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P. Keightley · SciRah

Researcher profile · Semantic Scholar

P. Keightley

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P. Keightley — researcher profile on SciRah

h-index: 63
Works: 193
Citations: 14K

Most-cited papers

A Comparison of Models to Infer the Distribution of Fitness Effects of New Mutations
A. Kousathanas, P. Keightley
2013Genetics1,235 citations Open access
Semantic Scholar
Estimating the rate of adaptive molecular evolution in the presence of slightly deleterious mutations and population size change.
A. Eyre-Walker, P. Keightley
2009Molecular biology and evolution439 citations Open access
Semantic Scholar
Spontaneous Mutation Accumulation Studies in Evolutionary Genetics
D. Halligan, P. Keightley
2009423 citations
Semantic Scholar
Joint Inference of the Distribution of Fitness Effects of Deleterious Mutations and Population Demography Based on Nucleotide Polymorphism Frequencies
P. Keightley, A. Eyre-Walker
2007Genetics398 citations Open access
Semantic Scholar
Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila
C. Haag-Liautard, M. Dorris, X. Maside, Steven Macaskill +3 more
2007Nature390 citations
Semantic Scholar
Interference among deleterious mutations favours sex and recombination in finite populations
P. Keightley, S. Otto
2006Nature379 citations
Semantic Scholar
Analysis of the genome sequences of three Drosophila melanogaster spontaneous mutation accumulation lines.
P. Keightley, U. Trivedi, M. Thomson, Fiona Oliver +2 more
2009Genome Research369 citations Open access
Semantic Scholar
Estimation of the Spontaneous Mutation Rate per Nucleotide Site in a Drosophila melanogaster Full-Sib Family
P. Keightley, R. W. Ness, D. Halligan, P. Haddrill
2013Genetics305 citations Open access
Semantic Scholar
Direct Estimation of the Mitochondrial DNA Mutation Rate in Drosophila melanogaster
C. Haag-Liautard, N. Coffey, D. Houle, M. Lynch +2 more
2008PLoS Biology299 citations Open access
Semantic Scholar
The distribution of fitness effects of new mutations
Adam Eyre-Walker, P. Keightley
2007Nature reviews genetics297 citations Open access
Semantic Scholar
Estimation of the Spontaneous Mutation Rate in Heliconius melpomene
P. Keightley, A. Pinharanda, R. W. Ness, F. Simpson +4 more
2014Molecular biology and evolution270 citations Open access
Semantic Scholar
Ubiquitous selective constraints in the Drosophila genome revealed by a genome-wide interspecies comparison.
D. Halligan, P. Keightley
2006Genome Research265 citations Open access
Semantic Scholar
Current hypotheses for the evolution of sex and recombination.
M. Hartfield, P. Keightley
2012Integrative Zoology190 citations
Semantic Scholar
Rates and Fitness Consequences of New Mutations in Humans
P. Keightley
2012Genetics189 citations Open access
Semantic Scholar
The Effect of Variation in the Effective Population Size on the Rate of Adaptive Molecular Evolution in Eukaryotes
T. Gossmann, P. Keightley, A. Eyre-Walker
2012Genome Biology and Evolution185 citations Open access
Semantic Scholar
Global population divergence and admixture of the brown rat (Rattus norvegicus)
Emily E. Puckett, Jane Park, M. Combs, M. Blum +17 more
2016bioRxiv165 citations Open access
Semantic Scholar
Evidence for Widespread Degradation of Gene Control Regions in Hominid Genomes
P. Keightley, Martin J Lercher, A. Eyre-Walker
2005PLoS Biology142 citations Open access
Semantic Scholar
Inferring the Probability of the Derived vs. the Ancestral Allelic State at a Polymorphic Site
P. Keightley, Benjamin C. Jackson
2018Genetics139 citations Open access
Semantic Scholar
Evidence for Pervasive Adaptive Protein Evolution in Wild Mice
D. Halligan, Fiona Oliver, A. Eyre-Walker, B. Harr +1 more
2010PLoS Genetics130 citations Open access
Semantic Scholar
Recommendations for improving statistical inference in population genomics
Parul Johri, C. Aquadro, M. Beaumont, B. Charlesworth +9 more
2021bioRxiv128 citations Open access
Semantic Scholar
Extensive de novo mutation rate variation between individuals and across the genome of Chlamydomonas reinhardtii
R. W. Ness, A. Morgan, R. B. Vasanthakrishnan, N. Colegrave +1 more
2015bioRxiv121 citations Open access
Semantic Scholar
Detecting positive selection in the genome
Tom R. Booker, Benjamin C. Jackson, P. Keightley
2017BMC Biology120 citations Open access
Semantic Scholar
A Method for Inferring the Rate of Occurrence and Fitness Effects of Advantageous Mutations
Adrian Schneider, B. Charlesworth, A. Eyre-Walker, P. Keightley
2011Genetics118 citations Open access
Semantic Scholar
Intron Size and Exon Evolution in Drosophila
G. Marais, P. Nouvellet, P. Keightley, B. Charlesworth
2005Genetics112 citations Open access
Semantic Scholar
Distributions of selectively constrained sites and deleterious mutation rates in the hominid and murid genomes.
L. Eory, D. Halligan, P. Keightley
2010Molecular biology and evolution105 citations Open access
Semantic Scholar
What can we learn about the distribution of fitness effects of new mutations from DNA sequence data?
P. Keightley, A. Eyre-Walker
