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Tara L. Kieffer · SciRah

Researcher profile · Semantic Scholar

Tara L. Kieffer

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Tara L. Kieffer — researcher profile on SciRah

h-index: 33
Works: 87
Citations: 9,932

Most-cited papers

Telaprevir for previously untreated chronic hepatitis C virus infection.
I. Jacobson, J. Mchutchison, G. Dusheiko, A. Di Bisceglie +20 more
2011New England Journal of Medicine2,552 citations Open access
Semantic Scholar
Telaprevir and peginterferon with or without ribavirin for chronic HCV infection.
C. Hézode, N. Forestier, G. Dusheiko, P. Ferenci +14 more
2009New England Journal of Medicine1,090 citations Open access
Semantic Scholar
Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir.
C. Sarrazin, Tara L. Kieffer, D. Bartels, B. Hanzelka +10 more
2007Gastroenterology661 citations Open access
Semantic Scholar
Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
Tara L. Kieffer, D. Bartels, B. Hanzelka, U. Müh +9 more
2009621 citations
Semantic Scholar
Residual Human Immunodeficiency Virus Type 1 Viremia in Some Patients on Antiretroviral Therapy Is Dominated by a Small Number of Invariant Clones Rarely Found in Circulating CD4+ T Cells
J. Bailey, A. Sedaghat, Tara L. Kieffer, T. Brennan +15 more
2006Journal of Virology432 citations
Semantic Scholar
Intermittent HIV-1 viremia (Blips) and drug resistance in patients receiving HAART.
R. Nettles, Tara L. Kieffer, Patty Kwon, Daphne Monie +11 more
2005Journal of the American Medical Association (JAMA)409 citations
Semantic Scholar
Telaprevir and pegylated interferon–alpha‐2a inhibit wild‐type and resistant genotype 1 hepatitis C virus replication in patients
Tara L. Kieffer, C. Sarrazin, Jane Miller, M. Welker +4 more
2007Hepatology408 citations Open access
Semantic Scholar
Hepatitis C virus drug resistance–associated substitutions: State of the art summary
Erik Lontok, Patrick R. Harrington, Anita Y. M. Howe, Tara L. Kieffer +7 more
2015Hepatology273 citations Open access
Semantic Scholar
Antiviral activity of telaprevir (VX‐950) and peginterferon alfa‐2a in patients with hepatitis C
N. Forestier, H. Reesink, C. Weegink, L. Mcnair +5 more
2007Hepatology269 citations
Semantic Scholar
Molecular Characterization of Preintegration Latency in Human Immunodeficiency Virus Type 1 Infection
Theodore C. Pierson, Yan Zhou, Tara L. Kieffer, C. Ruff +2 more
2002Journal of Virology261 citations Open access
Semantic Scholar
Genotypic analysis of HIV-1 drug resistance at the limit of detection: virus production without evolution in treated adults with undetectable HIV loads.
Tara L. Kieffer, M. Finucane, R. Nettles, T. Quinn +4 more
2004Journal of Infectious Diseases227 citations
Semantic Scholar
Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3.4A protease inhibitors in treatment-naive subjects.
D. Bartels, Yi Zhou, E. Zhang, M. Marcial +7 more
2008Journal of Infectious Diseases223 citations
Semantic Scholar
Evolution of treatment-emergent resistant variants in telaprevir phase 3 clinical trials.
J. Sullivan, S. De Meyer, D. Bartels, I. Dierynck +13 more
2013Clinical Infectious Diseases191 citations
Semantic Scholar
Intrinsic Stability of Episomal Circles Formed during Human Immunodeficiency Virus Type 1 Replication
Theodore C. Pierson, Tara L. Kieffer, C. Ruff, C. Buck +2 more
2002Journal of Virology188 citations Open access
Semantic Scholar
G→A Hypermutation in Protease and Reverse Transcriptase Regions of Human Immunodeficiency Virus Type 1 Residing in Resting CD4+ T Cells In Vivo
Tara L. Kieffer, Patty Kwon, R. Nettles, Yefei Han +2 more
2005Journal of Virology184 citations Open access
Semantic Scholar
Hepatitis C Virus Variants with Decreased Sensitivity to Direct-Acting Antivirals (DAAs) Were Rarely Observed in DAA-Naive Patients prior to Treatment
D. Bartels, J. Sullivan, E. Zhang, A. Tigges +7 more
2012Journal of Virology153 citations Open access
Semantic Scholar
In Vivo Clearance of an Intracellular Bacterium, Francisella tularensis LVS, Is Dependent on the p40 Subunit of Interleukin-12 (IL-12) but Not on IL-12 p70
K. Elkins, A. Cooper, Susan M Colombini, Siobhán C. Cowley +1 more
2002Infection and Immunity147 citations Open access
Semantic Scholar
Antiviral effects and safety of telaprevir, peginterferon alfa-2a, and ribavirin for 28 days in hepatitis C patients.
E. Lawitz, M. Rodríguez-Torres, A. Muir, Tara L. Kieffer +3 more
2008Journal of Hepatology141 citations
