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Christina M. Coughlan · SciRah

Researcher profile · Semantic Scholar

Christina M. Coughlan

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Christina M. Coughlan — researcher profile on SciRah

h-index: 20
Works: 87
Citations: 1,560

Most-cited papers

Exosome Isolation by Ultracentrifugation and Precipitation: A Comparison of Techniques for Downstream Analyses
Christina M. Coughlan, Kimberly Bruce, O. Burgy, Timothy D. Boyd +10 more
2020Current Protocols in Cell Biology285 citations Open access
Semantic Scholar
Increased Extracellular Vesicles Mediate WNT5A Signaling in Idiopathic Pulmonary Fibrosis
A. Martín-Medina, M. Lehmann, O. Burgy, S. Hermann +16 more
2018American Journal of Respiratory and Critical Care Medicine158 citations Open access
Semantic Scholar
Palliative Care and Parkinson's Disease: Caregiver Perspectives
Isabel M. Boersma, Jacqueline Jones, Christina M. Coughlan, J. Carter +4 more
2017Journal of Palliative Medicine83 citations Open access
Semantic Scholar
Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors
Miguel Flores-Bellver, Jason Mighty, Silvia Aparicio-Domingo, Kang V. Li +14 more
2021Journal of Extracellular Vesicles80 citations Open access
Semantic Scholar
Safety and efficacy of sargramostim (GM‐CSF) in the treatment of Alzheimer's disease
H. Potter, Jonathan H. Woodcock, Timothy D. Boyd, Christina M. Coughlan +13 more
2021Alzheimer's & Dementia79 citations Open access
Semantic Scholar
Astrogliosis and Episodic Memory in Late Life: Higher GFAP is Related to Worse Memory and White Matter Microstructure in Healthy Aging and Alzheimer’s Disease
Brianne M. Bettcher, Kaitlin E. Olson, Nichole E. Carlson, Brice V. McConnell +10 more
2021Neurobiology of Aging73 citations Open access
Semantic Scholar
Degradation of Mutated Bovine Pancreatic Trypsin Inhibitor in the Yeast Vacuole Suggests Post-endoplasmic Reticulum Protein Quality Control*
Christina M. Coughlan, Jennifer L. Walker, J. C. Cochran, K. Wittrup +1 more
2004Journal of Biological Chemistry69 citations Open access
Semantic Scholar
Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney
Peter S. Harris, S. Roy, Christina M. Coughlan, D. Orlicky +4 more
2015Redox Biology68 citations Open access
Semantic Scholar
The burden of trisomy 21 disrupts the proteostasis network in Down syndrome
S. Aivazidis, Christina M. Coughlan, Abhishek K. Rauniyar, Hua Jiang +3 more
2017PLoS ONE54 citations Open access
Semantic Scholar
Varicella Zoster Virus Infection of Primary Human Spinal Astrocytes Produces Intracellular Amylin, Amyloid-beta, and an Amyloidogenic Extracellular Environment.
Andrew N. Bubak, Christina N. Como, Christina M. Coughlan, Noah R. Johnson +9 more
2019Journal of Infectious Diseases53 citations Open access
Semantic Scholar
Increased plasma brain-derived neurotrophic factor (BDNF) as a potential biomarker for and compensatory mechanism in mild cognitive impairment: a case-control study
T. Ng, Christina M. Coughlan, P. Heyn, A. Tagawa +3 more
2021Aging46 citations Open access
Semantic Scholar
Rapid Activation of Neuroinflammation in Stroke: Plasma and Extracellular Vesicles Obtained on a Mobile Stroke Unit
R. Kowalski, Aurélie Ledreux, John E. Violette, Robert T Neumann +11 more
2023Stroke37 citations Open access
Semantic Scholar
IGF1 deficiency integrates stunted growth and neurodegeneration in Down syndrome
Paula Araya, Kohl T. Kinning, Christina M. Coughlan, Keith P. Smith +10 more
2022Cell Reports37 citations Open access
Semantic Scholar
Use of yeast as a model system to investigate protein conformational diseases
Christina M. Coughlan, J. Brodsky
2005Molecular Biotechnology36 citations
Semantic Scholar
Mitotic defects lead to neuronal aneuploidy and apoptosis in frontotemporal lobar degeneration caused by MAPT mutations
Julbert Caneus, A. Granic, R. Rademakers, D. Dickson +3 more
2017Molecular Biology of the Cell35 citations Open access
Semantic Scholar
Innate Immune System Activation and Neuroinflammation in Down Syndrome and Neurodegeneration: Therapeutic Targets or Partners?
Md. Mahiuddin Ahmed, Noah R. Johnson, Timothy D. Boyd, Christina M. Coughlan +2 more
2021Frontiers in Aging Neuroscience34 citations Open access
