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Václav Martínek · SciRah

Researcher profile · Semantic Scholar

Václav Martínek

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Václav Martínek — researcher profile on SciRah

h-index: 22
Works: 67
Citations: 1,921

Most-cited papers

Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes.
M. Stiborová, Václav Martínek, Helena Rýdlová, P. Hodek +1 more
2002Cancer Research305 citations
Semantic Scholar
Heme: emergent roles of heme in signal transduction, functional regulation and as catalytic centres.
T. Shimizu, A. Lengalova, Václav Martínek, M. Martínková
2019Chemical Society Reviews156 citations
Semantic Scholar
Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols.
V. Arlt, M. Stiborová, C. Henderson, M. Osborne +7 more
2005Cancer Research126 citations Open access
Semantic Scholar
Expression of cytochrome P450 1A1 and its contribution to oxidation of a potential human carcinogen 1-phenylazo-2-naphthol (Sudan I) in human livers.
M. Stiborová, Václav Martínek, Helena Rýdlová, T. Koblas +1 more
2005Cancer Letters111 citations
Semantic Scholar
Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta.
Christopher A. Sucato, T. Upton, B. Kashemirov, V. Batra +9 more
2007Biochemistry88 citations
Semantic Scholar
Decomposition of the solvation free energies of deoxyribonucleoside triphosphates using the free energy perturbation method.
U. Bren, Václav Martínek, J. Florián
2006Journal of Physical Chemistry B73 citations
Semantic Scholar
The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells.
J. Poljaková, T. Eckschlager, J. Hraběta, J. Hřebačková +5 more
2009Biochemical Pharmacology68 citations Open access
Semantic Scholar
Free energy simulations of uncatalyzed DNA replication fidelity: structure and stability of T.G and dTTP.G terminal DNA mismatches flanked by a single dangling nucleotide.
U. Bren, Václav Martínek, J. Florián
2006Journal of Physical Chemistry B62 citations
Semantic Scholar
The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases
M. Stiborová, Jaroslav Mareîs, E. Frei, V. Arlt +2 more
2011Environmental and Molecular Mutagenesis59 citations
Semantic Scholar
Enzymes metabolizing aristolochic acid and their contribution to the development of aristolochic acid nephropathy and urothelial cancer.
M. Stiborová, Václav Martínek, E. Frei, V. Arlt +1 more
2013Current drug metabolism57 citations
Semantic Scholar
Cytochrome b(5) shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy.
V. Kotrbová, Barbora Mrázová, Michaela Moserová, Václav Martínek +4 more
2011Biochemical Pharmacology54 citations Open access
Semantic Scholar
Cytochrome b5 increases cytochrome P450 3A4-mediated activation of anticancer drug ellipticine to 13-hydroxyellipticine whose covalent binding to DNA is elevated by sulfotransferases and N,O-acetyltransferases.
M. Stiborová, R. Indra, Michaela Moserová, V. Černá +5 more
2012Chemical Research in Toxicology44 citations
Semantic Scholar
Mechanisms of the different DNA adduct forming potentials of the urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone.
M. Stiborová, Václav Martínek, Martina Svobodová, J. Sístková +7 more
2010Chemical Research in Toxicology43 citations
Semantic Scholar
Mechanisms of Enzyme-Catalyzed Reduction of Two Carcinogenic Nitro-Aromatics, 3-Nitrobenzanthrone and Aristolochic Acid I: Experimental and Theoretical Approaches
M. Stiborová, E. Frei, H. Schmeiser, V. Arlt +1 more
2014International Journal of Molecular Sciences39 citations Open access
Semantic Scholar
A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches
M. Stiborová, F. Bárta, K. Levova, P. Hodek +3 more
2015International Journal of Molecular Sciences37 citations Open access
Semantic Scholar
DNA Duplex Stability: The Role of Preorganized Electrostatics
U. Bren, J. Lah, M. Bren, Václav Martínek +1 more
2010Journal of Physical Chemistry B31 citations Open access
Semantic Scholar
Homozygous missense mutation in UQCRC2 associated with severe encephalomyopathy, mitochondrial complex III assembly defect and activation of mitochondrial protein quality control.
