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I. Seppälä · SciRah

Researcher profile · Semantic Scholar

I. Seppälä

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I. Seppälä — researcher profile on SciRah

h-index: 58
Works: 245
Citations: 18K

Most-cited papers

Integrative approaches for large-scale transcriptome-wide association studies
Alexander Gusev, Arthur Ko, Huwenbo Shi, G. Bhatia +21 more
2015Nature Genetics2,316 citations Open access
Semantic Scholar
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
U. Võsa, A. Claringbould, H. Westra, M. Bonder +104 more
2021Nature Genetics2,043 citations Open access
Semantic Scholar
Multi-Ethnic Genome-wide Association Study for Atrial Fibrillation
C. Roselli, M. Chaffin, Lu-Chen Weng, S. Aeschbacher +214 more
2018Nature Genetics727 citations Open access
Semantic Scholar
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes
Angli Xue, Yang Wu, Zhihong Zhu, Futao Zhang +79 more
2018Nature Communications721 citations Open access
Semantic Scholar
Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors.
A. Ahola-Olli, P. Würtz, A. Havulinna, K. Aalto +17 more
2017American Journal of Human Genetics569 citations Open access
Semantic Scholar
Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis
U. Võsa, A. Claringbould, H. Westra, M. Bonder +96 more
2018bioRxiv512 citations Open access
Semantic Scholar
Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood
Ting Qi, Yang Wu, Jian Zeng, Futao Zhang +82 more
2018Nature Communications408 citations Open access
Semantic Scholar
Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error
M. Tedja, R. Wojciechowski, P. Hysi, N. Eriksson +251 more
2018Nature Genetics340 citations Open access
Semantic Scholar
A meta-analysis of genome-wide association studies identifies multiple longevity genes
J. Deelen, D. Evans, D. Arking, N. Tesi +80 more
2019Nature Communications335 citations Open access
Semantic Scholar
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation
I. Christophersen, M. Rienstra, C. Roselli, Xiao-Yan Yin +158 more
2017Nature Genetics323 citations Open access
Semantic Scholar
Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.
M. D. de Moor, S. M. van den Berg, K. Verweij, R. Krueger +114 more
2015JAMA psychiatry320 citations Open access
Semantic Scholar
Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances
P. Timmers, N. Mounier, K. Läll, K. Fischer +80 more
2019eLife252 citations Open access
Semantic Scholar
The Biomarker GlycA Is Associated with Chronic Inflammation and Predicts Long-Term Risk of Severe Infection.
S. Ritchie, P. Würtz, A. Nath, G. Abraham +22 more
2015Cell Systems232 citations Open access
Semantic Scholar
A genome‐wide approach to children's aggressive behavior: The EAGLE consortium
I. Pappa, B. St Pourcain, K. Benke, A. Cavadino +39 more
2016American Journal of Medical Genetics Part B: Neuropsychiatric Genetics190 citations Open access
Semantic Scholar
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity
Peter K. Joshi, N. Pirastu, K. Kentistou, K. Fischer +109 more
2017Nature Communications157 citations Open access
Semantic Scholar
A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms
Salome Mack, S. Coassin, R. Rueedi, N. Yousri +23 more
2017Journal of Lipid Research153 citations Open access
Semantic Scholar
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
M. Mills, Felix C. Tropf, D. Brazel, N. V. van Zuydam +202 more
2021Nature Human Behaviour130 citations Open access
Semantic Scholar
Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
Qiao Fan, V. Verhoeven, R. Wojciechowski, V. Barathi +150 more
2016Nature Communications130 citations Open access
Semantic Scholar
Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory
S. M. van den Berg, M. D. de Moor, M. McGue, E. Pettersson +84 more
2014Behavior Genetics124 citations Open access
Semantic Scholar
Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants.
H. Dashti, J. Follis, Caren E. Smith, Toshiko Tanaka +50 more
2015American Journal of Clinical Nutrition113 citations Open access
Semantic Scholar
Uncovering the complex genetics of human character
I. Zwir, J. Arnedo, C. Del-Val, L. Pulkki-Råback +23 more
2018Molecular Psychiatry111 citations Open access
Semantic Scholar
Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses
V. Aho, H. Ollila, E. Kronholm, I. Bondia-Pons +22 more
2016Scientific Reports107 citations Open access
Semantic Scholar
High Birth Weight Is Associated With Obesity and Increased Carotid Wall Thickness in Young Adults: The Cardiovascular Risk in Young Finns Study
M. Skilton, Niina Siitonen, P. Würtz, J. Viikari +8 more
2014Arteriosclerosis, Thrombosis and Vascular Biology98 citations
Semantic Scholar
Uncovering the complex genetics of human temperament
I. Zwir, J. Arnedo, C. Del-Val, L. Pulkki-Råback +23 more
2018Molecular Psychiatry92 citations Open access
Semantic Scholar
The effect of weight on labor market outcomes: An application of genetic instrumental variables
P. Böckerman, J. Cawley, Jutta Viinikainen, T. Lehtimäki +4 more
2016Health Economics90 citations Open access
Semantic Scholar
Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism—The Young Finns Study
E. Raitoharju, I. Seppälä, L. Lyytikäinen, J. Viikari +14 more
2016Scientific Reports85 citations Open access
Semantic Scholar
Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome: the cardiovascular risk in Young Finns Study.
E. Raitoharju, I. Seppälä, N. Oksala, L. Lyytikäinen +14 more
2014Molecular and Cellular Endocrinology82 citations
Semantic Scholar
Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians.
A. Fretts, J. Follis, J. Nettleton, R. Lemaitre +58 more
2015American Journal of Clinical Nutrition81 citations Open access
Semantic Scholar
Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium
S. M. van den Berg, M. D. de Moor, K. Verweij, R. Krueger +117 more
2015Behavior Genetics79 citations Open access
Semantic Scholar
Three genetic–environmental networks for human personality
I. Zwir, C. Del-Val, J. Arnedo, L. Pulkki-Råback +26 more
2019Molecular Psychiatry78 citations Open access
Semantic Scholar
DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures
Monica del C. Gomez-Alonso, A. Kretschmer, R. Wilson, Liliane Pfeiffer +27 more
2021Clinical Epigenetics77 citations Open access
Semantic Scholar
USF1 deficiency activates brown adipose tissue and improves cardiometabolic health
P. Laurila, J. Soronen, S. Kooijman, S. Forsström +43 more
2016Science Translational Medicine77 citations Open access
Semantic Scholar
Plasma Concentrations of Afamin Are Associated With Prevalent and Incident Type 2 Diabetes: A Pooled Analysis in More Than 20,000 Individuals
B. Kollerits, C. Lamina, C. Huth, P. Marques-Vidal +23 more
2017Diabetes Care72 citations Open access
Semantic Scholar
An epigenome-wide association study meta-analysis of educational attainment
R. Linnér, R. Marioni, CA Rietveld, AJ Simpkin +68 more
2017Molecular Psychiatry72 citations Open access
Semantic Scholar
Whole blood microRNA levels associate with glycemic status and correlate with target mRNAs in pathways important to type 2 diabetes
N. Mononen, L. Lyytikäinen, I. Seppälä, Pashupati P. Mishra +13 more
2019Scientific Reports71 citations Open access
Semantic Scholar
Genetic association study of childhood aggression across raters, instruments, and age
Hill F. Ip, C. M. van der Laan, E. Krapohl, I. Brikell +145 more
2019bioRxiv70 citations Open access
Semantic Scholar
Differentially expressed genes and canonical pathway expression in human atherosclerotic plaques – Tampere Vascular Study
M. Sulkava, E. Raitoharju, M. Levula, I. Seppälä +12 more
2017Scientific Reports55 citations Open access
Semantic Scholar
The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease
Marita Kalaoja, L. Corbin, Vanessa Y. Tan, A. Ahola-Olli +19 more
2021Obesity53 citations Open access
Semantic Scholar
Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits
H. Dashti, J. Follis, Caren E. Smith, Toshiko Tanaka +67 more
2015Diabetes Care53 citations Open access
Semantic Scholar
Genome-wide association study of circulating interleukin 6 levels identifies novel loci
T. Ahluwalia, B. Prins, M. Abdollahi, N. Armstrong +122 more
2021Human Molecular Genetics51 citations Open access
Semantic Scholar
Genetic and environmental perturbations lead to regulatory decoherence
A. Lea, M. Subramaniam, Arthur Ko, T. Lehtimäki +9 more
2018bioRxiv49 citations Open access
Semantic Scholar
Consortium-based genome-wide meta-analysis for childhood dental caries traits
S. Haworth, D. Shungin, J. T. van der Tas, S. Vucic +39 more
2018Human Molecular Genetics46 citations Open access
Semantic Scholar
Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti-inflammatory type II macrophages and upregulation of beta-2 integrins in all major arterial beds.
N. Oksala, Jenita Pärssinen, I. Seppälä, N. Klopp +9 more
2015Atherosclerosis40 citations
Semantic Scholar
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
I. Seppälä, M. Kleber, L. Lyytikäinen, J. Hernesniemi +18 more
2014European Heart Journal40 citations Open access
Semantic Scholar
Talin and vinculin are downregulated in atherosclerotic plaque; Tampere Vascular Study.
Magdaléna von Essen, Rolle Rahikainen, N. Oksala, E. Raitoharju +10 more
2016Atherosclerosis39 citations
Semantic Scholar
Identification of a Genetic Variation in ERAP1 Aminopeptidase that Prevents Human Cytomegalovirus miR-UL112-5p-Mediated Immunoevasion.
P. Romania, L. Cifaldi, Benedetta Pignoloni, Nadia Starc +19 more
2017Cell Reports38 citations Open access
Semantic Scholar
Association of Neuroimmune Guidance Cue Netrin-1 and Its Chemorepulsive Receptor UNC5B With Atherosclerotic Plaque Expression Signatures and Stability in Human(s): Tampere Vascular Study (TVS)
N. Oksala, Jenita Pärssinen, I. Seppälä, E. Raitoharju +10 more
2013Circulation: Cardiovascular Genetics38 citations Open access
Semantic Scholar
Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis
Nicola Mckeown, Hassan S. Dashti, Jian-Tao Ma, Danielle E. Haslam +46 more
2017Diabetologia36 citations Open access
Semantic Scholar
Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy
A. Nath, S. Ritchie, Nastasiya F. Grinberg, H. Tang +26 more
2019bioRxiv35 citations Open access
Semantic Scholar
A genome-wide expression quantitative trait loci analysis of proprotein convertase subtilisin/kexin enzymes identifies a novel regulatory gene variant for FURIN expression and blood pressure
H. Turpeinen, I. Seppälä, L. Lyytikäinen, E. Raitoharju +12 more
2015Human Genetics35 citations
Semantic Scholar

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