Semantic Scholar
Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs).
Tara L. Kieffer, A. Kwong, G. Picchio
2010Journal of Antimicrobial Chemotherapy126 citations
Semantic Scholar
Marked intraindividual variability in antiretroviral concentrations may limit the utility of therapeutic drug monitoring.
R. Nettles, Tara L. Kieffer, Teresa L. Parsons, James Johnson +5 more
2006Clinical Infectious Diseases123 citations Open access
Semantic Scholar
HIV-1 viral load blips are of limited clinical significance.
Patricia K Lee, Tara L. Kieffer, R. Siliciano, R. Nettles
2006Journal of Antimicrobial Chemotherapy118 citations
Semantic Scholar
Francisella novicida LPS has greater immunobiological activity in mice than F. tularensis LPS, and contributes to F. novicida murine pathogenesis.
Tara L. Kieffer, Siobhán C. Cowley, F. Nano, K. Elkins
2003Microbes and infection115 citations Open access
Semantic Scholar
Hepatitis C Viral Evolution in Genotype 1 Treatment-Naïve and Treatment-Experienced Patients Receiving Telaprevir-Based Therapy in Clinical Trials
Tara L. Kieffer, S. De Meyer, D. Bartels, J. Sullivan +16 more
2012PLoS ONE97 citations Open access
Semantic Scholar
Genotypic resistance in HIV-1-infected patients with persistently detectable low-level viremia while receiving highly active antiretroviral therapy.
R. Nettles, Tara L. Kieffer, Rachel P. Simmons, J. Cofrancesco +4 more
2004Clinical Infectious Diseases89 citations Open access
Semantic Scholar
A Multi-Variant, Viral Dynamic Model of Genotype 1 HCV to Assess the in vivo Evolution of Protease-Inhibitor Resistant Variants
B. Adiwijaya, E. Herrmann, B. Hare, Tara L. Kieffer +7 more
2010PLoS Comput. Biol.78 citations Open access
Semantic Scholar
Pimodivir Treatment in Adult Volunteers Experimentally Inoculated with Live Influenza Virus: A Phase IIa, Randomized, Double-Blind, Placebo-Controlled Study
J. Trevejo, M. Asmal, J. Vingerhoets, R. Polo +4 more
2018Antiviral Therapy59 citations
Semantic Scholar
Characterization of telaprevir treatment outcomes and resistance in patients with prior treatment failure: Results from the REALIZE trial
S. De Meyer, I. Dierynck, A. Ghys, M. Beumont +7 more
2012Hepatology48 citations Open access
Semantic Scholar
8 EVOLUTION OF TREATMENT-EMERGENT RESISTANT VARIANTS IN TELAPREVIR PHASE 3 CLINICAL TRIALS
J. Sullivan, S. De Meyer, D. Bartels, I. Dierynck +11 more
201146 citations Open access
Semantic Scholar
Successful treatment with telaprevir‐based regimens for chronic hepatitis C results in significant improvements to serum markers of liver fibrosis
E. Haseltine, M. Penney, S. George, Tara L. Kieffer
2015Journal of Viral Hepatitis45 citations
Semantic Scholar
A Novel Assay Allows Genotyping of the Latent Reservoir for Human Immunodeficiency Virus Type 1 in the Resting CD4+ T Cells of Viremic Patients
Daphne Monie, Rachel P. Simmons, R. Nettles, Tara L. Kieffer +13 more
2005Journal of Virology42 citations Open access
Semantic Scholar
Resistance to hepatitis C virus protease inhibitors.
Tara L. Kieffer, S. George
2014Current Opinion in Virology40 citations
Semantic Scholar
A Viral Dynamic Model for Treatment Regimens with Direct-acting Antivirals for Chronic Hepatitis C Infection
B. Adiwijaya, Tara L. Kieffer, J. Henshaw, K. Eisenhauer +4 more
2012PLoS Comput. Biol.38 citations Open access
Semantic Scholar
Sequence and phenotypic analysis for resistance monitoring in hepatitis C virus drug development: recommendations from the HCV DRAG.
A. Kwong, I. Nájera, J. Bechtel, S. Bowden +25 more
2011Gastroenterology37 citations Open access
Semantic Scholar
28 Days of the Hepatitis C Protease Inhibitor VX-950, in Combination With PEG-Interferon-ALFA-2a and Ribavirin, Is Well-Tolerated and Demonstrates Robust Antiviral Effects
E. Lawitz, M. Rodríguez-Torres, A. Muir, J. Keane +3 more
200633 citations Open access
Semantic Scholar
In Vitro Phenotypic Characterization of Hepatitis C Virus NS3 Protease Variants Observed in Clinical Studies of Telaprevir
M. Jiang, N. Mani, Chao Lin, A. Ardzinski +11 more
2013Antimicrobial Agents and Chemotherapy31 citations Open access
Semantic Scholar
Development of a sensitive RT-PCR method for amplifying and sequencing near full-length HCV genotype 1 RNA from patient samples
E. Zhang, D. Bartels, J. Frantz, Sheila Seepersaud +6 more
2013Virology Journal28 citations Open access
Semantic Scholar
Evaluation of Persistence of Resistant Variants with Ultra-Deep Pyrosequencing in Chronic Hepatitis C Patients Treated with Telaprevir