D. Burska, L. Stiburek, J. Křížová, M. Vanišová +7 more
2021Biochimica et Biophysica Acta - Molecular Basis of Disease29 citations Open access
Semantic Scholar
Induced expression of cytochrome P450 1A and NAD(P)H:quinone oxidoreductase determined at mRNA, protein, and enzyme activity levels in rats exposed to the carcinogenic azo dye 1-phenylazo-2-naphthol (Sudan I).
M. Stiborová, H. Dračínská, Václav Martínek, Dagmar Svášková +6 more
2013Chemical Research in Toxicology29 citations
Semantic Scholar
Modulation of CYP1A1-mediated oxidation of carcinogenic azo dye Sudan I and its binding to DNA by cytochrome b5.
M. Stiborová, Václav Martínek, H. Schmeiser, E. Frei
2006Neuro - endocrinology letters27 citations
Semantic Scholar
Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases.
Václav Martínek, B. Kubíĉková, V. Arlt, E. Frei +3 more
2011Neuro - endocrinology letters25 citations
Semantic Scholar
Structural characterization of the heme‐based oxygen sensor, AfGcHK, its interactions with the cognate response regulator, and their combined mechanism of action in a bacterial two‐component signaling system
M. Stráňava, Václav Martínek, P. Man, Veronika Fojtikova +4 more
2016Proteins: Structure, Function, and Bioinformatics23 citations
Semantic Scholar
Heme Peroxidases: Structure, Function, Mechanism and Involvement in Activation of Carcinogens. A Review
M. Stiborová, M. Mikšanová, Václav Martínek, E. Frei
200023 citations
Semantic Scholar
Glycosylation protects proteins against free radicals generated from toxic xenobiotics.
Václav Martínek, J. Skłenar, M. Dračínský, M. Sulc +4 more
2010Toxicological Sciences22 citations Open access
Semantic Scholar
Coordination and redox state–dependent structural changes of the heme-based oxygen sensor AfGcHK associated with intraprotein signal transduction
M. Stráňava, P. Man, T. Skálová, P. Kolenko +8 more
2017Journal of Biological Chemistry20 citations Open access
Semantic Scholar
Enzymes oxidizing the azo dye 1-phenylazo-2-naphthol (Sudan I) and their contribution to its genotoxicity and carcinogenicity.
M. Stiborová, H. Schmeiser, E. Frei, P. Hodek +1 more
2015Current drug metabolism20 citations
Semantic Scholar
DNA polymerase β catalytic efficiency mirrors the Asn279–dCTP H‐bonding strength
Václav Martínek, U. Bren, M. F. Goodman, A. Warshel +1 more
200720 citations Open access
Semantic Scholar
Highly conserved nucleotide phosphatase essential for membrane lipid homeostasis in Streptococcus pneumoniae
Kirsten Kuipers, Clément Gallay, Václav Martínek, M. Rohde +8 more
2016Molecular Microbiology19 citations Open access
Semantic Scholar
Preparation of a biologically active apo-cytochrome b5 via heterologous expression in Escherichia coli.
V. Kotrbová, D. Aimová, M. Ingr, L. Bořek-Dohalská +2 more
2009Protein Expression and Purification19 citations
Semantic Scholar
Mutagenic potential of nitrenium ions of nitrobenzanthrones: Correlation between theory and experiment
J. Reynisson, M. Stiborová, Václav Martínek, G. Gamboa da Costa +2 more
2008Environmental and Molecular Mutagenesis19 citations Open access
Semantic Scholar
Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation
R. Indra, P. Pompach, Václav Martínek, Paulina Takacsova +7 more
2019International Journal of Molecular Sciences18 citations Open access
Semantic Scholar
Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1
J. Milichovský, F. Bárta, H. Schmeiser, V. Arlt +3 more
2016International Journal of Molecular Sciences17 citations Open access
Semantic Scholar
In vivo metabolism of aristolochic acid I and II in rats is influenced by their co-exposure.
Alena Dedı́ková, F. Bárta, Václav Martínek, Kevin Kotalík +5 more
2020Chemical Research in Toxicology16 citations
Semantic Scholar
Comparison of the oxidation of carcinogenic aristolochic acid I and II by microsomal cytochromes P450 in vitro: experimental and theoretical approaches
Václav Martínek, F. Bárta, P. Hodek, E. Frei +3 more
2017Chemical Monthly16 citations Open access
