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William M. Wuest · SciRah

Researcher profile · Semantic Scholar

William M. Wuest

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William M. Wuest — researcher profile on SciRah

h-index: 35
Works: 173
Citations: 4,901

Most-cited papers

The silent pandemic: Emergent antibiotic resistances following the global response to SARS-CoV-2
A. Mahoney, M. Safaee, William M. Wuest, Ariel L. Furst
2021iScience150 citations Open access
Semantic Scholar
Are Quaternary Ammonium Compounds, the Workhorse Disinfectants, Effective against Severe Acute Respiratory Syndrome-Coronavirus-2?
Cassandra L. Schrank, K. Minbiole, William M. Wuest
2020ACS Infectious Diseases112 citations Open access
Semantic Scholar
Targeting S. mutans biofilms: a perspective on preventing dental caries.
Amber M Scharnow, Amy E. Solinski, William M. Wuest
2019MedChemComm84 citations Open access
Semantic Scholar
Broad Spectrum Antibiotic Xanthocillin X Effectively Kills Acinetobacter baumanniivia Dysregulation of Heme Biosynthesis
Ines Hübner, Justin A. Shapiro, Jörn Hoßmann, J. Drechsel +5 more
2021ACS Central Science35 citations Open access
Semantic Scholar
Quaternary Phosphonium Compounds: An Examination of Non-Nitrogenous Cationic Amphiphiles That Evade Disinfectant Resistance
Kyle J. Sommers, Marina E. Michaud, Cody E. Hogue, Amber M Scharnow +5 more
2022ACS Infectious Diseases33 citations Open access
Semantic Scholar
Virulence attenuating combination therapy: a potential multi-target synergy approach to treat Pseudomonas aeruginosa infections in cystic fibrosis patients.
Elana R. Shaw, William M. Wuest
2020RSC Medicinal Chemistry29 citations Open access
Semantic Scholar
Ribosome-targeting antibiotics and resistance via ribosomal RNA methylation.
Learnmore Jeremia, Benjamin E Deprez, D. Dey, G. Conn +1 more
2023RSC Medicinal Chemistry28 citations Open access
Semantic Scholar
Pyochelin Biosynthetic Metabolites Bind Iron and Promote Growth in Pseudomonads Demonstrating Siderophore-like Activity
Anna R. Kaplan, D. Musaev, William M. Wuest
2021ACS Infectious Diseases28 citations Open access
Semantic Scholar
A bisphenolic honokiol analog outcompetes oral antimicrobial agent cetylpyridinium chloride via a membrane-associated mechanism
C. Ochoa, Amy E. Solinski, Mark P. Nowlan, Madeline M. Dekarske +2 more
2019ACS Infectious Diseases27 citations Open access
Semantic Scholar
Advancements in the Development of Non-Nitrogen-Based Amphiphilic Antiseptics to Overcome Pathogenic Bacterial Resistance
Robert G. Carden, Kyle J. Sommers, Cassandra L. Schrank, Austin J Leitgeb +3 more
2020ChemMedChem26 citations Open access
Semantic Scholar
Soft QPCs: Biscationic Quaternary Phosphonium Compounds as Soft Antimicrobial Agents
Samantha R Brayton, Zachary E. A. Toles, Christian A Sanchez, Marina E. Michaud +6 more
2023ACS Infectious Diseases22 citations Open access
Semantic Scholar
Siderophores: A Case Study in Translational Chemical Biology
Andrew R LeBlanc, William M. Wuest
2024Biochemistry20 citations Open access
Semantic Scholar
Multi-objective Deep Data Generation with Correlated Property Control
Shiyu Wang, Xiaojie Guo, Xuanyang Lin, Bo Pan +10 more
2022Neural Information Processing Systems19 citations Open access
Semantic Scholar
From Natural Products to Small Molecules: Recent Advancements in Anti-MRSA Therapeutics
Jacqueline R. Smith, Andrew R LeBlanc, William M. Wuest
2025ACS Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Amphipathic Antimicrobial Peptides Illuminate a Reciprocal Relationship Between Self-assembly and Cytolytic Activity
Breana Laguera, Martina M. Golden, Feng-Bin Wang, O. Gnewou +4 more
2025Angewandte Chemie17 citations Open access
Semantic Scholar
Quaternary Phosphonium Compound Unveiled as a Potent Disinfectant against Highly Resistant Acinetobacter baumannii Clinical Isolates
Marina E. Michaud, Ryan A. Allen, Kelly R Morrison-Lewis, Christian A Sanchez +3 more