Semantic Scholar
Fibroblast-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosis
O. Burgy, C. Mayr, D. Schenesse, Efthymios Fousekis Papakonstantinou +28 more
2024JCI Insight30 citations Open access
Semantic Scholar
The Innate Immune System Stimulating Cytokine GM-CSF Improves Learning/Memory and Interneuron and Astrocyte Brain Pathology in Dp16 Down Syndrome Mice and Improves Learning/Memory in Wild-Type Mice
Mahiuddin Ahmed, Athena Ching-jung Wang, Mihret T. Elos, H. Chial +10 more
2022Neurobiology of Disease24 citations Open access
Semantic Scholar
Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice
Christina M. Coughlan, D. Walker, K. M. Lohr, J. Richardson +4 more
2015Parkinson's Disease21 citations Open access
Semantic Scholar
Zoster-associated Prothrombotic Plasma Exosomes and Increased Stroke Risk.
Andrew N. Bubak, Christina M. Coughlan, J. Posey, Anthony J. Saviola +10 more
2022Journal of Infectious Diseases20 citations Open access
Semantic Scholar
Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer’s disease cognition
Noah R. Johnson, Athena Ching-jung Wang, Christina M. Coughlan, Stefan H. Sillau +7 more
2021bioRxiv20 citations Open access
Semantic Scholar
Suppression of the host antiviral response by non-infectious varicella zoster virus extracellular vesicles
Christy S. Niemeyer, Seth E. Frietze, Christina M. Coughlan, Serena W. R. Lewis +12 more
2024Journal of Virology18 citations
Semantic Scholar
Amylin, Aβ42, and Amyloid in VZV Vasculopathy Cerebrospinal Fluid and Infected Vascular Cells.
Andrew N. Bubak, C. Beseler, Christina N. Como, Christina M. Coughlan +13 more
2020Journal of Infectious Diseases16 citations Open access
Semantic Scholar
Transcriptional Repression of the α7 Nicotinic Acetylcholine Receptor Subunit Gene (CHRNA7) by Activating Protein-2α (AP-2α)*
Jessica Finlay-Schultz, Andrew Canastar, M. Short, M. Elgazzar +2 more
2011Journal of Biological Chemistry15 citations Open access
Semantic Scholar
Astrogliosis, Neuritic Microstructure, and Sex Effects: GFAP is an Indicator of Neuritic Orientation in Women
A. Thaker, Brice V. McConnell, Dustin M. Rogers, Nichole E. Carlson +11 more
2023Brain, behavior, and immunity14 citations Open access
Semantic Scholar
Plasma Neurofilament Light Chain Concentrations are Elevated in Youth-onset Type 2 Diabetes and Associate with Neuropathy
V. Fridman, Stefan Sillau, Alanna M. Ritchie, Jacob Bockhorst +10 more
2023Journal of the peripheral nervous system14 citations Open access
Semantic Scholar
Proteomic analysis of the amyloid precursor protein fragment C99: expression in yeast.
L. J. Sparvero, Sarah Patz, J. Brodsky, Christina M. Coughlan
2007Analytical Biochemistry14 citations Open access
Semantic Scholar
Stability and Function of the Sec61 Translocation Complex Depends on the Sss1p Tail-Anchor Sequence
Domina Falcone, M. Henderson, Hendrik Nieuwland, Christina M. Coughlan +2 more
2011Biochemical Journal12 citations Open access
Semantic Scholar
Specific Binding of Alzheimer’s Aβ Peptides to Extracellular Vesicles
Christina M. Coughlan, Jared Lindenberger, Jeffrey G. Jacot, Noah R. Johnson +5 more
2024International Journal of Molecular Sciences11 citations Open access
Semantic Scholar
Extracellular vesicles from the CNS play pivotal roles in neuroprotection and neurodegeneration: lessons from in vitro experiments
Isaac Colvett, Hannah C. Saternos, Christina M. Coughlan, A. Vielle +1 more
2023Extracellular Vesicles and Circulating Nucleic Acids11 citations Open access
Semantic Scholar
Density Analysis of Enterovirus D68 Shows Viral Particles Can Associate with Exosomes
Michael J. Rudy, Christina M. Coughlan, Alison M. Hixon, P. Clarke +1 more
2022Microbiology spectrum11 citations Open access
Semantic Scholar
Obese adipose tissue-derived extracellular vesicles enriched with glycolytic cargo promote colorectal cancer tumorigenesis.
Parsa S. Haque, Sheré L. Paris, Rhonda F. Souza, Joseph C. Onyiah +4 more
2025Cancer Letters9 citations Open access
Semantic Scholar
Phenotype and Neuronal Cytotoxic Function of Glioblastoma Extracellular Vesicles
Wenbo Zhou, Daniel Lovasz, Zoe Zizzo, Qianbin He +9 more
2022Biomedicines7 citations Open access
Semantic Scholar
