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I. Rubio · SciRah

Researcher profile · Semantic Scholar

I. Rubio

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I. Rubio — researcher profile on SciRah

h-index: 29
Works: 68
Citations: 3,397

Most-cited papers

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase.
B. Stoyanov, Stefano Volinia, T. Hanck, I. Rubio +6 more
1995Science699 citations
Semantic Scholar
The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
M. Osuchowski, M. Winkler, Tomasz Skirecki, S. Cajander +30 more
2021The Lancet Respiratory Medicine392 citations Open access
Semantic Scholar
Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK.
T. Bondeva, L. Pirola, G. Bulgarelli-Leva, I. Rubio +2 more
1998Science344 citations
Semantic Scholar
Current gaps in sepsis immunology: new opportunities for translational research.
I. Rubio, M. Osuchowski, M. Shankar-Hari, Tomasz Skirecki +26 more
2019Lancet. Infectious Diseases (Print)301 citations Open access
Semantic Scholar
Ras activation revisited: role of GEF and GAP systems
A. Hennig, Robby Markwart, Manuel A. Esparza-Franco, G. Ladds +1 more
2015Biological chemistry111 citations
Semantic Scholar
Live‐cell imaging of endogenous Ras‐GTP illustrates predominant Ras activation at the plasma membrane
M. Augsten, Rico Pusch, C. Biskup, K. Rennert +6 more
2006EMBO Reports98 citations Open access
Semantic Scholar
Interaction of Ras with phosphoinositide 3-kinase gamma.
I. Rubio, P. Rodriguez-Viciana, J. Downward, R. Wetzker
1997Biochemical Journal98 citations Open access
Semantic Scholar
B- and C-RAF Display Essential Differences in Their Binding to Ras
A. Fischer, M. Hekman, Juergen Kuhlmann, I. Rubio +2 more
2007Journal of Biological Chemistry82 citations Open access
Semantic Scholar
Immunosuppression after Sepsis: Systemic Inflammation and Sepsis Induce a Loss of Naïve T-Cells but No Enduring Cell-Autonomous Defects in T-Cell Function
Robby Markwart, Stephanie A Condotta, R. Requardt, Farina Borken +8 more
2014PLoS ONE66 citations Open access
Semantic Scholar
Regulation of Ras Exchange Factors and Cellular Localization of Ras Activation by Lipid Messengers in T Cells
Jesse E Jun, I. Rubio, J. Roose
2013Frontiers in Immunology65 citations Open access
Semantic Scholar
Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway
K. Uhlenbrock, M. Weiwad, R. Wetzker, G. Fischer +2 more
2009FEBS Letters51 citations Open access
Semantic Scholar
Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma.
I. Rubio, U. Wittig, C. Meyer, Regina Heinze +4 more
1999European Journal of Biochemistry51 citations
Semantic Scholar
Role of cAMP in the promotion of colorectal cancer cell growth by Prostaglandin E2
Ivonne Löffler, M. Grün, F. Böhmer, I. Rubio
2008BMC Cancer50 citations Open access
Semantic Scholar
Inhibition of diacylglycerol kinase alpha restores restimulation-induced cell death and reduces immunopathology in XLP-1
Elisa Ruffo, Valeria Malacarne, S. E. Larsen, Rupali Das +13 more
2016Science Translational Medicine48 citations Open access
Semantic Scholar
Prostaglandin E2 Differentially Modulates Proinflammatory/Prodestructive Effects of TNF-α on Synovial Fibroblasts via Specific E Prostanoid Receptors/cAMP
E. Kunisch, A. Jansen, Fumiaki Kojima, Ivonne Löffler +5 more
2009Journal of Immunology47 citations Open access
Semantic Scholar
This information is current as Diacylglycerol Signaling Regulates TCR-Induced α Kinase SAP-Mediated Inhibition of Diacylglycerol and
G. Baldanzi, Andrea Pighini, Valentina Bettio, E. Rainero +16 more
201146 citations
Semantic Scholar
TCR-Induced Activation of Ras Proceeds at the Plasma Membrane and Requires Palmitoylation of N-Ras
I. Rubio, S. Grund, Shu-Ping Song, C. Biskup +6 more
2010Journal of Immunology46 citations Open access
Semantic Scholar
RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines
O. Ksionda, AA Melton, J. Bache, M. Tenhagen +5 more
