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A. Doig · SciRah

Researcher profile · Semantic Scholar

A. Doig

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A. Doig — researcher profile on SciRah

h-index: 45
Works: 144
Citations: 12K

Most-cited papers

Drug repurposing: progress, challenges and recommendations
S. Pushpakom, Francesco Iorio, P. Eyers, K. J. Escott +10 more
2018Nature reviews. Drug discovery4,074 citations
Semantic Scholar
Distinguishing enzyme structures from non-enzymes without alignments.
P. Dobson, A. Doig
2003Journal of Molecular Biology778 citations Open access
Semantic Scholar
Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis
P. Nguyen, A. Ramamoorthy, Bikash R. Sahoo, Jie Zheng +30 more
2021Chemical Reviews564 citations Open access
Semantic Scholar
Amyloid β-protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies
Jessica Nasica-Labouze, P. Nguyen, Fabio Sterpone, O. Berthoumieu +20 more
2015Chemical Reviews551 citations Open access
Semantic Scholar
Properties and identification of human protein drug targets
Tala Bakheet, A. Doig
2009Bioinform.300 citations Open access
Semantic Scholar
Inhibition of protein aggregation and amyloid formation by small molecules.
A. Doig, P. Derreumaux
2015Current Opinion in Structural Biology267 citations
Semantic Scholar
Why Is Research on Amyloid-β Failing to Give New Drugs for Alzheimer's Disease?
A. Doig, Maria P. del Castillo-Frias, O. Berthoumieu, B. Tarus +6 more
2017ACS Chemical Neuroscience180 citations Open access
Semantic Scholar
N-Methylated Peptide Inhibitors of β-Amyloid Aggregation and Toxicity. Optimization of the Inhibitor Structure†
Nicoleta Kokkoni, K. Stott, H. Amijee, J. Mason +1 more
2006179 citations
Semantic Scholar
Predicting enzyme class from protein structure without alignments.
P. Dobson, A. Doig
2005Journal of Molecular Biology175 citations Open access
Semantic Scholar
Properties of Protein Drug Target Classes
Simon C. Bull, A. Doig
2015PLoS ONE123 citations Open access
Semantic Scholar
Design strategies for anti-amyloid agents.
J. Mason, Nicoleta Kokkoni, K. Stott, A. Doig
2003Current Opinion in Structural Biology119 citations
Semantic Scholar
Design of an N-Methylated Peptide Inhibitor of α-Synuclein Aggregation Guided by Solid-State NMR
J. Madine, A. Doig, D. Middleton
2008Journal of the American Chemical Society92 citations Open access
Semantic Scholar
Viral Involvement in Alzheimer’s Disease
Ahmad M. Sait, C. Angeli, A. Doig, P. Day
2021ACS Chemical Neuroscience74 citations Open access
Semantic Scholar
Stabilizing interactions between aromatic and basic side chains in alpha-helical peptides and proteins. Tyrosine effects on helix circular dichroism.
C. Andrew, S. Bhattacharjee, Nicoleta Kokkoni, J. Hirst +2 more
2002Journal of the American Chemical Society71 citations
Semantic Scholar
Inhibitors of protein aggregation and toxicity.
H. Amijee, J. Madine, D. Middleton, A. Doig
2009Biochemical Society Transactions67 citations
Semantic Scholar
A phosphoserine-lysine salt bridge within an alpha-helical peptide, the strongest alpha-helix side-chain interaction measured to date.
N. Errington, A. Doig
2005Biochemistry64 citations
Semantic Scholar
The N-methylated peptide SEN304 powerfully inhibits Aβ(1-42) toxicity by perturbing oligomer formation.
H. Amijee, C. Bate, Alun Williams, J. Virdee +8 more
2012Biochemistry61 citations Open access
Semantic Scholar
Properties and identification of antibiotic drug targets
Tala Bakheet, A. Doig
2010BMC Bioinformatics55 citations Open access
Semantic Scholar
A study of the regional effects of alpha-synuclein on the organization and stability of phospholipid bilayers.
J. Madine, A. Doig, D. Middleton
2006Biochemistry54 citations
Semantic Scholar
Prediction of Saccharomyces cerevisiae protein functional class from functional domain composition
Yu-Dong Cai, A. Doig
2004Bioinform.53 citations
Semantic Scholar
N-methylated peptide inhibitors of β-amyloid aggregation and toxicity
A. Doig, J. Mark Treherne, D. Scopes, K. Stott +2 more
200752 citations
Semantic Scholar
Prediction of protein function in the absence of significant sequence similarity.
P. Dobson, Yu-Dong Cai, B. Stapley, A. Doig
2004Current Medicinal Chemistry52 citations
Semantic Scholar
Raman Spectroscopy to Monitor Post-Translational Modifications and Degradation in Monoclonal Antibody Therapeutics
B. McAvan, L. Bowsher, Thomas Powell, J. O'Hara +3 more
2020Analytical Chemistry51 citations Open access
Semantic Scholar
Accurate determination of protein secondary structure content from Raman and Raman optical activity spectra.
Myra Kinalwa, E. Blanch, A. Doig
2010Analytical Chemistry50 citations
Semantic Scholar
Secondary Structure and Glycosylation of Mucus Glycoproteins by Raman Spectroscopies
Heather S. Davies, Prabha Singh, Tanja Deckert-Gaudig, V. Deckert +7 more
