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Guang-Yaw Liu · SciRah

Researcher profile · Semantic Scholar

Guang-Yaw Liu

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Guang-Yaw Liu — researcher profile on SciRah

h-index: 25
Works: 79
Citations: 2,058

Most-cited papers

Mechanism-based in vitro screening of potential cancer chemopreventive agents.
C. Gerhäuser, K. Klimo, E. Heiss, I. Neumann +5 more
2003Mutation research347 citations
Semantic Scholar
Ornithine decarboxylase prevents methotrexate-induced apoptosis by reducing intracellular reactive oxygen species production
C.-C. Huang, P. Hsu, Ying-Cheng Hung, Yan-Li Liao +6 more
2005Apoptosis98 citations
Semantic Scholar
Overexpression of peptidylarginine deiminase IV features in apoptosis of haematopoietic cells
Guang-Yaw Liu, Yan-Li Liao, W. Chang, C.-C. Liu +4 more
2006Apoptosis81 citations
Semantic Scholar
Structural basis of antizyme-mediated regulation of polyamine homeostasis
Hsiang-Yi Wu, Shin-Fu Chen, Ju-Yi Hsieh, Fang-Yi Chou +11 more
2015Proceedings of the National Academy of Sciences of the United States of America78 citations Open access
Semantic Scholar
Functional Role of Dimerization of Human Peptidylarginine Deiminase 4 (PAD4)
Yi-Liang Liu, Yu-Hsiu Chiang, Guang-Yaw Liu, Hui-Chih Hung
2011PLoS ONE68 citations Open access
Semantic Scholar
A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22.
Hui-Hsin Chang, Guang-Yaw Liu, N. Dwivedi, Bo Sun +12 more
2016JCI Insight63 citations Open access
Semantic Scholar
The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases' cascade.
Yan-Li Liao, Ying-Cheng Hung, Wen-huei Chang, G. Tsay +3 more
2005Life Science59 citations
Semantic Scholar
Induction of apoptosis by thiuramdisulfides, the reactive metabolites of dithiocarbamates, through coordinative modulation of NFκB c‐fos/c‐jun, and p53 proteins
Guang-Yaw Liu, N. Frank, H. Bartsch, Jen-Kun Lin
1998Molecular Carcinogenesis57 citations
Semantic Scholar
Curcumin induces apoptosis through an ornithine decarboxylase-dependent pathway in human promyelocytic leukemia HL-60 cells.
Yan-Li Liao, Hui-Chih Hung, T. Hour, Pei-Chen Hsu +3 more
2008Life Science55 citations
Semantic Scholar
Ling-Zhi polysaccharides potentiate cytotoxic effects of anticancer drugs against drug-resistant urothelial carcinoma cells.
Chao‐Yuan Huang, J. Chen, Jia-En Wu, Y. Pu +7 more
2010Journal of Agricultural and Food Chemistry48 citations
Semantic Scholar
Human mitochondrial NAD(P)(+)-dependent malic enzyme participates in cutaneous melanoma progression and invasion.
Yung-Lung Chang, Hong-Wei Gao, Chien-Ping Chiang, Wei-Ming Wang +4 more
2015Journal of Investigative Dermatology45 citations Open access
Semantic Scholar
Vimentin Is Involved in Peptidylarginine Deiminase 2-Induced Apoptosis of Activated Jurkat Cells
Pei-Chen Hsu, Yan-Li Liao, Chin-Li Lin, Wen-hao Lin +2 more
2014Molecules and Cells45 citations Open access
Semantic Scholar
Characterization of membranous and cytoplasmic EGFR expression in human normal renal cortex and renal cell carcinoma
Y. Pu, Chao‐Yuan Huang, Yi-Zih Kuo, W. Kang +8 more
2009Journal of Biomedical Sciences44 citations Open access
Semantic Scholar
