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L. Shepherd · SciRah

Researcher profile · Semantic Scholar

L. Shepherd

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L. Shepherd — researcher profile on SciRah

h-index: 65
Works: 318
Citations: 29K

Most-cited papers

Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials
R. Gray, Rosie Bradley, J. Braybrooke, Zu-Lian Liu +162 more
2019The Lancet328 citations Open access
Semantic Scholar
Effect of Metformin vs Placebo on Invasive Disease-Free Survival in Patients With Breast Cancer: The MA.32 Randomized Clinical Trial.
P. Goodwin, Bing-Shu E. Chen, K. Gelmon, T. Whelan +20 more
2022Journal of the American Medical Association (JAMA)215 citations Open access
Semantic Scholar
Effect of Fibrinogen Concentrate vs Cryoprecipitate on Blood Component Transfusion After Cardiac Surgery: The FIBRES Randomized Clinical Trial.
J. Callum, M. Farkouh, D. Scales, N. Heddle +18 more
2019Journal of the American Medical Association (JAMA)162 citations Open access
Semantic Scholar
Genetic and evolutionary patterns of treatment resistance in relapsed B-cell lymphoma.
C. Rushton, S. Arthur, M. Alcaide, M. Cheung +24 more
2020Blood Advances101 citations Open access
Semantic Scholar
Patient-reported predictors of early treatment discontinuation: Treatment-related symptoms and health-related quality of life among postmenopausal women with primary breast cancer randomized to anastrozole or exemestane on NCIC Clinical Trials Group (CCTG) MA.27 (E1Z03)
L. Wagner, Feng-Min Zhao, P. Goss, J. W. Chapman +11 more
2018Breast Cancer Research and Treatment82 citations Open access
Semantic Scholar
Direct Oral Anticoagulant‐ or Warfarin‐Related Major Bleeding: Characteristics, Reversal Strategies, and Outcomes From a Multicenter Observational Study
Yan Xu, S. Schulman, D. Dowlatshahi, A. Holbrook +9 more
2017Chest77 citations Open access
Semantic Scholar
Role of Cytotoxic Tumor-Infiltrating Lymphocytes in Predicting Outcomes in Metastatic HER2-Positive Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial
Shu-Zhen Liu, Bing-Shu E. Chen, S. Burugu, S. Leung +7 more
2017JAMA Oncology48 citations Open access
Semantic Scholar
The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1
J. Cairns, J. Ingle, K. Kalari, L. Shepherd +4 more
2019Breast Cancer Research42 citations Open access
Semantic Scholar
Relapse Timing Is Associated With Distinct Evolutionary Dynamics in Diffuse Large B-Cell Lymphoma
L. Hilton, H. Ngu, B. Collinge, K. Dreval +27 more
2023Journal of Clinical Oncology40 citations Open access
Semantic Scholar
Contact Days Associated With Cancer Treatments in the CCTG LY.12 Trial
Arjun Gupta, A. Hay, M. Crump, M. Djurfeldt +5 more
2023The Oncologist35 citations Open access
Semantic Scholar
Anastrozole has an association between degree of estrogen suppression and outcomes in early breast cancer and is a ligand for estrogen receptor α
J. Ingle, J. Cairns, V. Suman, L. Shepherd +20 more
2020Clinical Cancer Research30 citations Open access
Semantic Scholar
Pharmacogenomics of aromatase inhibitors in postmenopausal breast cancer and additional mechanisms of anastrozole action
J. Cairns, J. Ingle, Tanda M. Dudenkov, K. Kalari +13 more
2020JCI Insight30 citations Open access
Semantic Scholar
