P. Unrau

Most-cited papers

RNA-Catalyzed RNA Polymerization: Accurate and General RNA-Templated Primer Extension
Wendy K. Johnston, P. Unrau, Michael S. Lawrence, M. E. Glasner +1 more
2001Science686 citations
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RNA mango aptamer-fluorophore: a bright, high-affinity complex for RNA labeling and tracking.
E. Dolgosheina, Sunny C. Y. Jeng, S. S. Panchapakesan, R. Cojocaru +5 more
2014ACS Chemical Biology398 citations
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Comparative analysis of the small RNA transcriptomes of Pinus contorta and Oryza sativa.
Ryan D. Morin, Gozde Aksay, E. Dolgosheina, H. Ebhardt +4 more
2008Genome Research309 citations Open access
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RNA-catalysed nucleotide synthesis
P. Unrau, D. Bartel
1998Nature272 citations
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Fluorogenic RNA Mango aptamers for imaging small non-coding RNAs in mammalian cells
Alexis Autour, Sunny C. Y. Jeng, A. Cawte, A. Abdolahzadeh +5 more
2018Nature Communications246 citations Open access
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Selection of an improved RNA polymerase ribozyme with superior extension and fidelity.
Hani S. Zaher, P. Unrau
2007RNA: A publication of the RNA Society186 citations Open access
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Extensive 3' modification of plant small RNAs is modulated by helper component-proteinase expression.
H. Ebhardt, Emily P. Thi, Ming‐Bo Wang, P. Unrau
2005Proceedings of the National Academy of Sciences of the United States of America163 citations Open access
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Small RNAs derived from tRNAs and rRNAs are highly enriched in exosomes from both old and new world Leishmania providing evidence for conserved exosomal RNA Packaging
U. Lambertz, Mariana E. Oviedo Ovando, Elton J R Vasconcelos, P. Unrau +2 more
2015BMC Genomics147 citations Open access
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Constructing an RNA world.
D. Bartel, P. Unrau
1999Trends in Cell Biology144 citations
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Live cell imaging of single RNA molecules with fluorogenic Mango II arrays
A. Cawte, P. Unrau, D. Rueda
2019Nature Communications140 citations Open access
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Structural basis for high-affinity fluorophore binding and activation by RNA Mango
R. Trachman, N. Demeshkina, M. Lau, S. S. Panchapakesan +3 more
2017Nature Chemical Biology133 citations Open access
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Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma
S. Arthur, A. Jiang, B. Grande, M. Alcaide +32 more
2018Nature Communications129 citations Open access
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Structure and functional reselection of the Mango-III fluorogenic RNA aptamer
Robert J. Iii Trachman, Alexis Autour, Sunny C. Y. Jeng, A. Abdolahzadeh +8 more
2019Nature Chemical Biology124 citations Open access
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Conifers have a unique small RNA silencing signature.
E. Dolgosheina, Ryan D. Morin, Gozde Aksay, S. Sahinalp +4 more
2008RNA: A publication of the RNA Society110 citations Open access
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Crystal structures of the Mango-II RNA aptamer reveal heterogeneous fluorophore binding and guide engineering of variants with improved selectivity and brightness.
R. Trachman, A. Abdolahzadeh, A. Andreoni, R. Cojocaru +4 more
2018Biochemistry65 citations Open access
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Fluorophore ligand binding and complex stabilization of the RNA Mango and RNA Spinach aptamers
Sunny C. Y. Jeng, Hedy Chan, E. Booy, Sean A. McKenna +1 more
2016RNA: A publication of the RNA Society64 citations Open access
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Isolation of fast purine nucleotide synthase ribozymes.
M. Lau, Kelly E. C. Cadieux, P. Unrau
2004Journal of the American Chemical Society58 citations
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Processive RNA polymerization and promoter recognition in an RNA World
R. Cojocaru, P. Unrau
2021Science56 citations
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Closing the circle: replicating RNA with RNA.
Leslie K L Cheng, P. Unrau
2010Cold Spring Harbor Perspectives in Biology53 citations Open access
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RNA Synthesis by in Vitro Selected Ribozymes for Recreating an RNA World
Lyssa L. Martin, P. Unrau, U. F. Müller
2015Life47 citations Open access
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Harmonizing the growing fluorogenic RNA aptamer toolbox for RNA detection and imaging.
Xiao-Cen Lu, Kristen Y S Kong, P. Unrau
2023Chemical Society Reviews41 citations
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Fluorophore‐binding RNA aptamers and their applications
E. Dolgosheina, P. Unrau
2016Wiley Interdisciplinary Reviews - RNA41 citations
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A promiscuous ribozyme promotes nucleotide synthesis in addition to ribose chemistry.
M. Lau, P. Unrau
2009Chemistry and Biology39 citations Open access
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RNA detection with high specificity and sensitivity using nested fluorogenic Mango NASBA
A. Abdolahzadeh, E. Dolgosheina, P. Unrau
2019RNA: A publication of the RNA Society38 citations Open access
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High-throughput detection of RNA processing in bacteria
Erin E. Gill, Luisa S. Chan, Geoffrey L. Winsor, Neil Dobson +9 more
2016BMC Genomics37 citations Open access
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T7 RNA polymerase mediates fast promoter-independent extension of unstable nucleic acid complexes.
