +16 more
2018Cancer & Metabolism72 citations Open access
Semantic Scholar
Emerging Immunotherapies for Malignant Glioma: From Immunogenomics to Cell Therapy.
G. Dunn, T. Cloughesy, Marcela V. Maus, R. Prins +2 more
2020Neuro-Oncology54 citations Open access
Semantic Scholar
Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI.
Jingwen Yao, Ararat Chakhoyan, D. Nathanson, W. Yong +11 more
2019Neuro-Oncology53 citations Open access
Semantic Scholar
IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing
Yang Pan, J. Phillips, Beatrice Zhang, Miyako Noguchi +22 more
2023Proceedings of the National Academy of Sciences of the United States of America49 citations Open access
Semantic Scholar
The current landscape of immunotherapy for pediatric brain tumors
E. Hwang, E. Sayour, C. Flores, G. Grant +14 more
2022Nature Cancer48 citations
Semantic Scholar
Validation of vessel size imaging (VSI) in high-grade human gliomas using magnetic resonance imaging, image-guided biopsies, and quantitative immunohistochemistry
Ararat Chakhoyan, Jingwen Yao, Kevin Leu, W. Pope +10 more
2019Scientific Reports46 citations Open access
Semantic Scholar
Efficacy of systemic adoptive transfer immunotherapy targeting NY-ESO-1 for glioblastoma.
R. Everson, J. Antonios, D. Lisiero, H. Soto +8 more
2016Neuro-Oncology43 citations Open access
Semantic Scholar
Immune checkpoint blockade induces distinct alterations in the microenvironments of primary and metastatic brain tumors
Lu Sun, J. Kienzler, J. Reynoso, Alexander H. Lee +15 more
2023Journal of Clinical Investigation34 citations Open access
Semantic Scholar
Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1
Yue Lu, Alphonsus H. C. Ng, Frances E. Chow, R. Everson +7 more
2021Nature Communications30 citations Open access
Semantic Scholar
Cytokines Produced by Dendritic Cells Administered Intratumorally Correlate with Clinical Outcome in Patients with Diverse Cancers
V. Subbiah, R. Murthy, D. Hong, R. Prins +13 more
2018Clinical Cancer Research30 citations Open access
Semantic Scholar
Antigen presentation by clonally diverse CXCR5+ B cells to CD4 and CD8 T cells is associated with durable response to immune checkpoint inhibitors
Lizhong Ding, Lu Sun, Melissa T. Bu, Yan-Jun Zhang +5 more
2023Frontiers in Immunology28 citations Open access
Semantic Scholar
Precision Medicine in Pediatric Neurooncology: A Review
A. Mochizuki, Isaura M. Frost, Melina Mastrodimos, Ashley Plant +5 more
2017ACS Chemical Neuroscience24 citations Open access
Semantic Scholar
Evidence for Innate and Adaptive Immune Responses in a Cohort of Intractable Pediatric Epilepsy Surgery Patients
G. Owens, Alejandro J. Garcia, A. Mochizuki, Julia W. Chang +5 more
2019Frontiers in Immunology21 citations Open access
Semantic Scholar
Epithelial Membrane Protein-2 (EMP2) Promotes Angiogenesis in Glioblastoma Multiforme
Yu Qin, Masamichi Takahashi, K. Sheets, H. Soto +9 more
2017Journal of Neuro-Oncology21 citations Open access
Semantic Scholar
IRIS: Big data-informed discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing
Yang Pan, Alexander H. Lee, H. Yang, Yuanyuan Wang +9 more
2019bioRxiv14 citations Open access
Semantic Scholar
Correction to: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma
L. Liau, K. Ashkan, David D. Tran, J. Campian +65 more
2018Journal of Translational Medicine14 citations Open access
Semantic Scholar
Amine-weighted chemical exchange saturation transfer magnetic resonance imaging in brain tumors
N. Cho, A. Hagiwara, Jingwen Yao, D. Nathanson +14 more
2022NMR in Biomedicine13 citations Open access
Semantic Scholar
B-cells Drive Response to PD-1 Blockade in Glioblastoma Upon Neutralization of TGFβ-mediated Immunosuppression
D. Hou, Brandyn Castro, Mark Dapash, A. Zolp +25 more
2023Research Square12 citations Open access
Semantic Scholar
The future of cancer immunotherapy for brain tumors: a collaborative workshop
Christine E. Brown, Samantha Bucktrout, L. Butterfield, O. Futer +7 more
2022Journal of Translational Medicine12 citations Open access
Semantic Scholar
SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation
Fei Liu, Christopher D. Cox, Reshmi Chowdhury, Laura Dovek +16 more
2019Journal of Neuro-Oncology12 citations Open access
Semantic Scholar
Tissue microarray analysis for epithelial membrane protein-2 as a novel biomarker for gliomas
Lawrance K. Chung, Panayiotis E. Pelargos, Ann M Chan, Joanna V. Demos +14 more
2017Brain Tumor Pathology12 citations Open access
Semantic Scholar
Spatial immune profiling of glioblastoma identifies an inflammatory, perivascular phenotype associated with longer survival
H. Wirsching, J. Felsberg, Michael Prummer, Vlad Moisoiu +12 more
2023Acta Neuropathologica9 citations Open access
Semantic Scholar
A vision of immuno-oncology: the Siena think tank of the Italian network for tumor biotherapy (NIBIT) foundation
M. Maio, M. Lahn, A. D. di Giacomo, A. Covre +84 more
2021Journal of experimental & clinical cancer research : CR8 citations Open access
Semantic Scholar
Immune-related pan-cancer gene expression signatures of patient survival revealed by NanoString-based analyses
A. D'Angelo, Huseyin Kilili, R. Chapman, D. Generali +17 more
2023PLoS ONE7 citations Open access
Semantic Scholar
Author Correction: TLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial
R. Everson, W. Hugo, Lu Sun, J. Antonios +11 more
2024Nature Communications3 citations Open access
Semantic Scholar
Commentary on "Dysfunctional dendritic cells limit antigen-specific T cell response in glioma."