Yeast as a model system to investigate protein conformational diseases.
Christina M. Coughlan, J. Brodsky
2003Methods in molecular biology7 citations
Semantic Scholar
Obese Adipose Tissue Extracellular Vesicles Activate Mitochondrial Fatty Acid β-oxidation to Drive Colonic Stemness
Parsa S. Haque, Desiree M Goodman, Thor Kuusivuori-Robinson, Christina M. Coughlan +4 more
2025Cellular and Molecular Gastroenterology and Hepatology6 citations Open access
Semantic Scholar
Possible regulation of the immune modulator tetraspanin CD81 by alpha-synuclein in melanoma
Nirjhar Mandal Aloy, Christina M. Coughlan, Michael W. Graner, Stephan N. Witt
2024bioRxiv6 citations Open access
Semantic Scholar
Epigenetic dysregulation of transposable elements in cognitive impairment and Alzheimer’s disease
A. Cavalier, Meghan E. Smith, Gabriella T. McWilliams, Cali M. McEntee +3 more
2025GeroScience5 citations
Semantic Scholar
Blood measure of neuronal death is exponentially higher with age, especially in females, and halted in Alzheimer’s disease by GM-CSF treatment
Stefan H. Sillau, Christina M. Coughlan, Md. Mahiuddin Ahmed, Kavita V. Nair +11 more
2025Cell Reports Medicine4 citations
Semantic Scholar
A Fluorescence Resonance Energy Transfer-Based Assay Targeting Tumor-Derived Extracellular Vesicles for Highly Specific Pancreatic Cancer Detection.
A. Akinlalu, Komila Rasuleva, Emmanuel Ogberefor, Tommy Gao +6 more
2025ACS Nano4 citations
Semantic Scholar
Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer’s disease cognition
Noah R. Johnson, Athena Ching-jung Wang, Christina M. Coughlan, Stefan H. Sillau +7 more
2022Alzheimer's Research & Therapy4 citations Open access
Semantic Scholar
Circulating Interleukin‐6 Levels and Timing of Acute Ischemic Stroke Onset
R. Kowalski, Aurélie Ledreux, John E. Violette, Whitney Paustian +12 more
2025Annals of Clinical and Translational Neurology3 citations Open access
Semantic Scholar
Synergistic effects of GFAP and Aβ42: Implications for white matter integrity and verbal memory across the cognitive spectrum
Brianne M. Bettcher, Dan Lopez Paniagua, Yue Wang, Brice V. McConnell +12 more
2024Brain, Behavior, & Immunity - Health3 citations Open access
Semantic Scholar
Biomarkers of Neurodegeneration and Alzheimer’s Disease Neuropathology in Adolescents and Young Adults with Youth-Onset Type 1 or Type 2 Diabetes: A Proof-of-Concept Study
Allison L B Shapiro, Christina M. Coughlan, Brianne M. Bettcher, Meghan E Pauley +11 more
2024Endocrines3 citations Open access
Semantic Scholar
Neuron loss in the brain starts in childhood, increases exponentially with age and is halted by GM-CSF treatment in Alzheimers disease
Stefan H. Sillau, Christina M. Coughlan, Md. Mahiuddin Ahmed, Kavita V. Nair +8 more
2024medRxiv3 citations Open access
Semantic Scholar
Associations of Circulating Insulin-Growth Factor-1 With Cognitive Functions and Quality of Life Domains in Ambulatory Young Adults With Cerebral Palsy: A Pilot Study
T. Ng, P. Heyn, A. Tagawa, Christina M. Coughlan +1 more
2022Frontiers in Neurology3 citations Open access
Semantic Scholar
CNS-compartmentalized IgG aggregates and glycosylation in multiple sclerosis contribute to oligoclonal bands and neuronal cytotoxicity
S. Asokan, Wenbo Zhou, Anthony R. Fringuello, Tiffany Pointon +7 more
2026Frontiers in Immunology2 citations
Semantic Scholar
A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells
Mary Wang, Arin N. Graner, Bryne Knowles, Charlotte McRae +17 more
2024bioRxiv2 citations Open access
Semantic Scholar
Differential Effects of Extracellular Vesicles from Two Different Glioblastomas on Normal Human Brain Cells
Mary Wang, Arin N. Graner, Bryne Knowles, Charlotte McRae +18 more
2024Neurology International2 citations Open access
Semantic Scholar
Abstracts of the 19th International Symposium on NeuroVirology October 2–5, 2023 Montreal, Quebec, Canada
Elena Alvarez Periel, A. Singh, K. Jordan-Sciutto, Michelle K. Ash +141 more
2023Journal of Neurovirology2 citations
Semantic Scholar
Proteasome activity modulates amyloid toxicity.
J. Galvin, Elizabeth Curran, Francisco Arteaga, A-L. Goossens +8 more
2022FEMS Yeast Research2 citations Open access
Semantic Scholar

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