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C. Shackleton · SciRah

Researcher profile · Semantic Scholar

C. Shackleton

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C. Shackleton — researcher profile on SciRah

h-index: 54
Works: 214
Citations: 9,868

Most-cited papers

Urine Steroid Metabolomics as a Biomarker Tool for Detecting Malignancy in Adrenal Tumors
W. Arlt, Michael Biehl, A. Taylor, S. Hahner +17 more
2011Journal of Clinical Endocrinology and Metabolism421 citations Open access
Semantic Scholar
Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review
L. Schiffer, Lise Barnard, E. Baranowski, L. Gilligan +4 more
2019Journal of Steroid Biochemistry and Molecular Biology375 citations Open access
Semantic Scholar
A novel form of human mendelian hypertension featuring nonglucocorticoid-remediable aldosteronism.
David S. Geller, Jun-Hui Zhang, M. Wisgerhof, C. Shackleton +2 more
2008Journal of Clinical Endocrinology and Metabolism270 citations Open access
Semantic Scholar
Hexose-6-phosphate Dehydrogenase Knock-out Mice Lack 11β-Hydroxysteroid Dehydrogenase Type 1-mediated Glucocorticoid Generation*
G. Lavery, E. Walker, N. Draper, Pancharatnam Jeyasuria +5 more
2006Journal of Biological Chemistry227 citations Open access
Semantic Scholar
Clinical steroid mass spectrometry: a 45-year history culminating in HPLC-MS/MS becoming an essential tool for patient diagnosis.
C. Shackleton
2010Journal of Steroid Biochemistry and Molecular Biology221 citations
Semantic Scholar
Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study
I. Bancos, A. Taylor, V. Chortis, A. Sitch +54 more
2020The Lancet Diabetes and Endocrinology181 citations Open access
Semantic Scholar
Genotype-Phenotype Analysis in Congenital Adrenal Hyperplasia due to P450 Oxidoreductase Deficiency
N. Krone, N. Reisch, Jan Idkowiak, V. Dhir +48 more
2011Journal of Clinical Endocrinology and Metabolism123 citations Open access
Semantic Scholar
Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism
K. Storbeck, L. Schiffer, E. Baranowski, V. Chortis +7 more
2019Endocrine reviews112 citations Open access
Semantic Scholar
Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency.
G. Lavery, E. Walker, A. Tiganescu, J. Ride +8 more
2008Journal of Clinical Endocrinology and Metabolism95 citations Open access
Semantic Scholar
Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5α-reductase, explaining the need for personalized glucocorticoid and androgen replacement.
V. Chortis, A. Taylor, P. Schneider, J. Tomlinson +21 more
2013Journal of Clinical Endocrinology and Metabolism85 citations Open access
Semantic Scholar
Differential inhibition of CYP17A1 and CYP21A2 activities by the P450 oxidoreductase mutant A287P.
V. Dhir, H. Ivison, N. Krone, C. Shackleton +3 more
2007Molecular Endocrinology78 citations Open access
Semantic Scholar
GC/MS in Recent Years Has Defined the Normal and Clinically Disordered Steroidome: Will It Soon Be Surpassed by LC/Tandem MS in This Role?
C. Shackleton, Ó. Pozo, J. Marcos
2018Journal of the Endocrine Society68 citations Open access
Semantic Scholar
11β-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function*
E. Walker, Adeeba Ahmed, G. Lavery, J. Tomlinson +9 more
2007Journal of Biological Chemistry63 citations Open access
Semantic Scholar
Identification of plasma glucocorticoids in pallid sturgeon in response to stress.
M. Webb, J. Allert, K. Kappenman, J. Marcos +3 more
2007General and Comparative Endocrinology61 citations
Semantic Scholar
Alternative pathway androgen biosynthesis and human fetal female virilization
N. Reisch, A. Taylor, Edson F. Nogueira, D. Asby +7 more
2019Proceedings of the National Academy of Sciences of the United States of America60 citations Open access
Semantic Scholar
Analysis of bioactive oxysterols in newborn mouse brain by LC/MS[S]
Anna Meljon, S. Theofilopoulos, C. Shackleton, G. Watson +6 more
2012Journal of Lipid Research59 citations Open access
Semantic Scholar
Pubertal Presentation in Seven Patients with Congenital Adrenal Hyperplasia due to P450 Oxidoreductase Deficiency
