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S. Saito · SciRah

Researcher profile · Semantic Scholar

S. Saito

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S. Saito — researcher profile on SciRah

h-index: 22
Works: 61
Citations: 1,211

Most-cited papers

Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells.
Ta-Kashi Ito, G. Ishii, S. Saito, K. Yano +3 more
2009Blood92 citations
Semantic Scholar
Molecular diagnosis of 65 families with mucopolysaccharidosis type II (Hunter syndrome) characterized by 16 novel mutations in the IDS gene: Genetic, pathological, and structural studies on iduronate-2-sulfatase.
M. Kosuga, R. Mashima, A. Hirakiyama, Naoko Fuji +7 more
2016Molecular Genetics and Metabolism72 citations
Semantic Scholar
Therapeutic Potential of Intracerebroventricular Replacement of Modified Human β-Hexosaminidase B for GM2 Gangliosidosis
Kazuhiko Matsuoka, Tomomi Tamura, Daisuke Tsuji, Yukie Dohzono +5 more
2011Molecular Therapy65 citations Open access
Semantic Scholar
Fabry-database.org: database of the clinical phenotypes, genotypes and mutant α-galactosidase A structures in Fabry disease
S. Saito, K. Ohno, H. Sakuraba
2011Journal of Human Genetics63 citations
Semantic Scholar
Late-onset Krabbe disease is predominant in Japan and its mutant precursor protein undergoes more effective processing than the infantile-onset form.
M. A. Hossain, T. Otomo, S. Saito, K. Ohno +4 more
2014Gene53 citations Open access
Semantic Scholar
Fabry disease: biochemical, pathological and structural studies of the α-galactosidase A with E66Q amino acid substitution.
Tadayasu Togawa, T. Tsukimura, Takashi Kodama, Toshie Tanaka +12 more
2012Molecular Genetics and Metabolism48 citations
Semantic Scholar
Human α-l-iduronidase uses its own N-glycan as a substrate-binding and catalytic module
N. Maita, T. Tsukimura, T. Taniguchi, S. Saito +3 more
2013Proceedings of the National Academy of Sciences of the United States of America45 citations Open access
Semantic Scholar
Molecular interaction of imino sugars with human alpha-galactosidase: Insight into the mechanism of complex formation and pharmacological chaperone action in Fabry disease.
K. Sugawara, Youichi Tajima, I. Kawashima, T. Tsukimura +6 more
2009Molecular Genetics and Metabolism40 citations
Semantic Scholar
Characterization of the post‐translational modification of recombinant human BMP‐15 mature protein
S. Saito, K. Yano, Shweta Sharma, H. McMahon +1 more
2008Protein Science38 citations Open access
Semantic Scholar
A stable engineered human IgG3 antibody with decreased aggregation during antibody expression and low pH stress
S. Saito, Hiroshi Namisaki, Keiko Hiraishi, N. Takahashi +1 more
2019Protein Science37 citations Open access
Semantic Scholar
Fabry disease in a Japanese population-molecular and biochemical characteristics
H. Sakuraba, T. Tsukimura, Tadayasu Togawa, Toshie Tanaka +5 more
2018Molecular Genetics and Metabolism Reports37 citations Open access
Semantic Scholar
Structural bases of Wolman disease and cholesteryl ester storage disease.
S. Saito, K. Ohno, Toshihiro Suzuki, H. Sakuraba
2012Molecular Genetics and Metabolism37 citations
Semantic Scholar
Gradual development of protein-like global structures through functional selection
T. Yomo, S. Saito, M. Sasai
1999Nature Structural Biology37 citations
Semantic Scholar
High-throughput screening identified disease-causing mutants and functional variants of α-galactosidase A gene in Japanese male hemodialysis patients
Kent Doi, E. Noiri, T. Ishizu, Kousuke Negishi +8 more
2012Journal of Human Genetics33 citations
Semantic Scholar
Structural bases of GM1 gangliosidosis and Morquio B disease
Mizuki Morita, S. Saito, K. Ikeda, K. Ohno +4 more
