Jie Zheng

Most-cited papers

Molecular Mechanism of TRP Channels
Jie Zheng
2013Comprehensive Physiology343 citations Open access
Semantic Scholar
Understand spiciness: mechanism of TRPV1 channel activation by capsaicin
Fan Yang, Jie Zheng
2017Protein & Cell334 citations Open access
Semantic Scholar
Structural mechanism underlying capsaicin binding and activation of TRPV1 ion channel
Fan Yang, Xian Xiao, Wei Cheng, Wei Yang +4 more
2015Nature Chemical Biology286 citations Open access
Semantic Scholar
Thermosensitive TRP channel pore turret is part of the temperature activation pathway
Fan Yang, Yuan-Yuan Cui, Ke-Wei Wang, Jie Zheng
2010Proceedings of the National Academy of Sciences of the United States of America202 citations Open access
Semantic Scholar
Handbook of ion channels
Jie Zheng, M. Trudeau
2015138 citations
Semantic Scholar
A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1
Shilong Yang, Fan Yang, Ning-ning Wei, Jing Hong +7 more
2015Nature Communications121 citations Open access
Semantic Scholar
Application of fluorescence resonance energy transfer in protein studies
Lin-Lin Ma, Fan Yang, Jie Zheng
2014Journal of Molecular Structure110 citations Open access
Semantic Scholar
Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations
Yuan-Yuan Cui, Fan Yang, Xu Cao, Vladimir Yarov-Yarovoy +2 more
2012The Journal of General Physiology106 citations Open access
Semantic Scholar
The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel
Fan Yang, Xian Xiao, B. Lee, S. Vu +3 more
2018Nature Communications87 citations Open access
Semantic Scholar
Heteromerization of TRP channel subunits: extending functional diversity
W. Cheng, Chang-Sen Sun, Jie Zheng
2010Protein & Cell83 citations Open access
Semantic Scholar
Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations
Seungil Kim, Devin M. Barry, Xian-Yu Liu, Shi-Jin Yin +12 more
2016Science Signaling82 citations Open access
Semantic Scholar
Molecular basis for heat desensitization of TRPV1 ion channels
Lei Luo, Yun-Fei Wang, Bowen Li, Li-Zhen Xu +5 more
2019Nature Communications81 citations Open access
Semantic Scholar
A non-covalent ligand reveals biased agonism of the TRPA1 ion channel
Chang Liu, Rebecca M. Reese, S. Vu, L. Rougé +20 more
2020Neuron80 citations Open access
Semantic Scholar
Heteromeric Heat-sensitive Transient Receptor Potential Channels Exhibit Distinct Temperature and Chemical Response*
W. Cheng, Fan Yang, Shuang Liu, C. K. Colton +7 more
2011Journal of Biological Chemistry77 citations Open access
Semantic Scholar
High temperature sensitivity is intrinsic to voltage-gated potassium channels
Fan Yang, Jie Zheng
2014eLife74 citations Open access
Semantic Scholar
Intracellular Proton-mediated Activation of TRPV3 Channels Accounts for the Exfoliation Effect of α-Hydroxyl Acids on Keratinocytes*
Xu Cao, Fan Yang, Jie Zheng, Ke-Wei Wang
2012Journal of Biological Chemistry67 citations Open access
Semantic Scholar
Divalent cations activate TRPV1 through promoting conformational change of the extracellular region
Fan Yang, Lin-Lin Ma, Xu Cao, Ke-Wei Wang +1 more
2014The Journal of General Physiology61 citations Open access
Semantic Scholar
Structural mechanisms underlying activation of TRPV1 channels by pungent compounds in gingers
Yue Yin, Ya-Wen Dong, S. Vu, Fan Yang +3 more
2019British Journal of Pharmacology59 citations Open access
Semantic Scholar
FRET analysis of protein tyrosine kinase c-Src activation mediated via aryl hydrocarbon receptor
B. Dong, W. Cheng, Wen Li, Jie Zheng +3 more
2010Biochimica et Biophysica Acta53 citations Open access
Semantic Scholar
Rational design and validation of a vanilloid-sensitive TRPV2 ion channel
Fan Yang, S. Vu, Vladimir Yarov-Yarovoy, Jie Zheng
2016Proceedings of the National Academy of Sciences of the United States of America52 citations Open access
Semantic Scholar
Divalent cations potentiate TRPV1 channel by lowering the heat activation threshold
Xu Cao, Lin-Lin Ma, Fan Yang, Ke-Wei Wang +1 more
2014The Journal of General Physiology52 citations Open access
Semantic Scholar
A distinct structural mechanism underlies TRPV1 activation by piperine
Ya-Wen Dong, Yue Yin, S. Vu, Fan Yang +3 more
2019Biochemical and Biophysical Research Communications - BBRC51 citations Open access
Semantic Scholar
A bimodal activation mechanism underlies scorpion toxin–induced pain
Shilong Yang, Fan Yang, Bei Zhang, B. Lee +4 more
2017Science Advances49 citations Open access
Semantic Scholar
Gain-of-Function Mutations in TRPM4 Activation Gate Cause Progressive Symmetric Erythrokeratodermia.
Hui-Jun Wang, Zhe Xu, B. Lee, S. Vu +8 more
2019Journal of Investigative Dermatology46 citations Open access
Semantic Scholar
A TRPV4 Channel C-terminal Folding Recognition Domain Critical for Trafficking and Function*
Lei Lei, Xu Cao, Fan Yang, D. Shi +3 more
2013Journal of Biological Chemistry44 citations Open access
Semantic Scholar
Prokineticin 2 Plays a Pivotal Role in Psoriasis
Xiaoqin He, Chuan-Bin Shen, Qiumin Lu, Jiong Li +8 more
2016EBioMedicine36 citations Open access
Semantic Scholar
Identification of a Tetrameric Assembly Domain in the C Terminus of Heat-activated TRPV1 Channels*
Feng Zhang, Shuang Liu, Fan Yang, Jie Zheng +1 more
2011Journal of Biological Chemistry35 citations Open access
Semantic Scholar
Movement of hClC-1 C-termini during common gating and limits on their cytoplasmic location.