2022ACS Infectious Diseases17 citations Open access
Semantic Scholar
Broadening Activity of Polymyxin by Quaternary Ammonium Grafting
George M. Ongwae, Kelly R. Morrison, Ryan A. Allen, Seonghoon Kim +3 more
2020ACS Infectious Diseases17 citations Open access
Semantic Scholar
Trivalent Sulfonium Compounds (TSCs): Tetrahydrothiophene-based amphiphiles exhibit similar antimicrobial activity to analogous ammonium-based amphiphiles
Javier A. Feliciano, Austin J Leitgeb, Cassandra L. Schrank, Ryan A. Allen +3 more
2021Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Highly Effective Biocides against Pseudomonas aeruginosa Reveal New Mechanistic Insights Across Gram-Negative Bacteria
Christian A Sanchez, Germán G. Vargas-Cuebas, Marina E. Michaud, Ryan A. Allen +4 more
2024ACS Infectious Diseases15 citations Open access
Semantic Scholar
Structure-Activity Relationship and Anticancer Profile of Second-Generation Anti-MRSA Synthetic Retinoids.
Ana V Cheng, Wooseong Kim, Iliana E. Escobar, E. Mylonakis +1 more
2019ACS Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Beyond Ergosterol: Strategies for Combatting Antifungal Resistance in Aspergillus fumigatus and Candida auris
R. Cruz, William M. Wuest
2023Tetrahedron14 citations Open access
Semantic Scholar
Tricepyridinium-inspired QACs yield potent antimicrobials and provide insight into QAC resistance
Michelle A. Garrison, A. Mahoney, William M. Wuest
2020ChemMedChem14 citations Open access
Semantic Scholar
Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures
Kyle J. Sommers, Brian S. Bentley, Robert G. Carden, Savannah J. Post +5 more
2020ChemMedChem13 citations Open access
Semantic Scholar
Cheap, Fast, Safe, Sustainable, and Positively Irresistible: The Future of Cationic Amphiphilic Disinfectant Development
Makayla R. Hedges, K. Minbiole, B. Selinsky, William M. Wuest
2025Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
Double BAC and Triple BAC: A Systematic Analysis of the Disinfectant Properties of Multicationic Derivatives of Benzalkonium Chloride (BAC)
Zachary E. A. Toles, A. Wu, Christian A Sanchez, Marina E. Michaud +3 more
2023ChemMedChem12 citations
Semantic Scholar
Atom Economical QPCs: Phenyl-Free Biscationic Quaternary Phosphonium Compounds as Potent Disinfectants
Laura M. Thierer, A. Petersen, Marina E. Michaud, Christian A Sanchez +3 more
2023ACS Infectious Diseases12 citations Open access
Semantic Scholar
Asymmetric Total Synthesis of the Naturally Occurring Antibiotic Anthracimycin
Emma K. Davison, J. Freeman, Wan-Li Zhang, William M. Wuest +2 more
2020Organic Letters12 citations Open access
Semantic Scholar
Mild Photochemical Reduction of Alkenes and Heterocycles via Thiol-Mediated Formate Activation
C. Brzezinski, Andrew R LeBlanc, M. Clerici, William M. Wuest
2024Organic Letters11 citations Open access
Semantic Scholar
Repurposing a drug to punish carbapenem-resistant Acinetobacter baumannii
Jennifer M. Colquhoun, C. Brzezinski, Andrew Ji, J. Marotta +7 more
2025Proceedings of the National Academy of Sciences of the United States of America10 citations Open access
Semantic Scholar
Rigidity-Activity Relationships of bisQPC Scaffolds Against Pathogenic Bacteria
A. Spahr, Marina E. Michaud, Lauren E. Amoo, Christian A Sanchez +5 more
2022ChemMedChem10 citations Open access
Semantic Scholar
Synthesis and biological evaluation of an antibacterial azaborine retinoid isostere.
Brittney A Haney, Cassandra L. Schrank, William M. Wuest
2020Tetrahedron Letters10 citations Open access
Semantic Scholar
Adaptations to cationic biocide exposure differentially influence virulence factors and pathogenicity in Pseudomonas aeruginosa
Germán G. Vargas-Cuebas, Christian A Sanchez, Elise L. Bezold, Gabrielle M. Walker +3 more
2024Virulence9 citations Open access
Semantic Scholar
Metal chelation as an antibacterial strategy for Pseudomonas aeruginosa and Acinetobacter baumannii
Martina M. Golden, Amelia C. Heppe, Cassandra L. Zaremba, William M. Wuest
2024RSC Chemical Biology9 citations Open access