2009Journal of Human Genetics33 citations
Semantic Scholar
Structural characterization of mutant α-galactosidases causing Fabry disease
K. Sugawara, K. Ohno, S. Saito, H. Sakuraba
2008Journal of Human Genetics33 citations
Semantic Scholar
Mutant α-galactosidase A with M296I does not cause elevation of the plasma globotriaosylsphingosine level.
Sayuri Mitobe, Tadayasu Togawa, T. Tsukimura, Takashi Kodama +10 more
2012Molecular Genetics and Metabolism32 citations
Semantic Scholar
Chaperone therapy for Krabbe disease: potential for late-onset GALC mutations
M. A. Hossain, K. Higaki, S. Saito, K. Ohno +5 more
2015Journal of Human Genetics31 citations
Semantic Scholar
Structural and clinical implications of amino acid substitutions in N-acetylgalactosamine-4-sulfatase: insight into mucopolysaccharidosis type VI.
S. Saito, K. Ohno, K. Sugawara, H. Sakuraba
2008Molecular Genetics and Metabolism25 citations
Semantic Scholar
Structural modeling of mutant α-glucosidases resulting in a processing/transport defect in Pompe disease
K. Sugawara, S. Saito, M. Sekijima, K. Ohno +4 more
2009Journal of Human Genetics24 citations
Semantic Scholar
Arginine residue 155 in the second intracellular loop plays a critical role in rat melanin-concentrating hormone receptor 1 activation.
Yumiko Saito, Mitsue Tetsuka, S. Saito, Kensaku Imai +3 more
2005Endocrinology24 citations Open access
Semantic Scholar
Understanding the molecular mechanism underlying the high catalytic activity of p-hydroxybenzoate hydroxylase mutants for producing gallic acid.
Yoshitaka Moriwaki, M. Yato, T. Terada, S. Saito +9 more
2019Biochemistry23 citations
Semantic Scholar
Late onset variants in Fabry disease: Results in high risk population screenings in Argentina
G. Serebrinsky, M. Calvo, S. Fernandez, S. Saito +5 more
2015Molecular Genetics and Metabolism Reports21 citations Open access
Semantic Scholar
Structural and clinical implications of amino acid substitutions in α-L-iduronidase: insight into the basis of mucopolysaccharidosis type I.
S. Saito, K. Ohno, N. Maita, H. Sakuraba
2014Molecular Genetics and Metabolism21 citations
Semantic Scholar
Prediction of the clinical phenotype of Fabry disease based on protein sequential and structural information
S. Saito, K. Ohno, Se-Se Jun, K. Sugawara +1 more
2010Journal of Human Genetics20 citations
Semantic Scholar
Structural consequences of amino acid substitutions causing Tay-Sachs disease.
K. Ohno, S. Saito, K. Sugawara, H. Sakuraba
2008Molecular Genetics and Metabolism20 citations
Semantic Scholar
Comparative Study of Structural Changes Caused by Different Substitutions at the Same Residue on α-Galactosidase A
S. Saito, K. Ohno, H. Sakuraba
2013PLoS ONE18 citations Open access
Semantic Scholar
Screening of Fabry disease in patients with chronic kidney disease in Japan
Akiko Nagata, M. Nasu, Y. Kaida, Yosuke Nakayama +9 more
2021Nephrology, Dialysis and Transplantation17 citations Open access
Semantic Scholar
Plasma mutant α-galactosidase A protein and globotriaosylsphingosine level in Fabry disease
T. Tsukimura, S. Nakano, Tadayasu Togawa, Toshie Tanaka +4 more
2014Molecular Genetics and Metabolism Reports17 citations Open access
Semantic Scholar
Structural basis of aspartylglucosaminuria.
S. Saito, K. Ohno, K. Sugawara, Toshihiro Suzuki +2 more
2008Biochemical and Biophysical Research Communications - BBRC17 citations
Semantic Scholar
R409K mutation prevents acid-induced aggregation of human IgG4
Hiroshi Namisaki, S. Saito, Keiko Hiraishi, T. Haba +4 more
2020PLoS ONE15 citations Open access
Semantic Scholar
Structural study on mutant α-L-iduronidases: insight into mucopolysaccharidosis type I
K. Sugawara, S. Saito, K. Ohno, T. Okuyama +1 more
2008Journal of Human Genetics14 citations
