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Di Chen · SciRah

Researcher profile · Semantic Scholar

Di Chen

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Di Chen — researcher profile on SciRah

h-index: 73
Works: 217
Citations: 20K

Most-cited papers

Osteoarthritis: toward a comprehensive understanding of pathological mechanism
Di Chen, Jie Shen, Weiwei Zhao, Ting-Yu Wang +3 more
2017Bone Research1,136 citations Open access
Semantic Scholar
Osteoarthritis Pathogenesis: A Review of Molecular Mechanisms
Bing-jiang Xia, Di Chen, Jushi Zhang, Songfeng Hu +2 more
2014Calcified Tissue International494 citations Open access
Semantic Scholar
Ankylosing spondylitis: etiology, pathogenesis, and treatments
Wei Zhu, Xu-Xia He, Kaiyuan Cheng, Linjie Zhang +5 more
2019Bone Research424 citations Open access
Semantic Scholar
Intestinal epithelial vitamin D receptor deletion leads to defective autophagyin colitis
Shaoping Wu, Yong-Guo Zhang, Rong Lu, Ying-Lin Xia +7 more
2014Gut326 citations Open access
Semantic Scholar
Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway
Song-Ho Chang, D. Mori, Hiroshi Kobayashi, Yoshifumi Mori +13 more
2019Nature Communications284 citations Open access
Semantic Scholar
Targeting VEGF and its Receptors for the Treatment of Osteoarthritis and Associated Pain
J. Hamilton, Masashi Nagao, B. Levine, Di Chen +2 more
2016Journal of Bone and Mineral Research261 citations Open access
Semantic Scholar
TGF-β signaling and the development of osteoarthritis
Jie Shen, Shan Li, Di Chen
2014Bone Research238 citations Open access
Semantic Scholar
Wnt/β-catenin Signaling in Osteoarthritis and in Other Forms of Arthritis
Ya-Chuan Zhou, Ting-Yu Wang, J. Hamilton, Di Chen
2017Current Rheumatology Reports202 citations Open access
Semantic Scholar
The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression
Jian Huang, Lan Zhao, Yunshan Fan, Lifan Liao +3 more
2019Nature Communications147 citations Open access
Semantic Scholar
Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis
Christopher J. O'Conor, Sendhilnathan Ramalingam, Nicole A. Zelenski, Halei C. Benefield +7 more
2016Scientific Reports139 citations Open access
Semantic Scholar
Vitamin D receptor pathway is required for probiotic protection in colitis.
Shaoping Wu, Sonia S. Yoon, Yong-Guo Zhang, Rong Lu +6 more
2015American Journal of Physiology - Gastrointestinal and Liver Physiology129 citations Open access
Semantic Scholar
Exploration of CRISPR/Cas9-based gene editing as therapy for osteoarthritis
Lan Zhao, Jian Huang, Yunshan Fan, Jun Li +4 more
2019Annals of the Rheumatic Diseases125 citations Open access
Semantic Scholar
Kindlin-2 Controls TGF-β signaling and Sox9 Expression to Regulate Chondrogenesis
Chuan-Yue Wu, Hong-Li Jiao, Yu-Mei Lai, Wei Zheng +13 more
2015Nature Communications118 citations Open access
Semantic Scholar
Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy
Yi-Min Ma, Yongxin Ren, Ethan Q Han, Hui-Wu Li +7 more
2013Biochemical and Biophysical Research Communications - BBRC117 citations Open access
Semantic Scholar
MicroRNA-146a reduces IL-1 dependent inflammatory responses in the intervertebral disc
S. Gu, Xin Li, J. Hamilton, Ana V. Chee +8 more
2014Gene104 citations Open access
Semantic Scholar
Deletion of Runx2 in Articular Chondrocytes Decelerates the Progression of DMM-Induced Osteoarthritis in Adult Mice
Lifan Liao, Shan-Xing Zhang, Jianhong Gu, T. Takarada +8 more
2017Scientific Reports90 citations Open access
Semantic Scholar
Anti-DKK1 antibody promotes bone fracture healing through activation of β-catenin signaling
Hong-Ting Jin, Baoli Wang, Jia Li, Wan-Qing Xie +8 more
2014Bone87 citations Open access
Semantic Scholar
Injectable nanofibrous spongy microspheres for NR4A1 plasmid DNA transfection to reverse fibrotic degeneration and support disc regeneration
