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P. Kirkham · SciRah

Researcher profile · Semantic Scholar

P. Kirkham

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P. Kirkham — researcher profile on SciRah

h-index: 34
Works: 87
Citations: 6,739

Most-cited papers

Regulation of inflammation and redox signaling by dietary polyphenols.
I. Rahman, S. Biswas, P. Kirkham
2006Biochemical Pharmacology1,023 citations
Semantic Scholar
Oxidative stress in COPD.
P. Kirkham, P. Barnes
2013Chest706 citations
Semantic Scholar
Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression.
I. Rahman, John A. Marwick, P. Kirkham
2004Biochemical Pharmacology531 citations
Semantic Scholar
Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy.
P. Kirkham, I. Rahman
2006Pharmacology and Therapeutics496 citations
Semantic Scholar
Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease
C. Wiegman, C. Michaeloudes, Gulam Haji, Priyanka Narang +22 more
2015Journal of Allergy and Clinical Immunology417 citations Open access
Semantic Scholar
Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs.
John A. Marwick, P. Kirkham, C. Stevenson, H. Danahay +5 more
2004American Journal of Respiratory Cell and Molecular Biology308 citations
Semantic Scholar
Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice.
John A. Marwick, G. Caramori, C. Stevenson, P. Casolari +6 more
2009American Journal of Respiratory and Critical Care Medicine223 citations Open access
Semantic Scholar
LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and Giα dependent PI-3kinase signalling
Anta Ngkelo, Koremu K. Meja, M. Yeadon, I. Adcock +1 more
2012Journal of Inflammation222 citations Open access
Semantic Scholar
Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2.
Koremu K. Meja, Saravanan Rajendrasozhan, D. Adenuga, S. Biswas +9 more
2008American Journal of Respiratory Cell and Molecular Biology216 citations Open access
Semantic Scholar
Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease.
P. Kirkham, G. Caramori, P. Casolari, A. Papi +12 more
2012American Journal of Respiratory and Critical Care Medicine178 citations Open access
Semantic Scholar
Macrophage phagocytosis of apoptotic neutrophils is compromised by matrix proteins modified by cigarette smoke and lipid peroxidation products.
P. Kirkham, G. Spooner, I. Rahman, A. G. Rossi
2004Biochemical and Biophysical Research Communications - BBRC178 citations
Semantic Scholar
A possible overwintering mechanism for bluetongue virus in the absence of the insect vector.
H. Takamatsu, P. Mellor, P. Mertens, P. Kirkham +2 more
2003Journal of General Virology158 citations Open access
Semantic Scholar
Cigarette smoke triggers macrophage adhesion and activation: role of lipid peroxidation products and scavenger receptor.
P. Kirkham, G. Spooner, C. Ffoulkes-Jones, R. Calvez
2003Free Radical Biology & Medicine130 citations
Semantic Scholar
A B lymphocyte surface molecule mediating activation and protection from apoptosis via calcium channels.
L. Santos-Argumedo, C. Teixeira, G. Preece, P. Kirkham +1 more
1993Journal of Immunology126 citations
Semantic Scholar
A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease.
John A. Marwick, G. Caramori, P. Casolari, F. Mazzoni +4 more
2010Journal of Allergy and Clinical Immunology116 citations Open access
Semantic Scholar
Brd4 Is Essential for IL-1β-Induced Inflammation in Human Airway Epithelial Cells
Younis Khan, P. Kirkham, P. Barnes, I. Adcock
2014PLoS ONE112 citations Open access
Semantic Scholar
Identification and characterization of the murine homologue of CD22, a B lymphocyte-restricted adhesion molecule.
Raul M. Torres, Che-Leung Law, L. Santos-Argumedo, P. Kirkham +3 more
1992Journal of Immunology106 citations
Semantic Scholar
Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition.
John A. Marwick, C. Stevenson, J. Giddings, W. Macnee +3 more
2006American Journal of Physiology - Lung cellular and Molecular Physiology105 citations