R. Prins, R. Everson
2022Neuro-Oncology3 citations Open access
Semantic Scholar
Is there a role for neoadjuvant anti-PD-1 therapies in glioma?
Lu Sun, Thomas J. Lai, R. Prins
2021Current Opinion in Neurology3 citations Open access
Semantic Scholar
ATIM-12. NEOADJUVANT ANTI-PD-1 IMMUNOTHERAPY PROMOTES INTRATUMORAL AND SYSTEMIC IMMUNE RESPONSES IN RECURRENT GLIOBLASTOMA: AN IVY CONSORTIUM TRIAL
R. Prins, A. Mochizuki, J. Orpilla, Alexander H. Lee +16 more
2018Neuro-Oncology3 citations Open access
Semantic Scholar
ATIM-25. NEOADJUVANT PD-1 ANTIBODY BLOCKADE IS ASSOCIATED WITH FOCAL UPREGULATION OF PD-L1 AND CD8 T CELL INFILTRATE IN RECURRENT GLIOBLASTOMA
J. Orpilla, A. Mochizuki, J. Reynoso, Neha Akkad +5 more
2018Neuro-Oncology3 citations Open access
Semantic Scholar
Publisher Correction: ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma
V. Arrieta, Andrew X. Chen, J. Kane, Seong Jae Kang +38 more
2022Nature Cancer2 citations Open access
Semantic Scholar
CTIM-25. NEOADJUVANT ANTI-PD1 IMMUNOTHERAPY FOR SURGICALLY ACCESSIBLE RECURRENT GLIOBLASTOMA: CLINICAL AND MOLECULAR OUTCOMES OF A STAGE 2 SINGLE-ARM EXPANSION COHORT
J. McFaline-Figueroa, R. Prins, Yu Qiao, Lu Sun +26 more
2022Neuro-Oncology2 citations Open access
Semantic Scholar
CTNI-47. PHASE II STUDY OF ABEMACICLIB IN RECURRENT GBM PATIENTS WITH CDKN2A/B LOSS AND INTACT RB
E. Lee, A. Muzikansky, I. Arrillaga-Romany, U. Chukwueke +11 more
20202 citations Open access
Semantic Scholar
ATIM-39. IMPROVED SURVIVAL NOTED IN GLIOBLASTOMA PATIENTS TREATED WITH ADJUVANT TLR-3 AGONIST IN SETTING OF AUTOLOGOUS LYSATE-PULSED DC VACCINATION
J. Antonios, R. Everson, H. Soto, Sara Khattab +11 more
2018Neuro-Oncology2 citations Open access
Semantic Scholar
TMIC-40. TRANSCRIPTOMIC CHARACTERIZATION OF PATIENT GLIOMAS AND DERIVED MODEL SYSTEMS REVEALS ENVIRONMENTAL INFLUENCE ON NEURODEVELOPMENTAL CELLULAR STATES
Nicholas A. Bayley, C. Tse, Jenna K. Minami, Henan Zhu +10 more
2022Neuro-Oncology1 citations Open access
Semantic Scholar
The future of cancer immunotherapy for brain tumors: a collaborative workshop
C. Brown, Samantha Bucktrout, L. Butterfield, O. Futer +7 more
2022Journal of Translational Medicine1 citations Open access
Semantic Scholar

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