Hani S. Zaher, P. Unrau
2004Biochemistry37 citations
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E. coli 6S RNA release from RNA polymerase requires σ70 ejection by scrunching and is orchestrated by a conserved RNA hairpin.
S. S. Panchapakesan, P. Unrau
2012RNA: A publication of the RNA Society35 citations Open access
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Combinatorial minimization and secondary structure determination of a nucleotide synthase ribozyme.
K. Chapple, D. Bartel, P. Unrau
2003RNA: A publication of the RNA Society35 citations Open access
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Ribonucleoprotein purification and characterization using RNA Mango
S. S. Panchapakesan, Matthew L. Ferguson, Eric J. Hayden, Xin Chen +2 more
2017RNA: A publication of the RNA Society32 citations Open access
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Faculty of 1000 evaluation for The challenges and scope of theoretical biology.
P. Unrau
201132 citations
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Ribozyme motif structure mapped using random recombination and selection.
Qing S Wang, P. Unrau
2005RNA: A publication of the RNA Society30 citations Open access
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An oxocarbenium-ion intermediate of a ribozyme reaction indicated by kinetic isotope effects
P. Unrau, D. Bartel
2003Proceedings of the National Academy of Sciences of the United States of America30 citations Open access
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Structure-guided engineering of the homodimeric Mango-IV fluorescence turn-on aptamer yields an RNA FRET pair
R. Trachman, R. Cojocaru, Di Wu, G. Piszczek +3 more
2020Structure29 citations Open access
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Fluorogenic aptamers resolve the flexibility of RNA junctions using orientation-dependent FRET
Sunny Jeng, R. Trachman, Florian P. Weissenboeck, L. Truong +6 more
2020RNA: A publication of the RNA Society26 citations Open access
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Binding and release of the 6S transcriptional control RNA.
Lindsay Shephard, Neil Dobson, P. Unrau
2010RNA: A publication of the RNA Society24 citations Open access
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Characterization of the B6.61 polymerase ribozyme accessory domain.
Qing S Wang, Leslie K L Cheng, P. Unrau
2011RNA: A publication of the RNA Society23 citations Open access
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RNA Peach and Mango: orthogonal two-color fluorogenic aptamers distinguish nearly identical ligands
Kristen Y S Kong, Sunny C. Y. Jeng, Batool Rayyan, P. Unrau
2021RNA: A publication of the RNA Society22 citations Open access
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Recombination During In Vitro Evolution
N. Lehman, P. Unrau
2005Journal of Molecular Evolution21 citations
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Two independently selected capping ribozymes share similar substrate requirements.
Hani S. Zaher, R. A. Watkins, P. Unrau
2006RNA: A publication of the RNA Society18 citations Open access
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smyRNA: A Novel Ab Initio ncRNA Gene Finder
R. Salari, Cagri Aksay, E. Karakoç, P. Unrau +2 more
2009PLoS ONE17 citations Open access
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Microchip RT-PCR Detection of Nasopharyngeal SARS-CoV-2 Samples
R. Cojocaru, Iqra Yaseen, P. Unrau, C. Lowe +5 more
2021Journal of Molecular Diagnostics13 citations Open access
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RNA Secondary Structure Prediction Via Energy Density Minimization
C. Alkan, E. Karakoç, S. Sahinalp, P. Unrau +3 more
2006Annual International Conference on Research in Computational Molecular Biology13 citations
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Nucleic acid library construction using synthetic DNA constructs.
Hani S. Zaher, P. Unrau
2005Methods in molecular biology12 citations
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Faculty Opinions recommendation of Functional hammerhead ribozymes naturally encoded in the genome of Arabidopsis thaliana.
P. Unrau
200512 citations
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Purification of histidine-tagged T4 RNA ligase from E. coli.
Qing S Wang, P. Unrau
2002BioTechniques12 citations Open access
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Transitioning to DNA genomes in an RNA world
R. Cojocaru, P. Unrau
2017eLife11 citations Open access
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In vitro characterization of 6S RNA release-defective mutants uncovers features of pRNA-dependent release from RNA polymerase in E. coli
Mariana E. Oviedo Ovando, Lindsay Shephard, P. Unrau
2014RNA: A publication of the RNA Society11 citations Open access
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Characterizing multiple exogenous and endogenous small RNA populations in parallel with subfemtomolar sensitivity using a streptavidin gel-shift assay.
H. Ebhardt, P. Unrau
2009RNA: A publication of the RNA Society10 citations Open access
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A general RNA-capping ribozyme retains stereochemistry during cap exchange.
Hani S. Zaher, P. Unrau
2006Journal of the American Chemical Society9 citations
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Symmetry breaking of fluorophore binding to a G-quadruplex generates an RNA aptamer with picomolar KD
Xiao-Cen Lu, Luiz F. M. Passalacqua, Matthew Nodwell, Kristen Y S Kong +5 more
2024Nucleic Acids Research8 citations Open access
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