Semantic Scholar
Drug-target identification from total cellular lysate by drug-induced conformational changes.
Y. Nishiya, Kenji Shibata, S. Saito, K. Yano +3 more
2009Analytical Biochemistry13 citations
Semantic Scholar
Database of the clinical phenotypes, genotypes and mutant arylsulfatase B structures in mucopolysaccharidosis type VI
S. Saito, K. Ohno, M. Sekijima, Toshihiro Suzuki +1 more
2012Journal of Human Genetics12 citations
Semantic Scholar
Biochemical and structural study on a S529V mutant acid α-glucosidase responsive to pharmacological chaperones
Youichi Tajima, S. Saito, K. Ohno, T. Tsukimura +2 more
2011Journal of Human Genetics12 citations
Semantic Scholar
Molecular mechanism for stabilization of a mutant α-galactosidase A involving M51I amino acid substitution by imino sugars.
T. Tsukimura, Y. Chiba, K. Ohno, S. Saito +2 more
2011Molecular Genetics and Metabolism11 citations
Semantic Scholar
Engineering a human IgG2 antibody stable at low pH
S. Saito, Hiroshi Namisaki, Keiko Hiraishi, N. Takahashi +1 more
2020Protein Science10 citations Open access
Semantic Scholar
Structural Basis of Mucopolysaccharidosis Type II and Construction of a Database of Mutant Iduronate 2-Sulfatases
S. Saito, K. Ohno, T. Okuyama, H. Sakuraba
2016PLoS ONE10 citations Open access
Semantic Scholar
A heterozygous female with Fabry disease due to a novel α-galactosidase A mutation exhibits a unique synaptopodin distribution in vacuolated podocytes.
Naoki Takahashi, S. Yokoi, K. Kasuno, Akiya Kogami +14 more
2015Clinical Nephrology10 citations
Semantic Scholar
Structural basis of neuronal ceroid lipofuscinosis 1.
K. Ohno, S. Saito, K. Sugawara, Toshihiro Suzuki +2 more
2010Brain & development (Tokyo. 1979)9 citations
Semantic Scholar
Quantum chemical study on the affinity maturation of 48G7 antibody
K. Ohno, M. Wada, S. Saito, Y. Inoue +1 more
20057 citations
Semantic Scholar
Human alpha-l-iduronidase
N. Maita, T. Tsukimura, T. Taniguchi, S. Saito +3 more
20134 citations
Semantic Scholar
Kinetic consistency in the protein folding process
S. Saito, M. Sasai
19994 citations
Semantic Scholar
Evaluation of GLA variants detected in newborn screening for Fabry disease using biomarker analysis
Takaaki Sawada, J. Kido, T. Tsukimura, K. Sugawara +8 more
2025Molecular Genetics and Metabolism Reports3 citations Open access
Semantic Scholar
Erratum to: Screening of Fabry disease in patients with chronic kidney disease in Japan
Akiko Nagata, M. Nasu, Y. Kaida, Yosuke Nakayama +9 more
2021Nephrology, Dialysis and Transplantation3 citations Open access
Semantic Scholar
Enzyme replacement therapy using a modified α-N-acetylgalactosaminidase to suppress progressive glycolipid accumulation and escape from antidrug antibody formation in young human NAGA-transgenic/Gla-knockout mice.
Hitoshi Sakuraba, T. Tsukimura, Tomoko Shiga, S. Saito +4 more
2025Molecular Genetics and Metabolism1 citations Open access
Semantic Scholar
Ebetsu Active Future Study (EAFS): cognitive function and physical and mental health in elderly residents of Ebetsu City, Japan – cohort profile
H. Kagami-Katsuyama, Naohito Ito, Makoto Hazama, Nobuyuki Toya +28 more
2026BMJ Open0 citations Open access
Semantic Scholar
Identification and functional analysis of Gdf11 enhancer that determines the hindlimb position.
S. Saito
20190 citations
Semantic Scholar
ERRATUM.
Akiko Nagata, M. Nasu, Y. Kaida, Yosuke Nakayama +8 more
2019Continuum0 citations
Semantic Scholar
Comparison of GLA variants of unknown significance and the specific mutations causing moderate Fabry disease
T. Tsukimura, Masashi Shigenaga, S. Saito, Tadayasu Togawa +1 more
20180 citations
Semantic Scholar

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