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S. Marchetti · SciRah

Researcher profile · Semantic Scholar

S. Marchetti

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S. Marchetti — researcher profile on SciRah

h-index: 25
Works: 76
Citations: 2,100

Most-cited papers

Concise review: Clinical relevance of drug drug and herb drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein).
S. Marchetti, R. Mazzanti, J. Beijnen, J. Schellens
2007The Oncologist298 citations Open access
Semantic Scholar
Phase II Study of WEE1 Inhibitor AZD1775 Plus Carboplatin in Patients With TP53-Mutated Ovarian Cancer Refractory or Resistant to First-Line Therapy Within 3 Months.
S. Leijen, R. van Geel, G. Sonke, D. de Jong +9 more
2016Journal of Clinical Oncology285 citations Open access
Semantic Scholar
Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1−/−/Mdr1a/1b−/− (triple-knockout) and wild-type mice
S. Marchetti, N. de Vries, T. Buckle, Maria J. Bolijn +5 more
2008Molecular Cancer Therapeutics194 citations
Semantic Scholar
The impact of FDA and EMEA guidelines on drug development in relation to Phase 0 trials
S. Marchetti, J. Schellens
2007British Journal of Cancer163 citations Open access
Semantic Scholar
NEUROFUNCTIONAL DOPAMINERGIC IMPAIRMENT IN ELDERLY AFTER LIFETIME EXPOSURE TO MANGANESE
R. Lucchini, S. Guazzetti, S. Zoni, Chiara Benedetti +9 more
2014Neurotoxicology89 citations Open access
Semantic Scholar
The Effect of St John’s Wort on the Pharmacokinetics of Docetaxel
A. Goey, I. Meijerman, H. Rosing, S. Marchetti +5 more
2013Clinical Pharmacokinetics66 citations
Semantic Scholar
The European Medicines Agency review of vemurafenib (Zelboraf®) for the treatment of adult patients with BRAF V600 mutation-positive unresectable or metastatic melanoma: summary of the scientific assessment of the Committee for Medicinal Products for Human Use.
S. da Rocha Dias, T. Salmonson, B. V. van Zwieten-Boot, B. Jonsson +4 more
2013European Journal of Cancer60 citations
Semantic Scholar
Hepatocyte growth factor and inducible nitric oxide synthase are involved in multidrug resistance-induced angiogenesis in hepatocellular carcinoma cell lines.
N. Lasagna, O. Fantappié, M. Solazzo, L. Morbidelli +4 more
2006Cancer Research58 citations Open access
Semantic Scholar
Long-term safety and anti-tumour activity of olaparib monotherapy after combination with carboplatin and paclitaxel in patients with advanced breast, ovarian or fallopian tube cancer
R. van der Noll, S. Marchetti, N. Steeghs, J. Beijnen +5 more
2015British Journal of Cancer49 citations Open access
Semantic Scholar
Abcc4 Together with Abcb1 and Abcg2 Form a Robust Cooperative Drug Efflux System That Restricts the Brain Entry of Camptothecin Analogues
Fan Lin, S. Marchetti, D. Pluim, D. Iusuf +4 more
2013Clinical Cancer Research48 citations Open access
Semantic Scholar
Pharmacokinetics of eribulin mesylate in patients with solid tumors and hepatic impairment
L. Devriese, P. Witteveen, S. Marchetti, M. Mergui-Roelvink +7 more
2012Cancer Chemotherapy and Pharmacology43 citations
Semantic Scholar
Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer
R. van Geel, E. van Brummelen, F. Eskens, S. Huijberts +13 more
2020British Journal of Cancer40 citations Open access
Semantic Scholar
Phase I study of lapatinib plus trametinib in patients with KRAS-mutant colorectal, non-small cell lung, and pancreatic cancer
S. Huijberts, R. van Geel, E. van Brummelen, F. Opdam +10 more
2020Cancer Chemotherapy and Pharmacology39 citations
Semantic Scholar
In vitro transport of gimatecan (7-t-butoxyiminomethylcamptothecin) by breast cancer resistance protein, P-glycoprotein, and multidrug resistance protein 2
S. Marchetti, R. Oostendorp, D. Pluim, M. V. Van Eijndhoven +6 more
2007Molecular Cancer Therapeutics36 citations
Semantic Scholar
Complete genomic characterization in patients with cancer of unknown primary origin in routine diagnostics
L. Schipper, K. Samsom, P. Snaebjornsson, T. Battaglia +15 more
2022ESMO Open35 citations Open access
Semantic Scholar
Eribulin mesylate pharmacokinetics in patients with solid tumors receiving repeated oral ketoconazole
L. Devriese, M. Mergui-Roelvink, J. Wanders, A. Jenner +7 more
2013Investigational new drugs34 citations
Semantic Scholar
Phase I Study of Afatinib and Selumetinib in Patients with KRAS-Mutated Colorectal, Non-Small Cell Lung, and Pancreatic Cancer.
E. van Brummelen, S. Huijberts, C. V. van Herpen, I. Desar +11 more
2020The Oncologist33 citations Open access
Semantic Scholar
Phase I study of olaparib in combination with carboplatin and/or paclitaxel in patients with advanced solid tumors.
R. van der Noll, J. Ang, A. Jager, S. Marchetti +10 more