Semantic Scholar
Cytochrome b5 plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine
M. Stiborová, R. Indra, E. Frei, K. Kopeckova +6 more
2017Chemical Monthly16 citations Open access
Semantic Scholar
Flexible docking-based molecular dynamics/steered molecular dynamics calculations of protein-protein contacts in a complex of cytochrome P450 1A2 with cytochrome b5.
P. Jeřábek, J. Florián, M. Stiborová, Václav Martínek
2014Biochemistry15 citations Open access
Semantic Scholar
Theoretical investigation of differences in nitroreduction of aristolochic acid I by cytochromes P450 1A1, 1A2 and 1B1.
P. Jeřábek, Václav Martínek, M. Stiborová
2012Neuro - endocrinology letters14 citations
Semantic Scholar
Metabolism of Carcinogenic Azo Dye Sudan I by Rat, Rabbit, Minipig and Human Hepatic Microsomes
Václav Martínek, M. Stiborová
200214 citations
Semantic Scholar
Lipid molecules can induce an opening of membrane-facing tunnels in cytochrome P450 1A2
P. Jeřábek, J. Florián, Václav Martínek
2016Physical Chemistry, Chemical Physics - PCCP13 citations Open access
Semantic Scholar
Oxidation of the carcinogenic non-aminoazo dye 1-phenylazo-2-hydroxy-naphthalene (Sudan I) by cytochromes P450 and peroxidases: a comparative study
M. Stiborová, Václav Martínek, Marcela Semanská, P. Hodek +4 more
2009Interdisciplinary Toxicology13 citations Open access
Semantic Scholar
Mechanism of formation of (deoxy)guanosine adducts derived from peroxidase-catalyzed oxidation of the carcinogenic nonaminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I).
M. Dračínský, J. Cvačka, Marcela Semanská, Václav Martínek +2 more
2009Chemical Research in Toxicology12 citations
Semantic Scholar
Linear energy relationships for the octahedral preference of Mg, Ca and transition metal ions.
George Pontikis, James Borden, Václav Martínek, J. Florián
2009Journal of Physical Chemistry A12 citations
Semantic Scholar
Membrane-Anchored Cytochrome P450 1A2-Cytochrome b5 Complex Features an X-Shaped Contact between Antiparallel Transmembrane Helices.
P. Jeřábek, J. Florián, Václav Martínek
2016Chemical Research in Toxicology11 citations Open access
Semantic Scholar
Introduction of water into the heme distal side by Leu65 mutations of an oxygen sensor, YddV, generates verdoheme and carbon monoxide, exerting the heme oxygenase reaction.
M. Stráňava, M. Martínková, M. Stiborová, P. Man +5 more
2014Journal of Inorganic Biochemistry11 citations
Semantic Scholar
Mapping of interaction between cytochrome P450 2B4 and cytochrome b5: the first evidence of two mutual orientations.
M. Sulc, Tomáš Ječmen, Renata Šnajdrová, P. Novák +4 more
2012Neuro - endocrinology letters9 citations
Semantic Scholar
A one-electron oxidation of carcinogenic nonaminoazo dye Sudan I by horseradish peroxidase.
Marcela Semanská, M. Dračínský, Václav Martínek, J. Hudeček +3 more
2008Neuro - endocrinology letters9 citations
Semantic Scholar
DNA polymerase beta catalytic efficiency mirrors the Asn279-dCTP H-bonding strength.
Václav Martínek, U. Bren, M. Goodman, A. Warshel +1 more
2007FEBS Letters8 citations
Semantic Scholar
Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)-hydroxylamine with deoxyguanosine in DNA
M. Stiborová, Karel Naiman, M. Martínková, Václav Martínek +3 more
2009Interdisciplinary Toxicology7 citations Open access
Semantic Scholar
Optimalization of preparation of apo-cytochrome b5 utilizing apo-myoglobin
Barbora Mrázová, M. Martínková, Václav Martínek, E. Frei +1 more
2008Interdisciplinary Toxicology7 citations Open access
Semantic Scholar
Mapping of cytochrome P450 2B4 substrate binding sites by photolabile probe 3-azidiamantane: identification of putative substrate access regions.
P. Hodek, M. Karabec, M. Sulc, B. Sopko +4 more
2007Archives of Biochemistry and Biophysics7 citations
Semantic Scholar
Heme Peroxidases: Structure, Function, Mechanism, and Involvement in Activation of Carcinogens
M. Stiborová, M. Mikšanová, Václav Martínek, E. Frei
20006 citations
Semantic Scholar

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