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J. Wijnen · SciRah

Researcher profile · Semantic Scholar

J. Wijnen

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J. Wijnen — researcher profile on SciRah

h-index: 69
Works: 253
Citations: 20K

Most-cited papers

Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts
H. Vasen, I. Blanco, K. Aktán-Collán, J. P. Gopie +32 more
2013Gut737 citations Open access
Semantic Scholar
Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database
P. Møller, T. Seppälä, I. Bernstein, E. Holinski-Feder +35 more
2017Gut548 citations Open access
Semantic Scholar
Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database
P. Møller, T. Seppälä, I. Bernstein, E. Holinski-Feder +32 more
2015Gut518 citations Open access
Semantic Scholar
Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer
J. Burn, A. Gerdes, F. Macrae, J. Mecklin +26 more
2016497 citations
Semantic Scholar
Application of a five-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants lodged on the InSiGHT locus-specific database
B. Thompson, A. Spurdle, J. Plazzer, M. Greenblatt +37 more
2013Nature Genetics478 citations Open access
Semantic Scholar
Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk
F. Couch, Xian-Shu Wang, L. McGuffog, Andrew Lee +259 more
2013PLoS Genetics411 citations Open access
Semantic Scholar
Identification of twelve new susceptibility loci for different histotypes of epithelial ovarian cancer
C. Phelan, Karoline B. Kuchenbaecker, J. Tyrer, S. Kar +410 more
2017Nature Genetics399 citations Open access
Semantic Scholar
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer
R. Milne, Karoline B. Kuchenbaecker, K. Michailidou, J. Beesley +466 more
2017Nature Genetics379 citations Open access
Semantic Scholar
Lynch syndrome caused by germline PMS2 mutations: delineating the cancer risk.
S. T. ten Broeke, R. Brohet, C. Tops, H. M. van der Klift +22 more
2015Journal of Clinical Oncology194 citations Open access
Semantic Scholar
Cancer Risks for PMS2-Associated Lynch Syndrome.
S. T. ten Broeke, H. M. van der Klift, C. Tops, S. Aretz +45 more
2018Journal of Clinical Oncology187 citations Open access
Semantic Scholar
Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database
P. Møller, T. Seppälä, I. Bernstein, E. Holinski-Feder +34 more
2016Gut149 citations Open access
Semantic Scholar
Association of Type and Location of BRCA1 and BRCA2 Mutations With Risk of Breast and Ovarian Cancer
T. Rebbeck, N. Mitra, F. Wan, O. Sinilnikova +252 more
2015Journal of the American Medical Association (JAMA)147 citations Open access
Semantic Scholar
Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk
M. M. Gaudet, Karoline B. Kuchenbaecker, J. Vijai, R. Klein +122 more
2013PLoS Genetics130 citations Open access
Semantic Scholar
Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers
A. M. Jansen, T. van Wezel, B. E. van den Akker, Marina Ventayol García +9 more
2015European Journal of Human Genetics127 citations Open access
Semantic Scholar
Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer
Fadwa A. Elsayed, C. M. Kets, D. Ruano, B. E. van den Akker +10 more
2014European Journal of Human Genetics127 citations Open access
Semantic Scholar
Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer
Manuel A. R. Ferreira, E. Gamazon, F. Al-Ejeh, K. Aittomäki +308 more
2019Nature Communications116 citations Open access
Semantic Scholar
Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
A. Mulligan, F. Couch, D. Barrowdale, S. Domchek +186 more
2011Breast Cancer Research102 citations Open access
Semantic Scholar
Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers
A. Antoniou, Karoline B. Kuchenbaecker, P. Soucy, J. Beesley +177 more
2012Breast Cancer Research99 citations Open access