Treatment Exposure and Discontinuation in the PALbociclib CoLlaborative Adjuvant Study of Palbociclib With Adjuvant Endocrine Therapy for Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Early Breast Cancer (PALLAS/AFT-05/ABCSG-42/BIG-14-03).
E. Mayer, C. Fesl, D. Hlauschek, L. García-Estévez +29 more
2022Journal of Clinical Oncology28 citations Open access
Semantic Scholar
Salvage chemotherapy and autologous stem cell transplantation for peripheral T-cell lymphoma: a subset analysis of the Canadian Cancer Trials Group LY.12 randomized phase 3 study*
T. Skamene, M. Crump, K. Savage, T. Reiman +14 more
2017Leukemia and Lymphoma27 citations Open access
Semantic Scholar
Effect of metformin versus placebo on metabolic factors in the MA.32 randomized breast cancer trial
P. Goodwin, Ryan J. O. Dowling, M. Ennis, Bing-Shu E. Chen +18 more
2021npj Breast Cancer26 citations Open access
Semantic Scholar
Estrogen, SNP-Dependent Chemokine Expression and Selective Estrogen Receptor Modulator Regulation.
Ming-Fen Ho, T. Bongartz, Mo-Han Liu, K. Kalari +7 more
2016Molecular Endocrinology26 citations Open access
Semantic Scholar
Effects of Celecoxib and Low-dose Aspirin on Outcomes in Adjuvant Aromatase Inhibitor–Treated Patients: CCTG MA.27
K. Strasser-Weippl, M. Higgins, J. W. Chapman, J. Ingle +12 more
2018Journal of the National Cancer Institute25 citations Open access
Semantic Scholar
A phase I study of romidepsin, gemcitabine, dexamethasone and cisplatin combination therapy in the treatment of peripheral T-cell and diffuse large B-cell lymphoma; the Canadian cancer trials group LY.15 study†
T. Reiman, K. Savage, M. Crump, M. Cheung +14 more
2018Leukemia and Lymphoma23 citations
Semantic Scholar
Effect of Metformin Versus Placebo on New Primary Cancers in Canadian Cancer Trials Group MA.32: A Secondary Analysis of a Phase III Randomized Double-Blind Trial in Early Breast Cancer
P. Goodwin, Bing-Shu E. Chen, K. Gelmon, T. Whelan +15 more
2023Journal of Clinical Oncology20 citations Open access
Semantic Scholar
Vitamin D Levels, Vitamin D Receptor Polymorphisms, and Inflammatory Cytokines in Aromatase Inhibitor-Induced Arthralgias: An Analysis of CCTG MA.27
P. Niravath, Bing-Shu E. Chen, J. Chapman, S. Agarwal +12 more
2017Clinical Breast Cancer20 citations Open access
Semantic Scholar
Impact of BMI in Patients With Early Hormone Receptor–Positive Breast Cancer Receiving Endocrine Therapy With or Without Palbociclib in the PALLAS Trial
G. Pfeiler, D. Hlauschek, E. Mayer, C. Deutschmann +47 more
2023Journal of Clinical Oncology19 citations
Semantic Scholar
The conditional survival analysis of relapsed DLBCL after autologous transplant: a subgroup analysis of LY.12 and CORAL.
S. Assouline, Shen Li, C. Gisselbrecht, P. Fogarty +13 more
2020Blood Advances19 citations Open access
Semantic Scholar
Outcomes in women with invasive ductal or invasive lobular early stage breast cancer treated with anastrozole or exemestane in CCTG (NCIC CTG) MA.27.
K. Strasser-Weippl, Gautam Sudan, R. Ramjeesingh, L. Shepherd +5 more
2018European Journal of Cancer18 citations
Semantic Scholar
TCL1A Single-Nucleotide Polymorphisms and Estrogen-Mediated Toll-Like Receptor-MYD88–Dependent Nuclear Factor-κB Activation: Single-Nucleotide Polymorphism– and Selective Estrogen Receptor Modulator–Dependent Modification of Inflammation and Immune Response
Ming-Fen Ho, J. Ingle, T. Bongartz, K. Kalari +6 more
2017Molecular Pharmacology18 citations Open access
Semantic Scholar