2015Oncogene41 citations Open access
Semantic Scholar
Activation of Ras Requires the ERM-Dependent Link of Actin to the Plasma Membrane
Tobias Sperka, Katja J Geissler, U. Merkel, I. Scholl +3 more
2011PLoS ONE41 citations Open access
Semantic Scholar
A permissive function of phosphoinositide 3-kinase in Ras activation mediated by inhibition of GTPase-activating proteins.
I. Rubio, R. Wetzker
2000Current Biology39 citations Open access
Semantic Scholar
Graded inhibition of oncogenic Ras-signaling by multivalent Ras-binding domains
M. Augsten, Anika Böttcher, R. Spanbroek, I. Rubio +1 more
2014Cell Communication and Signaling35 citations Open access
Semantic Scholar
Ras signals principally via Erk in G1 but cooperates with PI3K/Akt for Cyclin D induction and S-phase entry
Ledia Vasjari, Stephanie Bresan, C. Biskup, Govind Pai +1 more
2019Cell Cycle33 citations Open access
Semantic Scholar
Feedback activation of neurofibromin terminates growth factor-induced Ras activation
A. Hennig, Robby Markwart, Katharina Wolff, K. Schubert +5 more
2016Cell Communication and Signaling33 citations Open access
Semantic Scholar
Features of Ras activation by a mislocalized oncogenic tyrosine kinase: FLT3 ITD signals through K-Ras at the plasma membrane of acute myeloid leukemia cells
Susanne Köthe, J. Müller, Sylvia-Annette Böhmer, Todor Tschongov +6 more
2013Journal of Cell Science33 citations
Semantic Scholar
Ras activation in response to lysophosphatidic acid requires a permissive input from the epidermal growth factor receptor.
I. Rubio, K. Rennert, U. Wittig, R. Wetzker
2003Biochemical Journal32 citations Open access
Semantic Scholar
BCR-ABL- and Ras-independent activation of Raf as a novel mechanism of Imatinib resistance in CML.
J. Hentschel, I. Rubio, Melanie Eberhart, C. Hipler +6 more
2011International Journal of Oncology30 citations Open access
Semantic Scholar
S1P lyase inhibition protects against sepsis by promoting disease tolerance via the S1P/S1PR3 axis
Cynthia Weigel, Sören S. Hüttner, Kristin Ludwig, N. Krieg +10 more
2020EBioMedicine29 citations Open access
Semantic Scholar
Ras palmitoylation is necessary for N-Ras activation and signal propagation in growth factor signalling.
Shu-Ping Song, A. Hennig, K. Schubert, Robby Markwart +4 more
2013Biochemical Journal29 citations
Semantic Scholar
Tetraspanin 1 promotes invasiveness of cervical cancer cells.
S. Hölters, Jelena Anacker, L. Jansen, K. Beer-Grondke +2 more
2013International Journal of Oncology29 citations Open access
Semantic Scholar
Functional characterization of T-cells from palatine tonsils in patients with chronic tonsillitis
K. Geißler, Robby Markwart, R. Requardt, Cynthia Weigel +4 more
2017PLoS ONE27 citations Open access
Semantic Scholar
Regulation of Son of sevenless by the membrane-actin linker protein ezrin
Katja J Geissler, M. J. Jung, L. Riecken, Tobias Sperka +12 more
2013Proceedings of the National Academy of Sciences of the United States of America26 citations Open access
Semantic Scholar
Ras activation in response to phorbol ester proceeds independently of the EGFR via an unconventional nucleotide-exchange factor system in COS-7 cells.
I. Rubio, K. Rennert, U. Wittig, Katrin Beer +4 more
2006Biochemical Journal26 citations Open access
Semantic Scholar
Hormesis and Defense of Infectious Disease
S. Weis, I. Rubio, Kristin Ludwig, Cynthia Weigel +1 more
2017International Journal of Molecular Sciences25 citations Open access
Semantic Scholar
Cytokine production in patients with recurrent acute tonsillitis: analysis of tonsil samples and blood
K. Geißler, Cynthia Weigel, K. Schubert, I. Rubio +1 more
2020Scientific Reports24 citations Open access
Semantic Scholar
Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge
M. Winkler, Tomasz Skirecki, F. Brunkhorst, S. Cajander +19 more
2021EBioMedicine23 citations Open access
Semantic Scholar
Targeting PI3K in neuroblastoma
