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P. Costello · SciRah

Researcher profile · Semantic Scholar

P. Costello

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P. Costello — researcher profile on SciRah

h-index: 16
Works: 25
Citations: 2,754

Most-cited papers

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
M. Turner, P. Mee, P. Costello, O. Williams +5 more
1995Nature779 citations
Semantic Scholar
A Critical Role for Syk in Signal Transduction and Phagocytosis Mediated by Fcγ Receptors on Macrophages
M. Crowley, P. Costello, C. Fitzer-Attas, M. Turner +4 more
1997Journal of Experimental Medicine542 citations Open access
Semantic Scholar
Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells.
P. Costello, M. Turner, A. Walters, C. Cunningham +3 more
1996Oncogene318 citations
Semantic Scholar
The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways.
P. Costello, A. Walters, P. Mee, Martin Turner +5 more
1999Proceedings of the National Academy of Sciences of the United States of America272 citations Open access
Semantic Scholar
Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse
P. Costello, M. Gallagher, D. Cantrell
2002Nature Immunology244 citations
Semantic Scholar
Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr.
C. Vines, J. Potter, Ying-Jie Xu, R. Geahlen +6 more
2001Immunity96 citations Open access
Semantic Scholar
Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase‐deficient mice
P. Mee, M. Turner, M. Basson, P. Costello +2 more
1999European Journal of Immunology91 citations Open access
Semantic Scholar
Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection
P. Costello, R. Nicolas, Yasuyuki Watanabe, I. Rosewell +1 more
2004Nature Immunology90 citations
Semantic Scholar
The Gtpase Rho Controls a P53-Dependent Survival Checkpoint during Thymopoiesis
P. Costello, S. Cleverley, R. Galandrini, S. Henning +1 more
2000Journal of Experimental Medicine65 citations Open access
Semantic Scholar
The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto‐phosphorylated in vitro
Lucy MacCarthy Morrogh, S. Hinshelwood, P. Costello, G. Cory +1 more
1999European Journal of Immunology61 citations
Semantic Scholar
Loss of Rho function in the thymus is accompanied by the development of thymic lymphoma
Steve Cleverley, P. Costello, S. Henning, D. A. Cantrell
2000Oncogene48 citations
Semantic Scholar
Thymocyte Development but Not Net, Are Functionally Equivalent in Ternary Complex Factors SAP-1 and Elk-1,
P. Costello, R. Nicolas, J. Willoughby, B. Wasylyk +2 more
201038 citations
Semantic Scholar
MRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development.
P. Costello, Mathew Sargent, Diane Maurice, C. Esnault +3 more
2015Blood28 citations Open access
Semantic Scholar
The Essential Function for Serum Response Factor in T-Cell Development Reflects Its Specific Coupling to Extracellular Signal-Regulated Kinase Signaling
A. Mylona, R. Nicolas, Diane Maurice, Mathew Sargent +4 more
2010Molecular and Cellular Biology27 citations Open access
Semantic Scholar
ERK Signaling Controls Innate-like CD8+ T Cell Differentiation via the ELK4 (SAP-1) and ELK1 Transcription Factors
Diane Maurice, P. Costello, Mathew Sargent, R. Treisman
2018Journal of Immunology23 citations Open access
Semantic Scholar
Raf signalling but not the ERK effector SAP-1 is required for regulatory T cell development
J. Willoughby, P. Costello, R. Nicolas, Nicholas J. Robinson +3 more
2007Journal of Immunology19 citations Open access
Semantic Scholar
Usefulness of a flow cytometric analysis of intraplatelet vasodilator-stimulated phosphoprotein phosphorylation for the detection of patients with genetic defects of the platelet P2Y 12 receptor for ADP
K. Suzuki-Inoue, Gemma L. J. Fuller, Ángel García, S. Pöhlmann +21 more
20107 citations
Semantic Scholar
IL-2 delivery to CD8+ T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics
Diane Maurice, P. Costello, Jessica Diring, Francesco Gualdrini +2 more
2024Nature Communications3 citations Open access
Semantic Scholar
The MRTFs are required for thymocyte trafficking and Treg-mediated immune tolerance
P. Costello, Diane Maurice, María Benito-Jardón, Richard Treisman
2026bioRxiv0 citations Open access
Semantic Scholar
Penetrant PKCβ mutation in ATLL displays a mixed gain-of-function
Sophie J L Brown, D. Briggs, P. Costello, Hiroko Yaguchi +3 more
2025Biochemical Journal0 citations Open access
Semantic Scholar
Defective cytoskeletal dynamics underlies the essential role of MRTF-SRF in IL-2 delivery to CD8+ T cells during infectious challenge
Diane Maurice, P. Costello, Francesco Gualdrini, Bruno Frederico +1 more
2023bioRxiv0 citations Open access
Semantic Scholar
This information is current as Thymocyte Development but Not Net , Are Functionally Equivalent in Ternary Complex Factors SAP-1 and Elk
P. Costello, R. Nicolas, J. Willoughby, B. Wasylyk +2 more
20100 citations
Semantic Scholar
Thymocyte Development but Not Net , Are Functionally Equivalent in Ternary Complex Factors SAP-1 and Elk
P. Costello, Robert Nicolas, J. Willoughby, B. Wasylyk +2 more
20100 citations
Semantic Scholar
Thymocyte Development but Not Net , Are Functionally Equivalent in Ternary Complex Factors SAP-1 and Elk
P. Costello, Robert Nicolas, J. Willoughby, B. Wasylyk +2 more
20100 citations
Semantic Scholar
The role of 5' and 3' sequences in the control of HPRT gene expression
P. Costello
19930 citations
Semantic Scholar

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