Ornithine decarboxylase prevents tumor necrosis factor alpha-induced apoptosis by decreasing intracellular reactive oxygen species
Guang-Yaw Liu, Ying-Cheng Hung, Pei-Chen Hsu, Y.-F. Liao +3 more
2005Apoptosis41 citations
Semantic Scholar
Determinants of the Dual Cofactor Specificity and Substrate Cooperativity of the Human Mitochondrial NAD(P)+-dependent Malic Enzyme
Ju-Yi Hsieh, Guang-Yaw Liu, G. Chang, Hui-Chih Hung
2006Journal of Biological Chemistry40 citations Open access
Semantic Scholar
Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: Crosstalk between ODC and BCL-2
Pei-Chen Hsu, T. Hour, Yan-Li Liao, Ying-Cheng Hung +6 more
2006Apoptosis39 citations
Semantic Scholar
Epidermal growth factor receptor inhibitor (PD168393) potentiates cytotoxic effects of paclitaxel against androgen-independent prostate cancer cells.
Y. Pu, Min-Wei Hsieh, Chuang-Wei Wang, Guang-Yaw Liu +5 more
2006Biochemical Pharmacology38 citations
Semantic Scholar
Pine (Pinus morrisonicola Hayata) needle extracts sensitize GBM8901 human glioblastoma cells to temozolomide by downregulating autophagy and O(6)-methylguanine-DNA methyltransferase expression.
Chia-Leng Liao, Chien-Min Chen, Yan-Zin Chang, Guang-Yaw Liu +3 more
2014Journal of Agricultural and Food Chemistry37 citations
Semantic Scholar
A continuous spectrophotometric assay method for peptidylarginine deiminase type 4 activity.
Yan-Li Liao, H. Hsieh, Guang-Yaw Liu, Hui-Chih Hung
2005Analytical Biochemistry34 citations
Semantic Scholar
Characterization of the functional role of allosteric site residue Asp102 in the regulatory mechanism of human mitochondrial NAD(P)+-dependent malate dehydrogenase (malic enzyme).
Hui-Chih Hung, Meng-Wei Kuo, G. Chang, Guang-Yaw Liu
2005Biochemical Journal30 citations Open access
Semantic Scholar
The functional haplotype of peptidylarginine deiminase IV (S55G, A82V and A112G) associated with susceptibility to rheumatoid arthritis dominates apoptosis of acute T leukemia Jurkat cells
Hui-Chih Hung, Chien-Yu Lin, Yan-Li Liao, Pei-Chen Hsu +2 more
2007Apoptosis29 citations
Semantic Scholar
A small-molecule inhibitor suppresses the tumor-associated mitochondrial NAD(P)+-dependent malic enzyme (ME2) and induces cellular senescence
Ju-Yi Hsieh, Shao-Yu Li, Wen-Chen Tsai, Jyung-Hurng Liu +3 more
2015OncoTarget28 citations Open access
Semantic Scholar
Nitration and hydroxylation of aromatic amino acid and guanine by the air pollutant peroxyacetyl nitrate.
Jen-Kun Lin, Kang Chen, Guang-Yaw Liu, Yu-Rong Chu +1 more
2000Chemico-Biological Interactions28 citations
Semantic Scholar
Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4
Yi-Liang Liu, Chien-Yun Lee, Yu-Ni Huang, Hui-Yi Chen +2 more
2017Scientific Reports25 citations Open access
Semantic Scholar
Ornithine decarboxylase attenuates leukemic chemotherapy drugs-induced cell apoptosis and arrest in human promyelocytic HL-60 cells.
Pei-Chen Hsu, Hui-Chih Hung, Yan-Li Liao, Chu-Chen Liu +2 more
2008Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis25 citations
Semantic Scholar
Critical Factors Governing the Difference in Antizyme-Binding Affinities between Human Ornithine Decarboxylase and Antizyme Inhibitor
Yen-Chin Liu, Yi-Liang Liu, Jia-Yang Su, Guang-Yaw Liu +1 more
