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T. Higashimoto · SciRah

Researcher profile · Semantic Scholar

T. Higashimoto

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T. Higashimoto — researcher profile on SciRah

h-index: 14
Works: 36
Citations: 882

Most-cited papers

Mitochondrial DNA control region sequence variation in migraine headache and cyclic vomiting syndrome
Qingxue Wang, Masamichi Ito, K. Adams, B.-U.-K. Li +5 more
2004American Journal of Medical Genetics. Part A113 citations
Semantic Scholar
A novel human gamma-globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction.
A. Perumbeti, T. Higashimoto, F. Urbinati, R. Franco +3 more
2009Blood110 citations Open access
Semantic Scholar
The woodchuck hepatitis virus post-transcriptional regulatory element reduces readthrough transcription from retroviral vectors
T. Higashimoto, F. Urbinati, A. Perumbeti, G. Jiang +4 more
2007Gene Therapy103 citations Open access
Semantic Scholar
High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension.
Nambirajan Sundaram, A. Tailor, Laurel G Mendelsohn, J. Wansapura +8 more
2010Blood87 citations Open access
Semantic Scholar
Mechanism of reduction in titers from lentivirus vectors carrying large inserts in the 3'LTR.
F. Urbinati, P. Arumugam, T. Higashimoto, A. Perumbeti +3 more
2009Molecular Therapy75 citations Open access
Semantic Scholar
Genotoxic potential of lineage-specific lentivirus vectors carrying the beta-globin locus control region.
P. Arumugam, T. Higashimoto, F. Urbinati, U. Modlich +6 more
2009Molecular Therapy73 citations Open access
Semantic Scholar
The 3′ Region of the Chicken Hypersensitive Site-4 Insulator Has Properties Similar to Its Core and Is Required for Full Insulator Activity
P. Arumugam, F. Urbinati, C. S. Velu, T. Higashimoto +2 more
2009PLoS ONE71 citations Open access
Semantic Scholar
Regulation of IκB Kinase (IKK) Complex by IKKγ-dependent Phosphorylation of the T-loop and C Terminus of IKKβ*
Beth Schomer-Miller, T. Higashimoto, Yung-Kang Lee, E. Zandi
2006Journal of Biological Chemistry46 citations Open access
Semantic Scholar
Scale-up and manufacturing of clinical-grade self-inactivating γ-retroviral vectors by transient transfection
J. V. D. van der Loo, WP Swaney, E. Grassman, A. Terwilliger +8 more
2011Gene Therapy38 citations Open access
Semantic Scholar
TNFalpha induces chromosomal abnormalities independent of ROS through IKK, JNK, p38 and caspase pathways.
T. Higashimoto, A. Panopoulos, Chih-Lin Hsieh, E. Zandi
2006Cytokine26 citations
Semantic Scholar
High‐dose hydroxocobalamin achieves biochemical correction and improvement of neuropsychiatric deficits in adults with late onset cobalamin C deficiency
T. Higashimoto, Alexander Y. Kim, Jessica T. Ogawa, J. Sloan +6 more
2019JIMD Reports24 citations Open access
Semantic Scholar
Regulation of IkappaB kinase (IKK) complex by IKKgamma-dependent phosphorylation of the T-loop and C terminus of IKKbeta.
Beth Schomer-Miller, T. Higashimoto, Yung-Kang Lee, E. Zandi
2006Journal of Biological Chemistry24 citations
Semantic Scholar
Regulation of IκB Kinase Complex by Phosphorylation of γ-Binding Domain of IκB Kinase β by Polo-like Kinase 1*
T. Higashimoto, N. Chan, Yung-Kang Lee, E. Zandi
2008Journal of Biological Chemistry19 citations Open access
Semantic Scholar
Oncogenic N-Ras and Tet2 haploinsufficiency collaborate to dysregulate hematopoietic stem and progenitor cells.
Xi Jin, Tingting Qin, Meiling Zhao, N. Bailey +8 more
2018Blood Advances17 citations Open access
Semantic Scholar
Genotoxic Potential of Lineage-specific Lentivirus Vectors Carrying the β-Globin Locus Control Region.
P. Arumugam, T. Higashimoto, F. Urbinati, U. Modlich +6 more
2009Molecular Therapy14 citations Open access
Semantic Scholar
Critical Variables affecting clinical-grade production of the self-inactivating gamma-retroviral vector for the treatment of X-linked severe combined immunodeficiency
J. V. D. van der Loo, WP Swaney, E. Grassman, A. Terwilliger +9 more
2012Gene Therapy12 citations Open access
Semantic Scholar