Semantic Scholar
Visible-Light/Nickel-Catalyzed Carboxylation of C(sp2) Bromides via Formate Activation
Gavin C Smith, Drason H. Zhang, Wan-Li Zhang, Abigail Soliven +1 more
2023Journal of Organic Chemistry9 citations Open access
Semantic Scholar
Using membrane perturbing small molecules to target chronic persistent infections.
Cassandra L. Schrank, Ingrid K. Wilt, Carlos Monteagudo Ortiz, Brittney A Haney +1 more
2021RSC Medicinal Chemistry9 citations Open access
Semantic Scholar
Target-Based Design of Promysalin Analogues Identifies a New Putative Binding Cleft in Succinate Dehydrogenase
Savannah J. Post, Colleen E. Keohane, Lauren M. Rossiter, Anna R. Kaplan +4 more
2020ACS Infectious Diseases9 citations Open access
Semantic Scholar
Resorcinol-based Bolaamphiphilic Quaternary Ammonium Compounds
Johanna Y. D. Asante, Caroline M Casey, Elise L. Bezold, Asantha Fernando +3 more
2025ChemMedChem8 citations Open access
Semantic Scholar
Investigating the Role of Metabolism for Antibiotic Combination Therapies in Pseudomonas aeruginosa
Martina M. Golden, Savannah J. Post, Renata Rivera, William M. Wuest
2023ACS Infectious Diseases8 citations Open access
Semantic Scholar
Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition
L. Kavanaugh, A. Mahoney, D. Dey, William M. Wuest +1 more
2023bioRxiv8 citations Open access
Semantic Scholar
Exploration of Inhibitors of the Bacterial LexA Repressor-Protease
Ana Victoria Cheng Jaramillo, Michael B. Cory, Allen Li, R. Kohli +1 more
2022Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
Recent developments in antimicrobial small molecule quaternary phosphonium compounds (QPCs) - synthesis and biological insights.
Diana McDonough, Christian A Sanchez, William M. Wuest, K. Minbiole
2025RSC Medicinal Chemistry7 citations
Semantic Scholar
In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe
Amber M Scharnow, Amy E. Solinski, Sebastian J. Rowe, Ines Drechsel +6 more
2024Journal of the American Chemical Society7 citations Open access
Semantic Scholar
The histone-like protein AlgP regulon is distinct in mucoid and nonmucoid Pseudomonas aeruginosa and does not include alginate biosynthesis genes.
Ashley R. Cross, E. Csatary, V. Raghuram, F. Diggle +3 more
2020Microbiology7 citations Open access
Semantic Scholar
Discovery of First-in-Class Inhibitors Targeting a Pathogen-Associated Aminoglycoside-Resistance 16S rRNA Methyltransferase
D. Dey, Benjamin E Deprez, N. Zelinskaya, J. M. Castro +2 more
2025ACS Infectious Diseases6 citations
Semantic Scholar
Chimeric Amphiphilic Disinfectants: Quaternary Ammonium/Quaternary Phosphonium Hybrid Structures
Moneya S. Leatherbury, Laura M. Thierer, Christian A Sanchez, Germán G. Vargas-Cuebas +8 more
2024ChemMedChem6 citations
Semantic Scholar
Bushy-Tailed QACs: The Development of Multicationic Quaternary Ammonium Compounds with a High Degree of Alkyl Chain Substitution
Zachary E. A. Toles, Laura M. Thierer, Alice Wu, Elise L. Bezold +7 more
2024ChemMedChem6 citations Open access
Semantic Scholar
Deriving Novel Quaternary Ammonium Compound Disinfectant Scaffolds from a Natural Product: Mechanistic Insights of the Quaternization of Ianthelliformisamine C
Ryan A. Allen, Caroline McCormack, William M. Wuest
2023ChemMedChem6 citations Open access
Semantic Scholar
Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition
L. Kavanaugh, A. Mahoney, D. Dey, William M. Wuest +1 more
2023bioRxiv6 citations Open access
Semantic Scholar
Phylogeny-Guided Approach Yields Glycopeptides with Unique Action
Ana V Cheng, William M. Wuest
2020TIPS - Trends in Pharmacological Sciences6 citations Open access
Semantic Scholar
Exploring the Correlation of Dynamic Surface Tension with Antimicrobial Activities of Quaternary Ammonium-Based Disinfectants
Germán G. Vargas-Cuebas, Christian A Sanchez, Samantha R Brayton, Alexander Nikoloff +3 more
2024ChemMedChem5 citations Open access
Semantic Scholar

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