Volker Spitzenberg, Christian König, Susanne Ulm, Romina Marone +8 more
2010Journal of Cancer Research and Clinical Oncology23 citations Open access
Semantic Scholar
The residue at position 5 of the N-terminal region of Src and Fyn modulates their myristoylation, palmitoylation, and membrane interactions
Efrat Gottlieb-Abraham, O. Gutman, Govind Pai, I. Rubio +1 more
2016Molecular Biology of the Cell19 citations Open access
Semantic Scholar
Chemokine Unresponsiveness of Chronic Lymphocytic Leukemia Cells Results from Impaired Endosomal Recycling of Rap1 and Is Associated with a Distinctive Type of Immunological Anergy
Derek S. Pye, I. Rubio, Rico Pusch, Ke Lin +2 more
2013Journal of Immunology19 citations Open access
Semantic Scholar
Quantification of absolute Ras-GDP/GTP levels by HPLC separation of Ras-bound [(32)P]-labelled nucleotides.
I. Rubio, Rico Pusch, R. Wetzker
2004Journal of Biochemical and Biophysical Methods19 citations
Semantic Scholar
Differential Regulation of Lipid and Protein Kinase Activities of Phosphoinositide 3-Kinase γ in Vitro
A. Bondev, I. Rubio, R. Wetzker
199919 citations
Semantic Scholar
Raman Spectroscopy Follows Time-Dependent Changes in T Lymphocytes Isolated from Spleen of Endotoxemic Mice
A. Ramoji, O. Ryabchykov, Kerstin Galler, A. Tannert +7 more
2019ImmunoHorizons18 citations Open access
Semantic Scholar
Chronic Critical Illness from Sepsis Is Associated with an Enhanced TCR Response
Farina Borken, Robby Markwart, R. Requardt, K. Schubert +7 more
2017Journal of Immunology16 citations Open access
Semantic Scholar
Genetic variants of TRAF6 modulate peritoneal immunity and the risk of spontaneous bacterial peritonitis in cirrhosis: A combined prospective-retrospective study
M. Mai, S. Stengel, Eihab Al-Herwi, J. Peter +4 more
2017Scientific Reports15 citations Open access
Semantic Scholar
Serine 338 Phosphorylation Is Dispensable for Activation of c-Raf1*
W. Oehrl, I. Rubio, R. Wetzker
2003Journal of Biological Chemistry14 citations Open access
Semantic Scholar
C3G downregulation induces the acquisition of a mesenchymal phenotype that enhances aggressiveness of glioblastoma cells
S. Manzano, Á. Gutierrez-Uzquiza, P. Bragado, Celia Sequera +7 more
2021Cell Death and Disease13 citations Open access
Semantic Scholar
TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress
Govind Pai, A. Zielinski, Dennis Koalick, Kristin Ludwig +4 more
2016OncoTarget10 citations Open access
Semantic Scholar
Real-time visualization and quantification of native Ras activation in single living cells.
C. Biskup, I. Rubio
2014Methods in molecular biology9 citations
Semantic Scholar
Isolation of viable and functional T-cells from human palatine tonsils.
Cynthia Weigel, K. Geißler, Robby Markwart, K. Schubert +3 more
2015JIM - Journal of Immunological Methods8 citations
Semantic Scholar
Hormetic Signaling Patterns
R. Wetzker, I. Rubio
2012Dose-Response8 citations Open access
Semantic Scholar
Use of the Ras binding domain of c-Raf for biochemical and live-cell analysis of Ras activation.
I. Rubio
2005Biochemical Society Transactions8 citations
Semantic Scholar

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R. Wetzker×13
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R. Wetzker — researcher profile on SciRah
Robby Markwart×9
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K. Schubert×7
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U. Wittig×6
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Cynthia Weigel×6

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F. Brunkhorst×5

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M. Winkler — researcher profile on SciRah

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M. Osuchowski×3

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M. Osuchowski — researcher profile on SciRah

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