2011PLoS ONE24 citations Open access
Semantic Scholar
Critical Factors Determining Dimerization of Human Antizyme Inhibitor*
Kuo-Liang Su, Yan-Li Liao, Hui-Chih Hung, Guang-Yaw Liu
2009Journal of Biological Chemistry24 citations Open access
Semantic Scholar
Antizyme, a natural ornithine decarboxylase inhibitor, induces apoptosis of haematopoietic cells through mitochondrial membrane depolarization and caspases’ cascade
Guang-Yaw Liu, Yan-Li Liao, Pei-Chen Hsu, W. Chang +6 more
2006Apoptosis24 citations
Semantic Scholar
Suppression of the human malic enzyme 2 modifies energy metabolism and inhibits cellular respiration
Ju-Yi Hsieh, Kun-Chi Chen, Chun-Hsiung Wang, Guang-Yaw Liu +10 more
2023Communications Biology23 citations Open access
Semantic Scholar
Functional roles of ATP-binding residues in the catalytic site of human mitochondrial NAD(P)+-dependent malic enzyme.
Hui-Chih Hung, Yung-Ching Chien, Ju-Yi Hsieh, G. Chang +1 more
2005Biochemistry23 citations
Semantic Scholar
Functional Roles of the Non-Catalytic Calcium-Binding Sites in the N-Terminal Domain of Human Peptidylarginine Deiminase 4
Yi-Liang Liu, I-Chen Tsai, Chia-Wei Chang, Yan-Li Liao +2 more
2013PLoS ONE22 citations Open access
Semantic Scholar
Peroxyacetyl nitrate–induced apoptosis through generation of reactive oxygen species in HL‐60 cells
Guang-Yaw Liu, Kang Chen, S. Lin-Shiau, Jen-Kun Lin
1999Molecular Carcinogenesis21 citations
Semantic Scholar
The N-terminal 178-amino-acid domain only of the SV40 large T antigen acts as a transforming suppressor of the HER-2/neu oncogene
M. Kao, Guang-Yaw Liu, Tzu-Chao Chuang, Yen-Shing Lin +2 more
1998Oncogene21 citations Open access
Semantic Scholar
Aβ stimulates microglial activation through antizyme‐dependent downregulation of ornithine decarboxylase
Yu-Wen Cheng, Chun-Cheng Chang, T. Chang, Hsin‐Hua Li +3 more
2018Journal of Cellular Physiology20 citations
Semantic Scholar
Transglutaminase 2 Contributes to Apoptosis Induction in Jurkat T Cells by Modulating Ca2+ Homeostasis via Cross-Linking RAP1GDS1
Yu-Fan Hsieh, Guang-Yaw Liu, Yi-Ju Lee, Jiann-Jou Yang +7 more
2013PLoS ONE20 citations Open access
Semantic Scholar
Functional Roles of Metabolic Intermediates in Regulating the Human Mitochondrial NAD(P)+-Dependent Malic Enzyme
Ju-Yi Hsieh, WanRou Shih, Yu-Hsuan Kuo, Guang-Yaw Liu +1 more
2019Scientific Reports19 citations Open access
Semantic Scholar
miR-302 Attenuates Mutant Huntingtin-Induced Cytotoxicity through Restoration of Autophagy and Insulin Sensitivity
Ching-Chi Chang, Sing-Hua Tsou, Wei-Jen Chen, Ying-Jui Ho +5 more
2021International Journal of Molecular Sciences17 citations Open access
Semantic Scholar
Equilibrium protein folding-unfolding process involving multiple intermediates
Hui-Chih Hung, Yu-Hou Chen, Guang-Yaw Liu, Hwei-Jen Lee +1 more
2003Bulletin of Mathematical Biology17 citations
Semantic Scholar
Molecular Interplay between the Dimer Interface and the Substrate-Binding Site of Human Peptidylarginine Deiminase 4
Chien-Yun Lee, Chu-Cheng Lin, Yi-Liang Liu, Guang-Yaw Liu +2 more
2017Scientific Reports16 citations Open access
Semantic Scholar
Ornithine decarboxylase prevents dibenzoylmethane‐induced apoptosis through repressing reactive oxygen species generation