Semantic Scholar
Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation.
C. Stevenson, Cerys Docx, R. Webster, C. Battram +12 more
2007American Journal of Physiology - Lung cellular and Molecular Physiology101 citations
Semantic Scholar
A model of chronic inflammation and pulmonary emphysema after multiple ozone exposures in mice.
Kostas A. Triantaphyllopoulos, Farhana Hussain, M. Pinart, Min Zhang +5 more
2011American Journal of Physiology - Lung cellular and Molecular Physiology91 citations Open access
Semantic Scholar
Hydrogen Sulfide Inhibits Proliferation and Release of IL-8 from Human Airway Smooth Muscle Cells
Mark M. Perry, Christopher K. M. Hui, M. Whiteman, M. Wood +4 more
2011American Journal of Respiratory Cell and Molecular Biology85 citations Open access
Semantic Scholar
A comprehensive analysis of oxidative stress in the ozone-induced lung inflammation mouse model.
C. Wiegman, Feng Li, Colin J Clarke, E. Jazrawi +4 more
2014Clinical science80 citations
Semantic Scholar
Autoimmunity and COPD: Clinical Implications
G. Caramori, P. Ruggeri, A. Di Stefano, S. Mumby +3 more
2017Chest76 citations Open access
Semantic Scholar
Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy
John A. Marwick, K. Ito, I. Adcock, P. Kirkham
2007Expert opinion on therapeutic targets73 citations
Semantic Scholar
Preparation of monoclonal anti‐porcine CD3 antibodies and preliminary characterization of porcine T lymphocytes
H. Yang, C. Oura, P. Kirkham, R. Parkhouse
1996Immunology64 citations Open access
Semantic Scholar
Metabolic re-patterning in COPD airway smooth muscle cells
C. Michaeloudes, C. Kuo, Gulam Haji, D. Finch +4 more
2017European Respiratory Journal63 citations Open access
Semantic Scholar
Cigarette Smoke‐Induced Oxidative Stress and TGF‐β1 Increase p21waf1/cip1 Expression in Alveolar Epithelial Cells
John A. Marwick, P. Kirkham, P. Gilmour, Kenneth Donaldson +2 more
2002Annals of the New York Academy of Sciences56 citations
Semantic Scholar
Molecular pathogenesis of cigarette smoking–induced stable COPD
G. Caramori, P. Kirkham, A. Barczyk, A. Di Stefano +1 more
2015Annals of the New York Academy of Sciences49 citations
Semantic Scholar
Oxidative stress modulates theophylline effects on steroid responsiveness.
John A. Marwick, G. Wallis, Koremu K. Meja, B. Kuster +8 more
2008Biochemical and Biophysical Research Communications - BBRC49 citations
Semantic Scholar
Murine B-cell activation via CD38 and protein tyrosine phosphorylation.
P. Kirkham, L. Santos-Argumedo, M. Harnett, R. Parkhouse
1994Immunology49 citations
Semantic Scholar
A γδ T cell specific surface receptor (WC1) signaling G0/G1 cell cycle arrest
H. Takamatsu, P. Kirkham, R. Parkhouse
1997European Journal of Immunology46 citations
Semantic Scholar
Growth arrest of γδ T cells induced by monoclonal antibody against WC1 correlates with activation of multiple tyrosine phosphatases and dephosphorylation of MAP kinase erk2
P. Kirkham, H. Takamatsu, R. Parkhouse
199738 citations
Semantic Scholar
LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and Giα dependent PI-3kinase signalling
Anta Ngkelo, Koremu K. Meja, M. Yeadon, I. Adcock +1 more
2012Journal of Inflammation37 citations Open access
Semantic Scholar
Mapping of two new epitopes on the apomucin encoded by MUC5AC gene: Expression in normal GI tract and colon tumors
S. Nollet, M. Forgue-Lafitte, P. Kirkham, J. Bara
2002International Journal of Cancer36 citations Open access
Semantic Scholar
Influence of glutathione-S-transferase (GST) inhibition on lung epithelial cell injury: role of oxidative stress and metabolism.
M. Fletcher, P. Boshier, K. Wakabayashi, H. Keun +6 more
2015American Journal of Physiology - Lung cellular and Molecular Physiology32 citations
Semantic Scholar
Mechanisms of corticosteroid resistance in severe asthma and chronic obstructive pulmonary disease (COPD).
I. Adcock, John A. Marwick, P. Casolari, M. Contoli +4 more