Jan Idkowiak, S. O'Riordan, N. Reisch, E. Małunowicz +11 more
2010Journal of Clinical Endocrinology and Metabolism56 citations Open access
Semantic Scholar
Role of a Disordered Steroid Metabolome in the Elucidation of Sterol and Steroid Biosynthesis
C. Shackleton
2011Lipids55 citations Open access
Semantic Scholar
Potential of sterol analysis by liquid chromatography - tandem mass spectrometry for the prenatal diagnosis of Smith-Lemli-Opitz syndrome
W. Griffiths, Yu-Qin Wang, K. Karu, E. Samuel +3 more
2008Clinical Chemistry52 citations Open access
Semantic Scholar
Prenatal Diagnosis of Congenital Adrenal Hyperplasia Caused by P450 Oxidoreductase Deficiency
N. Reisch, Jan Idkowiak, B. Hughes, H. Ivison +10 more
2013Journal of Clinical Endocrinology and Metabolism47 citations Open access
Semantic Scholar
Sterols and Oxysterols in Plasma from Smith-Lemi-Opitz Syndrome Patients
W. Griffiths, J. Abdel-Khalik, P. J. Crick, M. Ogundare +11 more
2016Journal of Steroid Biochemistry and Molecular Biology46 citations Open access
Semantic Scholar
Human Delta4-3-oxosteroid 5beta-reductase (AKR1D1) deficiency and steroid metabolism.
M. Palermo, M. Marazzi, B. Hughes, P. Stewart +2 more
2008Steroids46 citations
Semantic Scholar
Evidence for Increased 5α-Reductase Activity During Early Childhood in Daughters of Women With Polycystic Ovary Syndrome
L. Torchen, Jan Idkowiak, Naomi R. Fogel, Donna M. O'Neil +3 more
2016Journal of Clinical Endocrinology and Metabolism45 citations Open access
Semantic Scholar
Redefining the initiation and maintenance of zebrafish interrenal steroidogenesis by characterizing the key enzyme cyp11a2.
Silvia Parajes, A. Griffin, A. Taylor, Ian T. Rose +6 more
2013Endocrinology44 citations Open access
Semantic Scholar
Prevalence of steroid sulfatase deficiency in California according to race and ethnicity
Wendy Y. Craig, M. Roberson, Glenn E. Palomaki, C. Shackleton +2 more
2010Prenatal Diagnosis42 citations
Semantic Scholar
Steroid Sulfatase Deficiency and Androgen Activation Before and After Puberty
Jan Idkowiak, A. Taylor, S. Subtil, Donna M. O'Neil +8 more
2016Journal of Clinical Endocrinology and Metabolism40 citations Open access
Semantic Scholar
17-Hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites.
C. Shackleton, Marcos S. Neres, B. Hughes, P. Stewart +1 more
2008Steroids39 citations
Semantic Scholar
Matrix relevance LVQ in steroid metabolomics based classification of adrenal tumors
Michael Biehl, P. Schneider, David Smith, H. Stiekema +5 more
2012The European Symposium on Artificial Neural Networks38 citations
Semantic Scholar
General Methods for the Extraction, Purification, and Measurement of Steroids by Chromatography and Mass Spectrometry
H. Makin, J. Honour, C. Shackleton, W. Griffiths
201036 citations
Semantic Scholar
Cholesterol biosynthesis from birth to adulthood in a mouse model for 7-dehydrosterol reductase deficiency (Smith-Lemli-Opitz syndrome).
J. Marcos, C. Shackleton, M. Buddhikot, F. Porter +1 more
2007Steroids34 citations Open access
Semantic Scholar
Analysis by liquid chromatography–mass spectrometry of sterols and oxysterols in brain of the newborn Dhcr7Δ3-5/T93M mouse: A model of Smith–Lemli–Opitz syndrome
Anna Meljon, G. Watson, Yu-Qin Wang, C. Shackleton +1 more
2013Biochemical Pharmacology30 citations Open access
Semantic Scholar
Maternal urine and serum steroid measurements to identify steroid sulfatase deficiency (STSD) in second trimester pregnancies
J. Marcos, W. Craig, Glenn E. Palomaki, E. Kloza +4 more
2009Prenatal Diagnosis30 citations
Semantic Scholar
Concomitant Mutations in the P450 Oxidoreductase and Androgen Receptor Genes Presenting with 46,XY Disordered Sex Development and Androgenization at Adrenarche
Jan Idkowiak, E. Małunowicz, V. Dhir, N. Reisch +7 more
2010Journal of Clinical Endocrinology and Metabolism28 citations Open access
Semantic Scholar
Longitudinal changes in glucocorticoid metabolism are associated with later development of adverse metabolic phenotype.
R. Crowley, B. Hughes, Joanna Gray, T. McCarthy +6 more