Semantic Scholar
Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms.
M. de la Hoya, O. Soukarieh, Irene López-Perolio, A. Vega +71 more
2016Human Molecular Genetics94 citations Open access
Semantic Scholar
Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination with interferon-γ
J. H. Pahl, K. Kwappenberg, E. Varypataki, S. Santos +9 more
2014Journal of experimental & clinical cancer research : CR94 citations Open access
Semantic Scholar
Impact of serotherapy on immune reconstitution and survival outcomes after stem cell transplantations in children: thymoglobulin versus alemtuzumab.
L. Willemsen, C. M. Jol-van der Zijde, R. Admiraal, H. Putter +8 more
2015Biology of Blood and Marrow Transplantation87 citations Open access
Semantic Scholar
Splicing analysis for exonic and intronic mismatch repair gene variants associated with Lynch syndrome confirms high concordance between minigene assays and patient RNA analyses
H. M. van der Klift, A. M. Jansen, Niki van der Steenstraten, E. Bik +3 more
2015Molecular Genetics & Genomic Medicine81 citations Open access
Semantic Scholar
Comprehensive Mutation Analysis of PMS2 in a Large Cohort of Probands Suspected of Lynch Syndrome or Constitutional Mismatch Repair Deficiency Syndrome
H. M. van der Klift, A. Mensenkamp, M. Drost, E. Bik +21 more
2016Human Mutation64 citations Open access
Semantic Scholar
Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers
Karoline B. Kuchenbaecker, S. Neuhausen, M. Robson, D. Barrowdale +206 more
2014Breast Cancer Research63 citations Open access
Semantic Scholar
Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers
F. Couch, M. Gaudet, A. Antoniou, S. Ramus +186 more
2012Cancer Epidemiology, Biomarkers and Prevention63 citations Open access
Semantic Scholar
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
C. Phelan, K. Kuchenbaecker, J. Tyrer, S. Kar +410 more
2017Nature Genetics62 citations Open access
Semantic Scholar
Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report
T. Seppälä, K. Pylvänäinen, D. G. Evans, H. Järvinen +35 more
2017Hereditary Cancer in Clinical Practice58 citations Open access
Semantic Scholar
Insertion of an SVA element, a nonautonomous retrotransposon, in PMS2 intron 7 as a novel cause of lynch syndrome
H. M. van der Klift, C. Tops, F. Hes, P. Devilee +1 more
2012Human Mutation54 citations Open access
Semantic Scholar
MUTYH gene variants and breast cancer in a Dutch case–control study
Astrid A. Out, Marijke Wasielewski, P. Huijts, Ivonne van Minderhout +10 more
2012Breast Cancer Research and Treatment53 citations Open access
Semantic Scholar
Rare variants in XRCC2 as breast cancer susceptibility alleles
F. Hilbers, J. Wijnen, N. Hoogerbrugge, J. Oosterwijk +19 more
2012Journal of Medical Genetics49 citations Open access
Semantic Scholar
Distinct Patterns of Somatic Mosaicism in the APC Gene in Neoplasms From Patients With Unexplained Adenomatous Polyposis.
A. M. Jansen, S. Crobach, W. Geurts-Giele, B. E. van den Akker +9 more
2017Gastroenterology46 citations
Semantic Scholar
Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers
I. Blanco, Karoline B. Kuchenbaecker, D. Cuadras, Xian-Shu Wang +190 more
2015PLoS ONE42 citations Open access
Semantic Scholar
A founder BRCA2 mutation in non‐Afrikaner breast cancer patients of the Western Cape of South Africa
N. C. van der Merwe, N. Hamel, Sue-Rica Schneider, J. Apffelstaedt +2 more
2012Clinical Genetics40 citations
Semantic Scholar
The predictive ability of the 313 variant–based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant
Inge M. M. Lakeman, A. J. van den Broek, J. A. Vos, D. Barnes +210 more
2021Genetics in Medicine37 citations Open access
Semantic Scholar
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
Juliette Coignard, M. Lush, J. Beesley, T. O'Mara +388 more