201333 citations
Semantic Scholar
The effect of Echinacea purpurea on the pharmacokinetics of docetaxel.
A. Goey, I. Meijerman, H. Rosing, J. Burgers +5 more
2013British Journal of Clinical Pharmacology33 citations Open access
Semantic Scholar
Vitamin E Protects DNA from Oxidative Damage in Human Hepatocellular Carcinoma Cell Lines
O. Fantappié, M. Lodovici, P. Fabrizio, S. Marchetti +5 more
2004Free radical research29 citations
Semantic Scholar
The Use of Dried Blood Spots for Pharmacokinetic Monitoring of Vemurafenib Treatment in Melanoma Patients
C. Nijenhuis, A. Huitema, S. Marchetti, C. Blank +5 more
2016Journal of clinical pharmacology28 citations Open access
Semantic Scholar
Effect of the drug transporters ABCG2, Abcg2, ABCB1 and ABCC2 on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA
S. Marchetti, D. Pluim, M. van Eijndhoven, O. van Tellingen +3 more
2013Investigational new drugs27 citations
Semantic Scholar
Eribulin mesylate pharmacokinetics in patients with hepatic impairment.
P. Witteveen, S. Marchetti, M. Mergui-Roelvink, L. Reyderman +6 more
201027 citations
Semantic Scholar
A Phase I Dose Escalation Study of Once-Weekly Oral Administration of Docetaxel as ModraDoc001 Capsule or ModraDoc006 Tablet in Combination with Ritonavir
V. D. de Weger, F. Stuurman, S. Koolen, J. Moes +11 more
2019Clinical Cancer Research25 citations Open access
Semantic Scholar
A dose-escalation study of bi-daily once weekly oral docetaxel either as ModraDoc001 or ModraDoc006 combined with ritonavir.
V. D. de Weger, F. Stuurman, J. Hendrikx, J. Moes +10 more
2017European Journal of Cancer25 citations Open access
Semantic Scholar
Transtympanic Sodium Thiosulfate for Prevention of Cisplatin-Induced Ototoxicity: A Randomized Clinical Trial
C. Duinkerken, V. D. de Weger, W. Dreschler, L. van der Molen +11 more
2021Otology and Neurotology24 citations Open access
Semantic Scholar
A phase I followed by a randomized phase II trial of two cycles carboplatin-olaparib followed by olaparib monotherapy versus capecitabine in BRCA1- or BRCA2-mutated HER2-negative advanced breast cancer as first line treatment (REVIVAL): study protocol for a randomized controlled trial
P. Schouten, G. Dackus, S. Marchetti, H. van Tinteren +3 more
2016Trials19 citations Open access
Semantic Scholar
Pharmacokinetics of eribulin mesylate in patients with solid tumours receiving repeated oral rifampicin
L. Devriese, P. Witteveen, J. Wanders, K. Law +9 more
2013British Journal of Clinical Pharmacology19 citations Open access
Semantic Scholar
Phase I pharmacological study of continuous chronomodulated capecitabine treatment
J. Roosendaal, B. Jacobs, D. Pluim, H. Rosing +7 more
2020Pharmaceutical Research18 citations Open access
Semantic Scholar
Disposition and metabolism of 14C-dovitinib (TKI258), an inhibitor of FGFR and VEGFR, after oral administration in patients with advanced solid tumors
A. C. Dubbelman, A. Upthagrove, J. Beijnen, S. Marchetti +4 more
2012Cancer Chemotherapy and Pharmacology18 citations
Semantic Scholar
Mitochondria of a human multidrug-resistant hepatocellular carcinoma cell line constitutively express inducible nitric oxide synthase in the inner membrane
O. Fantappié, C. Sassoli, A. Tani, D. Nosi +3 more
2015Journal of Cellular and Molecular Medicine17 citations Open access
Semantic Scholar
Survival and prognostic factors in patients with hepatocellular carcinoma treated by percutaneous ethanol injection: a 10-year experience.
R. Mazzanti, U. Arena, P. Pantaleo, Lorenzo Antonuzzo +6 more
2004Canadian journal of gastroenterology = Journal canadien de gastroenterologie17 citations Open access
Semantic Scholar
Phase I study of intermittent olaparib capsule or tablet dosing in combination with carboplatin and paclitaxel (part 2)
R. van der Noll, A. Jager, J. Ang, S. Marchetti +11 more
2019Investigational new drugs15 citations Open access
Semantic Scholar
Phase I study of continuous olaparib capsule dosing in combination with carboplatin and/or paclitaxel (Part 1)
R. van der Noll, A. Jager, J. Ang, S. Marchetti +10 more
2019Investigational new drugs15 citations Open access
Semantic Scholar
Pharmacokinetics and Toxicities of Oral Docetaxel Formulations Co-Administered with Ritonavir in Phase I Trials
M. Vermunt, S. Marchetti, J. Beijnen
2021Clinical Pharmacology : Advances and Applications14 citations Open access
Semantic Scholar
No relation between docetaxel administration route and high‐grade diarrhea incidence
J. Hendrikx, F. Stuurman, Ji-ying Song, V. D. de Weger +6 more
2020Pharmacology Research & Perspectives14 citations Open access
Semantic Scholar