The effect of metformin vs placebo on sex hormones in CCTG MA.32.
I. Pimentel, Bing-Shu E. Chen, A. Lohmann, M. Ennis +21 more
2020Journal of the National Cancer Institute17 citations Open access
Semantic Scholar
A bioclinical prognostic model using MYC and BCL2 predicts outcome in relapsed/refractory diffuse large B-cell lymphoma
Mark Bosch, A. Akhter, Bing-Shu E. Chen, A. Mansoor +6 more
2017Haematologica17 citations Open access
Semantic Scholar
The New NCI Precision Medicine Trials
L. Harris, C. Blanke, H. Erba, J. Ford +21 more
2023Clinical Cancer Research16 citations Open access
Semantic Scholar
Cancer Antigen 15-3/Mucin 1 Levels in CCTG MA.32: A Breast Cancer Randomized Trial of Metformin vs Placebo
P. Goodwin, Ryan J. O. Dowling, M. Ennis, Bing-Shu E. Chen +14 more
2021JNCI Cancer Spectrum16 citations Open access
Semantic Scholar
Drug-induced Thrombotic Microangiopathy with Concurrent Proteasome Inhibitor Use in the Treatment of Multiple Myeloma: A Case Series and Review of the Literature.
Bethany E. Monteith, C. Venner, D. Reece, A. Kew +5 more
2020Clinical Lymphoma, Myeloma & Leukemia16 citations
Semantic Scholar
Healthcare resource utilization and costs among patients with direct oral anticoagulant or warfarin-related major bleeding.
Yan Xu, S. Schulman, D. Dowlatshahi, A. Holbrook +9 more
2019Thrombosis Research16 citations
Semantic Scholar
Region-specific glucocorticoid receptor promoter methylation has both positive and negative prognostic value in patients with estrogen receptor-positive breast cancer
Hilary Snider, Brithica Villavarajan, Ying-Wei P. Peng, L. Shepherd +2 more
2019Clinical Epigenetics15 citations Open access
Semantic Scholar
Impact of serum HER2, TIMP-1, and CAIX on outcome for HER2+ metastatic breast cancer patients: CCTG MA.31 (lapatinib vs. trastuzumab)
D. Ho, Jessica Huang, J. W. Chapman, K. Leitzel +12 more
2017Breast Cancer Research and Treatment14 citations
Semantic Scholar
Effects of metformin versus placebo on Vitamin B12 metabolism in non-diabetic breast cancer patients in CCTG MA.32
A. Lohmann, M. Liebman, W. Brien, W. Parulekar +17 more
2017Breast Cancer Research and Treatment13 citations Open access
Semantic Scholar
Anthracycline-induced cardiotoxicity in patients with early-stage breast cancer: the Canadian Cancer Trials Group (CCTG) MA.21 experience
S. Dent, J. Botros, M. Rushton, O. Aseyev +7 more
2020Breast Cancer Research and Treatment12 citations
Semantic Scholar
Effect of the addition of rituximab to salvage chemotherapy prior to autologous stem cell transplant in aggressive CD20+ lymphoma: a cohort comparison from the NCIC Clinical Trials Group Study LY.12*
T. Baetz, Bing-Shu E. Chen, S. Couban, C. Kouroukis +10 more
2017Leukemia and Lymphoma12 citations Open access
Semantic Scholar
P025: RADAR: An international phase III, PET response-adapted, randomised trial in progress, comparing ABVD±ISRT with brentuximab vedotin+AVD±ISRT in patients with previously untreated limited-stage classical Hodgkin lymphoma
J. Radford, T. Adedayo, A. Ardavan, S. Barrington +19 more
2022HemaSphere11 citations Open access
Semantic Scholar
Influence of the competing risk of death on estimates of disease recurrence in trials of adjuvant endocrine therapy for early-stage breast cancer: A secondary analysis of MA.27, MA.17 and MA.17R.
J. Ethier, G. Anderson, P. Austin, M. Clemons +5 more
2021European Journal of Cancer11 citations