G. Feng, Zhan-Peng Zhang, Ming Dang, Xiao-Jin Zhang +4 more
2017Biomaterials75 citations Open access
Semantic Scholar
Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice
Hui-Ling Cao, Qin-Nan Yan, Dong Wang, Yu-Mei Lai +16 more
2020Bone Research73 citations Open access
Semantic Scholar
Combination Treatment of Biomechanical Support and Targeted Intra-arterial Infusion of Peripheral Blood Stem Cells mobilized by granulocyte-colony stimulating factor for the Osteonecrosis of the Femoral Head: a randomised controlled clinical trial
Qiang Mao, Weidong Wang, Tao-Tao Xu, Shan-Xing Zhang +4 more
2015Journal of Bone and Mineral Research72 citations Open access
Semantic Scholar
Characterization of degenerative human facet joints and facet joint capsular tissues
Jaesung Kim, Mir H. Ali, Frank Wydra, Xin Li +10 more
2015Osteoarthritis and Cartilage71 citations Open access
Semantic Scholar
ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment
Ke Zhu, Hong-Li Jiao, Shuai Li, Hui-Ling Cao +8 more
2013Journal of Bone and Mineral Research68 citations Open access
Semantic Scholar
FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice
Liang Kuang, Jiang-Yi Wu, Nan Su, Hua-Bing Qi +24 more
2019Annals of the Rheumatic Diseases66 citations
Semantic Scholar
FGFR3/fibroblast growth factor receptor 3 inhibits autophagy through decreasing the ATG12–ATG5 conjugate, leading to the delay of cartilage development in achondroplasia
Xiaofen Wang, Hua-Bing Qi, Quan Wang, Ying Zhu +11 more
2015Autophagy64 citations Open access
Semantic Scholar
Acute Synovitis after Trauma Precedes and is Associated with Osteoarthritis Onset and Progression
Lifan Liao, Shan-Xing Zhang, Lan Zhao, Xiaofeng Chang +3 more
2020International Journal on Biological Sciences63 citations Open access
Semantic Scholar
Wnt signaling in bone, kidney, intestine, and adipose tissue and inter-organ interaction in aging
Di Chen, Rong Xie, Bing Shu, A. Landay +7 more
2018Annals of the New York Academy of Sciences58 citations Open access
Semantic Scholar
ATF4 Promotes β-Catenin Expression and Osteoblastic Differentiation of Bone Marrow Mesenchymal Stem Cells
Shi-Bing Yu, Ke Zhu, Yu-Mei Lai, Zhong-Fang Zhao +4 more
2013International Journal on Biological Sciences58 citations Open access
Semantic Scholar
The E3 ubiquitin ligase CHIP in normal cell function and in disease conditions
Ting-Yu Wang, Wenbo Wang, Qishan Wang, Rong Xie +2 more
2019Annals of the New York Academy of Sciences57 citations Open access
Semantic Scholar
Environmental Disruption of Circadian Rhythm Predisposes Mice to Osteoarthritis-Like Changes in Knee Joint
R. Kc, Xin Li, R. Voigt, Michael B. Ellman +10 more
2015Journal of Cellular Physiology55 citations Open access
Semantic Scholar
Inhibition of Ihh Reverses Temporomandibular Joint Osteoarthritis via a PTH1R Signaling Dependent Mechanism
Hong-Xu Yang, Mian Zhang, Qian Liu, Hong-Yun Zhang +5 more
2019International Journal of Molecular Sciences52 citations Open access
Semantic Scholar
Chondrocyte β-Catenin Signaling Regulates Postnatal Bone Remodeling Through Modulation of Osteoclast Formation in a Murine Model
Baoli Wang, Hong-Ting Jin, Mei Zhu, Jia Li +7 more
2014Arthritis & Rheumatology52 citations Open access
Semantic Scholar
FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling
Siru Zhou, Yang-Li Xie, Junzhou Tang, Jun-Lan Huang +10 more
2015PLoS Genetics51 citations Open access
Semantic Scholar
Inactivation of Vhl in Osteochondral Progenitor Cells Causes High Bone Mass Phenotype and Protects Against Age-Related Bone Loss in Adult Mice
Tu-Jun Weng, Yang-Li Xie, Jun-Lan Huang, Feng-Tao Luo +4 more
2014Journal of Bone and Mineral Research50 citations Open access
Semantic Scholar