Lin-Lin Ma, G. Rychkov, E. Bykova, Jie Zheng +1 more
2011Biochemical Journal35 citations
Semantic Scholar
Nicotinic Acid Activates the Capsaicin Receptor TRPV1 – A Potential Mechanism for Cutaneous Flushing
Lin-Lin Ma, B. Lee, Rong-Rong Mao, Anping Cai +5 more
2014Arteriosclerosis, Thrombosis and Vascular Biology34 citations Open access
Semantic Scholar
Structure and function of the thermoTRP channel pore.
Jie Zheng, Lin-Lin Ma
2014Current topics in membranes31 citations
Semantic Scholar
An Unorthodox Mechanism Underlying Voltage Sensitivity of TRPV1 Ion Channel
Fan Yang, Li-Zhen Xu, B. Lee, Xian Xiao +2 more
2020bioRxiv29 citations Open access
Semantic Scholar
PSD-95 regulates D1 dopamine receptor resensitization, but not receptor-mediated Gs-protein activation
Peihua Sun, Jingru Wang, W. Gu, Wei Cheng +4 more
2009Cell Research29 citations Open access
Semantic Scholar
Proton block of proton-activated TRPV1 current
B. Lee, Jie Zheng
2015The Journal of General Physiology28 citations Open access
Semantic Scholar
Nicotinic Acid is a Common Regulator of Heat-Sensing TRPV1-4 Ion Channels
Lin-Lin Ma, B. Lee, Heather L. Clifton, S. Schaefer +1 more
2015Scientific Reports27 citations Open access
Semantic Scholar
Molecular mechanism of the tree shrew’s insensitivity to spiciness
Yalan Han, Bowen Li, Ting-Ting Yin, Cheng Xu +10 more
2018PLoS Biology24 citations Open access
Semantic Scholar
A simple device to illustrate the Einthoven triangle.
Benjamin E. Jin, H. Wulff, J. Widdicombe, Jie Zheng +2 more
2012Advances in Physiology Education24 citations Open access
Semantic Scholar
A centipede toxin causes rapid desensitization of nociceptor TRPV1 ion channel
A. Zhu, Aerziguli Aierken, Zhi-Hao Yao, S. Vu +4 more
2020Toxicon19 citations Open access
Semantic Scholar
A specialized pore turret in the mammalian cation channel TRPV1 is responsible for distinct and species-specific heat activation thresholds
Guangxu Du, Yu-Hua Tian, Zhi-Hao Yao, S. Vu +4 more
2020Journal of Biological Chemistry19 citations Open access
Semantic Scholar
The Latoia consocia Caterpillar Induces Pain by Targeting Nociceptive Ion Channel TRPV1
Zhi-Hao Yao, P. Kamau, Yalan Han, Jingmei Hu +5 more
2019Toxins16 citations Open access
Semantic Scholar
FRET and Its Biological Application as a Molecular Ruler
Jie Zheng
201015 citations
Semantic Scholar
Surfactant cocamide monoethanolamide causes eye irritation by activating nociceptor TRPV1
Fang Zhao, Shuangyan Wang, Yan Li, Jin Wang +9 more
2021British Journal of Pharmacology14 citations Open access
Semantic Scholar
New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket
S. Vu, Vikrant Singh, H. Wulff, Vladimir Yarov-Yarovoy +1 more
2020eLife14 citations Open access
Semantic Scholar
Exploring functional roles of TRPV1 intracellular domains with unstructured peptide-insertion screening
Lin-Lin Ma, Fan Yang, S. Vu, Jie Zheng
2016Scientific Reports13 citations Open access
Semantic Scholar
TRPV1 Channels Are Involved in Niacin-induced Cutaneous Vasodilation in Mice
Heather L. Clifton, B. Inceoglu, Lin-Lin Ma, Jie Zheng +1 more
2014Journal of Cardiovascular Pharmacology13 citations Open access
Semantic Scholar
Domain–domain interactions in ion channels
Jie Zheng
2013The Journal of General Physiology11 citations Open access
Semantic Scholar
De Novo Design of Peptidic Positive Allosteric Modulators Targeting TRPV1 with Analgesic Effects
Li-Zhen Xu, Heng Zhang, Yun-Fei Wang, Xian-Cui Lu +7 more
2021Advancement of science10 citations Open access
Semantic Scholar
Reply to Yao et al.: Is the pore turret just thermoTRP channels’ appendix?
Fan Yang, Yuan-Yuan Cui, Ke-Wei Wang, Jie Zheng
2010Proceedings of the National Academy of Sciences of the United States of America10 citations Open access
Semantic Scholar
Distribution and Assembly of TRP Ion Channels.
Wei Cheng, Jie Zheng
2021Advances in Experimental Medicine and Biology7 citations
Semantic Scholar
Opening of capsaicin receptor TRPV1 is stabilized equally by its four subunits
Shi-Sheng Li, P. Nguyen, S. Vu, Vladimir Yarov-Yarovoy +1 more
2023Journal of Biological Chemistry6 citations Open access
Semantic Scholar
The tetramerization domain potentiates Kv4 channel function by suppressing closed-state inactivation.
Yiquan Tang, Jing-heng Zhou, Fan Yang, Jie Zheng +1 more
2014Biophysical Journal6 citations Open access
Semantic Scholar