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Di Chen · SciRah

Researcher profile · Semantic Scholar

Di Chen

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Di Chen — researcher profile on SciRah

h-index: 47
Works: 98
Citations: 8,848

Most-cited papers

Bortezomib as the First Proteasome Inhibitor Anticancer Drug: Current Status and Future Perspectives
Di Chen, M. Frezza, S. Schmitt, J. Kanwar +1 more
2011Current Cancer Drug Targets777 citations Open access
Semantic Scholar
Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity.
Di Chen, Q. Cui, Huanjie Yang, Ping Q. Dou
2006Cancer Research630 citations Open access
Semantic Scholar
Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice.
Huanjie Yang, Di Chen, Q. Cui, Xiao Yuan +1 more
2006Cancer Research558 citations Open access
Semantic Scholar
Novel Metals and Metal Complexes as Platforms for Cancer Therapy
M. Frezza, S. Hindo, Di Chen, A. Davenport +3 more
2010Current pharmaceutical design507 citations Open access
Semantic Scholar
Novel Schiff base copper complexes of quinoline-2 carboxaldehyde as proteasome inhibitors in human prostate cancer cells.
Shreelekha Adsule, V. Barve, Di Chen, F. Ahmed +3 more
2006Journal of Medicinal Chemistry330 citations Open access
Semantic Scholar
Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells
K. Daniel, Di Chen, Shirley Orlu, Qiuzhi C. Indy Cui +2 more
2005Breast Cancer Research326 citations Open access
Semantic Scholar
Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells.
Di Chen, K. Daniel, Marina S. Chen, D. Kuhn +2 more
2005Biochemical Pharmacology307 citations
Semantic Scholar
A novel anticancer gold(III) dithiocarbamate compound inhibits the activity of a purified 20S proteasome and 26S proteasome in human breast cancer cell cultures and xenografts.
V. Milacic, Di Chen, L. Ronconi, K. Landis-Piwowar +2 more
2006Cancer Research290 citations Open access
Semantic Scholar
Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance
Ayman Khdair, Di Chen, Yogesh Patil, Linan Ma +3 more
2009Journal of Controlled Release261 citations Open access
Semantic Scholar
A novel prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate as a potential anticancer agent.
K. Landis-Piwowar, C. Huo, Di Chen, V. Milacic +3 more
2007Cancer Research226 citations Open access
Semantic Scholar
Androgen receptor and E2F-1 targeted thymoquinone therapy for hormone-refractory prostate cancer.
A. Kaseb, K. Chinnakannu, Di Chen, Arun Sivanandam +4 more
2007Cancer Research216 citations Open access
Semantic Scholar
Clioquinol, a therapeutic agent for Alzheimer's disease, has proteasome-inhibitory, androgen receptor-suppressing, apoptosis-inducing, and antitumor activities in human prostate cancer cells and xenografts.
Di Chen, Q. Cui, Huanjie Yang, R. Barrea +5 more
2007Cancer Research201 citations Open access
Semantic Scholar
EGCG, GREEN TEA POLYPHENOLS AND THEIR SYNTHETIC ANALOGS AND PRODRUGS FOR HUMAN CANCER PREVENTION AND TREATMENT
Di Chen, Sheng-Biao Wan, Huanjie Yang, Jian Yuan +2 more
2011Advances in Clinical Chemistry195 citations Open access
Semantic Scholar
Tea polyphenols, their biological effects and potential molecular targets.
Di Chen, V. Milacic, Marina S. Chen, Sheng-Biao Wan +7 more
2008Histology and Histopathology193 citations
Semantic Scholar
Metal complexes, their cellular targets and potential for cancer therapy.
Di Chen, V. Milacic, M. Frezza, Ping Q. Dou
2009Current pharmaceutical design170 citations
Semantic Scholar
Shikonin Exerts Antitumor Activity via Proteasome Inhibition and Cell Death Induction in vitro and in vivo
Huanjie Yang, P. Zhou, Hong-Biao Huang, Di Chen +9 more
2009International Journal of Cancer161 citations Open access
Semantic Scholar
Non-covalently functionalized single-walled carbon nanotube for topical siRNA delivery into melanoma.
K. Siu, Di Chen, Xiu-Fen Zheng, Xu-Sheng Zhang +6 more
2014Biomaterials153 citations
Semantic Scholar
The proteasome as a potential target for novel anticancer drugs and chemosensitizers.
K. Landis-Piwowar, V. Milacic, Di Chen, Huanjie Yang +4 more
2006Drug resistance updates150 citations
Semantic Scholar
Pyrrolidine dithiocarbamate-zinc(II) and -copper(II) complexes induce apoptosis in tumor cells by inhibiting the proteasomal activity.