Targeted Disruption of Shp2 in Chondrocytes Leads to Metachondromatosis With Multiple Cartilaginous Protrusions
Harry K. W. Kim, Gen-Sheng Feng, Di Chen, Philip D. King +1 more
2014Journal of Bone and Mineral Research50 citations Open access
Semantic Scholar
Lipoatrophy and metabolic disturbance in mice with adipose-specific deletion of kindlin-2.
Huanqing Gao, Yuxi Guo, Qin-Nan Yan, Wei Yang +7 more
2019JCI Insight48 citations Open access
Semantic Scholar
Activation of β-catenin signaling in aggrecan-expressing cells in temporomandibular joint causes osteoarthritis-like defects
T. Hui, Ya-Chuan Zhou, Ting-Yu Wang, Jun Li +6 more
2018International Journal of Oral Science48 citations Open access
Semantic Scholar
Bortezomib Attenuates Joint Tissue Damage in a Mouse Model of Experimental Post-Traumatic Osteoarthritis, which is Associated with Improved Synovial Lymphatic Function
Wensheng Wang, Xi Lin, Hao Xu, Wen Sun +5 more
2019Arthritis & Rheumatology47 citations Open access
Semantic Scholar
Enhanced BMP signaling prevents degeneration and leads to endochondral ossification of Meckel’s cartilage in mice
Ying Wang, Yu-Qian Zheng, Di Chen, Yi-Ping Chen
2013Developmental Biology47 citations Open access
Semantic Scholar
FGFR3 induces degradation of BMP type I receptor to regulate skeletal development
Hua-Bing Qi, Min Jin, Y. Duan, Xiao-Lan Du +15 more
2014Biochimica et Biophysica Acta45 citations Open access
Semantic Scholar
Inhibition of ERK1/2 Signaling Pathway is Involved in Melatonin's Antiproliferative Effect on Human MG-63 Osteosarcoma Cells
Lifeng Liu, Ying Xu, R. Reiter, Yu-Tao Pan +5 more
2016Cellular Physiology and Biochemistry44 citations Open access
Semantic Scholar
Baicalin prevents the apoptosis of endplate chondrocytes by inhibiting the oxidative stress induced by H2O2.
Yu-Tao Pan, Di Chen, Qing-You Lu, Lifeng Liu +2 more
2017Molecular Medicine Reports42 citations Open access
Semantic Scholar
Growth Factor Signalling in Osteoarthritis
Jian Huang, Lan Zhao, Di Chen
2018Growth Factors39 citations Open access
Semantic Scholar
MicroRNA-338-3p as a novel therapeutic target for intervertebral disc degeneration
Hua Jiang, A. Moro, Jiaqi Wang, Dihua Meng +3 more
2020Experimental and Molecular Medicine38 citations Open access
Semantic Scholar
A Novel Regulatory Mechanism of Type II Collagen Expression via a SOX9-dependent Enhancer in Intron 6*
H. Yasuda, C. Oh, Di Chen, B. De Crombrugghe +1 more
2016Journal of Biological Chemistry38 citations Open access
Semantic Scholar
Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice.
Yi-Shu Wang, Qin-Nan Yan, Yiran Zhao, Xin Liu +11 more
2019JCI Insight37 citations Open access
Semantic Scholar
SHP2 Regulates the Osteogenic Fate of Growth Plate Hypertrophic Chondrocytes
Li-Jun Wang, Jiahui Huang, D. Moore, Chunlin Zuo +8 more
2017Scientific Reports37 citations Open access
Semantic Scholar
Osthole Promotes Bone Fracture Healing through Activation of BMP Signaling in Chondrocytes
Ping-Er Wang, J. Ying, Cheng Luo, Xing Jin +7 more
2017International Journal on Biological Sciences37 citations Open access
Semantic Scholar
Impaired Bone Homeostasis in Amyotrophic Lateral Sclerosis Mice with Muscle Atrophy*
Ke Zhu, Jian-Xun Yi, Yajuan Xiao, Yu-Mei Lai +8 more
2015Journal of Biological Chemistry36 citations Open access
Semantic Scholar
Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis
Tu-Jun Weng, Yang-Li Xie, Ling-Xian Yi, Jun-Lan Huang +6 more
2014Osteoarthritis and Cartilage36 citations Open access
Semantic Scholar
Cell type-specific effects of Notch signaling activation on intervertebral discs: Implications for intervertebral disc degeneration
Yixin Zheng, Cun-Chang Liu, Li Ni, Zhaoyang Liu +7 more
2018Journal of Cellular Physiology35 citations Open access
Semantic Scholar

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