Phase II study with Wee1 inhibitor AZD1775 plus carboplatin in patients with p53 mutated ovarian cancer refractory or resistant (<3 months) to standard first line therapy.
S. Leijen, R. van Geel, G. Sonke, D. de Jong +8 more
201513 citations
Semantic Scholar
Phase I study of weekly oral docetaxel (ModraDoc001) plus ritonavir in patients with advanced solid tumors.
S. Marchetti, F. Stuurman, S. Koolen, J. Moes +10 more
201212 citations
Semantic Scholar
“Effect of the drug transporters ABCB1, ABCC2, and ABCG2 on the disposition and brain accumulation of the taxane analog BMS-275,183”
S. Marchetti, D. Pluim, J. Beijnen, R. Mazzanti +2 more
2014Investigational new drugs10 citations
Semantic Scholar
A Phase 1 Dose‐Escalation Study of Low‐Dose Metronomic Treatment With Novel Oral Paclitaxel Formulations in Combination With Ritonavir in Patients With Advanced Solid Tumors
Vincent A. Weger, M. Vermunt, F. Stuurman, A. Burylo +10 more
2020Clinical pharmacology in drug development9 citations
Semantic Scholar
Pharmacokinetic evaluation of three oral formulations of docetaxel boosted with ritonavir: two single-drug formulations vs. a fixed-dose combination tablet
J. Moes, F. Stuurman, J. Hendrikx, S. Marchetti +4 more
2013Drug Delivery and Translational Research8 citations
Semantic Scholar
Population Pharmacokinetics of Intracellular 5-Fluorouridine 5′-Triphosphate and its Relationship with Hand-and-Foot Syndrome in Patients Treated with Capecitabine
J. Janssen, B. Jacobs, J. Roosendaal, Ellen J B Derissen +4 more
2021AAPS Journal7 citations Open access
Semantic Scholar
The effect of hydroxyurea on P-glycoprotein/BCRP-mediated transport and CYP3A metabolism of imatinib mesylate
R. Oostendorp, S. Marchetti, J. Beijnen, R. Mazzanti +1 more
2007Cancer Chemotherapy and Pharmacology7 citations
Semantic Scholar
Pilot Study to Predict Pharmacokinetics of a Therapeutic Gemcitabine Dose From a Microdose
M. van Nuland, H. Rosing, B. Thijssen, J. Burgers +4 more
2020Clinical pharmacology in drug development6 citations
Semantic Scholar
A Phase I dose‐escalation study of two cycles carboplatin‐olaparib followed by olaparib monotherapy in patients with advanced cancer
J. Geenen, G. Dackus, P. Schouten, D. Pluim +7 more
2019International Journal of Cancer6 citations Open access
Semantic Scholar
574 Eribulin mesylate pharmacokinetics in patients with solid tumors receiving repeated oral ketoconazole (KET)
L. Deviese, J. Wanders, A. Jenner, G. Edwards +6 more
20106 citations
Semantic Scholar
Effect of Food on the Pharmacokinetics of the Oral Docetaxel Tablet Formulation ModraDoc006 Combined with Ritonavir (ModraDoc006/r) in Patients with Advanced Solid Tumours
M. Vermunt, V. D. de Weger, J. Janssen, M. I. Lopez-Yurda +6 more
2021Drugs in R&D5 citations Open access
Semantic Scholar
A phase 0 clinical trial of novel candidate extended-release formulations of capecitabine
B. Jacobs, J. Meulenaar, H. Rosing, D. Pluim +7 more
2016Cancer Chemotherapy and Pharmacology5 citations Open access
Semantic Scholar
Clinical Relevance: Drug–Drug Interactions, Pharmacokinetics, Pharmacodynamics, and Toxicity
S. Marchetti, R. Mazzanti, J. Beijnen, J. Schellens
20064 citations
Semantic Scholar
The impact of the ABC transporters P-gp and BCRP on the oral bioavailability and brain penetration of erlotinib using drug transporter knockout mouse models.
O. van Tellingen, S. Marchetti, N. de Vries, Jin Zhao +3 more
20073 citations
Semantic Scholar

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J. Beijnen×36
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J. Beijnen — researcher profile on SciRah
J. Schellens×34
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J. Schellens — researcher profile on SciRah
H. Rosing×16
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H. Rosing — researcher profile on SciRah
R. Mazzanti×12
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R. Mazzanti — researcher profile on SciRah

M. Mergui-Roelvink

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M. Mergui-Roelvink — researcher profile on SciRah

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D. Pluim — researcher profile on SciRah

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A. Huitema — researcher profile on SciRah

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B. Thijssen — researcher profile on SciRah

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B. Nuijen — researcher profile on SciRah

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A. Huitema — researcher profile on SciRah

O. van Tellingen×6

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O. van Tellingen — researcher profile on SciRah

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M. Keessen — researcher profile on SciRah