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L. Donehower · SciRah

Researcher profile · Semantic Scholar

L. Donehower

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L. Donehower — researcher profile on SciRah

h-index: 78
Works: 239
Citations: 67K

Most-cited papers

Comprehensive Molecular Characterization of Human Colon and Rectal Cancer
Donna M. Matthew N. Kyle Huyen H. Jennifer A. Gerald Chr Muzny Bainbridge Chang Dinh Drummond Fowler Kovar, Donna M. Matthew N. Kyle Huyen H. Jennifer A. Gerald Chr Muzny Bainbridge Chang Dinh Drummond Fowler Kovar, D. Muzny, M. Bainbridge +334 more
2012Nature7,915 citations Open access
Semantic Scholar
Comprehensive molecular portraits of human breast tumors
Daniel C. Robert S. Michael D. Heather Joelle Joshua F. L Koboldt Fulton McLellan Schmidt Kalicki-Veizer McM, Daniel C. Robert S. Michael D. Heather Joelle Joshua F. L Koboldt Fulton McLellan Schmidt Kalicki-Veizer McM, D. Koboldt, R. Fulton +377 more
2012Nature7,527 citations Open access
Semantic Scholar
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
R. McLendon, A. Friedman, D. Bigner, Erwin G. Van Meir +227 more
2008Nature7,110 citations Open access
Semantic Scholar
The Immune Landscape of Cancer
V. Thorsson, D. Gibbs, S. Brown, D. Wolf +496 more
2018Immunity4,928 citations Open access
Semantic Scholar
Oncogenic Signaling Pathways in The Cancer Genome Atlas
F. Sánchez-Vega, M. Mina, J. Armenia, W. Chatila +496 more
2018Cell2,752 citations Open access
Semantic Scholar
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma
A. Ally, M. Balasundaram, R. Carlsen, E. Chuah +232 more
2017Cell2,309 citations Open access
Semantic Scholar
Comprehensive Molecular Characterization of Urothelial Bladder Carcinoma
John N. Rehan Bradley M. Wenyi Roeland G. W. David Seth Weinstein Akbani Broom Wang Verhaak McConkey Lerne, John N. Rehan Bradley M. Wenyi Roeland G. W. David Weinstein Akbani Broom Wang Verhaak McConkey, J. Weinstein, R. Akbani +345 more
2014Nature2,115 citations Open access
Semantic Scholar
Comprehensive Characterization of Cancer Driver Genes and Mutations
M. Bailey, C. Tokheim, E. Porta-Pardo, Sohini Sengupta +496 more
2018Cell2,066 citations Open access
Semantic Scholar
Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas
T. Knijnenburg, Ling-Hua Wang, M. Zimmermann, N. Chambwe +34 more
2018Cell Reports982 citations Open access
Semantic Scholar
The somatic genomic landscape of chromophobe renal cell carcinoma
C. Davis, C. Ricketts, Min Wang, Li-Xing Yang +42 more
2014Cancer Cell815 citations Open access
Semantic Scholar
Trans-ancestry mutational landscape of hepatocellular carcinoma genomes
Y. Totoki, Kenji Tatsuno, K. Covington, H. Ueda +44 more
2014Nature Genetics732 citations
Semantic Scholar
Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas
L. Donehower, T. Soussi, A. Korkut, Yue-Xin Liu +9 more
2019Cell Reports568 citations Open access
Semantic Scholar
Dynamic Analyses of Alternative Polyadenylation from RNA-Seq Reveal 3′-UTR Landscape Across 7 Tumor Types
Zheng Xia, L. Donehower, T. Cooper, J. Neilson +3 more
2014Nature Communications507 citations Open access
Semantic Scholar
PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy
J. Hsu, Tajhal Dayaram, A. Tovy, E. De Braekeleer +16 more
2018Cell Stem Cell375 citations Open access
Semantic Scholar
Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas
Joshua D. Campbell, C. Yau, R. Bowlby, Yue-Xin Liu +56 more
2018Cell Reports319 citations Open access
Semantic Scholar
Genomic profiling of Sézary Syndrome identifies alterations of key T-cell signaling and differentiation genes
Ling-Hua Wang, X. Ni, K. Covington, Betty Y. Yang +12 more