2021Nature Communications37 citations Open access
Semantic Scholar
Combined analysis of three lynch syndrome cohorts confirms the modifying effects of 8q23.3 and 11q23.1 in MLH1 mutation carriers
Bente A. Talseth-Palmer, J. Wijnen, Ingvild S. Brenne, S. Jagmohan-Changur +15 more
2013International Journal of Cancer34 citations Open access
Semantic Scholar
CHEK2*1100delC homozygosity in the Netherlands—prevalence and risk of breast and lung cancer
P. Huijts, A. Hollestelle, Brunilda Balliu, J. Houwing-Duistermaat +13 more
2013European Journal of Human Genetics33 citations Open access
Semantic Scholar
Hereditary cancer registries improve the care of patients with a genetic predisposition to cancer: contributions from the Dutch Lynch syndrome registry
H. Vasen, M. Velthuizen, J. Kleibeuker, F. Menko +8 more
2016Familial Cancer29 citations Open access
Semantic Scholar
Increased frequency of 20q gain and copy‐neutral loss of heterozygosity in mismatch repair proficient familial colorectal carcinomas
Anneke Middeldorp, R. van Eijk, J. Oosting, G. Forte +8 more
2012International Journal of Cancer29 citations Open access
Semantic Scholar
Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer
M. Timofeeva, B. Kinnersley, S. Farrington, N. Whiffin +57 more
2015Scientific Reports28 citations Open access
Semantic Scholar
Genetic modifiers of cancer risk in Lynch syndrome: a review
Bente A. Talseth-Palmer, J. Wijnen, D. Grice, R. Scott
2013Familial Cancer27 citations Open access
Semantic Scholar
Genetic variant in the telomerase gene modifies cancer risk in Lynch syndrome
Fernando Bellido, E. Guinó, S. Jagmohan-Changur, Núria Seguí +9 more
2012European Journal of Human Genetics27 citations Open access
Semantic Scholar
Evaluation of RAD51C as cancer susceptibility gene in a large breast-ovarian cancer patient population referred for genetic testing
K. De Leeneer, M. V. Van Bockstal, S. de Brouwer, N. Swietek +18 more
2012Breast Cancer Research and Treatment27 citations Open access
Semantic Scholar
Validation and Implementation of BRCA1/2 Variant Screening in Ovarian Tumor Tissue.
M. D. de Jonge, D. Ruano, R. van Eijk, N. van der Stoep +13 more
2018Journal of Molecular Diagnostics26 citations Open access
Semantic Scholar
Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis
R. Tricarico, S. Cortellino, A. Riccio, S. Jagmohan-Changur +21 more
2015OncoTarget26 citations Open access
Semantic Scholar
Colorectal cancer risk variants on 11q23 and 15q13 are associated with unexplained adenomatous polyposis
F. Hes, D. Ruano, M. Nieuwenhuis, C. Tops +15 more
2013Journal of Medical Genetics26 citations Open access
Semantic Scholar
Meta-Analysis of Mismatch Repair Polymorphisms within the Cogent Consortium for Colorectal Cancer Susceptibility
S. Picelli, Justo Lorenzo Bermejo, J. Chang-Claude, M. Hoffmeister +32 more
2013PLoS ONE25 citations Open access
Semantic Scholar
Exome Sequencing of Germline DNA from Non-BRCA1/2 Familial Breast Cancer Cases Selected on the Basis of aCGH Tumor Profiling
F. Hilbers, C. M. Meijers, J. F. Laros, M. V. van Galen +6 more
2013PLoS ONE25 citations Open access
Semantic Scholar
Contribution of bi-allelic germline MUTYH mutations to early-onset and familial colorectal cancer and to low number of adenomatous polyps: case-series and literature review
Alain Knopperts, Maartje Nielsen, R. Niessen, C. Tops +11 more
2012Familial Cancer24 citations Open access
Semantic Scholar
Variants of Uncertain Significance in BRCA1 and BRCA2 assessment of in silico analysis and a proposal for communication in genetic counselling
S. Moghadasi, N. Hofland, Joyce N. Wouts, F. Hogervorst +3 more
2012Journal of Medical Genetics24 citations
Semantic Scholar

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