X. Thomas, J. de Bruijne, J. Sullivan, Tara L. Kieffer +7 more
2012PLoS ONE27 citations Open access
Semantic Scholar
1363 VX-222 WITH TVR ALONE OR IN COMBINATION WITH PEGINTERFERON ALFA-2A AND RIBAVIRIN IN TREATMENT-NAIVE PATIENTS WITH CHRONIC HEPATITIS C: ZENITH STUDY INTERIM RESULTS
A. Di Bisceglie, D. Nelson, E. Gane, K. Alves +7 more
201127 citations
Semantic Scholar
Update on HIV-1 viral load blips
R. Nettles, Tara L. Kieffer
2006Current Opinion in HIV and AIDS24 citations
Semantic Scholar
Deep-sequencing analysis of the gene encoding the hepatitis C virus nonstructural 3-4A protease confirms a low prevalence of telaprevir-resistant variants at baseline and the end of the REALIZE study.
I. Dierynck, K. Thys, A. Ghys, J. Sullivan +4 more
2014Journal of Infectious Diseases21 citations
Semantic Scholar
12 Wild-type HCV NS3 protease re-emerges during follow-up after 14 days of dosing with VX-950 in patients with genotype 1 HCV
Tara L. Kieffer, C. Sarrazin, D. Bartels, B. Hanzelka +9 more
200620 citations
Semantic Scholar
Genotypic and Phenotypic Analyses of Hepatitis C Virus Variants Observed in Clinical Studies of VX-222, a Nonnucleoside NS5B Polymerase Inhibitor
M. Jiang, E. Zhang, A. Ardzinski, A. Tigges +10 more
2014Antimicrobial Agents and Chemotherapy17 citations Open access
Semantic Scholar
VX-222, a non-nucleoside NS5B polymerase inhibitor, in telaprevir-based regimens for genotype 1 hepatitis C virus infection
A. Di Bisceglie, M. Sulkowski, E. Gane, I. Jacobson +9 more
2014European Journal of Gastroenterology and Hepathology16 citations
Semantic Scholar
55 FUTILITY RULES IN TELAPREVIR COMBINATION TREATMENT
I. Jacobson, D. Bartels, Linda R. Gritz, Tara L. Kieffer +8 more
201215 citations
Semantic Scholar
P1303 AN INTERFERON- AND RIBAVIRIN-FREE 12-WEEK REGIMEN OF ONCE-DAILY VX-135 AND DACLATASVIR IN TREATMENT-NAÏVE PATIENTS WITH GENOTYPE 1 HCV INFECTION
E. Gane, C. Stedman, V. Garg, S. George +5 more
201410 citations
Semantic Scholar
Futility rules for telaprevir combination treatment for patients with hepatitis C virus infection.
N. Adda, D. Bartels, Linda R. Gritz, Tara L. Kieffer +6 more
2013Clinical Gastroenterology and Hepatology10 citations Open access
Semantic Scholar
Sustained Virologic Response Rates With Telaprevir-Based Therapy in Treatment-Naive Patients Evaluated by Race or Ethnicity
S. Flamm, Andrew J. Muir, M. Fried, K. R. Reddy +10 more
2015Journal of Clinical Gastroenterology9 citations
Semantic Scholar
T-24 Retreatment with telaprevir/Peg-IFN/RBV after a short exposure to telaprevir in Phase I studies: interim results from a Phase IIIb rollover trial (C219)
G. Picchio, C. Sarrazin, H. Reesink, S. Zeuzem +7 more
20128 citations
Semantic Scholar
1202 CHARACTERISATION OF HCV VARIANTS IN NON-SVR PATIENTS IN THE REALIZE STUDY SUGGESTS THAT TELAPREVIR EXHIBITS A CONSISTENT RESISTANCE PROFILE IRRESPECTIVE OF A LEAD-IN
S. De Meyer, I. Dierynck, A. Ghys, Maria Beumont +6 more
20118 citations
Semantic Scholar
1242 LONG-TERM FOLLOW-UP OF CHRONIC HEPATITIS C INFECTED PATIENTS TREATED WITH TELAPREVIR: EVALUATION OF PERSISTENCE OF RESISTANT VARIANTS BY ULTRA-DEEP SEQUENCING
X. Thomas, J. de Bruijne, Tara L. Kieffer, J. Sullivan +6 more
20118 citations
Semantic Scholar

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D. Bartels — researcher profile on SciRah
A. Kwong×12
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A. Kwong — researcher profile on SciRah
J. Sullivan×12
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J. Sullivan — researcher profile on SciRah
G. Picchio×12
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G. Picchio — researcher profile on SciRah

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S. Zeuzem — researcher profile on SciRah

R. Siliciano×10

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R. Siliciano — researcher profile on SciRah

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R. Nettles — researcher profile on SciRah

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S. De Meyer — researcher profile on SciRah

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I. Jacobson — researcher profile on SciRah

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S. George — researcher profile on SciRah

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R. Kauffman — researcher profile on SciRah

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H. Reesink — researcher profile on SciRah