Chih-Lung Wu, Yan-Li Liao, Ying-Cheng Hung, Ko-Hsiu Lu +2 more
2011Journal of biochemical and molecular toxicology16 citations
Semantic Scholar
4-Phenylbutyric Acid (4-PBA) and Lithium Cooperatively Attenuate Cell Death during Oxygen–Glucose Deprivation (OGD) and Reoxygenation
Wai-Fai Tung, Wei-Jen Chen, Hui-Chih Hung, Guang-Yaw Liu +3 more
2015Cellular and molecular neurobiology15 citations
Semantic Scholar
Minimal Antizyme Peptide Fully Functioning in the Binding and Inhibition of Ornithine Decarboxylase and Antizyme Inhibitor
Ju-Yi Hsieh, Jung-Yen Yang, Chih-Li Lin, Guang-Yaw Liu +1 more
2011PLoS ONE15 citations Open access
Semantic Scholar
Determinants of the Differential Antizyme-Binding Affinity of Ornithine Decarboxylase
Yen-Chin Liu, Den-Hua Hsu, Chien-Jin Huang, Yi-Liang Liu +2 more
2011PLoS ONE15 citations Open access
Semantic Scholar
Baicalein, 7,8-Dihydroxyflavone and Myricetin as Potent Inhibitors of Human Ornithine Decarboxylase
Yun-Chi Liu, Yi-Liang Liu, Ju-Yi Hsieh, Changlian Wang +3 more
2020Nutrients14 citations Open access
Semantic Scholar
Humic Acid Increases Amyloid β-Induced Cytotoxicity by Induction of ER Stress in Human SK-N-MC Neuronal Cells
Hsin‐Hua Li, Fung-Jou Lu, Hui-Chih Hung, Guang-Yaw Liu +2 more
2015International Journal of Molecular Sciences14 citations Open access
Semantic Scholar
Dibenzoylmethane, hydroxydibenzoylmethane and hydroxymethyldibenzoylmethane inhibit phorbol-12-myristate 13-acetate‑induced breast carcinoma cell invasion.
Yan-Li Liao, Yew-Min Tzeng, Hui-Chih Hung, Guang-Yaw Liu
2015Molecular Medicine Reports14 citations Open access
Semantic Scholar
Hydroxydibenzoylmethane induces apoptosis through repressing ornithine decarboxylase in human promyelocytic leukemia HL-60 cells
Ming-Fu Wang, Yan-Li Liao, Ying-Cheng Hung, Chih-Li Lin +4 more
2011Experimental and Molecular Medicine14 citations Open access
Semantic Scholar
Targeting human mitochondrial NAD(P)+-dependent malic enzyme (ME2) impairs energy metabolism and redox state and exhibits antileukemic activity in acute myeloid leukemia
Kun-Chi Chen, I-hsin Hsiao, Yu-Nan Huang, Yu-Tung Chou +6 more
2023Cellular Oncology13 citations Open access
Semantic Scholar
Peptidylarginine deiminase 2 promotes T helper 17-like T cell activation and activated T cell-autonomous death (ACAD) through an endoplasmic reticulum stress and autophagy coupling mechanism
Yi-Fang Yang, Chuang-Ming Wang, I-hsin Hsiao, Yi-Liang Liu +4 more
2022Cellular & Molecular Biology Letters13 citations Open access
Semantic Scholar
Multifaceted interactions and regulation between antizyme and its interacting proteins cyclin D1, ornithine decarboxylase and antizyme inhibitor
Yen-Chin Liu, Chien-Yun Lee, Chi-Li Lin, Hui-Yi Chen +2 more
2015OncoTarget13 citations Open access
Semantic Scholar

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Hui-Chih Hung — researcher profile on SciRah
Yan-Li Liao×15
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Yan-Li Liao — researcher profile on SciRah
G. Tsay×10
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Ju-Yi Hsieh×9
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Pei-Chen Hsu×8

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