Rapid detection of FGFR mutations in syndromic craniosynostosis by temporal temperature gradient gel electrophoresis.
T. Higashimoto, S. Yano, Masamichi Ito, Noreen C. Clark-Sheehan +2 more
1999Clinical Chemistry6 citations
Semantic Scholar
Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation
Xi Jin, V. Ng, Meiling Zhao, Lu Liu +8 more
2022Disease Models & Mechanisms5 citations Open access
Semantic Scholar
Maple syrup urine disease decompensation misdiagnosed as a psychotic event
T. Higashimoto, M. Whitehead, E. Macleod, D. Starin +1 more
2022Molecular Genetics and Metabolism Reports5 citations Open access
Semantic Scholar
A method for overcoming plasma protein inhibition of tyrosine kinase inhibitors
David J. Young, Bao Nguyen, Li Li, T. Higashimoto +3 more
2021Cancer Discovery5 citations Open access
Semantic Scholar
Case report of bilateral ovarian fibromas associated with de novo germline variants in PTCH1 and SMARCA4
T. Higashimoto, Christy H Smith, M. Hopkins, John Gross +4 more
2022Molecular Genetics & Genomic Medicine4 citations Open access
Semantic Scholar
Brief report High levels of placenta growth factor in sickle cell disease promote pulmonary
Nambirajan Sundaram, A. Tailor, Laurel G Mendelsohn, J. Wansapura +8 more
20101 citations
Semantic Scholar
Lentivirus vectors for gene therapy for hemoglobinopathies
P. Arumugam, F. Urbinati, T. Higashimoto, A. Perumbeti +1 more
20081 citations
Semantic Scholar
Pulmozyme® Treatment of Vectors Produced by Transient Transfection Reduces Residual Plasmid DNA on Human CD34+ Hematopoietic Progenitor Cells without Loss of Transduction or Engraftment Efficiency
Elke Grassman, T. Higashimoto, J. Rohrbach, D. Hall +3 more
20081 citations
Semantic Scholar
Mechanism of Reduction in Titers from Lentivirus Vectors Carrying Chromatin Insulator Elements in the 3′ LTR
F. Urbinati, P. Arumugam, T. Higashimoto, A. Perumbeti +2 more
20081 citations
Semantic Scholar
Mechanism of Human Hematopoietic Stem Cell Loss during Ex Vivo Manipulation and Gene Transfer
A. Shrestha, T. Higashimoto, Sydney Felker, Anastacia Loberg +6 more
2018Experimental Hematology0 citations Open access
Semantic Scholar
A Novel Combination of Chicken Hypersensitive Site-4 Insulator Elements Improves Titers and Restores Full Insulator Activity.
P. Arumugam, F. Urbinati, C. S. Velu, T. Higashimoto +2 more
20090 citations
Semantic Scholar
mitochondrial disease and maternal inheritance pain syndrome type I in children with Reflex sympathetic dystrophy: complex regional
T. Higashimoto, Erin E. Baldwin, Jeffrey I. Gold, R. Boles
20080 citations
Semantic Scholar
Correction of Sickle Cell Anemia with γ-Globin Gene Delivered by Lentivirus Vector in the Setting of Myeloablative or Reduced Intensity Conditioning, and Establishing Critical Determinants for Successful Gene Therapy for Sickle Cell Disease.
A. Perumbeti, T. Higashimoto, F. Urbinati, Kristy Lauderback +7 more
20080 citations
Semantic Scholar
Mechanism of Reduction in Titers with Vectors Flanked by Chromatin Insulator Elements
F. Urbinati, P. Arumugam, T. Higashimoto, Ping Xia +1 more
20070 citations
Semantic Scholar
Dissertations
T. Higashimoto
20070 citations
Semantic Scholar
Novel Furanocoumarin Inhibitors of CYP 3 A 4 and PGp
T. Higashimoto
20070 citations
Semantic Scholar
Regulation of IKK complex by IKKγ-dependent Phosphorylation of the T-loop and C-terminus of IKKβ
B. Miller, T. Higashimoto, Yung-Kang Lee, E. Zandi
20060 citations
Semantic Scholar
Complex regional pain syndrome and maternal inheritance
T. Higashimoto, R. Boles
20060 citations
Semantic Scholar
Rapid Detection of FGFR Mutations in Syndromic Cra- niosynostosis by Temporal Temperature Gradient Gel
T. Higashimoto, S. Yano, Masamichi Ito, Noreen C. Clark-Sheehan +2 more
20050 citations
Semantic Scholar
[Differential diagnosis of schizophrenic symptoms complicated with brain anomalies including bilateral temporal arachnoid cysts by eye mark recorder and PET: a case study].
H. Shiraishi, K. Ishii, S. Takahashi, K. Shoda +4 more
1999Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica0 citations
Semantic Scholar

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