2010Philosophical Transactions of the Royal Society B: Biological Sciences94 citations Open access
Semantic Scholar
Genomic Selective Constraints in Murid Noncoding DNA
D. Gaffney, P. Keightley
2006PLoS Genetics74 citations Open access
Semantic Scholar
Mitochondrial Mutation Rate, Spectrum and Heteroplasmy in Caenorhabditis elegans Spontaneous Mutation Accumulation Lines of Differing Population Size
Anke Konrad, Owen A. Thompson, R. Waterston, D. Moerman +3 more
2017Molecular biology and evolution70 citations Open access
Semantic Scholar
Faster-X Adaptive Protein Evolution in House Mice
A. Kousathanas, D. Halligan, P. Keightley
2013Genetics67 citations Open access
Semantic Scholar
Comparative genomics of Chlamydomonas
Rory J. Craig, Ahmed R. Hasan, R. W. Ness, P. Keightley
2020bioRxiv65 citations Open access
Semantic Scholar
PAPPA2, an Enzyme That Cleaves an Insulin-Like Growth-Factor-Binding Protein, Is a Candidate Gene for a Quantitative Trait Locus Affecting Body Size in Mice
J. Christians, A. Hoeflich, P. Keightley
2006Genetics64 citations Open access
Semantic Scholar
The Nature of Genetic Variation for Complex Traits Revealed by GWAS and Regional Heritability Mapping Analyses
A. Caballero, A. Tenesa, P. Keightley
2015Genetics63 citations Open access
Semantic Scholar
Explorer Evidence for Widespread Degradation of Gene Control Regions in Hominid Genomes
P. Keightley, M. Lercher, A. Eyre-Walker
201562 citations
Semantic Scholar
Estimating the Rate of Adaptive Molecular Evolution When the Evolutionary Divergence Between Species is Small
P. Keightley, A. Eyre-Walker
2012Journal of Molecular Evolution59 citations Open access
Semantic Scholar
Inferring the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii
Katharina B. Böndel, S. Kraemer, T. Samuels, D. McClean +4 more
2019PLoS Biology52 citations Open access
Semantic Scholar
Inferring the Frequency Spectrum of Derived Variants to Quantify Adaptive Molecular Evolution in Protein-Coding Genes of Drosophila melanogaster
P. Keightley, J. L. Campos, Tom R. Booker, B. Charlesworth
2016Genetics49 citations Open access
Semantic Scholar
A Resolution of the Mutation Load Paradox in Humans
Yann Lesecque, P. Keightley, A. Eyre-Walker
2012Genetics49 citations Open access
Semantic Scholar
Variation in mutation, recombination, and transposition rates in Drosophila melanogaster and Drosophila simulans
Yiguan Wang, Paul McNeil, R. Abdulazeez, M. Pascual +3 more
2022bioRxiv48 citations Open access
Semantic Scholar
Analysis and implications of mutational variation
P. Keightley, D. Halligan
2009Genetica48 citations Open access
Semantic Scholar
Recent Evolution in Rattus norvegicus Is Shaped by Declining Effective Population Size
E. Deinum, D. Halligan, R. W. Ness, Yao-Hua Zhang +3 more
2015bioRxiv47 citations Open access
Semantic Scholar
Fitness decline in spontaneous mutation accumulation lines of Caenorhabditis elegans with varying effective population sizes
Vaishali Katju, Lucille B. Packard, Lijing Bu, P. Keightley +1 more
2015Evolution; international journal of organic evolution45 citations
Semantic Scholar
Understanding the Factors That Shape Patterns of Nucleotide Diversity in the House Mouse Genome
Tom R. Booker, P. Keightley
2018bioRxiv43 citations Open access
Semantic Scholar
The Role of Advantageous Mutations in Enhancing the Evolution of a Recombination Modifier
M. Hartfield, S. Otto, P. Keightley
2010Genetics43 citations Open access
Semantic Scholar
Direct estimate of the spontaneous mutation rate uncovers the effects of drift and recombination in the Chlamydomonas reinhardtii plastid genome
R. W. Ness, S. Kraemer, N. Colegrave, P. Keightley
2015bioRxiv38 citations Open access
Semantic Scholar
SPONTANEOUS MUTATION ACCUMULATION IN MULTIPLE STRAINS OF THE GREEN ALGA, CHLAMYDOMONAS REINHARDTII
A. Morgan, R. W. Ness, P. Keightley, N. Colegrave
2014Evolution; international journal of organic evolution38 citations Open access
Semantic Scholar
Inference of Site Frequency Spectra From High-Throughput Sequence Data: Quantification of Selection on Nonsynonymous and Synonymous Sites in Humans
P. Keightley, D. Halligan
2011Genetics38 citations Open access
Semantic Scholar
Inbred lab mice are not isogenic: genetic variation within inbred strains used to infer the mutation rate per nucleotide site
Jobran Chebib, Benjamin C. Jackson, E. López-Cortegano, D. Tautz +1 more
2020Heredity37 citations Open access
Semantic Scholar
Positive and negative selection on noncoding DNA close to protein-coding genes in wild house mice.
A. Kousathanas, Fiona Oliver, D. Halligan, P. Keightley
2011Molecular biology and evolution37 citations Open access
Semantic Scholar
Positive and negative selection in murine ultraconserved noncoding elements.
D. Halligan, Fiona Oliver, Jack Guthrie, K. Stemshorn +2 more
2011Molecular biology and evolution33 citations Open access
Semantic Scholar
MCALIGN2: Faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution
Jun Wang, P. Keightley, T. Johnson
2006BMC Bioinformatics32 citations Open access
Semantic Scholar

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