2010Current pharmaceutical design32 citations
Semantic Scholar
Porcine CD3ε: its characterization, expression and involvement in activation of porcine T lymphocytes
P. Kirkham, H. Takamatsu, H. Yang, R. Parkhouse
1996Immunology31 citations Open access
Semantic Scholar
Evidence That Differences in Fructosamine-3-Kinase Activity May Be Associated With the Glycation Gap in Human Diabetes
S. Dunmore, Amr S. Al-Derawi, A. Nayak, A. Narshi +6 more
2017Diabetes29 citations Open access
Semantic Scholar
Epigenetics in asthma and other inflammatory lung diseases.
A. Durham, P. Chou, P. Kirkham, I. Adcock
2010Epigenomics29 citations
Semantic Scholar
Strategies for improving the efficacy and therapeutic ratio of glucocorticoids.
I. Adcock, G. Caramori, P. Kirkham
2012Current opinion in pharmacology (Print)24 citations
Semantic Scholar
Chemokines and chemokine receptors blockers as new drugs for the treatment of chronic obstructive pulmonary disease.
G. Caramori, A. Di Stefano, P. Casolari, P. Kirkham +4 more
2013Current Medicinal Chemistry23 citations
Semantic Scholar
Mapping of SOMU1 and M1 Epitopes on the Apomucin Encoded by the 5′ End of the MUC5AC Gene
S. Nollet, F. Escande, M. Buisine, M. Forgue-Lafitte +3 more
2004Hybridoma and Hybridomics19 citations
Semantic Scholar
Impact of theophylline/corticosteroid combination therapy on sputum hydrogen sulfide levels in patients with COPD
P. Kirkham, M. Whiteman, P. Winyard, G. Caramori +5 more
2014European Respiratory Journal18 citations Open access
Semantic Scholar
Solid-phase immunoglobulins IgG and IgM activate macrophages with solid-phase IgM acting via a novel scavenger receptor a pathway.
J. Boyle, Ivy Christou, M. Iqbal, A. Nguyen +6 more
2012American Journal of Pathology18 citations Open access
Semantic Scholar
Transcription factor E2F controls the reversible gamma delta T cell growth arrest mediated through WC1.
P. Kirkham, Eric Lam, H. Takamatsu, R. Parkhouse
1998Journal of Immunology18 citations
Semantic Scholar
CALL FOR PAPERS Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies Glycogen synthase kinase-3 modulation of glucocorticoid responsiveness in COPD
X. A. Ngkelo, R. Hoffmann, A. Durham, John A. Marwick +23 more
201615 citations
Semantic Scholar
Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance
G. Scaramuzzo, F. Nucera, Alessio Asmundo, R. Messina +15 more
2023Journal of Inflammation13 citations Open access
Semantic Scholar
Analyses of monoclonal antibodies reacting with porcine CD3: results from the Second International Swine CD Workshop.
M. Pescovitz, B. K. Book, B. Aasted, J. Domínguez +15 more
1998Veterinary Immunology and Immunopathology13 citations
Semantic Scholar
Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD
Anta Ngkelo, Roland F. Hoffmann, Andrew L. Durham, John A. Marwick +23 more
2015American Journal of Physiology - Lung cellular and Molecular Physiology12 citations Open access
Semantic Scholar
Ligation of the WC1 Receptor Induces γδ T Cell Growth Arrest Through Fumonisin B1-Sensitive Increases in Cellular Ceramide1
P. Kirkham, H. Takamatsu, E. Lam, R. Parkhouse
2000Journal of Immunology12 citations Open access
Semantic Scholar

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I. Adcock×20
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I. Adcock — researcher profile on SciRah
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G. Caramori×12
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I. Rahman×9
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R. Parkhouse×7

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R. Parkhouse — researcher profile on SciRah

H. Takamatsu×6

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A. Papi — researcher profile on SciRah

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C. Stevenson — researcher profile on SciRah

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Koremu K. Meja — researcher profile on SciRah