2015Nature Genetics302 citations Open access
Semantic Scholar
Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice
Susie A. Lee, L. Donehower, A. Herron, D. Moore +1 more
2010PLoS ONE294 citations Open access
Semantic Scholar
The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways
Xiong-Bin Lu, Thuy-Ai T Nguyen, S. Moon, Yolanda F. Darlington +2 more
2008Cancer Metastasis Review256 citations Open access
Semantic Scholar
20 years studying p53 functions in genetically engineered mice
L. Donehower, G. Lozano
2009Nature Reviews. Cancer204 citations
Semantic Scholar
Widespread and tissue specific age-related DNA methylation changes in mice.
S. Maegawa, G. Hinkal, Hyun Soo Kim, Lan-Lan Shen +6 more
2010Genome Research191 citations Open access
Semantic Scholar
Notch signaling contributes to the pathogenesis of human osteosarcomas.
Feyza Engin, T. Bertin, Ou Ma, Ming-Ming Jiang +4 more
2009Human Molecular Genetics172 citations Open access
Semantic Scholar
Automated hypothesis generation based on mining scientific literature
Scott Spangler, A. Wilkins, Benjamin J. Bachman, Meena Nagarajan +15 more
2014Knowledge Discovery and Data Mining157 citations
Semantic Scholar
Notch Activation as a Driver of Osteogenic Sarcoma
Jianning Tao, Ming-Ming Jiang, Li-Chun Jiang, J. Salvo +8 more
2014Cancer Cell134 citations Open access
Semantic Scholar
Ampullary cancers harbor ELF3 tumor suppressor gene mutations and exhibit frequent WNT dysregulation
M. Gingras, K. Covington, D. Chang, L. Donehower +41 more
2016Cell Reports132 citations Open access
Semantic Scholar
NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma
Shu-Ying Zhao, L. Kurenbekova, Y. Gao, A. Roos +12 more
2015Oncogene127 citations Open access
Semantic Scholar
Review of Chromium (VI) Apoptosis, Cell-Cycle-Arrest, and Carcinogenesis
Arthur N. L. Chiu, J. Shi, Wkp Lee, R. Hill +8 more
2010Journal of Environmental Science And Health Part C - Environmental Carcinogenesis & Ecotoxicology Reviews108 citations Open access
Semantic Scholar
MMP13, Birc2 (cIAP1) and Birc3 (cIAP2), Amplified on Chromosome 9, Collaborate with p53 Deficiency in Mouse Osteosarcoma Progression
Ou Ma, Wei-wen Cai, L. Zender, Tajhal Dayaram +6 more
2009Cancer Research101 citations Open access
Semantic Scholar
Wild-type p53-induced Phosphatase 1 Dephosphorylates Histone Variant γ-H2AX and Suppresses DNA Double Strand Break Repair*
S. Moon, Lin Lin, Xin-Na Zhang, Thuy-Ai T Nguyen +4 more
2010Journal of Biological Chemistry92 citations Open access
Semantic Scholar
Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas.
L. Donehower, T. Soussi, A. Korkut, Yue-Xin Liu +9 more
2019Cell Reports90 citations Open access
Semantic Scholar
Effects of TP53 Mutational Status on Gene Expression Patterns Across Ten Human Cancer Types
Neha Parikh, S. Hilsenbeck, Chad J. Creighton, Tajhal Dayaram +6 more
2014Journal of Pathology87 citations Open access
Semantic Scholar
Combinatorial therapy discovery using mixed integer linear programming
Kaifang Pang, Y. Wan, W. T. Choi, L. Donehower +3 more
2014Bioinform.86 citations Open access
Semantic Scholar
Recommended guidelines for validation, quality control and reporting of TP53 variants in clinical practice
B. Leroy, M. Ballinger, F. Baran-Marszak, G. Bond +27 more
2017Cancer Research84 citations Open access
Semantic Scholar
Pla2g16 phospholipase mediates gain-of-function activities of mutant p53
S. Xiong, Huo-Lin Tu, M. Kollareddy, Vinod Pant +17 more
2014Proceedings of the National Academy of Sciences of the United States of America84 citations Open access
Semantic Scholar
Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin
Hugh S. Gannon, L. Donehower, S. Lyle, Stephen N. Jones
2011Developmental Biology84 citations Open access
Semantic Scholar
MLH1-Silenced and Non-Silenced Subgroups of Hypermutated Colorectal Carcinomas Have Distinct Mutational Landscapes
L. Donehower, Chad J. Creighton, N. Schultz, E. Shinbrot +7 more
2013Journal of Pathology77 citations Open access
Semantic Scholar
REGγ deficiency promotes premature aging via the casein kinase 1 pathway
Lei Li, Dengpan Zhao, Hai-Bin Wei, Liang-Fang Yao +23 more
2013Proceedings of the National Academy of Sciences of the United States of America75 citations Open access
Semantic Scholar
Cross-species identification of a plasma microRNA signature for detection, therapeutic monitoring, and prognosis in osteosarcoma
Wendy A Allen-Rhoades, L. Kurenbekova, Laura Satterfield, Neha Parikh +10 more
2015Cancer Medicine71 citations Open access
Semantic Scholar
WIP1 Phosphatase as a Potential Therapeutic Target in Neuroblastoma
Mark C Richter, Tajhal Dayaram, A. Gilmartin, G. Ganji +5 more
2015PLoS ONE68 citations Open access
Semantic Scholar
Timed Somatic Deletion of p53 in Mice Reveals Age-Associated Differences in Tumor Progression
G. Hinkal, Neha Parikh, L. Donehower
2009PLoS ONE68 citations Open access
Semantic Scholar
Dephosphorylation of γH2AX by WIP1
S. Moon, Thuy-Ai T Nguyen, Yolanda F. Darlington, Xiong-Bin Lu +1 more
2010Cell Cycle63 citations Open access
Semantic Scholar
Using mice to examine p53 functions in cancer, aging, and longevity.
L. Donehower
2009Cold Spring Harbor Perspectives in Biology61 citations Open access
Semantic Scholar
Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma
X. Shang, Sanjeev A. Vasudevan, Y. Yu, N. Ge +14 more
2010Oncogene58 citations Open access
Semantic Scholar
Exercise Effects on Tumorigenesis in a p53-deficient Mouse Model of Breast Cancer
L. Colbert, K. Westerlind, S. Perkins, D. Haines +4 more
2009Medicine & Science in Sports & Exercise57 citations Open access
Semantic Scholar
Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation
J. Reddy, S. Peddibhotla, W. Bu, Jing Zhao +6 more
2010Proceedings of the National Academy of Sciences of the United States of America54 citations Open access
Semantic Scholar
Literature-based automated discovery of tumor suppressor p53 phosphorylation and inhibition by NEK2
Byung-Kwon Choi, Tajhal Dayaram, Neha Parikh, A. Wilkins +21 more
2018Proceedings of the National Academy of Sciences of the United States of America52 citations Open access
Semantic Scholar
The Oncogenic Phosphatase WIP1 Negatively Regulates Nucleotide Excision Repair
Thuy-Ai T Nguyen, Scott D. Slattery, S. Moon, Yolanda F. Darlington +2 more
2010DNA Repair50 citations Open access
Semantic Scholar
Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging
G. Hinkal, Catherine E. Gatza, Neha Parikh, L. Donehower
2009Mechanisms of Ageing and Development48 citations Open access
Semantic Scholar
Secreted Frizzled-Related Protein 2 (sFRP2) promotes osteosarcoma invasion and metastatic potential
Piti Techavichit, Yang Gao, L. Kurenbekova, R. Shuck +2 more
2016BMC Cancer47 citations Open access
Semantic Scholar
miR-130b directly targets Arhgap1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma
Laura Satterfield, R. Shuck, L. Kurenbekova, Wendy A Allen-Rhoades +6 more
2017International Journal of Cancer46 citations Open access
Semantic Scholar
55K isoform of CDK9 associates with Ku70 and is involved in DNA repair
Hong-Bing Liu, C. Herrmann, K. Chiang, T. Sung +3 more
2010Biochemical and Biophysical Research Communications - BBRC46 citations Open access
Semantic Scholar

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