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J. Manley · SciRah

Researcher profile · Semantic Scholar

J. Manley

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J. Manley — researcher profile on SciRah

h-index: 115
Works: 328
Citations: 43K

Most-cited papers

Alternative polyadenylation of mRNA precursors
Bin Tian, J. Manley
2016Nature reviews. Molecular cell biology1,062 citations Open access
Semantic Scholar
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged.
Charles J. David, J. Manley
2010Genes & Development818 citations Open access
Semantic Scholar
Mechanisms and consequences of alternative polyadenylation
D. C. Di Giammartino, Kensei Nishida, J. Manley
2011Molecules and Cells713 citations Open access
Semantic Scholar
The RNA polymerase II CTD coordinates transcription and RNA processing.
Jing-Ping Hsin, J. Manley
2012Genes & Development664 citations Open access
Semantic Scholar
R-loop-mediated genomic instability is caused by impairment of replication fork progression.
Wenjian Gan, Zhishuang Guan, Jie Liu, T. Gui +3 more
2011Genes & Development442 citations Open access
Semantic Scholar
A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins).
J. Manley, A. Krainer
2010Genes & Development347 citations Open access
Semantic Scholar
Alternative cleavage and polyadenylation: the long and short of it
Bin Tian, J. Manley
2013TIBS -Trends in Biochemical Sciences. Regular ed307 citations Open access
Semantic Scholar
Misregulation of pre-mRNA alternative splicing in cancer
Jian Zhang, J. Manley
2013Cancer Discovery291 citations Open access
Semantic Scholar
The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains
Erin G. Conlon, Lei Lu, Aarti Sharma, Takashi Yamazaki +3 more
2016eLife256 citations Open access
Semantic Scholar
The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site
Yong-Sheng Shi, J. Manley
2015Genes & Development248 citations Open access
Semantic Scholar
Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation
Wencheng Li, Bei You, M. Hoque, Dinghai Zheng +7 more
2015PLoS Genetics243 citations Open access
Semantic Scholar
Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities
Jian Zhang, Y. Lieu, A. Ali, A. Penson +5 more
2015Proceedings of the National Academy of Sciences of the United States of America235 citations Open access
Semantic Scholar
CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3′ processing
Serena L. Chan, Ina Huppertz, C. Yao, Lingjie Weng +5 more
2014Genes & Development216 citations Open access
Semantic Scholar
RNA-binding proteins in neurodegeneration: mechanisms in aggregate
Erin G. Conlon, J. Manley
2017Genes & Development205 citations Open access
Semantic Scholar
R Loops and Links to Human Disease
Patricia Richard, J. Manley
2016Journal of Molecular Biology199 citations Open access
Semantic Scholar
The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex.
Charles J. David, Alex R. Boyne, S. Millhouse, J. Manley
2011Genes & Development189 citations Open access
Semantic Scholar
RNAP II CTD Phosphorylated on Threonine 4 Is Required for Histone mRNA 3′ end Processing
Jing-Ping Hsin, Amit P. Sheth, J. Manley
2011Science174 citations Open access
Semantic Scholar
Molecular basis for the recognition of the human AAUAAA polyadenylation signal
Yadong Sun, Yixiao Zhang, K. Hamilton, J. Manley +3 more
2017Proceedings of the National Academy of Sciences of the United States of America141 citations Open access
Semantic Scholar
An Mtr4/ZFC3H1 complex facilitates turnover of unstable nuclear RNAs to prevent their cytoplasmic transport and global translational repression
Koichi Ogami, Patricia Richard, Ya-Qiong Chen, M. Hoque +5 more
2017Genes & Development136 citations Open access
Semantic Scholar
Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells
N. T. Pfister, Vitalay Fomin, K. Regunath, Jeffrey Y Zhou +14 more
2015Genes & Development136 citations Open access
Semantic Scholar
TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements
Adelene Y. Tan, Todd Riley, Tristan H. Coady, H. Bussemaker +1 more
2012Proceedings of the National Academy of Sciences of the United States of America130 citations Open access
Semantic Scholar
Structural and biochemical studies of the 5′→3′ exoribonuclease Xrn1
J. Chang, S. Xiang, K. Xiang, J. Manley +1 more
2011Nature Structural &Molecular Biology120 citations Open access
Semantic Scholar
SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3
B. Drisaldi, Luca Colnaghi, L. Fioriti, Nishta Rao +8 more
2015Cell Reports117 citations Open access
Semantic Scholar
XRN2 Links Transcription Termination to DNA Damage and Replication Stress
Julio C. Morales, Patricia Richard, Praveen L. Patidar, Edward A. Motea +3 more
2016PLoS Genetics116 citations Open access
Semantic Scholar
A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage
Patricia Richard, Shuang Feng, J. Manley
2013Genes & Development116 citations Open access
Semantic Scholar
Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins
Chen Mo, Charles J. David, J. Manley
2012Nature Structural &Molecular Biology116 citations Open access
Semantic Scholar
Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1
Jian Zhang, A. Ali, Y. Lieu, Zhao-Qi Liu +5 more
2019Molecules and Cells113 citations Open access
Semantic Scholar
RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3′ UTRs
D. C. Di Giammartino, Wencheng Li, Koichi Ogami, Jossie J. Yashinskie +3 more
2014Genes & Development92 citations Open access