V. Milacic, Di Chen, Lorena Giovagnini, A. Díez +2 more
2008Toxicology and Applied Pharmacology136 citations Open access
Semantic Scholar
The Ubiquitin-Proteasome System as a Prospective Molecular Target for Cancer Treatment and Prevention
Di Chen, Ping Q. Dou
2010Current protein and peptide science130 citations Open access
Semantic Scholar
Inhibition of proteasome activity by the dietary flavonoid apigenin is associated with growth inhibition in cultured breast cancer cells and xenografts
Di Chen, K. Landis-Piwowar, Marina S. Chen, Ping Q. Dou
2007Breast Cancer Research120 citations Open access
Semantic Scholar
Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells
Di Chen, Sreedhar Pamu, Q. Cui, T. Chan +1 more
2012Bioorganic & Medicinal Chemistry111 citations Open access
Semantic Scholar
Green tea and tea polyphenols in cancer prevention.
Di Chen, K. Daniel, D. Kuhn, Aslamuzzaman Kazi +7 more
2004Frontiers in Bioscience111 citations Open access
Semantic Scholar
Tea Polyphenols and Their Roles in Cancer Prevention and Chemotherapy
Di Chen, Ping Q. Dou
2008International Journal of Molecular Sciences107 citations Open access
Semantic Scholar
Inhibition of the proteasome activity by gallium(III) complexes contributes to their anti prostate tumor effects.
Di Chen, M. Frezza, Rajendra Shakya, Q. Cui +3 more
2007Cancer Research100 citations Open access
Semantic Scholar
Structure-proteasome-inhibitory activity relationships of dietary flavonoids in human cancer cells.
Di Chen, Marina S. Chen, Q. Cui, Huanjie Yang +1 more
2007Frontiers in Bioscience100 citations Open access
Semantic Scholar
Silencing IDO in dendritic cells: A novel approach to enhance cancer immunotherapy in a murine breast cancer model
Xiu-Fen Zheng, J. Koropatnick, Di Chen, T. Velenosi +7 more
2013International Journal of Cancer97 citations Open access
Semantic Scholar
Disulfiram Treatment Facilitates Phosphoinositide 3-Kinase Inhibition in Human Breast Cancer Cells In vitro and In vivo
Haijun Zhang, Di Chen, Jonathan W Ringler, Wei Chen +4 more
2010Cancer Research97 citations Open access
Semantic Scholar
Inhibition of prostate cancer cellular proteasome activity by a pyrrolidine dithiocarbamate-copper complex is associated with suppression of proliferation and induction of apoptosis.
Di Chen, Fangyu Peng, Q. Cui, K. Daniel +3 more
2005Frontiers in Bioscience97 citations Open access
Semantic Scholar
Sirtuin Inhibition: Strategies, Inhibitors, and Therapeutic Potential.
Yanhong Jiang, Jiajia Liu, Di Chen, Lingling Yan +1 more
2017TIPS - Trends in Pharmacological Sciences78 citations
Semantic Scholar
Study of the green tea polyphenols catechin-3-gallate (CG) and epicatechin-3-gallate (ECG) as proteasome inhibitors.
Sheng-Biao Wan, Di Chen, Ping Q. Dou, T. Chan
2004Bioorganic & Medicinal Chemistry71 citations Open access
Semantic Scholar
Gambogic acid enhances proteasome inhibitor-induced anticancer activity
Hong-Biao Huang, Di Chen, Shu-Jue Li, Xiao-Fen Li +13 more
2011Cancer Letters67 citations Open access
Semantic Scholar
New uses for old copper-binding drugs: converting the pro-angiogenic copper to a specific cancer cell death inducer
Di Chen, Ping Q. Dou
2008Expert opinion on therapeutic targets65 citations Open access
Semantic Scholar
Molecular study on copper-mediated tumor proteasome inhibition and cell death
Yan Xiao, Di Chen, Xia Zhang, Q. Cui +3 more
2010International Journal of Oncology63 citations Open access
Semantic Scholar
Comparative Activities of Nickel(II) and Zinc(II) Complexes of Asymmetric [NN'O] Ligands as 26S Proteasome Inhibitors
M. Frezza, Sarmad Sahiel Hindo, Dajena Tomco, Marco M. Allard +5 more
2009Inorganic Chemistry61 citations Open access
Semantic Scholar
Sodium diethyldithiocarbamate, an AIDS progression inhibitor and a copper-binding compound, has proteasome-inhibitory and apoptosis-inducing activities in cancer cells.
Hai-Yan Pang, Di Chen, Q. Cui, Ping Q. Dou
2007International Journal of Molecular Medicine60 citations Open access
Semantic Scholar
Beta-lactams and their potential use as novel anticancer chemotherapeutics drugs.
D. Kuhn, Cristina M. Coates, K. Daniel, Di Chen +4 more
2004Frontiers in Bioscience59 citations Open access
Semantic Scholar
Inhibition of proteasome activity by various fruits and vegetables is associated with cancer cell death.
