K. Fitzgerald

Most-cited papers

Long non-coding RNAs: definitions, functions, challenges and recommendations
J. Mattick, Paulo P. Amaral, Piero Carninci, S. Carpenter +25 more
2023Nature reviews. Molecular cell biology1,985 citations Open access
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Toll-like Receptors and the control of immunity
K. Fitzgerald, J. Kagan
2020Cell1,910 citations Open access
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DNA sensing by the cGAS–STING pathway in health and disease
M. Motwani, Scott Pesiridis, K. Fitzgerald
2019Nature reviews genetics1,328 citations
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Pathogen blockade of TAK1 triggers caspase-8 dependent cleavage of Gasdermin D and cell death
Pontus Orning, D. Weng, K. Starheim, D. Ratner +14 more
2018Science922 citations Open access
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Succination inactivates gasdermin D and blocks pyroptosis
F. Humphries, Liraz Shmuel-Galia, Natália Ketelut-Carneiro, Sheng Li +13 more
2020Science623 citations Open access
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Apoptosis, Pyroptosis, and Necroptosis-Oh My! The Many Ways a Cell Can Die.
Natália Ketelut-Carneiro, K. Fitzgerald
2021Journal of Molecular Biology362 citations
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HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation
V. Magupalli, R. Negro, Yuzi Tian, Arthur V. Hauenstein +15 more
2020Science345 citations Open access
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Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling
A. Hansen, G. Buchan, Michael Rühl, Kojiro Mukai +25 more
2018Proceedings of the National Academy of Sciences of the United States of America293 citations Open access
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Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
D. Olagnier, Aske M. Brandtoft, Camilla Gunderstofte, Nikolaj L. Villadsen +30 more
2018Nature Communications274 citations Open access
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Gasdermins and their role in immunity and inflammation
Pontus Orning, E. Lien, K. Fitzgerald
2019Journal of Experimental Medicine262 citations Open access
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Gasdermin D restrains type I interferon response to cytosolic DNA by disrupting ionic homeostasis
Ishita Banerjee, Bharat Behl, Morena Mendonça, G. Shrivastava +8 more
2018Immunity238 citations Open access
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Inflammasomes.
Natália Ketelut-Carneiro, K. Fitzgerald
2020Current Biology215 citations Open access
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cGAS drives non-canonical inflammasome activation in age-related macular degeneration
N. Kerur, S. Fukuda, Daipayan Banerjee, Young-hee Kim +34 more
2017Nature Medicine214 citations Open access
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Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis
Joseph Sarhan, Bei-Yun C. Liu, Hayley I. Muendlein, C. Weindel +7 more
2018Cell Death and Differentiation169 citations Open access
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Overcoming innate immune barriers that impede AAV gene therapy vectors.
Manish Muhuri, Y. Maeda, Hong Ma, S. Ram +3 more
2021Journal of Clinical Investigation167 citations Open access
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A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection
F. Humphries, Liraz Shmuel-Galia, Zhao-Zhao Jiang, R. Wilson +10 more
2021Science immunology145 citations Open access
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STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression
J. Balic, H. Albargy, Kevin Luu, Francis J Kirby +11 more
2020Nature Communications145 citations Open access
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Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells
Liraz Shmuel-Galia, F. Humphries, Xuqiu Lei, Simona Ceglia +13 more
2021Immunity140 citations Open access
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Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM.
Michael Carty, J. Kearney, Katharine A. Shanahan, E. Hams +9 more
2019Immunity136 citations Open access
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Hierarchy of clinical manifestations in SAVI N153S and V154M mouse models
M. Motwani, Sudesh Pawaria, Jennifer Bernier, S. Moses +5 more
2019Proceedings of the National Academy of Sciences of the United States of America133 citations Open access
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Cutting Edge: Plasmodium falciparum Induces Trained Innate Immunity
Jacob E. Schrum, J. Crabtree, K. Dobbs, Michael C. Kiritsy +7 more
2018Journal of Immunology126 citations Open access
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HiChIRP reveals RNA-associated chromosome conformation
Maxwell R. Mumbach, Jeffrey M. Granja, Ryan A. Flynn, Caitlin M. Roake +15 more
2019Nature Methods87 citations Open access
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Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3‐Driven Inflammation and Gouty Arthritis
Gabsik Yang, H. Lee, Su-Jin Moon, K. M. Ko +9 more
2020Arthritis & Rheumatology85 citations
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Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2
R. Elling, E. K. Robinson, Barbara Shapleigh, S. C. Liapis +14 more
2018Cell Reports83 citations Open access
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Targeting STING oligomerization with small-molecule inhibitors
F. Humphries, Liraz Shmuel-Galia, Zhao-Zhao Jiang, Jeffrey Y Zhou +9 more
2023Proceedings of the National Academy of Sciences of the United States of America81 citations Open access
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The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans
S. Agarwal, T. Vierbuchen, Sreya Ghosh, Jennie Chan +4 more
2020Nature Communications77 citations Open access
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A mitochondrial micropeptide is required for activation of the Nlrp3 Inflammasome
A. Bhatta, M. Atianand, Zhao-Zhao Jiang, J. Crabtree +2 more
2019Journal of Immunology75 citations Open access
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Cytokines and Long Noncoding RNAs.