Semantic Scholar
Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation
Xue-Xia Zhou, Wen-Wu Wu, Huang Li, Yuanming Cheng +8 more
2014Nucleic Acids Research92 citations Open access
Semantic Scholar
Transcriptional activators enhance polyadenylation of mRNA precursors
Takashi Nagaike, J. Manley
2011RNA Biology79 citations Open access
Semantic Scholar
Delineating the Structural Blueprint of the Pre-mRNA 3′-End Processing Machinery
K. Xiang, L. Tong, J. Manley
2014Molecular and Cellular Biology77 citations Open access
Semantic Scholar
PARP1 REPRESSES PAP AND INHIBITS POLYADENYLATION DURING HEAT SHOCK
D. C. Di Giammartino, Yong-Sheng Shi, J. Manley
2012Molecules and Cells77 citations Open access
Semantic Scholar
Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism
Erin G. Conlon, D. Fagegaltier, P. Agius, Julia Davis-Porada +35 more
2018eLife76 citations Open access
Semantic Scholar
ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs
Yueh-Lin Tsai, Tristan H. Coady, Lei Lu, Dinghai Zheng +4 more
2020Genes & Development74 citations Open access
Semantic Scholar
TCF3 alternative splicing controlled by hnRNP H/F regulates E-cadherin expression and hESC pluripotency
Takashi Yamazaki, Li-Zhi Liu, Denis Lazarev, Amr Al-Zain +6 more
2018Genes & Development74 citations Open access
Semantic Scholar
SRSF10 Connects DNA Damage to the Alternative Splicing of Transcripts Encoding Apoptosis, Cell-Cycle Control, and DNA Repair Factors
L. Shkreta, Johanne Toutant, Mathieu Durand, J. Manley +1 more
2016Cell Reports68 citations Open access
Semantic Scholar
SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes
Y. Lieu, Zhao-Qi Liu, A. Ali, Xin Wei +7 more
2020Proceedings of the National Academy of Sciences of the United States of America65 citations Open access
Semantic Scholar
RNA surveillance by the nuclear RNA exosome: mechanisms and significance
Koichi Ogami, Ya-Qiong Chen, J. Manley
2018Non-Coding RNA63 citations Open access
Semantic Scholar
Comparative analysis of alternative polyadenylation in S. cerevisiae and S. pombe
Xiaochuan Liu, M. Hoque, Marc Larochelle, J. Lemay +4 more
2017Genome Research56 citations Open access
Semantic Scholar
Function and Control of RNA Polymerase II C-Terminal Domain Phosphorylation in Vertebrate Transcription and RNA Processing
Jing-Ping Hsin, K. Xiang, J. Manley
2014Molecular and Cellular Biology56 citations Open access
Semantic Scholar
RNAP II CTD tyrosine 1 performs diverse functions in vertebrate cells
Jing-Ping Hsin, Wencheng Li, M. Hoque, Bin Tian +1 more
2014eLife55 citations Open access
Semantic Scholar
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation
Patricia Richard, Shuang Feng, Yueh-Lin Tsai, Wencheng Li +14 more
2020Autophagy54 citations Open access
Semantic Scholar
Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation
Larry C. Cheng, Dinghai Zheng, E. Baljinnyam, Fangzheng Sun +6 more
2020Nature Communications54 citations Open access
Semantic Scholar
Sumoylation of transcription factor Gcn4 facilitates its Srb10-mediated clearance from promoters in yeast.
E. Rosonina, S. Duncan, J. Manley
2012Genes & Development54 citations Open access
Semantic Scholar
The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity
K. Xiang, J. Manley, L. Tong
2012Nature Communications53 citations Open access
Semantic Scholar
An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72.
K. Xiang, J. Manley, L. Tong
2012Genes & Development51 citations Open access
Semantic Scholar
Transcriptional activators enhance polyadenylation of mRNA precursors
Takashi Nagaike, Charlotte J. Logan, Ikuko Hotta, O. Rozenblatt-Rosen +2 more
2011Molecules and Cells50 citations Open access
Semantic Scholar
Mdm2 and MdmX as Regulators of Gene Expression.
L. Biderman, J. Manley, C. Prives
2012Genes & cancer49 citations Open access
Semantic Scholar
Crystal structure of human PAPD1, a noncanonical poly(A) polymerase
Yun Bai, S. Srivastava, J. Chang, J. Manley +1 more
2011Molecules and Cells48 citations Open access
Semantic Scholar
Widespread intron retention impairs protein homeostasis in C9orf72 ALS brains
Qing-Qing Wang, Erin G. Conlon, J. Manley, D. Rio
2020Genome Research46 citations Open access
Semantic Scholar

Frequent co-authors

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Bin Tian×11
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Bin Tian — researcher profile on SciRah
M. Hoque×8
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M. Hoque — researcher profile on SciRah
L. Tong×6
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L. Tong — researcher profile on SciRah
Wencheng Li×5
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Wencheng Li — researcher profile on SciRah

Patricia Richard

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Patricia Richard — researcher profile on SciRah

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K. Xiang — researcher profile on SciRah

Jing-Ping Hsin×4

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Jian Zhang — researcher profile on SciRah

Erin G. Conlon×4

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Erin G. Conlon — researcher profile on SciRah

Yong-Sheng Shi×4

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Yong-Sheng Shi — researcher profile on SciRah

Koichi Ogami×4

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Charles J. David×3

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Charles J. David — researcher profile on SciRah