2014European Journal of Endocrinology26 citations
Semantic Scholar
A SULT2A1 genetic variant identified by GWAS as associated with low serum DHEAS does not impact on the actual DHEA/DHEAS ratio
R. Haring, H. Wallaschofski, A. Teumer, H. Kroemer +6 more
2012Journal of Molecular Endocrinology24 citations Open access
Semantic Scholar
Genetic Disorders of Steroid Metabolism Diagnosed by Mass Spectrometry
C. Shackleton
200824 citations
Semantic Scholar
Diminished 11β-hydroxysteroid dehydrogenase type 2 activity is associated with decreased weight and weight gain across the first year of life.
Samantha L. Rogers, B. Hughes, Christopher A. Jones, L. Freedman +7 more
2014Journal of Clinical Endocrinology and Metabolism22 citations Open access
Semantic Scholar
Steroid analysis and doping control 1960-1980: scientific developments and personal anecdotes.
C. Shackleton
2009Steroids22 citations
Semantic Scholar
Steroid profiling and analytics: going towards sterome.
U. Ceglarek, C. Shackleton, F. Stanczyk, J. Adamski
2010Journal of Steroid Biochemistry and Molecular Biology20 citations
Semantic Scholar
Bile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates
J. Abdel-Khalik, T. Hearn, Alison L. Dickson, P. J. Crick +15 more
2020Journal of Steroid Biochemistry and Molecular Biology19 citations Open access
Semantic Scholar
SULFATION PATHWAYS: Alternate steroid sulfation pathways targeted by LC-MS/MS analysis of disulfates: application to prenatal diagnosis of steroid synthesis disorders.
Ó. Pozo, J. Marcos, O. Khymenets, Andy Pranata +3 more
2018Journal of Molecular Endocrinology19 citations Open access
Semantic Scholar
The broad phenotypic spectrum of 17α-hydroxylase/17,20-lyase (CYP17A1) deficiency: a case series
Min Sun, Jonathan Wolf Mueller, L. Gilligan, A. Taylor +14 more
2021European Journal of Endocrinology18 citations Open access
Semantic Scholar
Remission of hypertension and electrolyte abnormalities following renal transplantation in a patient with apparent mineralocorticoid excess well documented throughout childhood
A. Khattab, C. Shackleton, B. Hughes, Jayesh B. Bodalia +1 more
2014Journal of Pediatric Endocrinology & Metabolism (JPEM)17 citations
Semantic Scholar
A half-century of anabolic steroids in sport.
L. Bowers, R. V. Clark, C. Shackleton
2009Steroids14 citations
Semantic Scholar
Biochemical and Physiological Improvement in a Mouse Model of Smith-Lemli-Opitz Syndrome (SLOS) Following Gene Transfer with AAV Vectors
Ying Lee, Xavier Matabosch, Montserrat Serra, Berna Watson +2 more
2014Molecular Genetics and Metabolism Reports12 citations Open access
Semantic Scholar
Hair and skin sterols in normal mice and those with deficient dehydrosterol reductase (DHCR7), the enzyme associated with Smith-Lemli-Opitz syndrome
Montserrat Serra, Xavier Matabosch, Ying Lee, G. Watson +1 more
2010Journal of Steroid Biochemistry and Molecular Biology12 citations Open access
Semantic Scholar
Increasing cholesterol synthesis in 7-dehydrosterol reductase (DHCR7) deficient mouse models through gene transfer
Xavier Matabosch, Ying Lee, Montserrat Serra, C. Wassif +3 more
2010Journal of Steroid Biochemistry and Molecular Biology11 citations Open access
Semantic Scholar
11beta-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function.
E. Walker, Adeeba Ahmed, G. Lavery, J. Tomlinson +9 more
2007Journal of Biological Chemistry11 citations
Semantic Scholar
Distinctive profile of the 17-hydroxylase and 17,20-lyase activities revealed by urinary steroid metabolomes of patients with CYP17 deficiency.
Marcos S. Neres, R. Auchus, C. Shackleton, C. Kater
2010Arquivos brasileiros de endocrinologia e metabologia9 citations Open access
Semantic Scholar
Increased central adiposity and decreased subcutaneous adipose tissue 11β‐hydroxysteroid dehydrogenase type 1 are associated with deterioration in glucose tolerance—A longitudinal cohort study
R. Crowley, C. Woods, B. Hughes, Joanna Gray +8 more
2019Clinical Endocrinology8 citations Open access
Semantic Scholar

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