S. Carpenter, K. Fitzgerald
2018Cold Spring Harbor Perspectives in Biology68 citations Open access
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AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma
K. Fukuda, Ken Okamura, R. Riding, Xueli Fan +11 more
2021Journal of Experimental Medicine66 citations Open access
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cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE
M. Motwani, J. McGowan, Jennifer Antonovitch, K. M. Gao +6 more
2021Frontiers in Immunology62 citations Open access
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Fas ligand promotes an inducible TLR‐dependent model of cutaneous lupus‐like inflammation
P. Mande, Bahar Zirak, Wei-Che Ko, Keyon Taravati +10 more
2018Journal of Clinical Investigation53 citations Open access
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Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2
S. Mondal, Yong-Zhi Chen, G. J. Lockbaum, Sudeshna Sen +10 more
2022Journal of the American Chemical Society52 citations Open access
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Activation of Stimulator of Interferon Genes (STING) and Sjögren Syndrome
Joanna Papinska, H. Bagavant, G. Gmyrek, Magdalena Sroka +3 more
2018Journal of dentistry research50 citations Open access
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MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection
Xuqiu Lei, Yong-Zhi Chen, E. Lien, K. Fitzgerald
2023mBio49 citations Open access
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miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN)
Parisa Kalantari, O. Harandi, Sarika Agarwal, Florentina Rus +4 more
2017Journal of Biological Chemistry48 citations Open access
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The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2
T. Vierbuchen, S. Agarwal, John L. Johnson, Liraz Galia +11 more
2022Proceedings of the National Academy of Sciences of the United States of America46 citations Open access
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Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection
V. Hariharan, Min-Kyu Shin, Ching-Wen Chang, D. O'reilly +42 more
2023Proceedings of the National Academy of Sciences of the United States of America44 citations Open access
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Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7
Lili Gu, David Casserly, G. Brady, S. Carpenter +4 more
2022Nature Communications44 citations Open access
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CNBP controls IL-12 gene transcription and Th1 immunity
Yong-Zhi Chen, Shruti Sharma, P. A. Assis, Zhao-Zhao Jiang +9 more
2018Journal of Experimental Medicine44 citations Open access
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Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly(dA:dT)
Jeffrey Y Zhou, M. Sarkar, Ken Okamura, J. Harris +2 more
2023Proceedings of the National Academy of Sciences of the United States of America39 citations Open access
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STING-dependent interferon signatures restrict osteoclast differentiation and bone loss in mice
Susan MacLauchlan, P. Kushwaha, A. Tai, Jia Chen +6 more
2023Proceedings of the National Academy of Sciences of the United States of America38 citations Open access
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Long non-coding RNAs in antiviral immunity.
T. Vierbuchen, K. Fitzgerald
2020Seminars in Cell and Developmental Biology38 citations
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Radioresistant cells initiate lymphocyte-dependent lung inflammation and IFNγ-dependent mortality in STING gain-of-function mice
K. M. Gao, M. Motwani, T. Tedder, A. Marshak-Rothstein +1 more
2022Proceedings of the National Academy of Sciences of the United States of America34 citations Open access
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Lymphocyte crosstalk is required for monocyte-intrinsic trained immunity to Plasmodium falciparum
J. Crabtree, D. Caffrey, Leandro Honorato de Souza Silva, E. Kurt-Jones +4 more
2022Journal of Clinical Investigation31 citations Open access
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A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation
Michael C. Kiritsy, Laurisa M. Ankley, Justin D. Trombley, Gabrielle P. Huizinga +5 more
2021eLife31 citations Open access
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Dendritic cell RIPK1 maintains immune homeostasis by preventing inflammation and autoimmunity
Joanne A. O’Donnell, J. Lehman, J. Roderick, D. Martinez-Marin +8 more
2017Journal of Immunology31 citations Open access
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Cellular nucleic acid–binding protein is essential for type I interferon–mediated immunity to RNA virus infection
Yong-Zhi Chen, Xuqiu Lei, Zhao-Zhao Jiang, K. Fitzgerald
2021Proceedings of the National Academy of Sciences of the United States of America30 citations Open access
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Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection
Federica Agliano, K. Fitzgerald, A. Vella, Vijay A. K. Rathinam +1 more
2020Frontiers in Cellular and Infection Microbiology27 citations Open access
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The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis.
Liraz Shmuel-Galia, F. Humphries, T. Vierbuchen, Zhao-Zhao Jiang +13 more
2023Cell Metabolism26 citations Open access
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Epithelial HNF4A shapes the intraepithelial lymphocyte compartment via direct regulation of immune signaling molecules
Xuqiu Lei, Natália Ketelut-Carneiro, Liraz Shmuel-Galia, Weili Xu +8 more
2022Journal of Experimental Medicine26 citations Open access
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