2016Analytical Chemistry48 citations Open access
Semantic Scholar
Local control of a disorder–order transition in 4E-BP1 underpins regulation of translation via eIF4E
S. Tait, K. Dutta, D. Cowburn, J. Warwicker +2 more
2010Proceedings of the National Academy of Sciences of the United States of America45 citations Open access
Semantic Scholar
The CXXC motif at the N terminus of an α‐helical peptide
T. Iqbalsyah, Efrosini Moutevelis, J. Warwicker, N. Errington +1 more
200643 citations Open access
Semantic Scholar
Determination of Protein Secondary Structure from Infrared Spectra Using Partial Least-Squares Regression.
Kieaibi E Wilcox, E. Blanch, A. Doig
2016Biochemistry41 citations Open access
Semantic Scholar
Positive Feedback Loops in Alzheimer’s Disease: The Alzheimer’s Feedback Hypothesis
A. Doig
2018Journal of Alzheimer's Disease38 citations Open access
Semantic Scholar
A Phosphoserine–Lysine Salt Bridge within an α-Helical Peptide, the Strongest α-Helix Side-Chain Interaction Measured to Date
T. Iqbalsyah, A. Doig
2005Biochemistry37 citations
Semantic Scholar
Length preferences and periodicity in β‐strands. Antiparallel edge β‐sheets are more likely to finish in non‐hydrogen bonded rings
S. Penel, R. Morrison, P. Dobson, R. Mortishire-Smith +1 more
200336 citations
Semantic Scholar
Frozen, but no accident – why the 20 standard amino acids were selected
A. Doig
2017The FEBS Journal35 citations Open access
Semantic Scholar
Peptide inhibitors of beta-amyloid aggregation.
A. Doig
2007Current opinion in drug discovery & development28 citations
Semantic Scholar
Molecular structure of the NQTrp inhibitor with the Alzheimer Aβ1-28 monomer.
B. Tarus, P. Nguyen, O. Berthoumieu, P. Faller +2 more
2015European journal of medicinal chemistry27 citations
Semantic Scholar
SitesIdentify: a protein functional site prediction tool
T. Bray, Pedro Chan, S. Bougouffa, Richard B. Greaves +2 more
2009BMC Bioinformatics26 citations Open access
Semantic Scholar
Quantification of protein glycation using vibrational spectroscopy.
B. McAvan, Aidan P. France, Bruno Bellina, P. Barran +2 more
2020In Analysis25 citations Open access
Semantic Scholar
The effects of α-synuclein on phospholipid vesicle integrity: a study using 31P NMR and electron microscopy
J. Madine, E. Hughes, A. Doig, D. Middleton
2008Molecular membrane biology23 citations Open access
Semantic Scholar
Effect of the N3 residue on the stability of the α‐helix
T. Iqbalsyah, A. Doig
200423 citations Open access
Semantic Scholar
Inhibition of toxicity and protofibril formation in the amyloid-β peptide β(25–35) using N-Methylated derivatives
A. Doig, E. Hughes, R. Burke, T. Su +2 more
200223 citations
Semantic Scholar
Properties of genes essential for mouse development
M. Kabir, A. Barradas, G. Tzotzos, Kathryn E. Hentges +1 more
2017PLoS ONE22 citations Open access
Semantic Scholar
Identifying mouse developmental essential genes using machine learning
David Tian, S. Wenlock, M. Kabir, G. Tzotzos +2 more
2018Disease Models & Mechanisms21 citations Open access
Semantic Scholar
Sequence and structural features of enzymes and their active sites by EC class.
T. Bray, A. Doig, J. Warwicker
2009Journal of Molecular Biology21 citations
Semantic Scholar
Cellular kinetics of murine lung: model system to determine basis for radioprotection with keratinocyte growth factor.
N. Terry, J. Brinkley, A. Doig, Jun Ma +4 more
2004International Journal of Radiation Oncology, Biology, Physics21 citations
Semantic Scholar
Improved prediction for N‐termini of α‐helices using empirical information
Claire L. Wilson, Paul E. Boardman, A. Doig, S. Hubbard
200419 citations
Semantic Scholar
Structure and stability of the alpha-helix: lessons for design.
N. Errington, T. Iqbalsyah, A. Doig
2006Methods in molecular biology18 citations
Semantic Scholar
Combined experimental and simulation studies suggest a revised mode of action of the anti-Alzheimer disease drug NQ-Trp.
O. Berthoumieu, P. Nguyen, Maria P. del Castillo-Frias, Sabrina Ferré +8 more
2015Chemistry17 citations
Semantic Scholar
Maximising the Size of Non-Redundant Protein Datasets Using Graph Theory
Simon C. Bull, Mark R. Muldoon, A. Doig
2013PLoS ONE16 citations Open access
Semantic Scholar
Determination of protein fold class from Raman or Raman optical activity spectra using random forests
Myra Kinalwa, E. Blanch, A. Doig
2011Protein Science16 citations Open access
Semantic Scholar
Random-coil:α-helix equilibria as a reporter for the Lewis(X)-Lewis(X) interaction.
T. Altamore, C. Fernández-García, Andrew H. Gordon, Tina Hübscher +5 more
2011Angewandte Chemie15 citations
Semantic Scholar
Determination of α‐helix N1 energies after addition of N1, N2, and N3 preferences to helix/coil theory
Jia-Ke Sun, S. Penel, A. Doig
2008Protein Science15 citations Open access
Semantic Scholar

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