Marina S. Chen, Di Chen, Ping Q. Dou
2004In Vivo58 citations
Semantic Scholar
Inhibition of catechol-O-methyltransferase activity in human breast cancer cells enhances the biological effect of the green tea polyphenol (-)-EGCG
K. Landis-Piwowar, Di Chen, T. Chan, Ping Q. Dou
2010Oncology Report55 citations Open access
Semantic Scholar
Evaluation of proteasome-inhibitory and apoptosis-inducing potencies of novel (-)-EGCG analogs and their prodrugs.
K. Landis-Piwowar, D. Kuhn, Sheng-Biao Wan, Di Chen +2 more
2005International Journal of Molecular Medicine53 citations
Semantic Scholar
Discovery of a new family of bis-8-hydroxyquinoline substituted benzylamines with pro-apoptotic activity in cancer cells: synthesis, structure-activity relationship, and action mechanism studies.
V. Moret, Y. Laras, T. Cresteil, Geneviève Aubert +14 more
2009European journal of medicinal chemistry52 citations
Semantic Scholar
Disulfiram promotes the conversion of carcinogenic cadmium to a proteasome inhibitor with pro-apoptotic activity in human cancer cells.
Lihua Li, Huanjie Yang, Di Chen, C. Cui +1 more
2008Toxicology and Applied Pharmacology52 citations Open access
Semantic Scholar
Structure-activity study of epi-gallocatechin gallate (EGCG) analogs as proteasome inhibitors.
Sheng-Biao Wan, K. Landis-Piwowar, D. Kuhn, Di Chen +2 more
2005Bioorganic & Medicinal Chemistry52 citations Open access
Semantic Scholar
Activation of AMP-Activated Protein Kinase by 3,3′-Diindolylmethane (DIM) Is Associated with Human Prostate Cancer Cell Death In Vitro and In Vivo
Di Chen, Sanjeev Banerjee, Q. Cui, D. Kong +2 more
2012PLoS ONE51 citations Open access
Semantic Scholar
Induction of tumor cell apoptosis by taurine Schiff base copper complex is associated the with inhibition of proteasomal activity
Xia Zhang, C. Bi, Yu-Hua Fan, Q. Cui +3 more
2008International Journal of Molecular Medicine51 citations Open access
Semantic Scholar
Indoleamine 2,3-dioxygenase mediates immune-independent human tumor cell resistance to olaparib, gamma radiation, and cisplatin
S. M. Vareki, Mateusz Rytelewski, R. Figueredo, Di Chen +5 more
2014OncoTarget47 citations Open access
Semantic Scholar
S-Nitrosated human serum albumin dimer is not only a novel anti-tumor drug but also a potentiator for anti-tumor drugs with augmented EPR effects.
Y. Ishima, Di Chen, Jun Fang, H. Maeda +5 more
2012Bioconjugate chemistry47 citations
Semantic Scholar
Anti-tumor activity of N-thiolated beta-lactam antibiotics.
Di Chen, S. Falsetti, M. Frezza, V. Milacic +5 more
2008Cancer Letters47 citations Open access
Semantic Scholar
A Novel In Vivo siRNA Delivery System Specifically Targeting Liver Cells for Protection of ConA-Induced Fulminant Hepatitis
N. Jiang, Xu-Sheng Zhang, Xiu-Fen Zheng, Di Chen +7 more
2012PLoS ONE46 citations Open access
Semantic Scholar
Copper-binding compounds as proteasome inhibitors and apoptosis inducers in human cancer.
K. Daniel, Di Chen, B. Yan, Ping Q. Dou
2007Frontiers in Bioscience46 citations Open access
Semantic Scholar

Frequent co-authors

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Ping Q. Dou×41
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Ping Q. Dou — researcher profile on SciRah
Q. Cui×15
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Q. Cui — researcher profile on SciRah
K. Landis-Piwowar×9
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K. Landis-Piwowar — researcher profile on SciRah
T. Chan×9
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Huanjie Yang — researcher profile on SciRah

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V. Milacic — researcher profile on SciRah

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M. Frezza — researcher profile on SciRah

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K. Daniel — researcher profile on SciRah

Marina S. Chen×5

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Marina S. Chen — researcher profile on SciRah

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D. Kuhn — researcher profile on SciRah

Sheng-Biao Wan×5

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Sheng-Biao Wan — researcher profile on SciRah

Xiu-Fen Zheng×4

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Xiu-Fen Zheng — researcher profile on SciRah