Wen Y. Wu

Most-cited papers

1. Multiplex gene editing by CRISPR-Cpf1 through autonomous processing of a single crRNA array

   Bernd Zetsche, Matthias Heidenreich, Prarthana Mohanraju, I. Fedorova +11 more

   2016Nature Biotechnology691 citations Open access

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2. Erratum: Multiplex gene editing by CRISPR–Cpf1 using a single crRNA array

   Bernd Zetsche, Matthias Heidenreich, Prarthana Mohanraju, I. Fedorova +11 more

   2017Nature Biotechnology173 citations Open access

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3. Genome editing by natural and engineered CRISPR-associated nucleases

   Wen Y. Wu, J. Lebbink, R. Kanaar, N. Geijsen +1 more

   2018Nature Chemical Biology104 citations Open access

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4. Cryo-EM structure of the transposon-associated TnpB enzyme

   R. Nakagawa, H. Hirano, Satoshi N. Omura, Suchita P. Nety +18 more

   2023Nature99 citations Open access

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5. Good guide, bad guide: spacer sequence-dependent cleavage efficiency of Cas12a

   Sjoerd C. A. Creutzburg, Wen Y. Wu, Prarthana Mohanraju, Thomas Swartjes +4 more

   2020Nucleic Acids Research98 citations Open access

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6. The miniature CRISPR-Cas12m effector binds DNA to block transcription.

   Wen Y. Wu, Prarthana Mohanraju, Chunyu Liao, Belén Adiego-Pérez +15 more

   2022Molecules and Cells96 citations Open access

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7. Biology and applications of CRISPR–Cas12 and transposon-associated homologs

   Wen Y. Wu, Belén Adiego-Pérez, J. van der Oost

   2024Nature Biotechnology51 citations Open access

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8. Mechanistic and evolutionary insights into a type V-M CRISPR–Cas effector enzyme

   Satoshi N. Omura, R. Nakagawa, C. Sudfeld, Ricardo Villegas Warren +9 more

   2023Nature Structural & Molecular Biology29 citations Open access

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9. Live-cell imaging reveals the trade-off between target search flexibility and efficiency for Cas9 and Cas12a

   Lorenzo Olivi, Cleo Bagchus, Victor D. Pool, Ezra T. Bekkering +7 more

   2023bioRxiv14 citations Open access

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10. Adaptation by Type V-A and V-B CRISPR-Cas Systems Demonstrates Conserved Protospacer Selection Mechanisms Between Diverse CRISPR-Cas Types

    Wen Y. Wu, S. Jackson, C. Almendros, Anna C. Haagsma +5 more

    2022The CRISPR Journal4 citations Open access

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11. TldR: TnpB's evolutionary shift from transposon nucleases to RNA-guided transcriptional regulators.

    Prarthana Mohanraju, Wen Y. Wu

    2024Trends in Microbiology2 citations Open access

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12. Size and sequence variation of the Lid of the Cas12a nuclease domain results in a nickase phenotype

    Ricardo Villegas Warren, Satoshi N. Omura, Diana León-Castro, C. Sudfeld +11 more

    2026Nucleic Acids Research0 citations Open access

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13. Along for the ride: prophage-induced flagellar remodelling.

    Victor D. Pool, Wen Y. Wu

    2026Trends in Microbiology0 citations

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14. Base editing both DNA strands in distinct editing windows with small CRISPR-associated effector Cas12f1

    Thomas Swartjes, Evgenios Bouzetos, Belén Adiego-Pérez, Victor D. Pool +3 more

    2025iScience0 citations Open access

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15. The Miniature CRISPR-Cas12m Effector Binds DNA To Block Transcription

    Wen Y. Wu, Prarthana Mohanraju, Chunyu Liao, Belén Adiego-Pérez +15 more

    2021Social Science Research Network0 citations Open access

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