Semantic Scholar
Competing risks of death in women treated with adjuvant aromatase inhibitors for early breast cancer on NCIC CTG MA.27
J. W. Chapman, L. Shepherd, J. Ingle, H. Muss +5 more
2016Breast Cancer Research and Treatment11 citations Open access
Semantic Scholar
The Effect of Metformin vs Placebo on Sex Hormones in Canadian Cancer Trials Group MA.32.
I. Pimentel, Bing-Shu E. Chen, A. Lohmann, M. Ennis +21 more
2021Journal of the National Cancer Institute10 citations Open access
Semantic Scholar
Can we transfuse wisely in patients undergoing chemotherapy for acute leukemia or autologous stem cell transplantation?
Michelle C Lamarche, D. Hammond, W. Hopman, Angela Sirosky-Yanyk +2 more
2019Transfusion10 citations
Semantic Scholar
Interaction between SNP Genotype and Efficacy of Anastrozole and Exemestane in Early Stage Breast Cancer
J. Cairns, K. Kalari, J. Ingle, L. Shepherd +9 more
2021Clinical pharmacology and therapy7 citations Open access
Semantic Scholar
TCL1A, a Novel Transcription Factor and a Coregulator of Nuclear Factor κB p65: Single Nucleotide Polymorphism and Estrogen Dependence
Ming-Fen Ho, E. Lummertz da Rocha, Cheng Zhang, J. Ingle +6 more
2018Journal of Pharmacology and Experimental Therapeutics7 citations Open access
Semantic Scholar
Leukocytoclastic vasculitis following lenalidomide during the treatment of follicular lymphoma
J. Loree, Ellen Cai, B. Sheffield, J. Dutz +5 more
2017Leukemia and Lymphoma7 citations
Semantic Scholar
Higher serum PD‐L1 level predicts increased overall survival with lapatinib versus trastuzumab in the CCTG MA.31 phase 3 trial
P. Moku, L. Shepherd, Suhail M. Ali, K. Leitzel +20 more
2020Cancer6 citations Open access
Semantic Scholar
Unusual Carfilzomib Toxicity: Three Cases of Drug-induced Thrombotic Microangiopathy (TMA) after Treatment with High-dose weekly Carfilzomib, Cyclophosphamide, and Dexamethasone (wCCD)
Bethany E. Monteith, C. Venner, D. Reece, A. Kew +7 more
2019Clinical Lymphoma, Myeloma & Leukemia6 citations
Semantic Scholar
CA15-3/MUC1 in CCTG MA-32 (NCT01101438): A phase III RCT of the effect of metformin vs. placebo on invasive disease free and overall survival in early stage breast cancer (BC).
Ryan J. O. Dowling, W. Parulekar, K. Gelmon, L. Shepherd +15 more
20186 citations
Semantic Scholar
A prospective economic analysis of early outcome data from the Alliance A041202/ CCTG CLC.2 randomized phase III trial of bendamustine-rituximab compared with ibrutinib-based regimens in untreated older patients with chronic lymphocytic leukemia
M. Cheung, N. Mittmann, C. Owen, N. Abdel-Samad +16 more
2021Clinical Lymphoma, Myeloma & Leukemia5 citations Open access
Semantic Scholar
Serum PD-L1 and outcomes in CCTG MA.31 phase 3 trial of anti-HER2 therapy in first-line HER2+ metastatic breast cancer patients (trastuzumab arm only).
K. Leitzel, Suhail M. Ali, L. Shepherd, W. Parulekar +16 more
20185 citations
Semantic Scholar
A Canadian Prospective Study of Linkage of Randomized Clinical Trial to Cancer and Mortality Registry Data
A. Hay, N. Mittmann, M. Crump, M. Cheung +8 more
2021Current Oncology4 citations Open access
Semantic Scholar
Relapse timing is associated with distinct evolutionary dynamics in DLBCL
L. Hilton, H. Ngu, B. Collinge, K. Dreval +25 more
2023medRxiv3 citations Open access
Semantic Scholar

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